Abstract：
:Effective management of pain remains an important indicator of the quality of care provided to neonates. Since the review of McIntosh in this journal over a decade ago, an extensive number of papers on assessment, prevention, and treatment of pain have been reported. In addition, preclinical insights into neurodevelopmental aspects of pain processing and the neuro-apoptotic effects of analgesics and sedatives were unveiled. Based on the newly collected evidence, the practice of "one-drug, one dose and one treatment fits all" became obsolete, necessitating a more individualized analgesia, based on non-pharmacological and pharmacological therapies and preventive strategies for effective management of neonatal pain. The progress made is impressive, but the current major challenge is to implement the available knowledge in clinical care. Future research should therefore focus on the evaluation of the effectiveness of non-opioid and moderately potent opioids compared to morphine and should also describe the methods to facilitate effective implementation. Finally, there is an extensive field of procedural techniques that need to be evaluated on their pain related response.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Allegaert K,Veyckemans F,Tibboel Ddoi
10.1007/s00431-009-0932-1subject
Has Abstractpub_date
2009-07-01 00:00:00pages
765-70issue
7eissn
0340-6199issn
1432-1076journal_volume
168pub_type
杂志文章,评审abstract：UNLABELLED:Melatonin is secreted during the night in adults but not in infants. It has a hypnotic effect as well as a relaxing effect on the smooth muscle of the gastrointestinal tract. It is plausible that breast milk, which consists of melatonin, may have an effect on improving infants' sleep and reducing infantile c...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1659-3
更新日期：2012-04-01 00:00:00
abstract：UNLABELLED:Hypotension is a commonly diagnosed and treated complication of extremely low gestational age newborns (ELGAN), but enormous variation in diagnosis, management and clinical practice has been documented. We sought to evaluate practice regarding the management of hypotension in ELGANs and developed a web-based...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-013-2251-9
更新日期：2014-06-01 00:00:00
abstract：:In 238 boys with cryptorchidism, between the ages of 4 and 48 months, luteinizing hormone releasing hormone (LHRH) was administered as nasal spray 1.2 mg/day for 4 weeks. The nonresponders received human chorionic gonadotropin (HCG) 500 I.U. i.m. three times a week for 3 weeks. With the combined treatment 37.8% of tes...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02125433
更新日期：1993-01-01 00:00:00
abstract：:Mutation in the orphan nuclear receptor DAX-1 gene causes X-linked adrenal hypoplasia congenita (AHC). Affected male children classically suffer a salt-losing crisis and adrenal insufficiency in their early infancy or, in some rare exceptions, with late-onset subtype. We report here a patient manifesting late-onset ad...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0779-x
更新日期：2009-03-01 00:00:00
abstract：:Female patients with congenital adrenal hyperplasia have been frequently studied in order to determine the impact of prenatal androgen exposure on various aspects of psychological, psychosocial and psychosexual development. There is no published study to evaluate the impact of the genital malformation, genital operati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02276713
更新日期：1995-09-01 00:00:00
abstract：:A 17-year-old patient suffering from Crohn disease (CD) and liver cirrhosis is presented. At an advanced stage of the disease, he died of a concomitant urosepsis. Autopsy showed that the liver cirrhosis was caused by sclerosing cholangitis. This very rare complication of CD in adolescence is discussed. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072206
更新日期：1991-06-01 00:00:00
abstract：UNLABELLED:Paediatric care places great demands on interpersonal communication skills, especially as regards the handling of psychosocial issues. Recent shifts in paediatric morbidity and increases in patient empowerment furthermore emphasize the need for continuing paediatric education in communication skills. It is, ...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s004310051316
更新日期：2000-07-01 00:00:00
abstract：:In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441477
更新日期：1980-09-01 00:00:00
abstract：UNLABELLED:A retrospective analysis was performed of the records of 133 patients with extrahepatic biliary atresia (EHBA) who had undergone a Kasai portoenterostomy. The patients were divided into a non-transplantation group who survived but did not receive liver transplantation after the procedure and a failure group ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1268-x
更新日期：2003-09-01 00:00:00
abstract：LARYNGOSCOPE BURNS IN NEONATAL INTUBATION:Following burns during neonatal intubation, we mounted an in vitro study of laryngoscopes to determine the temperatures reached during clinical use. The temperature of 10 different bulb laryngoscopes heads and two fibre optic heads were measured with a thermocouple, once opened...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03381-0
更新日期：2019-07-01 00:00:00
abstract：UNLABELLED:We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION:Pulm...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050684
更新日期：1997-08-01 00:00:00
abstract：UNLABELLED:Newborn screening for cystic fibrosis (CF), a chronic progressive disease affecting mucus viscosity, has been beneficial in both improving life expectancy and the quality of life for individuals with CF. In New York State from 2007 to 2012 screening for CF involved measuring immunoreactive trypsinogen (IRT) ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2616-3
更新日期：2016-02-01 00:00:00
abstract：:Twenty-six children with cerebral palsy were examined with respect to structural asymmetry of the mouth. In 19 children there were clear cut correlations between symmetry/asymmetry of voluntary function and the oral findings. Patients with symmetrical patterns of movements had symmetrical dentition, while in those wit...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441639
