Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.


:We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20 +/- 6 to 156 +/- 82 ng/dl and from 107 +/- 105 to 615 +/- 293 ng/dl, following a single hCG injection, and from 30 +/- 19 to 439 +/- 298 ng/dl and from 94 +/- 55 to 826 +/- 272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P < 0.01). Conclusion. Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis.


Eur J Pediatr


Kauschansky A,Frydman M,Nussinovitch M,Varsano I




Has Abstract


1995-11-01 00:00:00












  • Neonatal screening for hypothyroidism in Greece.

    abstract::One year's experience in screening for congenital hypothyroidism in Greece is reported. Thyroid stimulating hormone (TSH) determination by a radioimmunoassay on dried blood spots was selected as the screening method. During the first year of screening 75,879 newborn infants were tested from Guthrie blood spots taken o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Mengreli C,Kassiou K,Tsagaraki S,Pantelakis S

    更新日期:1981-10-01 00:00:00

  • "Negative growth" in anorexia nervosa assessed by knemometry.

    abstract::Recently a novel and non-invasive technique of lower leg length measurement (knemometry) was introduced. The method estimates the distance between heel and knee in the sitting child with an accuracy of 0.09 mm(SD). Two female patients with anorexia nervosa, aged 14:4 and 13:7 years, weighing minus 27 and minus 38% of ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Hermanussen M,Geiger-Benoit K,Sippell WG

    更新日期:1987-11-01 00:00:00

  • Postnatal course of plasma levels of adrenocortical steroids in premature infants with and without NaCl supplementation.

    abstract::To assess the adrenocortical response of premature infants to alterations in sodium balance, the postnatal course of plasma progesterone, 11-deoxycorticosterone, corticosteronoe, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone was compared in healthy premature infants kept on low (1-2 mEq...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Sulyok E,Dörr HG,Ertl T,Gyódi G

    更新日期:1988-12-01 00:00:00

  • Effect of inhaled nitric oxide on intrapulmonary right-to-left-shunting in two rabbit models of saline lavage induced surfactant deficiency and meconium instillation.

    abstract::Marked hypoxia secondary to intrapulmonary right-to-left shunting is a characteristic of respiratory failure in human neonates and can sometimes be complicated by additional extrapulmonary right-to-left shunting. To investigate the effect of inhaled nitric oxide (iNO) on intrapulmonary shunting, two typical pulmonary ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Krause MF,Lienhart HG,Haberstroh J,Hoehn T,Schulte-Mönting J,Leititis JU

    更新日期:1998-05-01 00:00:00

  • Anatomy of the naso-lacrimal duct in new-borns: therapeutic considerations.

    abstract::The topography and morphology of the lacrimal ducts in newborn infants was demonstrated by means of post mortem dacryocystograms and microphotograms of histologic slides. Because of bends in the course of the lower tear duct, a percentage of probings will fail to effect satisfactory perforation of the Hasner membrane....

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Müller KM,Busse H,Osmers F

    更新日期:1978-09-08 00:00:00

  • Hypercalcaemia in cerebellar medulloblastoma: pathogenesis of solid tumour-associated hypercalcaemia.

    abstract::A 7-year-old boy developed acute, severe hypercalcaemia following the partial excision of a cerebellar medulloblastoma. The serum calcium level was extremely high (19.8 mg/100 ml), but a skeletal survey revealed no apparent bone metastatic lesions; such lesions were only detected by X-ray 3 weeks after the onset of hy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Arisaka O,Obinata K,Yabuta K,Ishimoto K,Sato K

    更新日期:1987-07-01 00:00:00

  • Latent chronic cholangitis in congenital hepatic fibrosis.

    abstract::In a five-year-old girl with congenital hepatic fibrosis raised erythrocyte sedimentation rate and serum gammaglobulins were noted for 3 years. Needle liver biopsy showed histological features of cholangitis and Klebsiella oxytoca was cultured from a liver biopsy specimen. Antibiotic treatment resulted in normalizatio...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Alvarez F,Hadchouel M,Bernard O

    更新日期:1982-11-01 00:00:00

  • Dopamine versus epinephrine for fluid-refractory septic shock in neonates.

    abstract:: ...

    journal_title:European journal of pediatrics

    pub_type: 评论,信件


    authors: Sasidharan R,Gupta N,Chawla D

    更新日期:2019-01-01 00:00:00

  • Extensive brown tumors caused by parathyroid adenoma in an adolescent patient.

    abstract::Primary hyperparathyroidism is a rare endocrine disease in children and young adults. The early detection and treatment of primary hyperparathyroidism led to a marked decrease in classical bone and renal manifestations of the disease. Osteitis fibrosa cystica and brown tumors have become extremely rare clinical entiti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Atabek ME,Pirgon O,Sert A,Esen HH

    更新日期:2008-01-01 00:00:00

  • Echocardiographic assessment of hemodynamic changes in preterm neonates with shock: a prospective pragmatic cohort study.

