Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.

Abstract:

:We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20 +/- 6 to 156 +/- 82 ng/dl and from 107 +/- 105 to 615 +/- 293 ng/dl, following a single hCG injection, and from 30 +/- 19 to 439 +/- 298 ng/dl and from 94 +/- 55 to 826 +/- 272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P < 0.01). Conclusion. Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis.

journal_name

Eur J Pediatr

authors

Kauschansky A,Frydman M,Nussinovitch M,Varsano I

doi

10.1007/BF01957499

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

890-2

issue

11

eissn

0340-6199

issn

1432-1076

journal_volume

154

pub_type

临床试验,杂志文章
  • Heme oxygenase-1 expression in premature and mature neonates during the first week of life.

    abstract::Newborns are exposed to mechanical and oxidative stress during labor and to relative hyperoxia thereafter during the course of adaptation to the extrauterine conditions. Part of the adaptation mechanism is the rapid degradation of fetal hemoglobin and the oxidation of its heme moiety by heme oxygenases (HOs). Heme oxy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0375-x

    authors: Maróti Z,Katona M,Orvos H,Németh I,Farkas I,Túri S

    更新日期:2007-10-01 00:00:00

  • Low birth weight at term impairs cord serum lipoprotein compositions and concentrations.

    abstract:UNLABELLED:The purpose of this study was to determine the effect of low birth weight at term on serum lipoproteins. Lipid and apolipoprotein (apo) contents were investigated in cord sera of small-for-gestational-age (SGA) newborns at term (2290 g +/- 33 g) and compared with those of appropriate-for-gestational-age (AGA...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050820

    authors: Merzouk H,Meghelli-Bouchenak M,el-Korso N,Belleville J,Prost J

    更新日期:1998-04-01 00:00:00

  • Nocturnal lagophthalmos in children with urofacial syndrome (Ochoa): a novel sign.

    abstract::The urofacial syndrome is a rare condition that occurs in both genders and characterized by uropathy and facial abnormalities. Early diagnosis is crucial for the management and prognosis of urinary problems. Paradoxical inversion of facial musculature when smiling, giving an appearance of crying associated with severe...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2172-7

    authors: Mermerkaya M,Süer E,Öztürk E,Gülpınar Ö,Gökçe Mİ,Yalçındağ FN,Soygür T,Burgu B

    更新日期:2014-05-01 00:00:00

  • Structural alteration of the insulin-like growth factor II-gene in Wilms tumour.

    abstract::In this study messenger ribonucleic acid (mRNA) and DNA of five Wilms tumours were investigated. As expected, the level of insulin-like growth factor (IGF) II-mRNA was elevated up to 50 times in tumour tissue as compared to normal adjacent kidney tissue. In addition, genomic DNA was isolated and digested with appropri...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF00441514

    authors: Irminger JC,Schoenle EJ,Briner J,Humbel RE

    更新日期:1989-06-01 00:00:00

  • Hemidystonia secondary to acquired toxoplasmosis in a non-immunodeficient patient.

    abstract::We discuss the unusual presentation of acquired toxoplasmosis in a girl with severe and transient hemidystonia as a unique symptom. Serum titres of anti-toxoplasma antibodies increased whereas no specific antibody response in the CSF was observed. While symptomatic drugs were inefficacious, specific anti-toxoplasmosis...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954489

    authors: Micheli R,Perini A,Duse M

    更新日期:1994-10-01 00:00:00

  • The effect of age and body size on the urinary excretion of C-peptide from birth to 14 years of age.

    abstract::The daily excretion of C-peptide in the urine was measured in 105 healthy infants and children from birth to 14 years of age. For technical reasons no studies were performed from 1-3 years of age. The excretion of C-peptide showed a close positive correlation with age and weight. The relationship with weight was alrea...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442133

    authors: Gács G,Jakabfi P,Zubovich L

    更新日期:1985-01-01 00:00:00

  • The influence of growth hormone monotherapy and growth hormone in combination with oxandrolone or testosterone on thyroxid hormone parameters and thyroxine binding globulin in patients with Ullrich-Turner syndrome.

