Low thyroxinaemia occurs in the majority of very preterm newborns.

Abstract:

UNLABELLED:Transient hypothyroxinaemia with normal thyroid stimulating hormone (TSH) levels is a well-known condition in preterm neonates and is generally assumed to be a harmless epiphenomenon of prematurity. This assumption is, however, based on studies that included very few neonates with a gestational age (GA) below 30 weeks. We therefore measured serum free thyroxine (FT4) and serum TSH on days 1 and 14 in 263 neonates with a GA between 26 and 41 weeks. In 13 infants (5%), transient hypothyroidism (low FT4 and TSH >20 mU/l on day 14) was found. In the remaining 250 patients FT4 on days 1 and 14 but not TSH correlated positively with GA. In neonates with a GA of 35-41 weeks, FT4 increased postnatally to levels within or above the normal adult range. In contrast, in the very preterm group (26-31 weeks) the already low FT4 levels declined to values significantly below the range observed in term neonates. A significant proportion of these neonates had FT4 levels within the hypothyroid range. There was no difference in thyroid function between neonates treated with povidone-iodine or chlorhexidine. CONCLUSION:Very preterm neonates have FT4 levels on day 14 that are much lower than is generally assumed while TSH remains in the normal range. We therefore propose to measure FT4 in all preterms with a GA below 33 weeks, during the 2nd week of life.

journal_name

Eur J Pediatr

authors

Rooman RP,Du Caju MV,De Beeck LO,Docx M,Van Reempts P,Van Acker KJ

doi

10.1007/BF01953940

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

211-5

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

155

pub_type

杂志文章
  • Clinical practice: neonatal resuscitation. A Dutch consensus.

    abstract::The updated Dutch guidelines on Neonatal Resuscitation assimilate the latest evidence in neonatal resuscitation. Important changes with regard to the 2004 guidelines and controversial issues concerning neonatal resuscitation are reviewed, and recommendations for daily practice are provided and argued in the context of...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-009-1091-0

    authors: van den Dungen FA,van Veenendaal MB,Mulder AL

    更新日期:2010-05-01 00:00:00

  • Hypercalcaemia in cerebellar medulloblastoma: pathogenesis of solid tumour-associated hypercalcaemia.

    abstract::A 7-year-old boy developed acute, severe hypercalcaemia following the partial excision of a cerebellar medulloblastoma. The serum calcium level was extremely high (19.8 mg/100 ml), but a skeletal survey revealed no apparent bone metastatic lesions; such lesions were only detected by X-ray 3 weeks after the onset of hy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00444958

    authors: Arisaka O,Obinata K,Yabuta K,Ishimoto K,Sato K

    更新日期:1987-07-01 00:00:00

  • The effect of obesity, age, puberty and gender on resting metabolic rate in children and adolescents.

    abstract:UNLABELLED:During puberty fat-free mass (FFM) and fat mass (FM) change quickly and these changes are influenced by sex and obesity. Since it is not completely known how these changes affect resting metabolic rate (RMR), the aim of the present study was to investigate the effect of body composition, age, sex and puberta...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050618

    authors: Molnár D,Schutz Y

    更新日期:1997-05-01 00:00:00

  • Phenytoin elimination kinetics in two children with drug intoxication.

    abstract::Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 microgram/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Mente...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00445896

    authors: Abe K,Okano M,Sasaki H

    更新日期:1980-10-01 00:00:00

  • Somatomedin-binding proteins: what role do they play in the growth process?

    abstract::The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01995850

    authors: Cianfarani S,Holly JM

    更新日期:1989-11-01 00:00:00

  • Obstructive endocarditis in an immunodeficient infant.

    abstract::We report the case of 5-week-old male infant who presented as a 'near miss cot death'. He had the immunodeficient syndrome of defective neutrophil mobility and delayed umbilical cord separation. He was shown to have staphylococcal endocarditis with a large vegetation on the mitral valve, and acute obstruction of the m...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02429063

    authors: Walters MD,Deanfield JE,Robinson PJ,Matthew DJ

    更新日期:1986-12-01 00:00:00

  • Complement studies in children with treated coeliac disease after gluten challenge.

