当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PEDIATRICS期刊下所有文献 > Circadian growth hormone secretion in short multitransfused prepubertal children with thalassaemia major.

Circadian growth hormone secretion in short multitransfused prepubertal children with thalassaemia major.

Abstract：

UNLABELLED:Growth hormone (GH) secretion was determined by evaluating circadian GH profiles for 24 h and GH responses to clonidine stimulation test and insulin-stimulated hypoglycaemia (ITT), in nine prepubertal children with beta-thalassaemia major (TM) and 17 with non-GH deficient short stature (NGHDSS). The TM children were multitransfused and had early and intensive chelation therapy. All patients had normal hypoglycaemia to ITT, with peak GH levels of 15.71 +/- 5.86 ng/ml for children with NGHDSS and 13.91 +/- 7.20 ng/ml for children with TM. Peak GH levels during a clonidine test were 17.54 +/- 5.30 and 17.15 +/- 1.38 ng/ml, respectively. The GH peak parameters such as the number of peaks, the integrated GH concentration and the area under the curve (AUC) were similar in both groups of children and reflected the total 24-h secretion and the daily and nocturnal secretion separately. An abnormal 24-h GH profile compatible with the diagnosis of endogenous neurosecretory GH dysfunction was found in only two out of nine children with TM and in four out of seven children with NGHDSS. CONCLUSION:Our data suggest that growth hormone neurosecretory dysfunction is not a universal finding in children with thalassaemia major but might depend on the degree of iron deposit in the pituitary.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Katzos G,Harsoulis F,Papadopoulou M,Athanasiou M,Sava K

doi

10.1007/BF02029352

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

445-9

issue

6

eissn

0340-6199

issn

1432-1076

journal_volume

154

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PEDIATRICS文献大全
  • Intellectual capacity of subjects exposed to methimazole or propylthiouracil in utero.

    abstract：:Antithyroid drugs, considered the treatment of choice for hyperthyroidism during pregnancy, may have an adverse effect on intellectual development of the offspring. We examined the intellectual capacity of 31 subjects aged 4-23 years, born to women with Graves disease who received antithyroid drugs throughout pregnanc...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01957719

    authors： Eisenstein Z,Weiss M,Katz Y,Bank H

    更新日期：1992-08-01 00:00:00

  • Evaluation of the current use of imaging modalities and pathogen detection in children with acute osteomyelitis and septic arthritis.

    abstract：:Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA be...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-018-3157-3

    authors： Manz N,Krieg AH,Heininger U,Ritz N

    更新日期：2018-07-01 00:00:00

  • Breast-feeding influences thymic size in late infancy.

    abstract：:We have previously shown that breast-fed infants have a considerably larger thymus at 4 months than formula-fed infants. The aim of the present study was to investigate whether breast-feeding also influences the thymic size in late infancy. In a cohort of 50 infants, all being partially breast-fed when recruited at 8 ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s004310051258

    authors： Hasselbalch H,Engelmann MD,Ersboll AK,Jeppesen DL,Fleischer-Michaelsen K

    更新日期：1999-12-01 00:00:00

  • Use of a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka) in healthy children.

    abstract：UNLABELLED:The first live-attenuated Oka strain varicella vaccines needed to be stored at -20 degrees C. Reformulation of this vaccine by SmithKline Beecham Biologicals has provided a vaccine shelf life of up to 2 years when stored at +4 degrees C to +8 degrees C. In this study the immunogenicity and reactogenicity of ...

    journal_title：European journal of pediatrics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01957158

    authors： Tan AY,Connett CJ,Connett GJ,Quek SC,Yap HK,Meurice F,Lee BW

    更新日期：1996-08-01 00:00:00

  • Healthy lifestyle promotion in primary schools through the board game Kaledo: a pilot cluster randomized trial.

    abstract：:The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten scho...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00431-018-3091-4

    authors： Viggiano E,Viggiano A,Di Costanzo A,Viggiano A,Viggiano A,Andreozzi E,Romano V,Vicidomini C,Di Tuoro D,Gargano G,Incarnato L,Fevola C,Volta P,Tolomeo C,Scianni G,Santangelo C,Apicella M,Battista R,Raia M,Valentino I

    更新日期：2018-09-01 00:00:00

  • Low birth weight at term impairs cord serum lipoprotein compositions and concentrations.

