Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.


:We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20 +/- 6 to 156 +/- 82 ng/dl and from 107 +/- 105 to 615 +/- 293 ng/dl, following a single hCG injection, and from 30 +/- 19 to 439 +/- 298 ng/dl and from 94 +/- 55 to 826 +/- 272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P < 0.01). Conclusion. Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis.


Eur J Pediatr


Kauschansky A,Frydman M,Nussinovitch M,Varsano I




Has Abstract


1995-11-01 00:00:00












  • Comparison of two treatment eras and sonographic long-term outcome of blunt splenic injuries in children.

    abstract:UNLABELLED:The treatment of blunt splenic injuries (BSI) has undergone a significant shift away from an operative approach to a conservative treatment regimen in the last decades. Data concerning long-term follow-up of children sustaining BSI are largely confined to telephone surveys. Children treated with BSI over a 3...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Singer G,Rieder S,Eberl R,Wegmann H,Hoellwarth ME

    更新日期:2013-09-01 00:00:00

  • Growth of pulmonary artery after arterial switch operation for simple transposition of the great arteries.

    abstract:UNLABELLED:This retrospective study attempts to assess the size and growth pattern of the pulmonary artery about 1 year after neonatal arterial switch operation for simple transposition of the great arteries. Sixty-seven patients underwent cardiac catheterization, including catheterization of the right and left pulmona...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Massin MM,Nitsch GB,Däbritz S,Seghaye MC,Messmer BJ,von Bernuth G

    更新日期:1998-02-01 00:00:00

  • Correlation between the cord vitamin D levels and regulatory T cells in newborn infants.

    abstract::Vitamin D is important for calcium homeostasis, muscle, and bone health. It has also immunomodulatory capacities in vivo and in vitro. Regulatory T cells (Treg) have been found to suppress a number of T cell-mediated immune disorders, including allergic responses and autoimmune diseases. This study aimed to investigat...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Güven A,Ecevit A,Sözer O,Tarcan A,Tarcan A,Ozbek N

    更新日期:2012-08-01 00:00:00

  • Time course of nocturnal cough and wheezing in children with acute bronchitis monitored by lung sound analysis.

    abstract::Cough and wheezing are the predominant symptoms of acute bronchitis. Hitherto, the evaluation of respiratory symptoms was limited to subjective methods such as questionnaires. The main objective of this study was to objectively determine the time course of cough and wheezing in children with acute bronchitis. The impa...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Koehler U,Hildebrandt O,Fischer P,Gross V,Sohrabi K,Timmesfeld N,Peter S,Urban C,Steiß JO,Koelsch S,Kerzel S,Weissflog A

    更新日期:2019-09-01 00:00:00

  • Prevalence of congenital adrenal hyperplasia among sudden infant death in the Czech Republic and Austria.

    abstract::This study aimed to estimate the number of infants who died of unrecognized congenital adrenal hyperplasia (CAH) in Austria and the Czech Republic within the past 13 years, before the introduction of adequate neonatal screening. The study was based on retrospective analysis of neonatal screening cards of 242 infants w...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Strnadová KA,Votava F,Lebl J,Mühl A,Item C,Bodamer OA,Torresani T,Bouska I,Waldhauser F,Sperl W

    更新日期:2007-01-01 00:00:00

  • Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life.

    abstract:UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究


    authors: Cabrerizo M,Trallero G,Pena MJ,Cilla A,Megias G,Muñoz-Almagro C,Del Amo E,Roda D,Mensalvas AI,Moreno-Docón A,García-Costa J,Rabella N,Omeñaca M,Romero MP,Sanbonmatsu-Gámez S,Pérez-Ruiz M,Santos-Muñoz MJ,Calvo C,study

    更新日期:2015-11-01 00:00:00

  • From sleep duration to childhood obesity--what are the pathways?

    abstract:UNLABELLED:Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究


    authors: Börnhorst C,Hense S,Ahrens W,Hebestreit A,Reisch L,Barba G,von Kries R,Bayer O,IDEFICS Consortium.

    更新日期:2012-07-01 00:00:00

  • European paediatric hepatitis C virus network. Antenatal hepatitis C virus screening and management of infected women and their children: policies in Europe.

    abstract:UNLABELLED:A postal survey of 31 European centres was conducted to document current practices regarding screening and management of hepatitis C virus (HCV)-infected pregnant women and their children. Antenatal HCV prevalence was low. Universal antenatal screening programmes were in place in ten centres, selective scree...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Pembrey L,Newell ML,Tovo PA

    更新日期:1999-10-01 00:00:00

  • Acute transverse myelitis caused by ECHO virus type 18 infection.

    abstract:UNLABELLED:A 14-year-old boy developed acute quadriplegia, associated with sensory impairment and bowel and urinary dysfunction. MRI of the cervical cord showed diffuse increased signal intensity on T2-weighted images with gadolinium-diethylenetriamine penta-acetic acid enhancement. Based on the clinical presentation a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Takahashi S,Miyamoto A,Oki J,Azuma H,Okuno A