    abstract::Shock is a state of circulatory dysfunction and its diagnosis is complex in neonates. Hemodynamic assessment using echocardiography has potential to guide better management regimes in neonates with shock. Objective of this study is to analyze changes in the echocardiographic parameters in preterm neonates with shock a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Pawale D,Murki S,Kulkarni D,Vardhelli V,Sharma D,Oleti T,Kiran S,Bakhru S,Koneti NR

    更新日期:2020-12-01 00:00:00

  • A comparison of ceftazidime and aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. European Society for Paediatric Infectious Diseases--Neonatal Sepsis Study Group.

    abstract::We report a prospective, non-blind, randomised, multicentre, parallel group, multinational investigation to compare ceftazidime to aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. In each of the 15 study centres either ceftazidime alone (CAZ) or ceftazidime + ampic...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Louvois J,Dagan R,Tessin I

    更新日期:1992-12-01 00:00:00

  • Pulmonary thrombo-embolism in nephrotic syndrome treated with tissue plasminogen activator.

    abstract:UNLABELLED:We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION:Pulm...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Reid CJ,Segal T

    更新日期:1997-08-01 00:00:00

  • Staphylococcus saprophyticus urinary tract infections in children.

    abstract::Staphylococcus saprophyticus commonly causes urinary tract infection (UTI) in young women; in males it is found mainly in the elderly. In this study S. saprophyticus UTI occurred in 59 children (45 girls and 14 boys) below 16 years of age, of whom 20 were less than 13 years of age. The common presentation was dysuria ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Abrahamsson K,Hansson S,Jodal U,Lincoln K

    更新日期:1993-01-01 00:00:00

  • Infected breast milk associated with late-onset and recurrent group B streptococcal infection in neonatal twins: a genetic analysis.

    abstract::Asymptomatic excretion of group B streptococcus (GBS) in breast milk may be an underrecognized cause of neonatal and recurrent infection. We report the case of late-onset and recurrent infection in newborn twins resulting from ingestion of maternal breast milk infected with GBS. Genetic analysis of isolates is equally...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Gagneur A,Héry-Arnaud G,Croly-Labourdette S,Gremmo-Feger G,Vallet S,Sizun J,Quentin R,Tandé D

    更新日期:2009-09-01 00:00:00

  • Acute septicaemic acalculous cholecystitis complicated by empyema caused by Salmonella group D in a previously healthy child.

    abstract:UNLABELLED:We describe a rare case of acute acalculous cholecystitis (AC) due to Salmonella group D infection in a previously healthy child who developed gall bladder empyema and bacteraemia. Salmonella group D was recovered from blood culture, as well as cultures of stool, bile and gall bladder wall samples. The patie...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Lo WT,Wang CC,Chu ML

    更新日期:2002-11-01 00:00:00

  • Familial trisomy 9p and spinal muscular atrophy: clinical, cytogenetic and embryological findings.

    abstract::The pre- and postnatal clinical, cytogenetic and embryological findings in a family suffering from trisomy 9p and spinal muscular atrophy are presented. The clinical picture of the "trisomy 9p" -syndrome is delineated. Concurrence of autosomal aberration and spinal muscular atrophy, probably of the Werdnig-Hoffmann ty...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Tolksdorf M,Kunze J,Gross-Selbeck G,Sperling K,Wegner RD,Wieczorek V,Vogel M

    更新日期:1977-08-23 00:00:00

  • Effects of naloxone on apnoea duration during sleep in infants at risk for SIDS.

    abstract::The effects of intravenous injections of the opiate antagonist naloxone (0.005-0.4 mg/kg body weight) on respiratory pattern, apnoea duration and frequency were investigated in six infants with severe sleep apnoea syndrome. Since several authors found elevated plasma- and CSF-levels of endogenous opioids (endorphines)...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Haidmayer R,Kerbl R,Meyer U,Kerschhaggl P,Kurz R,Kenner T

    更新日期:1986-10-01 00:00:00

  • Association of increased numbers of peripheral blood double-negative T-lymphocytes with elevated serum IgG levels in severely handicapped children.

    abstract::CD3+4-8- double negative cells in peripheral blood lymphocytes were examined in 21 severely handicapped children divided into two groups according to serum IgG level. All children were bedridden and were taking multiple anticonvulsants and there were no apparent clinical differences between these two groups. Serum lev...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kawano Y,Noma T,Yoshizawa I,Maruki K,Yata J

    更新日期:1994-12-01 00:00:00

  • The associations between serum 25-hydroxyvitamin D and red blood cell indices reported from the KiGGS study are, except for mean corpuscular hemoglobin, not mediated by health-related quality of life.

    abstract:: ...

    journal_title:European journal of pediatrics

    pub_type: 信件


    authors: Doudin A,Becker A,Rothenberger A,Meyer T

    更新日期:2018-11-01 00:00:00

  • Zinc deficiency in an exclusively breast-fed preterm infant.

    abstract:UNLABELLED:A formerly premature, exclusively breast-fed infant with severe zinc deficiency syndrome is presented. He showed the characteristic erosive skin changes, including alopecia, as seen in acrodermatitis enteropathica. In addition, he manifested a failure to thrive and irritability. The diagnosis was confirmed b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Heinen F,Matern D,Pringsheim W,Leititis JU,Brandis M