    abstract：UNLABELLED:The purpose of this study was to determine the effect of low birth weight at term on serum lipoproteins. Lipid and apolipoprotein (apo) contents were investigated in cord sera of small-for-gestational-age (SGA) newborns at term (2290 g +/- 33 g) and compared with those of appropriate-for-gestational-age (AGA...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s004310050820

    authors： Merzouk H,Meghelli-Bouchenak M,el-Korso N,Belleville J,Prost J

    更新日期：1998-04-01 00:00:00

  • Carcinoid and mucoepidermoid bronchial tumours in children.

    abstract：UNLABELLED:The aim of the study was to determine the characteristic features and outcome of carcinoid or mucoepidermoid tumours in children. A retrospective analysis of all patients treated for a carcinoid or mucoepidermoid tumour in France between 1984 and 2001 was performed. There were 11 cases of carcinoid tumour an...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-005-1740-x

    authors： Fauroux B,Aynie V,Larroquet M,Boccon-Gibod L,Ducou le Pointe H,Tamalet A,Clément A

    更新日期：2005-12-01 00:00:00

  • Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence.

    abstract：:Severe complications due to Shigatoxin-associated hemolytic uremic syndrome (STEC-HUS) currently present a serious challenge since no specific treatment for this condition is available. Eculizumab, a terminal complement inhibitor, has been used especially in STEC-HUS patients with severe neurological involvement, but ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-017-3077-7

    authors： Keenswijk W,Raes A,Vande Walle J

    更新日期：2018-03-01 00:00:00

  • Achondrogenesis type I: light and electron-microscopic studies.

    abstract：:The light- and electron-microscopic structure of articular and costal cartilage in a case of achondrogenesis type I has been described. The most characteristic ultrastructural change in the chondrocytes was conspicuous dilatation of the rough endoplasmatic reticulum (RER) which contained amorphous electronopaque mater...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00442406

    authors： Molz G,Spycher MA

    更新日期：1980-06-01 00:00:00

  • Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.

    abstract：UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that c...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00431-014-2416-1

    authors： Ogawa Y,Irikura M,Kobaru Y,Tomiyasu M,Kochiyama Y,Uriu M,Ishitsuka Y,Kondo Y,Yukawa E,Kamada N,Ohno H,Yamazaki T,Irie T

    更新日期：2015-04-01 00:00:00

  • Balloon occlusion aortography.

    abstract：:We review the validity of balloon occlusion aortography (BOA) on the basis of our personal experience with 18 patients with congenital heart disease (mean weight 4.55 g, including 8 neonates). Four of the 18 patients underwent aortic arch angiography using balloon occlusion of the descending aorta. Pulmonary angiograp...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01955515

    authors： Ino T,Shimazaki S,Nishimoto K,Akimoto K,Iwahara M,Yabuta K,Watanabe M,Tanaka A,Hosoda Y

    更新日期：1991-02-01 00:00:00

  • Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis.

    abstract：:Pentoxifylline (PTX) is a candidate adjuvant medication for the treatment of sepsis and necrotizing enterocolitis in preterm infants. There is only limited data on safety and compatibility with other commonly used intravenous medications. This retrospective single-center study of 198 preterm infants (September 2012-Se...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-020-03612-9

    authors： Schüller SS,Kempf K,Unterasinger L,Strunk T,Berger A

    更新日期：2020-08-01 00:00:00

  • What's new in metabolic and genetic hypoglycaemias: diagnosis and management.

    abstract：:Hypoglycaemia in children can be a life-threatening situation that needs to be assessed rigorously in order to treat efficiently and avoid relapse that can be responsible for cerebral damage. The diagnosis of impairment in glucose homeostasis requires the knowledge of the mechanisms regulating blood glucose concentrat...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-007-0600-2

    authors： Valayannopoulos V,Romano S,Mention K,Vassault A,Rabier D,Polak M,Robert JJ,de Keyzer Y,de Lonlay P

    更新日期：2008-03-01 00:00:00

  • Refining clinical phenotypes in septo-optic dysplasia based on MRI findings.

