Periventricular leucomalacia: a review.

Abstract:

UNLABELLED:Periventricular leucomalacia is a condition that causes lifelong disability and considerable economic burden. It occurs in premature infants of less than 32 weeks gestation due to their unique anatomical features. The white matter of these infants is poorly vascularised and contains oligodendrocyte progenitors (pre-oligodendrocytes), which are sensitive to the effects of ischaemia and infection. Only recently have newer imaging techniques identified both a diffuse and focal component of white matter damage. The most immature infants with diffuse injury develop white matter atrophy and ventriculomegaly; others with focal injury have cyst formation, resorption and gliosis. Since the original description by Virchow in 1867, much progress has been made in establishing the underlying cause of this condition. It is an ischaemia reperfusion injury of the white matter, free radicals being the final pathway to pre-oligodendrocyte destruction and impaired myelination. Contributory factors include hypotension, hypocarbia and infection. CONCLUSION:new imaging and EEG techniques are likely to improve our ability to predict disability in this vulnerable group of infants. Research is needed into blocking the pathway to pre-oligodendrocyte destruction and the safe use of free radical scavengers.

journal_name

Eur J Pediatr

authors

Blumenthal I

doi

10.1007/s00431-004-1477-y

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

435-42

issue

8

eissn

0340-6199

issn

1432-1076

journal_volume

163

pub_type

杂志文章,评审
  • Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case.

    abstract::Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to the macrophage--histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteris...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01957571

    authors: Paulli M,Locatelli F,Kindl S,Boveri E,Facchetti F,Porta F,Rosso R,Nespoli L,Magrini U

    更新日期:1992-09-01 00:00:00

  • Benign papilloma of the cervix in childhood: immunohistochemical findings and review of the literature.

    abstract:UNLABELLED:Papillomas of the genital region are rare benign tumours causing sanguineous vaginal discharge in prepubertal girls. We report on a papilloma of the cervix in a 2-year-old girl. We characterize the tumour immunohistochemically and give a brief review about the current literature. CONCLUSION:Genital tract pa...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s004310050609

    authors: Schmedding A,Zense M,Fuchs J,Glüer S

    更新日期:1997-04-01 00:00:00

  • Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: a cohort study.

    abstract:UNLABELLED:Implementation of guidelines for group B streptococcal (GBS) prepartum screening (PS) rarely has been prospectively evaluated. To assess PS at 35-37 weeks of gestation and compare its predictive value to that of an intrapartum screening (IS) within 7 days of delivery, a surveillance cohort study was conducte...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2548-y

    authors: Kunze M,Zumstein K,Markfeld-Erol F,Elling R,Lander F,Prömpeler H,Berner R,Hufnagel M

    更新日期:2015-06-01 00:00:00

  • Glucose phosphate isomerase deficiency: biochemical and molecular genetic studies on the enzyme variants of two patients with severe haemolytic anaemia.

    abstract:UNLABELLED:Biochemical and molecular genetic studies were performed on the enzyme variants of two patients compound heterozygous for glucose phosphate isomerase (GPI) deficiency, both suffering from severe haemolytic anaemia. The enzymes of case 1 (GPI 'Zwickau') and case 2 (GPI 'Nordhorn' [25]), revealed reduced GPI a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050674

    authors: Huppke P,Wünsch D,Pekrun A,Kind R,Winkler H,Schröter W,Lakomek M

    更新日期:1997-08-01 00:00:00

  • Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases.

    abstract::Health-related quality of life (HRQOL) is an important indicator of the burden of illness in moderate-to-severe plaque psoriasis. This study evaluated self-reported generic HRQOL among pediatric patients with moderate-to-severe plaque psoriasis based on pooled baseline clinical trial data and compared them to four com...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1587-2

    authors: Varni JW,Globe DR,Gandra SR,Harrison DJ,Hooper M,Baumgartner S

    更新日期:2012-03-01 00:00:00

  • Asymmetric dimethylarginine as a potential biomarker for management and follow-up of phenylketonuria.

