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The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis.

Abstract：

INTRODUCTION:Impaired vitamin K status in cystic fibrosis (CF) has been considered as a newly emerged pathogenetic factor for reduced bone mineral density (BMD). OBJECTIVES:Our aim was to evaluate the effectiveness of vitamin K supplementation in managing bone formation abnormalities in children and adolescents with CF. MATERIALS AND METHODS:The statuses of vitamins K and D in relation to biochemical markers of bone metabolism and BMD were examined in 20 CF children receiving vitamin D supplements but not vitamin K supplements. Laboratory tests were carried out at the beginning of the study period and after 1 year of vitamin K supplementation (10 mg single oral dose/week) and the results were compared; the results were also compared with those of 25 healthy controls. RESULTS AND DISCUSSION:Ten of the CF patients had BMD z-score

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Nicolaidou P,Stavrinadis I,Loukou I,Papadopoulou A,Georgouli H,Douros K,Priftis KN,Gourgiotis D,Matsinos YG,Doudounakis S

doi

10.1007/s00431-006-0132-1

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

540-5

issue

8

eissn

0340-6199

issn

1432-1076

journal_volume

165

pub_type

杂志文章

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