    更新日期:1995-05-01 00:00:00

  • Arterial versus venous lactate: a measure of sepsis in children.

    abstract::This study assessed the agreement between arterial and venous blood lactate and pH levels in children with sepsis. This retrospective, three-year study involved 60 PICU patients, with data collected from electronic or paper patient records. The inclusion criteria comprised of children (≤17 years old) with sepsis and t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Samaraweera SA,Gibbons B,Gour A,Sedgwick P

    更新日期:2017-08-01 00:00:00

  • Iodine deficiency during infancy and early childhood in Belgium: does it pose a risk to brain development?

    abstract::Iodine deficiency is well documented in Belgium in adults including pregnant women, adolescents, schoolchildren, and neonates, but no data are available in the age group 6 months-3 years. We investigated the status of iodine nutrition in 111 healthy subjects in this age group in an attempt to evaluate the risk of brai...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Delange F,Wolff P,Gnat D,Dramaix M,Pilchen M,Vertongen F

    更新日期:2001-04-01 00:00:00

  • Phenytoin elimination kinetics in two children with drug intoxication.

    abstract::Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 microgram/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Mente...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Abe K,Okano M,Sasaki H

    更新日期:1980-10-01 00:00:00

  • Stress response and procedural pain in the preterm newborn: the role of pharmacological and non-pharmacological treatments.

    abstract:UNLABELLED:Repeated invasive procedures occur routinely in neonates who require intensive care, causing pain at a time when it is developmentally unexpected. Multiple lines of evidence suggest that repeated and prolonged pain exposure alters their subsequent pain processing, long-term development, and behaviour. Primar...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,随机对照试验


    authors: Gitto E,Pellegrino S,Manfrida M,Aversa S,Trimarchi G,Barberi I,Reiter RJ

    更新日期:2012-06-01 00:00:00

  • Haemostatic changes in tall girls treated with high doses of ethinyloestradiol.

    abstract::Haemostasis was studied in 8 tall girls during treatment with high doses of synthetic oestrogens for a period of 1 to 28 months. The girls received 0.5 mg ethinyloestradiol daily from day 1 to day 25 and 15 mg norethisteron daily from day 21 to day 25. All were without clinical signs of thromboembolism. Factors of the...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Muntean W,Borkenstein M

    更新日期:1980-09-01 00:00:00

  • Maculopapular rash in the convalescent phase of Kawasaki disease: case series and literature review.

    abstract:UNLABELLED:Intravenous immunoglobulin (IVIG) is currently the standard treatment for Kawasaki disease (KD). Although IVIG therapy is generally well tolerated, several minor adverse reactions have been reported. We report a patient with KD treated with IVIG, who developed a cutaneous reaction in the convalescent phase (...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Takeuchi M,Oda Y,Suzuki I

    更新日期:2013-03-01 00:00:00

  • Clinical practice treatment of HIV infection in children.

    abstract::Perinatal transmission remains the main cause of HIV infection in the pediatric population. Treatment of HIV-infected children has become less of a problem in resource-rich countries with a remarkable decrease of perinatal infections, resulting in an effective prevention of mother-to-child transmission and antiretrovi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Brichard B,Van der Linden D

    更新日期:2009-04-01 00:00:00

  • Hyaline membrane disease: prognostic factors and medium-term follow-up.

    abstract::One hundred and twenty two cases of severe hyaline membrane disease are reported. 68 of them survived (57%). Adverse clinical, radiological and laboratory factors, and their effects on the early mortality rate, are analysed with particular reference to the referring centers, delay in admission, transport and the criti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Goenen M,Ninane J,Ducoffre B,Declerck Y,Claus D,Ferriere G,Thomas-van Moerbeke RM,Moulin D,De Meyer R,Tremouroux J

    更新日期:1978-03-13 00:00:00

  • Dopamine versus epinephrine for fluid-refractory septic shock in neonates.

    abstract:: ...

    journal_title:European journal of pediatrics

    pub_type: 评论,信件


    authors: Sasidharan R,Gupta N,Chawla D

    更新日期:2019-01-01 00:00:00

  • Frequency of coeliac disease in Hungarian children with type 1 diabetes mellitus.

    abstract::Coeliac disease and type 1 diabetes mellitus can frequently coexist, presumably due to a common genetic predisposition. The present study was designed to evaluate the frequency of coeliac disease among Hungarian diabetic children and to study the effect of gluten-free diet on glycaemic control. A total of 205 diabetic...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Arató A,Körner A,Veres G,Dezsöfi A,Ujpál I,Madácsy L

    更新日期:2003-01-01 00:00:00

  • Systematic review: probiotics for functional constipation in children.

    abstract::We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children. The MEDLINE, EMBASE, and Cochrane Library databases; clinical trial registries; and reference lists of included studies were searched to February 2017 for randomized controlled trials (RCTs) performed in c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Wojtyniak K,Szajewska H