    abstract::Phenylketonuria's (PKU) treatment based on low-protein diet may affect other metabolic pathways, such as that of asymmetric dimethylarginine (ADMA). The aim of this study was to evaluate the reliability of ADMA as a biomarker of adequate metabolic control and possible nutritional risk in a long-term PKU patient popula...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00431-019-03365-0

    authors: Andrade F,Villate O,Couce ML,Bueno MA,Alcalde C,de Las Heras J,Ceberio L,Núñez-Marcos S,Nambo PS,Aldámiz-Echevarría L

    更新日期:2019-06-01 00:00:00

  • Implantable cardioverter defibrillator implantation in children in The Netherlands.

    abstract:UNLABELLED:To evaluate the indications, underlying cardiac disorders, efficacy and complications involved with implantable cardioverter-defibrillators (ICDs) in paediatric patients in The Netherlands, the records of all patients aged 18 years or younger who underwent ICD placement were reviewed retrospectively. Between...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-005-1668-1

    authors: Ten Harkel AD,Blom NA,Reimer AG,Tukkie R,Sreeram N,Bink-Boelkens MT

    更新日期:2005-07-01 00:00:00

  • Pulse oximetry used for documenting oxygen saturation and right-to-left shunting immediately after birth.

    abstract::The objective of this study was to investigate the clinical applicability of pulse oximetry to measure haemoglobin oxygen saturation and heart rate in the first 20 min of life and to analyse the effect of pre- or post-ductal (hand, respectively, foot) fixation of sensors on oxygen saturation. Measurements were carried...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02072072

    authors: Meier-Stauss P,Bucher HU,Hürlimann R,König V,Huch R

    更新日期:1990-09-01 00:00:00

  • A novel missense mutation in SUCLG1 associated with mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria.

    abstract::Mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria is associated with mutations in SUCLA2, the gene encoding a beta subunit of succinate-CoA ligase, where 17 patients have been reported. Mutations in SUCLG1, encoding the alpha subunit of the enzyme, have been reported in only one family,...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-009-1007-z

    authors: Ostergaard E,Schwartz M,Batbayli M,Christensen E,Hjalmarson O,Kollberg G,Holme E

    更新日期:2010-02-01 00:00:00

  • Hepatotoxicity of rifampicin and isoniazid in children treated for tuberculosis.

    abstract::In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441477

    authors: Linna O,Uhari M

    更新日期:1980-09-01 00:00:00

  • Evaluation of the current use of imaging modalities and pathogen detection in children with acute osteomyelitis and septic arthritis.

    abstract::Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA be...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-018-3157-3

    authors: Manz N,Krieg AH,Heininger U,Ritz N

    更新日期:2018-07-01 00:00:00

  • The role of IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's obesity.

    abstract:UNLABELLED:The aim of this study was to establish the correlations between the polymorphisms of the genes interleukin (IL)-6 572, 190, and 174 in obese children. We assessed 222 hospitalized children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-014-2315-5

    authors: Oana MC,Claudia B,Carmen D,Maria PA,Septimiu V,Claudiu M

    更新日期:2014-10-01 00:00:00

  • The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia.

    abstract::L-asparaginase is an effective antileukaemic drug and a potent inhibitor of hepatic protein synthesis. Its effect on lipid metabolism was studied in two cohorts of children with ALL, one of whom received L-asparaginase concomitantly with three other drugs (protocol BFM 79). In the second protocol (BFM 83) administrati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442614

    authors: Cremer P,Lakomek M,Beck W,Prindull G

    更新日期:1988-01-01 00:00:00

  • Pulmonary alveolar proteinosis in infants.

    abstract:UNLABELLED:We investigated the histological and molecular characteristics of pulmonary alveolar proteinosis (PAP) in two siblings (a brother and sister) who did not exhibit respiratory distress at birth but who each developed symptoms during infancy. Histological analysis of lung specimens showed positive staining for ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051107

    authors: Sakai Y,Abo W,Yoshimura H,Sano H,Kuroki Y,Satoh M,Kaimori M

    更新日期:1999-05-01 00:00:00

  • Lung function testing--useless in ventilated newborns?

