Abstract：
:Phenobarbital has been shown to offer effective prophylaxis against childhood febrile convulsions. However, a high percentage of children do not tolerate phenobarbital, mainly due to behavioral changes. Valproate, due to its low toxicity, appears to be an attractive alternative to phenobarbital treatment. Ninety children admitted with their first febrile convulsion were offered prophylactic treatment with either phenobarbital 3-5 mg/kg/day or valproate 20-30 mt/kg/day. Twenty-five children whose parents refused prophylactic treatment make up an untreated control group. Serum levels of the appropriate drug were measured at each follow-up visit. The three groups appear to be comparable. Twenty-one per cent of the phenobarbital treated children required discontinuation of the drug due to side effects. All the children tolerated valproate therapy. Twelve out of 25 untreated children suffered recurrences. Eight out of 33 children treated with phenobarbital suffered recurrences. Four out of 32 children on valproate therapy had recurrences. The difference between valproate treatment and no therapy at all is highly significant (p less than 0.001). Phenobarbital did not reduce the risk of recurrence. We now recommend prophylactic treatment with valproate to children with febrile seizures.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Lee K,Melchior JCdoi
10.1007/BF00441308subject
Has Abstractpub_date
1981-10-01 00:00:00pages
151-3issue
2eissn
0340-6199issn
1432-1076journal_volume
137pub_type
杂志文章abstract：:Despite the sudden and often alarming clinical manifestations of ITP, few patients in the pediatric age group develop serious complications or long-term sequellae. Conservative therapy, without use of pharmacologic or surgical intervention, is the most convenient, safe, and cost-effective approach in the vast majority...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02343213
更新日期：1987-03-01 00:00:00
abstract：:Scimitar syndrome is a rare congenital cardiopulmonary malformation characterized by hypoplasia of the right lung and drainage of the right pulmonary veins into the vena cava inferior. It may also be associated with cardiac dextroversion and anomalies of the tracheobronchial system, cardiovascular system, and diaphrag...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1153-3
更新日期：2010-10-01 00:00:00
abstract：:A 22 years old female with the late-onset of argininosuccinic aciduria was successfully treated for 5 months with a mixture of essential amino acids and their keto-analogues. There was a marked change in plasma ammonia, plasma amino acids and argininosuccinic acid excretion. A long term anabolic response was reflected...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445607
更新日期：1978-07-19 00:00:00
abstract：:Sandifer syndrome is a rare complication of gastro-oesophageal reflux disease (GERD) when a patient presents with extraoesophageal symptoms, typically neurological. The aim of this study was to review the existing literature and describe a typical presentation and most appropriate investigations and management for the...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-019-03567-6
更新日期：2020-02-01 00:00:00
abstract：UNLABELLED:Although bacterial colonisation of bronchi may occur from early childhood onwards, infections extending beyond the lungs are uncommon in patients with cystic fibrosis. A 12-year-old boy with cystic fibrosis, receiving oral corticosteroids for 3 weeks because of allergic bronchopulmonary aspergillosis, experi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00008408
更新日期：2000-09-01 00:00:00
abstract：:A comprehensive program for proficiency testing of biochemical genetics laboratories is described. Inborn errors of metabolism of amino acids, organic acids, glycosaminoglycans and oligosaccharides are covered, as well as the assay of galactose-1-phosphate. Participants are not only required to report the analytical r...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02138772
更新日期：1994-01-01 00:00:00
abstract：:Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA be...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3157-3
更新日期：2018-07-01 00:00:00
abstract：:A multistage liquid impinger was used to collect the nebulised cloud from three separate nebulisers. The output of sodium cromoglycate collected was determined by a spectrophotometric assay. Estimating drug output purely from weight loss during nebulisation resulted in a considerable overestimate compared with direct ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00595919
更新日期：1989-02-01 00:00:00
abstract：UNLABELLED:A 9-year-old boy lost almost all his small bowel after an acute volvulus due to a congenital, but previously unsuspected malrotation. Survival using total parenteral nutrition is possible in these cases, but the medical burden is heavy. Small intestinal transplantation was performed for the first time in the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1294-8
更新日期：2003-11-01 00:00:00
abstract：:Using a randomized double blind study design, the bronchodilating effect of 200 micrograms inhaled oxitropium bromide (OB) was compared with 200 micrograms inhaled fenoterol (F) after an interval of 20 min, in 20 asthmatic children aged 12.7 years (range: 4.9-15.1 years), suffering from mild bronchoconstriction (mean ...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02190670
更新日期：1994-08-01 00:00:00
abstract：:The renal function of 12 patients with non vitamin B12 responsive methylmalonic acidaemia has been investigated. Eight patients had reduced glomerular filtration rates, but the plasma creatinine concentration was only raised in those with values of less than 40 ml/min per 1.73 m2 surface area. The reduction in glomeru...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444131
更新日期：1989-01-01 00:00:00
abstract：UNLABELLED:Medical care for persons with chronic diseases like cystic fibrosis (CF) is provided by multi-professional teams. We assessed the patients' perspective of care by reporting the results of two consecutive patient satisfaction surveys performed within a 2-year interval at our CF centre. The newly developed, di...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2545-1
更新日期：2015-11-01 00:00:00
abstract：UNLABELLED:The aim of this study is to give a systematic overview on publications having investigated the allergy preventive effect of extensively and/or partially hydrolysed infant formulas. Publications were searched by several strategies. Inclusion criteria were: prospective cohort study, randomisation, family histo...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00008442
更新日期：2001-06-01 00:00:00
abstract：:Adolescence is a period characterized by rapid physical maturation, involving bodily changes that often necessitate a reorganization of self-perception. The current study investigated the impact of menarche on the determinants of quality of life in healthy female adolescents. Data were collected from 361 healthy femal...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03594-8
更新日期：2020-06-01 00:00:00
abstract：UNLABELLED:We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing nu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02002905
更新日期：1996-09-01 00:00:00
abstract：:Shock is a state of circulatory dysfunction and its diagnosis is complex in neonates. Hemodynamic assessment using echocardiography has potential to guide better management regimes in neonates with shock. Objective of this study is to analyze changes in the echocardiographic parameters in preterm neonates with shock a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03775-5
更新日期：2020-12-01 00:00:00
abstract：:Female patients with congenital adrenal hyperplasia have been frequently studied in order to determine the impact of prenatal androgen exposure on various aspects of psychological, psychosocial and psychosexual development. There is no published study to evaluate the impact of the genital malformation, genital operati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02276713
更新日期：1995-09-01 00:00:00
abstract：:Retraction Note to: Eur J Pediatr (1994) 153:668-671 DOI 10.1007/BF02190689. This article, "Adenosine triphosphate treatment for supraventricular tachycardia in infants", published in the European Journal of Pediatrics (1994) 153/9: 668-671, Springer-Verlag 1994, has been retracted at the request of the Publisher as i...
