Abstract：
UNLABELLED:To investigate the toxic effect of tobacco smoke on the fetus, we measured in cord blood the concentrations of alpha-fetoprotein (AFP), the principal serum protein in early ontogenic development, and erythropoietin (EPO), as an index of chronic fetal hypoxia. A total of 103 consecutively enrolled term newborns of smoking mothers and 103 term infants of nonsmoking parents were studied. The mean +/- SD AFP concentrations in the newborns of the mothers who smoked 1-50, 5-50, and 10-50 cigarettes/day were 86.4 +/- 88.9, 96.3 +/- 91.9 and 118.7 +/- 103.7 ng/ml, respectively. The difference of all three groups from the control neonates (57.7 +/- 37.2) was significant. The EPO concentrations in the newborns of the mothers who smoked 1-50 (53.9 +/- 64.6 mU/ml) and 5-50 (56.3 +/- 68.5) cigarettes/day were significantly greater than in the control neonates (29.5 +/- 16.1). In the newborns of the smoking mothers there was a significant positive correlation between AFP concentrations and number of cigarettes smoked per day, and a negative correlation between AFP and birth weight or length. There was no correlation between AFP and EPO concentrations, as well as between EPO and birth weight, length or number of cigarettes smoked per day. CONCLUSION:The absence of a correlation between erythropoietin and birth weight or length and the negative correlations between alpha-fetoprotein and these anthropometric parameters suggest that the intra-uterine growth retardation caused by maternal smoking is not due to tissue hypoxia, but that both growth retardation and elevated alpha-fetoprotein result from the direct or indirect toxic effect of a factor(s) present in tobacco smoke.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Beratis NG,Varvarigou A,Christophidou M,Vassilakos P,Tsapanos V,Kourounis Gdoi
10.1007/s004310051152keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
583-8issue
7eissn
0340-6199issn
1432-1076journal_volume
158pub_type
临床试验,杂志文章abstract：UNLABELLED:Papillomas of the genital region are rare benign tumours causing sanguineous vaginal discharge in prepubertal girls. We report on a papilloma of the cervix in a 2-year-old girl. We characterize the tumour immunohistochemically and give a brief review about the current literature. CONCLUSION:Genital tract pa...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310050609
更新日期：1997-04-01 00:00:00
abstract：UNLABELLED:The aim of this study was to evaluate to what extent serum vitamins A and E cystic fibrosis are affected by the underlying disease, pancreatic sufficiency or insufficiency, meconium ileus, nutritional status, age and treatment (enzyme and vitamin supplementation). Serum vitamin A and E levels were determined...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02002713
更新日期：1996-04-01 00:00:00
abstract：:Plasma vitamin E levels were determined serially in preterm infants surviving respiratory distress syndrome (RDS) and in premature infants without RDS (control). Vitamin E intakes of the RDS and control infant group were not significantly different. The results of the study show that preterm infants surviving RDS have...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00446056
更新日期：1986-08-01 00:00:00
abstract：:Mitochondrial disorders are a clinically and biochemically diverse group of disorders which may involve multiple organ systems. General anaesthesia (GA) poses a potential risk of decompensation in children with mitochondrial disorders, and there is little guidance for anaesthetists and other clinicians regarding the o...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-016-2813-8
更新日期：2017-01-01 00:00:00
abstract：OVERVIEW:In newborns with symptomatic congenital cytomegalovirus (CMV) infection, neuroimaging is the best available predictor of neurodevelopmental outcome. Cerebrospinal fluid (CSF) findings in congenital CMV infection have seldom been described. Neonates with central nervous system infections present high CSF Beta(2...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0160-x
更新日期：2006-09-01 00:00:00
abstract：:A 2-month-old infant was admitted to hospital because of recurrent vomiting for 1 week, progressive apathy, and focal seizures. The cranial MRI showed a noticeable result. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1681-0
更新日期：2012-06-01 00:00:00
abstract：UNLABELLED:The treatment of blunt splenic injuries (BSI) has undergone a significant shift away from an operative approach to a conservative treatment regimen in the last decades. Data concerning long-term follow-up of children sustaining BSI are largely confined to telephone surveys. Children treated with BSI over a 3...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2022-7