    更新日期:1995-01-01 00:00:00

  • Glucose-6-phosphate: a key compound in glycogenosis I and favism leading to hyper- or hypolipidaemia.

    abstract::The glycogen storage disorders (GSD)-I, -III, -VI and -VIII are associated with hypertriglyceridaemia or mixed hyperlipidaemia which poses the question whether these patients have an increased risk for atherosclerosis. The atherogenicity of triglycerides has remained controversial, while increased plasma cholesterol l...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Schmitz G,Hohage H,Ullrich K

    更新日期:1993-01-01 00:00:00

  • Changes in red cell phosphate metabolism of preterm and fullterm infants with perinatal problems during their first month of life.

    abstract::The effects of perinatal problems on red cell phosphate metabolism were studied in two groups of infants (preterms B and fullterms D) during the first month of life. All infants started milk feeding from day three after birth. The results were compared to those of healthy preterms (A) and fullterms (C), respectively. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Cholevas V,Challa A,Lapatsanis PD,Andronikou S

    更新日期:2008-02-01 00:00:00

  • Short stature homeobox-containing gene deletion screening by fluorescence in situ hybridisation in patients with short stature.

    abstract:UNLABELLED:The short stature homeobox-containing gene (SHOX) on the short arm of the X and Y chromosomes is an important determining factor of stature phenotype. Absence of the SHOX gene is a main cause for short stature in patients with Turner syndrome. Mutations of the SHOX gene can also be responsible for Léri-Weill...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Musebeck J,Mohnike K,Beye P,Tönnies H,Neitzel H,Schnabel D,Grüters A,Wieacker PF,Stumm M

    更新日期:2001-09-01 00:00:00

  • Clinical and genetic characterisation of a series of patients with triple A syndrome.

    abstract::Triple A syndrome (TAS) or Allgrove syndrome (OMIM #231550) is a rare autosomal recessive disorder characterised by adrenocorticotropic hormone-resistant adrenal insufficiency, alacrima, achalasia, and neurological and dermatological abnormalities. Mutations in the AAAS gene on chromosome 12q13 encoding the nuclear po...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kurnaz E,Duminuco P,Aycan Z,Savaş-Erdeve Ş,Muratoğlu Şahin N,Keskin M,Bayramoğlu E,Bonomi M,Çetinkaya S

    更新日期:2018-03-01 00:00:00

  • Discolored leg syndrome after vaccination--descriptive epidemiology.

    abstract::Discoloration of the leg following vaccination is a relatively unknown entity. We carried out a study of discolored leg syndrome (DLS) during a 10-year consecutive period with the objective of characterizing DLS in infants following vaccination received in the Dutch National Vaccination Program as well as its occurren...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kemmeren JM,Vermeer-de Bondt PE,van der Maas NA

    更新日期:2009-01-01 00:00:00

  • Psychological effects of liver disease and transplantation.

    abstract:UNLABELLED:Psychological adjustment in children with liver disease was investigated. Three groups of children 6-15 years old participated: ten had undergone a liver transplant (Gp1), 15 had ongoing chronic liver disease (Gp2) and 15 were healthy controls (Gp3). Children who had had a transplant appeared well adjusted a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Mastroyannopoulou K,Sclare I,Baker A,Mowat AP

    更新日期:1998-10-01 00:00:00

  • A patient with Dent disease and features of Bartter syndrome caused by a novel mutation of CLCN5.

    abstract:UNLABELLED:Dent disease is an X-linked tubulopathy mainly caused by inactivating mutations of CLCN5. Features of Bartter syndrome such as hypokalemic metabolic alkalosis are rarely observed in patients with Dent disease. We report a Japanese male patient with Dent disease who also manifested features of Bartter syndrom...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Okamoto T,Tajima T,Hirayama T,Sasaki S

    更新日期:2012-02-01 00:00:00

  • Human milk bank and personalized nutrition in the NICU: a narrative review.

    abstract::The number of infants born preterm including extremely premature babies is rising worldwide, particularly in low- and middle-income countries, which challenge neonatologists and milk banks for the provision of the most adequate nutrition for successful infant's growth and development. The benefits of mother's own milk...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Sánchez Luna M,Martin SC,Gómez-de-Orgaz CS

    更新日期:2020-11-27 00:00:00

  • Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.

    abstract::When boys affected with steroid sulfatase deficiency are delivered, the lack of the enzyme in the placenta may cause birth complications. In postnatal life this gene defect gives rise to X-linked recessive ichthyosis. In a series of 25 patients birth complications were reported in 9 cases. Of these boys, 4 displayed b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Traupe H,Happle R

    更新日期:1983-03-01 00:00:00

  • Factors influencing breastfeeding duration: a survey in a Turkish population.

    abstract:UNLABELLED:Breastfeeding provides perfect nutrition for infants and is a source of many health benefits for both mother and baby. To obtain the maximum beneficial effects of breast milk, it is necessary to prolong the breastfeeding duration. In this study, we investigated the factors influencing the duration of breastf...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Sencan I,Tekin O,Tatli MM

    更新日期:2013-11-01 00:00:00