Abstract：
:Gradenigo's syndrome (GS) is a rare disease characterised by the triad otitis media, pain in the region innervated by the first and the second division of trigeminal nerve and abducens nerve palsy. Septic sinus thrombosis is one of the most frequent and relevant complication of GS; it is often due to persistent damage and late diagnosis. Computed tomography (CT) scan and magnetic resonance imaging (MRI) allow the correct diagnosis in most cases. Surgical therapy may be necessary for a better and more rapid resolution of the disease. We report the case of a 4-year-old child that was admitted for facial nerve palsy and abducens nerve palsy subsequent to a 2-week persistent pain in the right ear. MRI showed infective acute process of the right mastoid and partial ipsilateral sinus thrombophlebitis. The child was treated with high-dose intravenous antibiotics and with oral anticoagulants. A complete resolution of symptoms and radiological alterations were observed within 7 weeks. In conclusion, lateral sinus thrombosis and Gradenigo's syndrome are rare but potential fatal complications of otitis media and mastoiditis. High-dose intravenous antibiotics and a low dose of anticoagulant can achieve a complete recovery without surgery.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Scardapane A,Del Torto M,Nozzi M,Elio C,Breda L,Chiarelli Fdoi
10.1007/s00431-009-1047-4subject
Has Abstractpub_date
2010-04-01 00:00:00pages
437-40issue
4eissn
0340-6199issn
1432-1076journal_volume
169pub_type
杂志文章abstract：UNLABELLED:We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. The deficiency was secondary to prolonged exclusive breastfeeding with inadequate nutritional amounts of vitamin B12 from the mother. There were no clinical or biological signs of ma...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1577-4
更新日期：2012-01-01 00:00:00
abstract：UNLABELLED:In patients with propionic acidaemia (PA), the increased intracellular concentration of propionyl-CoA leads to a relative abundance of odd-numbered long-chain fatty acids (OLCFAs) in body lipids. We investigated the relative amount of OLCFA in erythrocyte membrane lipids over a period of 1-8 years in five pa...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050010
更新日期：2000-01-01 00:00:00
abstract：UNLABELLED:Chronic lung disease (CLD) is an inflammatory disorder; in patients with other inflammatory disorders exhaled nitric oxide (NO) levels are elevated. The aim of this study was to test the hypothesis that prematurely born infants with CLD would have elevated exhaled NO levels compared to those without CLD and ...
journal_title：European journal of pediatrics
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doi：10.1007/s00431-004-1480-3
更新日期：2004-09-01 00:00:00
abstract：:Severe complications due to Shigatoxin-associated hemolytic uremic syndrome (STEC-HUS) currently present a serious challenge since no specific treatment for this condition is available. Eculizumab, a terminal complement inhibitor, has been used especially in STEC-HUS patients with severe neurological involvement, but ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-017-3077-7
更新日期：2018-03-01 00:00:00
abstract：:Our prior studies of the molecular epidemiology of group A streptococcus (GAS) pharyngitis indicated that the most common emm types associated with pediatric pharyngitis in North America were 12, 1, 28, and 4. We previously reported that the proportions of pediatric pharyngitis due to emm types 12 and 4 decreased with...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0819-6
更新日期：2009-06-01 00:00:00
abstract：:We report a 19-year-old boy with an interstitial deletion of the long arm of chromosome 8 (46, XY, del(8)(pter----q23.3: :q24.13----qter)). He shows the typical clinical symptoms of tricho-rhino-phalangeal syndrome (TRPI) and severe mental retardation, however without multiple exostoses. This is the second report of a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02034746
更新日期：1990-06-01 00:00:00
abstract：:To evaluate the feasibility and clinical usefulness of immunocytochemical detection of bone marrow metastases in neuroblastoma, we studied bone marrow samples from patients undergoing intensive therapy, followed in the majority of cases by autologous bone marrow rescue. Two monoclonal antibodies were used in an indire...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442474
更新日期：1988-08-01 00:00:00
abstract：:We report a 16-year-old girl who was diagnosed with acute leukaemia and a marked leucocytosis >200 × 109/L. She presented with marked hypophosphatemia, hypokalemia, acute renal failure and acute respiratory failure. These electrolytes disturbances may indicate rapid tumour genesis. These ominous findings required urge...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2899-7
更新日期：2017-08-01 00:00:00
abstract：:The development of visual acuity and stereopsis was studied in 321 boys and 340 girls aged between 5 and 10 years. Visual acuity was assessed by the E test and a modified version of the STYCAR test, stereo acuity by the Lang-Stereo test [17]. Both vision tests showed an increase in the median visual acuity between the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02429046
更新日期：1986-12-01 00:00:00