更新日期：2013-09-01 00:00:00
abstract：UNLABELLED:Coronary artery disease (CAD) is a major cause of death in patients with insulin-dependent diabetes mellitus. Qualitative changes in low density lipoprotein (LDL) and high density lipoprotein (HDL) are thought to be important for evaluating the risk for CAD. In the present study, we evaluated LDL particle si...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050810
更新日期：1998-04-01 00:00:00
abstract：:A case-control study was conducted to examine the association of beta-haemolytic non-group A streptococci and pharyngitis in a paediatric population (n = 502). No association could be found between disease and traditional Lancefield groups B, C, F, or G. When the analysis included the clustering of genetically related...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02026709
更新日期：1991-09-01 00:00:00
abstract：:In a case of hypochondrogenesis, abnormal fat deposits were found in the chondrocytes, by anatomopathological and by ultrastructural examination. In the cultured fibroblast we were unable to demonstrate abnormal lipid loading. Our case could be isolated from other types of lethal congenital chondrodysplasias--especial...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443377
更新日期：1983-06-01 00:00:00
abstract：UNLABELLED:The objective of this open study was to monitor the long-term effectiveness of the Lederle-Takeda diphtheria and tetanus toxoids and acellular pertussis antigen(s) (DTaP) vaccine and the Wyeth-Lederle diphtheria and tetanus toxoids and pertussis whole cell (DTP) vaccine in children who had received four dose...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-001-0893-5
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVES:The aim of the 'Motorik-Modul' (MoMo Basiserhebung, www.motorik-modul.de ) was to establish prevalence measurements on physical fitness and physical activity in German children and adolescents and to identify differences between age groups and genders. A total of 4,529 children and adolescents between the ag...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1391-4
更新日期：2011-09-01 00:00:00
abstract：UNLABELLED:Gain-of-function mutations of the extracellular calcium (Ca(2+)e)-sensing receptor (CaR) have been identified in patients with familial and sporadic hypercalciuric hypocalcaemia. We describe a patient with sporadic severe hypercalciuric hypocalcaemia with undetectable or very low levels of serum parathyroid ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1331-7
更新日期：2004-02-01 00:00:00
abstract：:Perinatal transmission remains the main cause of HIV infection in the pediatric population. Treatment of HIV-infected children has become less of a problem in resource-rich countries with a remarkable decrease of perinatal infections, resulting in an effective prevention of mother-to-child transmission and antiretrovi...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-008-0914-8
更新日期：2009-04-01 00:00:00
abstract：:To investigate the changes in the 1 alpha,25-dihydroxyvitamin D [1,25(OH)2D] level and the role of parathyroid hormone (PTH) and calcitonin (CT) during the early neonatal periods, we measured 1,25(OH)2D, 25-hydroxyvitamin D [25(OH)D], PTH specific for mid-regions (mPTH) and urinary cAMP (UcAMP) to evaluate the renal t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442212
更新日期：1988-02-01 00:00:00
abstract：:Clinically visible corneal opacities were observed in a patient with an extremely severe form of mucopolysaccharidosis II. In a second patient with an unusually mild form of mucopolysaccharidosis II, discrete corneal opacities were detected by slit-lamp examination. Thus clear corneae can no longer be regarded as a ha...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441369
更新日期：1978-08-17 00:00:00
abstract：:Prolonged emergency department (ED) length of stay (LOS) is used as a proxy for ED overcrowding and is associated with adverse outcomes of patients requiring therapy and reduced patient satisfaction. Our aim was to identify and quantify variables which affect ED-LOS. Patients admitted to the pediatric ED of a large re...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2879-y
更新日期：2017-05-01 00:00:00
abstract：:Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealin...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03328-5
更新日期：2019-04-01 00:00:00
abstract：:We compared epinephrine and dopamine as a first-line vasoactive drug in 40 neonates (enrolled in two gestational age strata ≤ 306/7 and ≥ 310/7 weeks) with fluid-refractory septic shock. Epinephrine or dopamine was initiated at 0.2 or 10 μg/kg/min, respectively. If shock persisted after 15 min, epinephrine or dopamine...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-018-3195-x