    更新日期:2017-09-01 00:00:00

  • Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases.

    abstract::Health-related quality of life (HRQOL) is an important indicator of the burden of illness in moderate-to-severe plaque psoriasis. This study evaluated self-reported generic HRQOL among pediatric patients with moderate-to-severe plaque psoriasis based on pooled baseline clinical trial data and compared them to four com...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Varni JW,Globe DR,Gandra SR,Harrison DJ,Hooper M,Baumgartner S

    更新日期:2012-03-01 00:00:00

  • Practical aspects of resuscitating asphyxiated newborn infants.

    abstract::Of all newborn infants, 5% require some degree of basic life support at birth. Newborn resuscitation therefore is one of the most frequent procedures carried out in medicine. It is therefore important that the routines in use are evidence based. Newborn resuscitation can be divided into ten steps: (1) initial stabilis...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Saugstad OD

    更新日期:1998-01-01 00:00:00

  • Prevalence of complementary/alternative medicine for children: a systematic review.

    abstract:UNLABELLED:Complementary/alternative medicine (CAM) has become an important topic, not least because of its popularity with patients. This systematic review is aimed at summarising the data known about CAM use in paediatric populations. A thorough search strategy was designed to identify all surveys on the prevalence o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Ernst E

    更新日期:1999-01-01 00:00:00

  • International survey on diagnosis and management of hypotension in extremely preterm babies.

    abstract:UNLABELLED:Hypotension is a commonly diagnosed and treated complication of extremely low gestational age newborns (ELGAN), but enormous variation in diagnosis, management and clinical practice has been documented. We sought to evaluate practice regarding the management of hypotension in ELGANs and developed a web-based...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究


    authors: Stranak Z,Semberova J,Barrington K,O'Donnell C,Marlow N,Naulaers G,Dempsey E,HIP consortium.

    更新日期:2014-06-01 00:00:00

  • Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.

    abstract:INTRODUCTION:IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma. MATERIALS AND METHODS:We genotyped 650 children for allelic determinants at tw...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kim ES,Kim SH,Kim KW,Park HS,Shin ES,Lee JE,Sohn MH,Kim KE

    更新日期:2009-12-01 00:00:00

  • Sex-, age-, and height-specific reference curves for the 6-min walk test in healthy children and adolescents.

    abstract:UNLABELLED:The 6-min walk test is a simple and accurate method to measure functional exercise capacity in children. We provide smooth reference curves for the modified 6-min walk test in 696 healthy children and adolescents aged 4-19 years, enabling calculation of sex-, age-, and height-specific Z-scores. CONCLUSION:T...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Saraff V,Schneider J,Colleselli V,Ruepp M,Rauchenzauner M,Neururer S,Geiger R,Högler W

    更新日期:2015-06-01 00:00:00

  • Aetiological heterogeneity of asymptomatic hyperglycaemia in children and adolescents.

    abstract:INTRODUCTION:Randomly estimated fasting hyperglycaemia in an asymptomatic individual may represent the first sign of pancreatic beta-cell dysfunction. OBJECTIVE:We aimed at specifying the genetic aetiology of asymptomatic hyperglycaemia in a cohort of children and adolescents. SUBJECTS AND METHODS:We analysed the aet...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Feigerlová E,Pruhová S,Dittertová L,Lebl J,Pinterová D,Kolostová K,Cerná M,Pedersen O,Hansen T

    更新日期:2006-07-01 00:00:00

  • Growth and sexual development in children with meningomyelocele.

    abstract::Forty-five children (25 girls; 20 boys) with meningomyelocele (MMC) were assessed for growth, skeletal maturation and pubertal development. The spinal defects were operated on shortly after birth and all children required cerebral drainage for hydrocephalus. Standard deviation scores for height, sitting height, sub-is...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Greene SA,Frank M,Zachmann M,Prader A

    更新日期:1985-07-01 00:00:00

  • Balloon occlusion aortography.

    abstract::We review the validity of balloon occlusion aortography (BOA) on the basis of our personal experience with 18 patients with congenital heart disease (mean weight 4.55 g, including 8 neonates). Four of the 18 patients underwent aortic arch angiography using balloon occlusion of the descending aorta. Pulmonary angiograp...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Ino T,Shimazaki S,Nishimoto K,Akimoto K,Iwahara M,Yabuta K,Watanabe M,Tanaka A,Hosoda Y

    更新日期:1991-02-01 00:00:00

  • Prevalence of iron deficiency and related factors in Spanish adolescents.

    abstract::Iron deficiency anaemia continues to be the world's most important cause of years lived with disability in children and adolescents. Assessment of iron deficiency traditionally depended on laboratory parameters that may be modified by inflammation states, including obesity, which is nowadays a current condition in ado...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Ibáñez-Alcalde MM,Vázquez-López MÁ,López-Ruzafa E,Lendínez-Molinos FJ,Bonillo-Perales A,Parrón-Carreño T

    更新日期:2020-10-01 00:00:00