journal_title：European journal of pediatrics
pub_type： 撤回出版物
doi：10.1007/s00431-015-2640-3
更新日期：2015-11-01 00:00:00
abstract：UNLABELLED:The phenotypes of chromosomal 22q11.2 microdeletion are quite variable among individuals and hypoparathyroidism (HP) constitutes a definite portion of the clinical spectrum. For the correct diagnosis and pertinent follow up of the HP children due to del22q11.2, we tried to delineate the clinical characterist...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050762
更新日期：1998-01-01 00:00:00
abstract：:Niemann-Pick disease type C (NPC) is a lysosomal storage disorder caused by mutations in either NPC-1 or NPC-2 genes, resulting in abnormal intracellular cholesterol trafficking. The estimated prevalence of NPC disease is 1: 120,000-150,000. Lung involvement has been described in only few patients with NPC, mostly NPC...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3219-6
更新日期：2018-11-01 00:00:00
abstract：:Complete masculinisation of the external genitalia (type V of Prader classification) is reported in two siblings with normal internal female genitalia, normal ovaries and a 46,XX chromosome constitution in different cell lines without any detectable source of exposure to androgen during pregnancy. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445596
更新日期：1984-06-01 00:00:00
abstract：:The role of the type-2 T helper (Th2) cell-mediated immune response in the immunopathogenesis of atopic dermatitis (AD) is well documented. Whether polarized immunoresponse is confined to antigen-specific T cells or is distributed among all T cell subsets is still controversial. We investigated frequencies of interleu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0319-5
更新日期：2007-08-01 00:00:00
abstract：:Gradenigo's syndrome (GS) is a rare disease characterised by the triad otitis media, pain in the region innervated by the first and the second division of trigeminal nerve and abducens nerve palsy. Septic sinus thrombosis is one of the most frequent and relevant complication of GS; it is often due to persistent damage...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1047-4
更新日期：2010-04-01 00:00:00
abstract：:A girl, 13 months of age, presented with generalised granulomatous skin, hair and mucosal candidiasis. Her lymphocytes failed to respond in vitro to Candida antigen (CA); the intradermal test with CA was also negative. Serum immunoglobulins, complement components, granulocyte functions (phagocytic and fungicidal), T-c...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442747
更新日期：1984-11-01 00:00:00
abstract：:A 4-month-old infant was admitted to the Pediatric Intensive Care Unit with Pneumococcal meningitis. A few hours after admission he developed intractable convulsions that could not be stopped with phenytoin, phenobarbitone and a continuous drip of diazepam. Thiopentone sodium anaesthesia was induced for 24 h terminati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441663
更新日期：1983-04-01 00:00:00
abstract：UNLABELLED:Successful therapy of vasodilatory shock in adults and children with arginine-vasopressin (AVP) has been reported previously. Data on the use of vasopressin in neonates is limited. This retrospective study reports the effects of AVP-treatment in neonates with catecholamine-resistant systemic vasodilatation a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0400-0
更新日期：2007-12-01 00:00:00
abstract：:Given the worldwide increase prevalence of overweight, obesity, and nonalcoholic fatty liver disease (NAFLD), the objective of this study was to evaluate whether the triglycerides and glucose (TyG) index is associated with hepatic steatosis in children with overweight or obesity. Apparently healthy children aged 5‑17 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03951-1
更新日期：2021-01-25 00:00:00
abstract：:The concentration of mRNA of insulin-like growth factor-II is (IGF-II) much elevated in some embryonic tumours such as Wilms tumour (nephroblastoma). In order to prove whether or not IGF-II is produced by the tumour tissue, IGF-II was extracted from freshly frozen tissue of Wilms tumour and hepatoblastoma. Normal adja...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072483
更新日期：1993-02-01 00:00:00
abstract：UNLABELLED:Intensive multimodality treatment has led to a remarkable improvement of prognosis in paediatric cancer patients, however, a great number of long-term survivors suffer from considerable tumour- or treatment-related late effects. Between January 1990 and December 1998, 223 consecutive survivors of childhood m...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00008340
更新日期：2000-10-01 00:00:00
abstract：:We aimed to assess the prevalence and outcomes of esophageal perforation in very low birth weight infants. This retrospective cohort study utilized the US National Inpatient Sample dataset for the years 2000 to 2017. A total of 1,755,418 very low birth weight infants were included; of them, 861 (0.05%) were diagnosed ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03894-z
更新日期：2021-02-01 00:00:00