    abstract:UNLABELLED:Administration of human growth hormone (GH) has yielded conflicting results concerning its role on thyroid function in patients with Ullrich-Turner syndrome. Therefore, we investigated the course of thyroid hormone parameters and thyroxin binding globulin in relation to GH therapy, IGF-I and additional oxand...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s004310050563

    authors: Schmitt K,Häusler G,Blümel P,Plöchl E,Waldhör T,Frisch H

    更新日期:1997-02-01 00:00:00

  • Psychological effects of liver disease and transplantation.

    abstract:UNLABELLED:Psychological adjustment in children with liver disease was investigated. Three groups of children 6-15 years old participated: ten had undergone a liver transplant (Gp1), 15 had ongoing chronic liver disease (Gp2) and 15 were healthy controls (Gp3). Children who had had a transplant appeared well adjusted a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050953

    authors: Mastroyannopoulou K,Sclare I,Baker A,Mowat AP

    更新日期:1998-10-01 00:00:00

  • Glucocorticosteroids and growth hormone secretion under physiological conditions and in states of steroid excess.

    abstract::Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortiso...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00496996

    authors: Mühlendahl KE,Weber B,Müller-Hess R,Korth-Schütz S,Helge H

    更新日期:1978-06-20 00:00:00

  • Partial 3-methylcrotonyl-CoA carboxylase deficiency in an infant with fatal outcome due to progressive respiratory failure.

    abstract:UNLABELLED:Isolated partial 3-methylcrotonyl-CoA carboxylase (MCC) deficiency has been described to be the cause for a distinct relatively mild clinical picture in a single patient. We describe another patient with isolated partial MCC deficiency who suffered from failure to thrive, muscular hypotonia and progressive r...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050800

    authors: Wiesmann UN,Suormala T,Pfenninger J,Baumgartner ER

    更新日期:1998-03-01 00:00:00

  • The calorie intake and weight gain of low birth weight infants fed on fresh breast milk or a special formula milk.

    abstract::The calorie intake and weight gain of 24 low birth weight (LBW) infants, less than 33 weeks gestation and less than 1500 g birth weight, was studied prospectively. Fourteen infants were fed on a commercially available LBW formula milk and ten were fed on their own mother's fresh unpasteurised expressed breast milk (EB...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442748

    authors: Hendrickse WA,Spencer SA,Roberton DM,Hull D

    更新日期:1984-11-01 00:00:00

  • Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia.

    abstract::Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00443266

    authors: Urban C,Sager WD

    更新日期:1981-11-01 00:00:00

  • Growth failure due to protein loss in dermatitis.

    abstract::A 10-month-old infant is described who suffered from extensive atopic dermatitis, failure to thrive, hypoalbuminaemia and oedema. Large amounts of sticky exudate were lost through the skin and were shown to be rich in albumin. As renal and intestinal loss of protein was excluded, the patient's condition was ascribed t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00446072

    authors: Abrahamov A,Schifmann R,Goldstein R,Tal Y,Freier S

    更新日期:1986-08-01 00:00:00

  • Influence of mask type and mask position on the effectiveness of bag-mask ventilation in a neonatal manikin.

    abstract:UNLABELLED:Anatomical face mask with an air cushion rim might be placed accidentally in a false orientation on the newborn's face or filled with various amounts of air during neonatal resuscitation. Both false orientation as well as variable filling may reduce a tight seal and therefore hamper effective positive pressu...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2122-4

    authors: Deindl P,O'Reilly M,Zoller K,Berger A,Pollak A,Schwindt J,Schmölzer GM

    更新日期:2014-01-01 00:00:00

  • A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia.

    abstract::Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. All 39 achondroplasia alleles studied so far carried point mutations which caused the same amino acid exchange, a substitution of glycine by arg...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954274

    authors: Superti-Furga A,Eich G,Bucher HU,Wisser J,Giedion A,Gitzelmann R,Steinmann B

