Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.

Abstract:

:We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20 +/- 6 to 156 +/- 82 ng/dl and from 107 +/- 105 to 615 +/- 293 ng/dl, following a single hCG injection, and from 30 +/- 19 to 439 +/- 298 ng/dl and from 94 +/- 55 to 826 +/- 272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P < 0.01). Conclusion. Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis.

journal_name

Eur J Pediatr

authors

Kauschansky A,Frydman M,Nussinovitch M,Varsano I

doi

10.1007/BF01957499

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

890-2

issue

11

eissn

0340-6199

issn

1432-1076

journal_volume

154

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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    更新日期:1998-01-01 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:1999-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章

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