    abstract::Changes of the complement components in the sera of 13 children with treated coeliac disease were studied after gluten challenge. The levels of C 1 and C3-activator (factor B) were significantly decreased at 4 h after the challenge, as were the levels of total complement (CH 50) and the components C 1, C 4 and C 1-ina...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01846034

    authors: Bosch C,Becker M,Rotthauwe HW,Opferkuch W

    更新日期:1980-08-01 00:00:00

  • Pseudohyperkalaemia in Kawasaki disease.

    abstract::Pseudohyperkalaemia was observed in 3 of 16 patients with Kawasaki disease showing remarkably increased platelet counts. Their plasma potassium concentration, which is not affected by in vitro coagulation, was in the normal range despite the increased serum level. A significant correlation was observed between the pla...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01957752

    authors: Shimizu T,Yamashiro Y,Yabuta K

    更新日期:1992-07-01 00:00:00

  • Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.

    abstract:INTRODUCTION:IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma. MATERIALS AND METHODS:We genotyped 650 children for allelic determinants at tw...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-009-0960-x

    authors: Kim ES,Kim SH,Kim KW,Park HS,Shin ES,Lee JE,Sohn MH,Kim KE

    更新日期:2009-12-01 00:00:00

  • A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia.

    abstract::Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. All 39 achondroplasia alleles studied so far carried point mutations which caused the same amino acid exchange, a substitution of glycine by arg...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954274

    authors: Superti-Furga A,Eich G,Bucher HU,Wisser J,Giedion A,Gitzelmann R,Steinmann B

    更新日期:1995-03-01 00:00:00

  • Two novel glucose-6-phosphate dehydrogenase variants found in newborn mass-screening for galactosaemia.

    abstract:UNLABELLED:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disorder in which haemolytic anaemia is the major symptom. The Beutler spot test employed in mass-screening for galactosaemia in newborns requires several intrinsic erythrocyte enzymes such as G6PD for its reaction and can theoretic...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310000652

    authors: Okano Y,Fujimoto A,Miyagi T,Hirono A,Miwa S,Niihira S,Hirokawa H,Yamano Y

    更新日期:2001-02-01 00:00:00

  • A comparison of ceftazidime and aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. European Society for Paediatric Infectious Diseases--Neonatal Sepsis Study Group.

    abstract::We report a prospective, non-blind, randomised, multicentre, parallel group, multinational investigation to compare ceftazidime to aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. In each of the 15 study centres either ceftazidime alone (CAZ) or ceftazidime + ampic...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/BF01954122

    authors: de Louvois J,Dagan R,Tessin I

    更新日期:1992-12-01 00:00:00

  • Relapsing acute encephalopathy: a complication of diphtheria-tetanus-poliomyelitis immunization in a young boy.

    abstract:UNLABELLED:Neurological complications of immunizations are rare. We report the case of relapsing acute encephalitis in a boy after two subsequent diphtheria-tetanus-poliomyelitis vaccinations. First the clinical signs were those of acute disseminated encephalitis. During the second episode, the boy experienced optic ne...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02075768

    authors: Mancini J,Chabrol B,Moulene E,Pinsard N

    更新日期:1996-02-01 00:00:00

  • Septic arthritis of the hip by Fusobacterium necrophorum after tonsillectomy: a form of Lemierre syndrome?

    abstract:UNLABELLED:Lemierre syndrome used to be a complication of severe oropharyngeal infection with regional thrombophlebitis, septicaemia and septic metastatic infections caused by Fusobacterium necrophorum in the pre-antibiotic era. A case of septic arthritis of the hip caused by F. necrophorum as a complication of tonsill...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050730

    authors: Beldman TF,Teunisse HA,Schouten TJ

    更新日期:1997-11-01 00:00:00

  • Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.

