Abstract：
UNLABELLED:This prospective clinical case-control study describes the effect of an inpatient multicomponent treatment programme for obese children and adolescents on their weight and psychological well being. We studied 38 patients and 38 controls on the waiting list, matched for age and gender, referred because of obesity, with a median age of 13 years (range 10-17 years) and a median adjusted body mass index (BMI) of 173% (range 130%-257%). The treatment consisted of a 10-month inpatient programme focussing on attaining a healthy lifestyle by increasing physical activity and offering a healthy diet within a cognitive-behavioural framework. At base line, at the end of the treatment, 6 months and 14 months after completion of the treatment, the adjusted BMI was calculated and psychological variables were measured with the Dutch Eating Behaviour Questionnaire, the Eating Disorder Inventory and the Self-Perception Profile for Children. All patients lost weight during treatment (median -48% of the adjusted BMI, range -4% to -102%), in contrast to the non-treated control subjects (median +6%, range -29% to +27%). The children treated developed a higher self-esteem and were more capable of coping with external eating stimuli. They did not develop anorexia nor bulimia nervosa. At the 6-months follow-up, a median increase in the adjusted BMI of +6% (range -19% to +37%) was found; with an additional increase of +4% (range -30% to +41%) at 14-months follow-up. CONCLUSION:a multicomponent long-term inpatient treatment programme is a valuable treatment option for obese children, with a lasting effect up to 14 months post-treatment. Nevertheless, more research is needed to characterise those children who regain weight after treatment and how this may be prevented.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Braet C,Tanghe A,Bode PD,Franckx H,Winckel MVdoi
10.1007/s00431-003-1155-5keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
391-6issue
6eissn
0340-6199issn
1432-1076journal_volume
162pub_type
杂志文章abstract：:Following a description of the genetic aspects of the human histocompatibility antigens system HLA and its principle typing methods, this paper reviews the relationship between HLA antigens, transplantation immunology and certain diseases. In particular, the role of the lymphocyte-defined antigens of the HLA-D system ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF00441576
更新日期：1980-03-01 00:00:00
abstract：UNLABELLED:To examine the value of surfactant protein D and KL-6 as markers for the diagnosis and the severity of interstitial pneumonia caused by measles infection, surfactant protein D, KL-6 and lactic acid dehydrogenase were measured serially in three patients with measles complicated by interstitial pneumonia as co...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310100763
更新日期：2001-07-01 00:00:00
abstract：:Blunt cardiac injury may occur in patients after suffering nonpenetrating trauma of the chest. It encompasses a wide spectrum of cardiac injury with varied severity and clinical presentation. Electrocardiographic abnormalities are frequently encountered. This article presents a case of a child who presented with compl...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0663-0
更新日期：2008-11-01 00:00:00
abstract：UNLABELLED:In a prospective study, brain ultrasound scans were performed in 42 newborns (median birth weight 1700 g, range 1020-3720 g; gestational age 32 weeks, 26-36) to reveal peri-intraventricular haemorrhage (PIVH) (grades I-IV) as well as echodensities (ED) and/or periventricular leucomalacia (PVL). ECG and arter...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01972894
更新日期：1994-11-01 00:00:00
abstract：:Portal hypertension was observed in a 17-year-old girl with urticaria pigmentosa since 2 months of age. Liver biopsies showed portal and sinusoidal infiltration with mast cells although spleen biopsies showed only fibrosis. CONCLUSION. Portal hypertension is a complication of systemic mastocytosis that can lead to dea...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959789
更新日期：1995-10-01 00:00:00
abstract：:Since the first description by Catel and Manzke of hyperphalangy and clinodactyly of the index finger associated with Robin malformation sequence, seven further cases have been published. In two families more than one case occurred. Another family is presented with possibly two affected boys showing variable features ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442455
更新日期：1984-08-01 00:00:00
abstract：:Child maltreatment is a major social problem with many adverse consequences, and a substantial number of maltreated children are not identified by health care professionals. In 2010, in order to improve the identification of maltreated children in hospitals, a new hospital-based policy was developed in Amsterdam, The ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1869-3
更新日期：2013-02-01 00:00:00
abstract：UNLABELLED:The present case report describes a patient with Klippel-Feil anomaly (KFA) and oligodontia, carrying a de novo pericentric inversion of chromosome 2 (p12q34). KFA is characterised by congenital vertebral fusion of the cervical spine and a wide spectrum of associated anomalies. It therefore constitutes a het...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1262-3
更新日期：2003-09-01 00:00:00
abstract：:We have investigated four patients from three unrelated families with typical clinical and biochemical features of "late-onset" multiple carboxylase deficiency. All patients suffered from biotinidase deficiency (plasma biotinidase activities 1.4%-3% of normal). Intestinal absorption of biotin, measured in three of the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00491919
更新日期：1985-05-01 00:00:00
abstract：:Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02171565
更新日期：1990-02-01 00:00:00
abstract：:The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely ass...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2949-1
更新日期：2017-08-01 00:00:00
abstract：:Cerebral blood flow velocities (CBFV) were measured by the pulsed Doppler method in 41 infants of smoking mothers and in 59 apparently healthy control infants. Although gestational age, birth weight, and systolic blood pressure were lower in infants exposed to tobacco smoke prenatally, systolic (65 +/- 11 vs. 47 +/- 1...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01956151
更新日期：1993-03-01 00:00:00
abstract：:We review the validity of balloon occlusion aortography (BOA) on the basis of our personal experience with 18 patients with congenital heart disease (mean weight 4.55 g, including 8 neonates). Four of the 18 patients underwent aortic arch angiography using balloon occlusion of the descending aorta. Pulmonary angiograp...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955515