更新日期：2018-09-01 00:00:00
abstract：:Monocytes play an essential role in cellular host defense as circulating phagocytes, as well as precursors of macrophages. We investigated the principal phagocytic activities in monocytes from cord blood of term infants by analysing adherence, random migration, chemotaxis, bactericidal activity, phagocytosis-associate...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00439252
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abstract：:Since the first description by Catel and Manzke of hyperphalangy and clinodactyly of the index finger associated with Robin malformation sequence, seven further cases have been published. In two families more than one case occurred. Another family is presented with possibly two affected boys showing variable features ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442455
更新日期：1984-08-01 00:00:00
abstract：:Given the worldwide increase prevalence of overweight, obesity, and nonalcoholic fatty liver disease (NAFLD), the objective of this study was to evaluate whether the triglycerides and glucose (TyG) index is associated with hepatic steatosis in children with overweight or obesity. Apparently healthy children aged 5‑17 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03951-1
更新日期：2021-01-25 00:00:00
abstract：:In this study, we compare the prevalence of alcohol and cigarette use among Polish adolescents with type 1 diabetes mellitus (T1DM) (n = 209), aged 15-18 years, with that of a large cohort of their healthy peers, using standardized questionnaire used in the European School Survey Project on Alcohol and Drugs (ESPAD). ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2895-y
更新日期：2017-06-01 00:00:00
abstract：UNLABELLED:Five neonates who suffered from an unexpected long period of respiratory failure, muscular hypotonia, and drowsiness were observed in a retrospective study. Prior to this general depression, unusually high doses of diazepam were administered to all patients via intravenous bolus injection. Serum levels of di...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310100745
更新日期：2001-06-01 00:00:00
abstract：UNLABELLED:Two patients are described with acute collapse caused by pericardial effusion following central venous catheterisation. Echocardiography during resuscitation allowed prompt identification and management. CONCLUSION:Pericardial effusion should be considered in any baby experiencing acute deterioration with a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310100828
更新日期：2001-12-01 00:00:00
abstract：:The phenylalanine hydroxylase (PAH) deficiency trait is heterogeneous with a continuum of metabolic phenotypes ranging from classical phenylketonuria (PKU) to mild hyperphenylalaninaemia (MHP). More than 200 mutations in the PAH gene are associated with PAH deficiency. From theoretical considerations or in vitro expre...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014253
更新日期：1996-07-01 00:00:00
abstract：UNLABELLED:Neurological complications of immunizations are rare. We report the case of relapsing acute encephalitis in a boy after two subsequent diphtheria-tetanus-poliomyelitis vaccinations. First the clinical signs were those of acute disseminated encephalitis. During the second episode, the boy experienced optic ne...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02075768
更新日期：1996-02-01 00:00:00
abstract：:It is known that the 5%-10% of adults infected with hepatitis B virus (HBV) develop a chronic infection and that HBV infection acquired at birth by an hepatitis B surface antigen (HBsAg)/hepatitis B "e" antigen (HBeAg)-positive mother almost invariably leads to chronic infection. Little information is, however, availa...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954381
更新日期：1992-03-01 00:00:00
abstract：UNLABELLED:This prospective clinical case-control study describes the effect of an inpatient multicomponent treatment programme for obese children and adolescents on their weight and psychological well being. We studied 38 patients and 38 controls on the waiting list, matched for age and gender, referred because of obe...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1155-5
更新日期：2003-06-01 00:00:00
abstract：:Education is necessary to improve child physical abuse detection and management. A few studies have described national child abuse training programs, but none has measured changes in knowledge among participants. A collaboration of child abuse experts from the USA, an academic pediatric department, and a non-governmen...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03625-4
更新日期：2020-09-01 00:00:00