    abstract::We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later,...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01957499

    authors: Kauschansky A,Frydman M,Nussinovitch M,Varsano I

    更新日期:1995-11-01 00:00:00

  • Osteoporosis-pseudoglioma syndrome: clinical, genetic, and treatment-response study of 10 new cases in Greece.

    abstract::Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal-recessive disorder, characterized by severe osteoporosis and early-onset blindness. Loss of function mutations in the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5) have been established as the genetic defect of the disease. We repo...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-018-3299-3

    authors: Papadopoulos I,Bountouvi E,Attilakos A,Gole E,Dinopoulos A,Peppa M,Nikolaidou P,Papadopoulou A

    更新日期:2019-03-01 00:00:00

  • Elective cesarean delivery at term and the long-term risk for respiratory morbidity of the offspring.

    abstract::Maternal morbidity is associated with cesarean deliveries. However, new evidence suggests that short- and long-term neonatal morbidity is also associated. This includes respiratory morbidity with conflicting results. To determine whether mode of delivery has an impact on the long-term risk for respiratory morbidity in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-018-3225-8

    authors: Baumfeld Y,Walfisch A,Wainstock T,Segal I,Sergienko R,Landau D,Sheiner E

    更新日期:2018-11-01 00:00:00

  • Vascular origin of Poland syndrome? A comparative rheographic study of the vascularisation of the arms in eight patients.

    abstract::Vascularization of the arms has been studied by impedance plethysmography (rheography) in eight children with Poland syndrome, a common malformation characterized by unilateral hand anomaly and ipsilateral aplasia of the inferior head of the pectoralis major muscle. A marked decrease of the velocity of the systolic in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00496922

    authors: Bouvet JP,Leveque D,Bernetieres F,Gros JJ

    更新日期:1978-05-22 00:00:00

  • Spinal tuberculosis in a 14-year-old immigrant in the Netherlands.

    abstract::We present a case of Pott's disease, where the patient presented with neurological impairment due to vertebral granulomatous necrosis, needing immediate decompression and later stabilizing and reconstructive orthopaedic surgery, in order to create awareness for TB in general, especially this forgotten form of spinal t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0347-1

    authors: van Well GT,van der Mark LB,Vermeulen RJ,van Royen BJ,Wuisman PI,van Furth AM

    更新日期:2007-10-01 00:00:00

  • Long-term clinical effectiveness of an acellular pertussis component vaccine and a whole cell pertussis component vaccine.

    abstract:UNLABELLED:The objective of this open study was to monitor the long-term effectiveness of the Lederle-Takeda diphtheria and tetanus toxoids and acellular pertussis antigen(s) (DTaP) vaccine and the Wyeth-Lederle diphtheria and tetanus toxoids and pertussis whole cell (DTP) vaccine in children who had received four dose...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-001-0893-5

    authors: Lugauer S,Heininger U,Cherry JD,Stehr K

    更新日期:2002-03-01 00:00:00

  • Acute idiopathic scrotal oedema: four cases and a short review.

    abstract::We report four cases of acute idiopathic scrotal oedema, an underreported cause of acute painless or moderately painfull swelling and erythema of the scrotum in young boys. It is a self-limiting disease and to prevent unnecessary surgical exploration or antibiotic therapy, it is very important to distinguish acute idi...

    journal_title:European journal of pediatrics

    pub_type: 信件

    doi:10.1007/s004310100771

    authors: van Langen AM,Gal S,Hulsmann AR,De Nef JJ

    更新日期:2001-07-01 00:00:00

  • Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence.

    abstract::Severe complications due to Shigatoxin-associated hemolytic uremic syndrome (STEC-HUS) currently present a serious challenge since no specific treatment for this condition is available. Eculizumab, a terminal complement inhibitor, has been used especially in STEC-HUS patients with severe neurological involvement, but ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-017-3077-7

    authors: Keenswijk W,Raes A,Vande Walle J

    更新日期:2018-03-01 00:00:00

  • Faltering growth in the critically ill child: prevalence, risk factors, and impaired outcome.