    abstract::Several methods have been used for lung function testing in the ventilated newborn. The interest in the field has been stimulated by the recent appearance of commercially available equipment for assessment of mechanical parameters and of functional residual capacity in this group. Nevertheless, lung function testing i...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02179669

    authors: Hjalmarson O

    更新日期:1994-01-01 00:00:00

  • Arterial versus venous lactate: a measure of sepsis in children.

    abstract::This study assessed the agreement between arterial and venous blood lactate and pH levels in children with sepsis. This retrospective, three-year study involved 60 PICU patients, with data collected from electronic or paper patient records. The inclusion criteria comprised of children (≤17 years old) with sepsis and t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-2925-9

    authors: Samaraweera SA,Gibbons B,Gour A,Sedgwick P

    更新日期:2017-08-01 00:00:00

  • Unexpected side-effects of inhaled steroids: a case report.

    abstract::An asthmatic child is presented who developed a cushingoid appearance with evidence of adrenal suppression and growth impairment while on low dose inhaled topical steroids. When the inhaled steroids were replaced by inhaled sodium cromoglycate his adrenal function recovered while his appearance and growth returned to ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02093730

    authors: Priftis K,Everard ML,Milner AD

    更新日期:1991-04-01 00:00:00

  • Infrared thermography: experience from a decade of pediatric imaging.

    abstract::The aim of this study was to evaluate the feasibility of clinical application of infrared thermography (IRT) in the pediatric population and to identify pathological states that can be diagnosed as well as followed up using this non-invasive technique. In real time computer-assisted IRT, 483 examinations were performe...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-007-0583-z

    authors: Saxena AK,Willital GH

    更新日期:2008-07-01 00:00:00

  • A further case of renal tubular dysgenesis surviving the neonatal period.

    abstract::Renal tubular dysgenesis is a critical disorder characterized by the Potter phenotype and severe hypotension in the early neonatal period. We herein report a 3-year-old female with renal tubular dysgenesis. Endocrinological studies showed a high plasma renin activity (over 49.2 ng/ml/h; normal range 2.0-15.2), high ac...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0743-9

    authors: Uematsu M,Sakamoto O,Ohura T,Shimizu N,Satomura K,Tsuchiya S

    更新日期:2009-02-01 00:00:00

  • Rheumatoid arthritis and growth retardation in children: treatment with human growth hormone.

    abstract::Twenty patients with rheumatoid arthritis or Still's disease associated with growth failure were treated with human growth hormone, 7.5 to 17 U/m2 body surface per week. Five patients did not respond with better growth. In the remainder the mean growth rate increased from 1.9 cm/year (range: 0 to 3.3) to 6.2 cm/year (...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441894

    authors: Butenandt O

    更新日期:1979-01-18 00:00:00

  • Regulation of galactose-1-phosphate uridyltransferase gene expression.

    abstract::Analysis of both the human and rat galactose-1-phosphate uridyltransferase (GALT) genes reveal 5' regulatory consensus sequences suggestive of a housekeeping gene. This is in accord with the finding of GALT activity in all tissues. However, the complications seen in galactosemia, in particular ovarian dysfunction and ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02143799

    authors: Heidenreich RA

    更新日期:1995-01-01 00:00:00

  • Beta2-microglobulin concentrations in cerebrospinal fluid correlate with neuroimaging findings in newborns with symptomatic congenital cytomegalovirus infection.

    abstract:OVERVIEW:In newborns with symptomatic congenital cytomegalovirus (CMV) infection, neuroimaging is the best available predictor of neurodevelopmental outcome. Cerebrospinal fluid (CSF) findings in congenital CMV infection have seldom been described. Neonates with central nervous system infections present high CSF Beta(2...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0160-x

    authors: Alarcon A,Garcia-Alix A,Cabañas F,Hernanz A,Pascual-Salcedo D,Martin-Ancel A,Cabrera M,Tagarro A,Quero J