    更新日期:1995-03-01 00:00:00

  • Pacemaker implantation post congenital heart disease surgical repair: tertiary center experience.

    abstract::This was a retrospective study documenting all pacemaker implantations (PMIs) secondary to postoperative atrioventricular block. A total of 26 patients were included between 2011 and 2020. The incidence rate was 1.8%, with a median follow-up time of 4.5 years. At the time of the initial PMI, the median weight was 5 kg...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03739-9

    authors: Ebrahim MA,Ashkanani HK,Alramzi RS,Malhas ZI,Al-Bahrani M,Sadek AA,Elsayed MA,Lyubomudrov VG

    更新日期:2020-12-01 00:00:00

  • Recent progress in clinical and basic pertussis research.

    abstract:UNLABELLED:Over the last decade, substantial progress has been made in the field of pertussis research. This includes better understanding of virulence mechanisms and their influence on the pathogenicity of Bordetella pertussis, increased awareness of the broad spectrum of disease and more insight into the host's immun...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/pl00008429

    authors: Heininger U

    更新日期:2001-04-01 00:00:00

  • Tetra-amelia with multiple malformations in six male fetuses of one kindred.

    abstract::An Arab Moslem kindred is reported in which six abnormal male fetuses were born in three closely related sibships. They had amelia, malformed head and other severe skeletal and visceral malformations. The similarities and differences between the developmental and inherent characteristics found in our patients and in f...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441792

    authors: Zimmer EZ,Taub E,Sova Y,Divon MY,Pery M,Peretz BA

    更新日期:1985-11-01 00:00:00

  • High-flow nasal cannula oxygen for bronchiolitis in a pediatric ward: a pilot study.

    abstract:UNLABELLED:High-flow nasal cannula (HFNC) is a widely used ventilatory support in children with bronchiolitis in the intensive care setting. No data is available on HFNC use in the general pediatric ward. The aim of this study was to evaluate the feasibility of HFNC oxygen therapy in infants hospitalized in a pediatric...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2094-4

    authors: Bressan S,Balzani M,Krauss B,Pettenazzo A,Zanconato S,Baraldi E

    更新日期:2013-12-01 00:00:00

  • Lamivudine and high-dose interferon alpha 2a combination treatment in naïve HBeAg-positive immunoactive chronic hepatitis B in children: an East Mediterranean center's experience.

    abstract::Chronic hepatitis B virus infection is among the most common causes of chronic liver disease in children. The aim of this study was to document prospectively our experiences related to lamivudine and high-dose interferon-alpha2a combination in naïve, e antigen positive, chronic hepatitis B virus infection treatment in...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00431-006-0220-2

    authors: Yilmaz A,Akcam M,Gelen T,Artan R

    更新日期:2007-03-01 00:00:00

  • Alcohol and cigarette use among adolescents with type 1 diabetes.

    abstract::In this study, we compare the prevalence of alcohol and cigarette use among Polish adolescents with type 1 diabetes mellitus (T1DM) (n = 209), aged 15-18 years, with that of a large cohort of their healthy peers, using standardized questionnaire used in the European School Survey Project on Alcohol and Drugs (ESPAD). ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-2895-y

    authors: Hogendorf AM,Fendler W,Sierosławski J,Bobeff K,Węgrewicz K,Malewska KI,Przudzik MW,Szmigiero-Kawko M,Sztangierska B,Myśliwiec M,Szadkowska A,Młynarski WM

    更新日期:2017-06-01 00:00:00

  • De novo inv(2)(p12q34) associated with Klippel-Feil anomaly and hypodontia.