    abstract：:Septo-optic dysplasia (SOD) is a heterogeneous brain midline anomaly associated with ophthalmological, endocrinological, and/or neurodevelopmental symptoms. The clinical phenotype correlates with abnormal brain magnetic resonance imaging (MRI) findings. However, variations of the septum pellucidum (SP) appearance and ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-007-0666-x

    authors： Riedl S,Vosahlo J,Battelino T,Stirn-Kranjc B,Brugger PC,Prayer D,Müllner-Eidenböck A,Kapelari K,Blümel P,Waldhör T,Krasny J,Lebl J,Frisch H

    更新日期：2008-11-01 00:00:00

  • Immunoglobulin deficiency with increased immunoglobulin M in three siblings: effect of long-term immunoglobulin therapy.

    abstract：:Diagnosis of immunoglobulin deficiency with increased IgM (hyper-IgM syndrome) was made in three siblings (two girls and a boy) on the basis of history, physical findings, and laboratory data. The prominent clinical findings were recurrent viral and bacterial infections of the respiratory tract. The most severe infect...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00441406

    authors： Maródi L,Szabó I,Kalmár A

    更新日期：1988-12-01 00:00:00

  • Effect of inhaled nitric oxide on intrapulmonary right-to-left-shunting in two rabbit models of saline lavage induced surfactant deficiency and meconium instillation.

    abstract：:Marked hypoxia secondary to intrapulmonary right-to-left shunting is a characteristic of respiratory failure in human neonates and can sometimes be complicated by additional extrapulmonary right-to-left shunting. To investigate the effect of inhaled nitric oxide (iNO) on intrapulmonary shunting, two typical pulmonary ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s004310050841

    authors： Krause MF,Lienhart HG,Haberstroh J,Hoehn T,Schulte-Mönting J,Leititis JU

    更新日期：1998-05-01 00:00:00

  • Prediction of final height in boys with non-tumorous hypopituitarism.

    abstract：:The total height gain was studied in 19 adult male subjects with non-tumorous hypopituitarism after they had been treated with human growth hormone (hGH) for more than 3 years and achieved final adult height. In patients with a history of breech delivery or severe perinatal asphyxia, a high multiple correlation was fo...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00442688

    authors： Van den Broeck J,Vanderschueren-Lodeweyckx M,Eggermont E

    更新日期：1988-04-01 00:00:00

  • Vitamin B12 deficiency in a 9-month-old boy.

    abstract：UNLABELLED:We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. The deficiency was secondary to prolonged exclusive breastfeeding with inadequate nutritional amounts of vitamin B12 from the mother. There were no clinical or biological signs of ma...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-011-1577-4

    authors： Quentin C,Huybrechts S,Rozen L,De Laet C,Demulder A,Ferster A

    更新日期：2012-01-01 00:00:00

  • Radioisotopic evaluation of the renal parenchymal function in children with ureteropelvic junction obstruction. A retrospective study.

    abstract：:Separate glomerular filtration rates were evaluated in 21 children with uni- or bilateral ureteropelvic junction stenosis, using the Tc-99m DTPA complex and the scintillation camera. The grade of alteration seen on urograms has influenced the surgeon in his decision to use a conservative or a surgical treatment, where...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00446067

    authors： Piepsz A,Hall M,Ham HR,Perlmutter N,Collier F

    更新日期：1986-08-01 00:00:00

  • The "4A" syndrome: adrenocortical insufficiency associated with achalasia, alacrima, autonomic and other neurological abnormalities.

    abstract：:The triad of adrenocortical insufficiency with alacrima and achalasia is an unusual disease entity in paediatrics. The association of autonomic and peripheral neuropathies has more commonly been reported in older individuals. We describe four children (two siblings) with this disorder, aged between 3 and 6 years at di...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01972967

    authors： Gazarian M,Cowell CT,Bonney M,Grigor WG

    更新日期：1995-01-01 00:00:00

  • Surgical approach to male pseudohermaphroditism.

    abstract：:Male pseudohermaphroditism (MPH) is defined as incomplete masculinization in patients with normal male karyotype (XY) and testicular histology. MPH encompasses a spectrum of female to male phenotypes and presents both diagnostic and technical challenges to the surgeon. Once gender is assigned, based on phenotype, adeq...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/BF02125449

    authors： Packer MG

    更新日期：1993-01-01 00:00:00

  • A national educational campaign to raise awareness of child physical abuse among health care professionals.