    更新日期:2006-09-01 00:00:00

  • Early fluid overload is associated with mortality and prolonged mechanical ventilation in extremely low birth weight infants.

    abstract::Recent studies revealed that fluid overload is associated with higher mortality in critically ill children and adults. This study aimed to evaluate the association between fluid overload in the first 3 days of life and mortality in extremely low birth weight infants. This single-center retrospective cohort study inclu...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03654-z

    authors: Matsushita FY,Krebs VLJ,Ferraro AA,de Carvalho WB

    更新日期:2020-11-01 00:00:00

  • Postnatal course of plasma levels of adrenocortical steroids in premature infants with and without NaCl supplementation.

    abstract::To assess the adrenocortical response of premature infants to alterations in sodium balance, the postnatal course of plasma progesterone, 11-deoxycorticosterone, corticosteronoe, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone was compared in healthy premature infants kept on low (1-2 mEq...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441415

    authors: Sulyok E,Dörr HG,Ertl T,Gyódi G

    更新日期:1988-12-01 00:00:00

  • Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis.

    abstract:UNLABELLED:Increased plasma tumour necrosis factor alpha (TNF) concentration correlates with mortality in sepsis. We suggested that pentoxifylline (PTXF), which is known to inhibit TNF production, may improve survival and attenuate clinical symptoms of sepsis in neonates. Plasma TNF levels were evaluated in 29 newborn ...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01955273

    authors: Lauterbach R,Zembala M

    更新日期:1996-05-01 00:00:00

  • Response to single oral dose vitamin D in obese vs non-obese vitamin D-deficient children.

    abstract::Obese individuals are prone to vitamin D deficiency because of sequestration of vitamin D in their body fat. We planned to evaluate the rise in serum 25(OH)D levels in vitamin D-deficient obese vs normal body mass index(BMI) children, after administration of identical single dose of vitamin D. Twenty-two obese and 22 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03831-0

    authors: Tayde A,Mittal M,Khadgawat R,Sharma S,Sreenivas V,Rai A

    更新日期:2020-10-12 00:00:00

  • Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey.

    abstract:UNLABELLED:Ischaemic stroke is a rare event in childhood. In approximately one-fourth of cases an underlying cardiac disease can be detected. We investigated the importance of genetic risk factors of venous thromboembolism in childhood or stroke in adulthood as risk factors for ischaemic stroke in children in a multice...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/pl00014336

    authors: Sträter R,Vielhaber H,Kassenböhmer R,von Kries R,Göbel U,Nowak-Göttl U

    更新日期:1999-12-01 00:00:00

  • Immunocytochemical detection of neuroblastoma cells infiltrating clinical bone marrow samples.

    abstract::To evaluate the feasibility and clinical usefulness of immunocytochemical detection of bone marrow metastases in neuroblastoma, we studied bone marrow samples from patients undergoing intensive therapy, followed in the majority of cases by autologous bone marrow rescue. Two monoclonal antibodies were used in an indire...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442474

    authors: Beck D,Maritaz O,Gross N,Favrot M,Vultier N,Bailly C,Villa I,Gentilhomme O,Philip T

    更新日期:1988-08-01 00:00:00

  • COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities.

    abstract::Data show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and de...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-020-03801-6

    authors: Williams N,Radia T,Harman K,Agrawal P,Cook J,Gupta A

    更新日期:2020-09-10 00:00:00

  • A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging.

    abstract:UNLABELLED:The pathogenesis of sporadic hemiplegic migraine remains unclear, and perfusion-weighted magnetic resonance imaging (PWI) has been used for characterization of hemodynamic changes in migraine aura. We report a case of sporadic hemiplegic migraine in which magnetic resonance perfusion imaging showed left cere...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2609-2

    authors: Kim S,Kang M,Choi S

    更新日期:2016-02-01 00:00:00