更新日期：1980-12-01 00:00:00
abstract：:An immunocompetent 9-year-old boy with disseminated cat scratch disease involving spleen, cervical and abdominal lymph nodes, skull, and one clavicle is reported. Antibodies to Rochalimaea quintana and R. henselae were detected, at increasing, then decreasing concentration. DNA extracted from the biopsied skull lesion...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：UNLABELLED:Scorpion envenomation is a health problem in children in tropical and subtropical regions. The aim of this study was to evaluate demographic and clinical characteristics as well as outcomes in referred children to Assiut University Children Hospital during the year 2012 with a history of scorpion sting. The ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2244-8
更新日期：2014-06-01 00:00:00
abstract：:A case of subacute meningitis caused by Brucella mellitensis is described. The meningitis was refractory to an antibiotic regime. Diagnosis was established by raised antibody titres to Brucella in serum and cerebrospinal fluid (CSF) and positive bone marrow and blood cultures. While treatment with tetracycline trimeth...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445917
更新日期：1988-11-01 00:00:00
abstract：:We report the 9-year follow-up of a patient suffering from N-acetylglutamate synthetase deficiency, an urea cycle disorder leading to severe neonatal hyperammonaemia. Hitherto two patients from two families with this inborn error of metabolism had been observed. Our management consisted mainly of a protein-restricted ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955939
更新日期：1991-03-01 00:00:00
abstract：:Phenobarbital has been shown to offer effective prophylaxis against childhood febrile convulsions. However, a high percentage of children do not tolerate phenobarbital, mainly due to behavioral changes. Valproate, due to its low toxicity, appears to be an attractive alternative to phenobarbital treatment. Ninety child...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441308
更新日期：1981-10-01 00:00:00
abstract：:By the description of two cases of osteoarticular infections due to Kingella kingae in two young children we wish to draw the attention of clinicians to invasive infections due to this micro-organism. Since its biological characterization in 1976, K. kingae has been increasingly reported as a human pathogen. Most comm...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02072618
更新日期：1991-07-01 00:00:00
abstract：UNLABELLED:The aim of this study was to assess whether the severity of congenital heart defects (CHD) affects disease-specific health-related quality of life (HRQOL) in children after open heart surgery. One hundred and fourteen children with CHD and one of their parents participated in the study. HRQOL was evaluated b...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1060-7
更新日期：2010-03-01 00:00:00
abstract：:The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02024330
更新日期：1989-10-01 00:00:00
abstract：UNLABELLED:The symptoms of urinary tract infections in infants are very non-specific and have historically included prolonged hyperbilirubinaemia. We studied the results of routine urine samples in 319 infants with prolonged jaundice. Convincing findings of UTI was not found in any of these children even if one of them...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2499-3
更新日期：2015-07-01 00:00:00
abstract：:We have investigated four patients from three unrelated families with typical clinical and biochemical features of "late-onset" multiple carboxylase deficiency. All patients suffered from biotinidase deficiency (plasma biotinidase activities 1.4%-3% of normal). Intestinal absorption of biotin, measured in three of the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00491919
更新日期：1985-05-01 00:00:00
abstract：UNLABELLED:Overweight and obesity are major public health issues. Childhood obesity often persists throughout adulthood. Recently a higher prevalence of obesity in adults whose mothers smoked during pregnancy was reported. The aim of this study was to assess whether this association is also detectable in pre-school chi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-0983-z
更新日期：2002-08-01 00:00:00
abstract：:A 22 years old female with the late-onset of argininosuccinic aciduria was successfully treated for 5 months with a mixture of essential amino acids and their keto-analogues. There was a marked change in plasma ammonia, plasma amino acids and argininosuccinic acid excretion. A long term anabolic response was reflected...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445607
更新日期：1978-07-19 00:00:00
abstract：UNLABELLED:The purpose of this study was to assess how much of the variance in intellectual outcome at 2 and 6 years of age could be attributed to treatment variables in children with congenital hypothyroidism, and which of the parameters used for monitoring treatment predicted later development. Forty-five children, e...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955261
更新日期：1996-05-01 00:00:00
abstract：UNLABELLED:Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2364-9
更新日期：2015-01-01 00:00:00
abstract：:Pediatric headache is an increasingly reported phenomenon. Cervicogenic headache (CGH) is a subgroup of headache, but there is limited information about cervical spine physical examination signs in children with CGH. Therefore, a cross-sectional study was designed to investigate cervical spine physical examination sig...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2046-z
更新日期：2013-10-01 00:00:00
abstract：UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02079073
更新日期：1995-08-01 00:00:00
abstract：:Spontaneous pneumomediastinum is uncommon in paediatric practice. We describe two cases of spontaneous pneumomediastinum in a child and an adolescent with anorexia nervosa. Thorough investigation failed to reveal any underlying cause for secondary pneumomediastinum. Pneumomediastinum in anorexia nervosa can be caused ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0444-9
更新日期：2008-02-01 00:00:00