    abstract:UNLABELLED:The present case report describes a patient with Klippel-Feil anomaly (KFA) and oligodontia, carrying a de novo pericentric inversion of chromosome 2 (p12q34). KFA is characterised by congenital vertebral fusion of the cervical spine and a wide spectrum of associated anomalies. It therefore constitutes a het...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-003-1262-3

    authors: Papagrigorakis MJ,Synodinos PN,Daliouris CP,Metaxotou C

    更新日期:2003-09-01 00:00:00

  • Mother-to-child transmission of human immunodeficiency virus type 1: influence of parity and mode of delivery. Paediatric AIDS Group of Switzerland.

    abstract:UNLABELLED:In a national prospective study of risk factors for mother-to-child transmission of human immunodeficiency virus (HIV), 316 children of HIV-positive mothers were followed up for at least 6 months. Infection status was determined in 254 of them and 46 were found to be infected giving a transmission rate of 18...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02074831

    authors: Kind C

    更新日期:1995-07-01 00:00:00

  • The urgent matter of online pro-eating disorder content and children: clinical practice.

    abstract:UNLABELLED:During the last decade, much concern has been expressed about online pro-eating disorder communities (e.g., pro-anorexia websites and blogs) which encourage their users to engage in disordered eating behavior. The aim of the current paper is to reemphasize the importance of pro-eating disorder communities in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-015-2487-7

    authors: Custers K

    更新日期:2015-04-01 00:00:00

  • Cytokines in chronic lung disease of prematurity.

    abstract::Chronic lung disease of prematurity (CLD) is a common respiratory disorder of preterm infants. At autopsy, fibroblast proliferation, and components of the extracellular matrix, including collagen and fibronectin, are markedly increased in the lungs of infants who die from CLD. Examination of broncho-alveolar fluid sug...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01958074

    authors: Kotecha S

    更新日期:1996-08-01 00:00:00

  • Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life.

    abstract:UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00431-015-2566-9

    authors: Cabrerizo M,Trallero G,Pena MJ,Cilla A,Megias G,Muñoz-Almagro C,Del Amo E,Roda D,Mensalvas AI,Moreno-Docón A,García-Costa J,Rabella N,Omeñaca M,Romero MP,Sanbonmatsu-Gámez S,Pérez-Ruiz M,Santos-Muñoz MJ,Calvo C,study

    更新日期:2015-11-01 00:00:00

  • Drug administration errors in paediatric wards: a direct observation approach.

    abstract::Paediatric patients are more vulnerable to drug administration errors due to a lack of appropriate drug dosages and strengths for use in this group of patients. Therefore, the aim of the present study was to determine the extent and types of drug administration errors in two paediatric wards and to identify measures t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-009-1084-z

    authors: Chua SS,Chua HM,Omar A

    更新日期:2010-05-01 00:00:00

  • Fear effects by the media.

    abstract:UNLABELLED:Both news media and entertainment fiction may lead to short-term and enduring fright reactions. Even TV programs, movies and news made for children may trigger fear. Preoperational children (3 to 7 years of age) are most afraid of fantasy characters, transformations and interpersonal violence. Operational ch...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1632-1

    authors: Custers K,Van den Bulck J

    更新日期:2012-04-01 00:00:00

  • Prevalence of coeliac disease in diabetic children and adolescents. A multicentre study.

    abstract::Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024 children, 33 had an elevated AGA titre in the first serum sample. On follow-up an elevated AGA titre was conf...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF00445915

    authors: Koletzko S,Bürgin-Wolff A,Koletzko B,Knapp M,Burger W,Grüneklee D,Herz G,Ruch W,Thon A,Wendel U

    更新日期:1988-11-01 00:00:00

  • Parameters affecting length of stay in a pediatric emergency department: a retrospective observational study.

    abstract::Prolonged emergency department (ED) length of stay (LOS) is used as a proxy for ED overcrowding and is associated with adverse outcomes of patients requiring therapy and reduced patient satisfaction. Our aim was to identify and quantify variables which affect ED-LOS. Patients admitted to the pediatric ED of a large re...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-2879-y

    authors: Hofer KD,Saurenmann RK

    更新日期:2017-05-01 00:00:00