    abstract::Low body mass index (BMI) z score is commonly used to define undernutrition, but faltering growth allows for a complementary dynamic assessment of nutritional status. We studied the prevalence of undernutrition and faltering growth at admission in the pediatric intensive care (PICU) setting and their impacts on outcom...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00431-017-3062-1

    authors: Valla FV,Berthiller J,Gaillard-Le-Roux B,Ford-Chessel C,Ginhoux T,Rooze S,Cour-Andlauer F,Meyer R,Javouhey E

    更新日期:2018-03-01 00:00:00

  • Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl.

    abstract::Henoch-Schonlein purpura (HSP) is an inflammatory vasculitis involving the skin, joints, gastrointestinal (GI) tract, and kidneys. This is the first case report describing a 5-year-old girl with HSP presenting duodenal involvement which might be associated with superior mesenteric artery syndrome (SMAS). ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0254-5

    authors: Harada T,Machida H,Ito S,Aihara Y,Yokota S

    更新日期:2007-05-01 00:00:00

  • Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections.

    abstract::Human metapneumovirus (hMPV) is a recently discovered pathogen in respiratory tract infection. The published literature suggests milder illness severity in hMPV compared with respiratory syncytial virus (RSV) infection. In two consecutive seasons, 637 nasopharyngeal aspirates from pediatric patients were tested by hMP...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0105-4

    authors: Wilkesmann A,Schildgen O,Eis-Hübinger AM,Geikowski T,Glatzel T,Lentze MJ,Bode U,Simon A

    更新日期:2006-07-01 00:00:00

  • Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life.

    abstract::Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-018-3096-z

    authors: Janaillac M,Beausoleil TP,Barrington KJ,Raboisson MJ,Karam O,Dehaes M,Lapointe A

    更新日期:2018-04-01 00:00:00

  • Recombinant human interferon-gamma treatment in severe leucocyte adhesion deficiency.

    abstract::We describe a patient with leucocyte adhesion deficiency (LAD). Clinically, the patient had delayed umbilical cord detachment, omphalitis, impaired wound healing and persistent leucocytosis. The patient had the severe form of LAD, with a total absence of leucocyte cell adhesion molecules (LeuCAMs) and undetectable mRN...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01958952

    authors: Weening RS,Bredius RG,Vomberg PP,van der Schoot CE,Hoogerwerf M,Roos D

    更新日期:1992-02-01 00:00:00

  • Efficiency of heparin in the treatment of newborn infants with respiratory distress syndrome and disseminated intravascular coagulation.

    abstract::Forty newborns with severe shock and disseminated intravascular coagulation were randomized for treatment with heparin or placebo. Mortality was equal in both groups. The heparin group required significantly shorter periods of artificial ventilation. The coagulation system improved faster, and the coagulation pattern ...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00444754

    authors: Göbel U,von Voss H,Jürgens H,Petrich C,Pothmann R,Sprock I,Lemburg P

    更新日期:1980-01-01 00:00:00

  • Outcome and survival of 88 patients with urea cycle disorders: a retrospective evaluation.

    abstract:UNLABELLED:This paper presents data obtained by questionnaires sent to local hospitals and metabolic centres in Germany, Austria, Italy and Switzerland concerning the survival and outcome of patients with urea cycle disorders treated between 1975 and 1986. A total of 130 questionnaires were sent out of which 88 questio...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-003-1188-9

    authors: Bachmann C

    更新日期:2003-06-01 00:00:00

  • What is new in ventilation strategies for the neonate?

    abstract::A large number of ventilation strategies are now available for the neonate. This review has focused on new information, that is, studies published since 2000 and the implication of their results for current clinical practice. Meta-analysis of randomised trials has demonstrated that assist control and synchronous inter...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-007-0513-0

    authors: Greenough A,Sharma A

    更新日期:2007-10-01 00:00:00