    abstract：:Education is necessary to improve child physical abuse detection and management. A few studies have described national child abuse training programs, but none has measured changes in knowledge among participants. A collaboration of child abuse experts from the USA, an academic pediatric department, and a non-governmen...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-020-03625-4

    authors： Soldatou A,Stathi A,Panos A,Paouri B,Koutsoukou E,Krepis P,Tsolia M,Oral R,Leventhal JM

    更新日期：2020-09-01 00:00:00

  • Demographic characteristics and metabolic risk factors in Croatian children with urolithiasis.

    abstract：:The aim of this study was to assess demographic data, clinical presentation, metabolic features, and treatment in 76 children with urolithiasis presented from 2002 to 2011. Urolithiasis is responsible for 2.5/1,000 pediatric hospitalizations, with new cases diagnosed in 1.1/1,000 admissions. From the observed period, ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-013-2165-6

    authors： Milošević D,Batinić D,Turudić D,Batinić D,Topalović-Grković M,Gradiški IP

    更新日期：2014-03-01 00:00:00

  • Oral vitamin A supplementation in very low birth weight neonates: a randomized controlled trial.

    abstract：:This randomized double-blind placebo-controlled trial evaluated the effects of early postnatal oral vitamin A supplementation (VAS) in 196 inborn very-low birth weight (VLBW) infants requiring respiratory support at 24 h of age. Eligible infants were randomized to receive aqueous syrup of vitamin A (10,000 IU of retin...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00431-019-03412-w

    authors： Basu S,Khanna P,Srivastava R,Kumar A

    更新日期：2019-08-01 00:00:00

  • Latent chronic cholangitis in congenital hepatic fibrosis.

    abstract：:In a five-year-old girl with congenital hepatic fibrosis raised erythrocyte sedimentation rate and serum gammaglobulins were noted for 3 years. Needle liver biopsy showed histological features of cholangitis and Klebsiella oxytoca was cultured from a liver biopsy specimen. Antibiotic treatment resulted in normalizatio...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01377359

    authors： Alvarez F,Hadchouel M,Bernard O

    更新日期：1982-11-01 00:00:00

  • Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases.

    abstract：:The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely ass...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-017-2949-1

    authors： de Vetten L,van Stuijvenberg M,Kema IP,Bocca G

    更新日期：2017-08-01 00:00:00

  • Pierre Robin sequence and hyperphalangy--a genetic entity (Catel-Manzke syndrome).

    abstract：:Since the first description by Catel and Manzke of hyperphalangy and clinodactyly of the index finger associated with Robin malformation sequence, seven further cases have been published. In two families more than one case occurred. Another family is presented with possibly two affected boys showing variable features ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00442455

    authors： Brude E

    更新日期：1984-08-01 00:00:00

  • GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia.

    abstract：:A Japanese patient presented with lymphedema, severe Varicella zoster, and Salmonella infection, recurrent respiratory infections, panniculitis, monocytopenia, B- and NK-cell lymphopenia, and myelodysplasia. The phenotype was a mixture of the monocytopenia and mycobacterial infection (MonoMAC) and Emberger syndromes. ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-012-1715-7

    authors： Ishida H,Imai K,Honma K,Tamura S,Imamura T,Ito M,Nonoyama S

    更新日期：2012-08-01 00:00:00

  • Severe anemia due to transient pure red cell aplasia in early childhood. Arrest at the level of the committed stem cells?

    abstract：:Five patients, 11 months to 3 4/12 years old with severe normochromic, normocytis anemia and reticulocytopenia are reported. At the height of erythropoietic arrest when erythroid precursor cells were completely absent, undifferentiated stem cells (transitional cells), accumulated in the bone marrow. They disappeared a...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00497680

    authors： Tillmann W,Prindull G,Schröter W

    更新日期：1976-08-16 00:00:00

  • Staphylococcus saprophyticus urinary tract infections in children.

    abstract：:Staphylococcus saprophyticus commonly causes urinary tract infection (UTI) in young women; in males it is found mainly in the elderly. In this study S. saprophyticus UTI occurred in 59 children (45 girls and 14 boys) below 16 years of age, of whom 20 were less than 13 years of age. The common presentation was dysuria ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF02072520

    authors： Abrahamsson K,Hansson S,Jodal U,Lincoln K

    更新日期：1993-01-01 00:00:00