更新日期：1991-02-01 00:00:00
abstract：:Newborns are exposed to mechanical and oxidative stress during labor and to relative hyperoxia thereafter during the course of adaptation to the extrauterine conditions. Part of the adaptation mechanism is the rapid degradation of fetal hemoglobin and the oxidation of its heme moiety by heme oxygenases (HOs). Heme oxy...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0375-x
更新日期：2007-10-01 00:00:00
abstract：:A case of subacute meningitis caused by Brucella mellitensis is described. The meningitis was refractory to an antibiotic regime. Diagnosis was established by raised antibody titres to Brucella in serum and cerebrospinal fluid (CSF) and positive bone marrow and blood cultures. While treatment with tetracycline trimeth...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445917
更新日期：1988-11-01 00:00:00
abstract：:The relationship between nicotine and cotinine concentrations in mother's milk (including 24 h profiles) and the number of cigarettes consumed was studied. A total of 206 milk samples were collected from 34 nursing, smoking mothers. The mothers were distributed into three groups: Group I (1-10 cigarettes/day), group I...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00647276
更新日期：1987-01-01 00:00:00
abstract：:We present an infant with Dubowitz syndrome diagnosed at birth and followed for 2 years. Presence of the syndrome was suspected at birth on the basis of the anthropometric data and peculiar facial appearance. However, during the follow-up period some changes in the appearance have taken place. It is suggested that the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441881
更新日期：1986-04-01 00:00:00
abstract：UNLABELLED:To investigate the toxic effect of tobacco smoke on the fetus, we measured in cord blood the concentrations of alpha-fetoprotein (AFP), the principal serum protein in early ontogenic development, and erythropoietin (EPO), as an index of chronic fetal hypoxia. A total of 103 consecutively enrolled term newbor...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s004310051152
更新日期：1999-07-01 00:00:00
abstract：:The factors influencing the final height of central precocious puberty patients treated with gonadotrophin releasing hormone (GnRH) analogues remain a critical issue. This study compares the predicted final height before and after GnRH analogue therapy to identify predictive factors for final height. Fourteen girls wi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959077
更新日期：1992-10-01 00:00:00
abstract：:The aim of this study was to assess demographic data, clinical presentation, metabolic features, and treatment in 76 children with urolithiasis presented from 2002 to 2011. Urolithiasis is responsible for 2.5/1,000 pediatric hospitalizations, with new cases diagnosed in 1.1/1,000 admissions. From the observed period, ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2165-6
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:Population modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the drug will be used clinically. DISCUSSION:The advantages of these models in paediatric studies are that they can be used to analyse sparse data, sam...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-006-0188-y
更新日期：2006-11-01 00:00:00
abstract：:All 270 patients presenting with Henoch-Schönlein Purpura over a 13-year period from a total childhood population of 155,000 were studied. This is an incidence of 13.5/100,000 children per year. Fifty-five (20%) were found to have initial evidence of renal involvement, and were re-examined at a mean of 8.3 years later...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442205
更新日期：1988-02-01 00:00:00
abstract：UNLABELLED:The fatty acid composition of human breast milk was determined longitudinally after term and preterm delivery by high resolution gas liquid chromatography. Milk samples were obtained at days 5, 10, 20 and 30 after term (n = 38) or preterm (n = 19) delivery. The saturated fatty acids C10:0 and C12:0 and the p...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050573
更新日期：1997-02-01 00:00:00
abstract：UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-015-2566-9
更新日期：2015-11-01 00:00:00
abstract：:The role of the type-2 T helper (Th2) cell-mediated immune response in the immunopathogenesis of atopic dermatitis (AD) is well documented. Whether polarized immunoresponse is confined to antigen-specific T cells or is distributed among all T cell subsets is still controversial. We investigated frequencies of interleu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0319-5
更新日期：2007-08-01 00:00:00
abstract：:A large number of ventilation strategies are now available for the neonate. This review has focused on new information, that is, studies published since 2000 and the implication of their results for current clinical practice. Meta-analysis of randomised trials has demonstrated that assist control and synchronous inter...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-007-0513-0
更新日期：2007-10-01 00:00:00
abstract：:The growth hormone (GH) gene (hGH-N) cluster was analysed using polymerase chain reaction, Southern and polymorphism analysis in five patients (including two pairs of siblings) with extreme short stature and absence of GH secretion. Patients 1 and 2 (siblings) were homozygous for a large deletion removing four genes o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02190682
更新日期：1994-09-01 00:00:00
abstract：:We studied the incidence of IgG subclass deficiency in children with recurrent bronchitis. Recurrent bronchitis was defined as three or more episodes a year during at least 2 consecutive years, of bronchopulmonary infection, productive cough with or without fever and/or diffuse râles by physical examination in the abs...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072228
更新日期：1992-04-01 00:00:00
abstract：:A case of neonatal suppurative parotitis due to Klebsiella pneumoniae is described. This is the first case reported in the last 20 years. Infection with unusual microorganisms should be taken into account when planning antibiotic treatment, especially in hospital acquired infections of the salivary glands in the newbo...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957226
更新日期：1993-12-01 00:00:00
abstract：:A series of information processing tasks was administered to 22 PKU children aged 8.5 years who had been under dietary treatment since birth as well as to 20 controls of the same age. This contribution presents the results of two tasks from this series: a continuous performance task and a calculation task. The continu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02126298
更新日期：1990-01-01 00:00:00