abstract：:A 4-year-old boy is described with abdominal pain, emesis, weight loss, hypoproteinemia and edema. The diagnosis of Menetrier disease was made based on radiographic studies, gastroscopy and gastric biopsy. There was little response to medical treatment and enteral feedings were poorly tolerated for many weeks. Althoug...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441749
更新日期：1986-02-01 00:00:00
abstract：UNLABELLED:Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Recently, we reported a newly recognised inborn error due to deficiency of P5CS in two sibs, one presenting at birth w...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1545-3
更新日期：2005-01-01 00:00:00
abstract：:The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02024330
更新日期：1989-10-01 00:00:00
abstract：:Eight patients with the syndrome of benign paroxysmal vertigo of childhood are presented. This symptom complex is characterized by attacks of vertigo in young children combined with nystagmus, ataxia and transiently decreased vestibular function, but without impaired consciousness. Diagnostic and follow-up studies rev...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01846035
更新日期：1980-08-01 00:00:00
abstract：:Central line-associated bloodstream infection (CLABSI) is a significant cause of morbidity and mortality in neonatal intensive care units (NICUs). A "bundle" is defined as a combination of evidence-based interventions that provided they are followed collectively and reliably, are proven to improve patient outcomes. Th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03844-9
更新日期：2021-02-01 00:00:00
abstract：:Vascularization of the arms has been studied by impedance plethysmography (rheography) in eight children with Poland syndrome, a common malformation characterized by unilateral hand anomaly and ipsilateral aplasia of the inferior head of the pectoralis major muscle. A marked decrease of the velocity of the systolic in...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496922
更新日期：1978-05-22 00:00:00
abstract：UNLABELLED:Click-evoked oto-acoustic emissions (CEOAE) are acoustic responses produced by the inner ear, reflecting functional auditory integrity. We studied both the success rate of the CEOAE method and the CEOAE presence in preterm infants during their stay at the Neonatal Intensive Care Unit (NICU), by analysis of t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050986
更新日期：1998-12-01 00:00:00
abstract：:Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442471
更新日期：1988-08-01 00:00:00
abstract：UNLABELLED:Five neonates who suffered from an unexpected long period of respiratory failure, muscular hypotonia, and drowsiness were observed in a retrospective study. Prior to this general depression, unusually high doses of diazepam were administered to all patients via intravenous bolus injection. Serum levels of di...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310100745
更新日期：2001-06-01 00:00:00
abstract：:By the description of two cases of osteoarticular infections due to Kingella kingae in two young children we wish to draw the attention of clinicians to invasive infections due to this micro-organism. Since its biological characterization in 1976, K. kingae has been increasingly reported as a human pathogen. Most comm...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02072618
更新日期：1991-07-01 00:00:00
abstract：:Iron deficiency is frequently associated with anemia. Iron is a transition-metal ion, and it can induce free radical formation, which leads to formation of various lesions in DNA, proteins, and lipids. The aim of this study was to investigate baseline oxidative DNA damage and to clarify the role of the administration ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1147-1
更新日期：2010-08-01 00:00:00
abstract：:It is known that the 5%-10% of adults infected with hepatitis B virus (HBV) develop a chronic infection and that HBV infection acquired at birth by an hepatitis B surface antigen (HBsAg)/hepatitis B "e" antigen (HBeAg)-positive mother almost invariably leads to chronic infection. Little information is, however, availa...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954381
更新日期：1992-03-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01972977
更新日期：1995-01-01 00:00:00
abstract：UNLABELLED:Neutrophils are an essential component of the human host defence system against infection. Recombinant human granulocyte colony-stimulating factor induces neutrophilia and enhances effector functions of mature neutrophils. Since the biological effects of granulocyte colony-stimulating factor (G-CSF) are medi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051129
更新日期：1999-06-01 00:00:00
abstract：UNLABELLED:Ischaemic stroke is a rare event in childhood. In approximately one-fourth of cases an underlying cardiac disease can be detected. We investigated the importance of genetic risk factors of venous thromboembolism in childhood or stroke in adulthood as risk factors for ischaemic stroke in children in a multice...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/pl00014336
更新日期：1999-12-01 00:00:00
abstract：:A Japanese patient presented with lymphedema, severe Varicella zoster, and Salmonella infection, recurrent respiratory infections, panniculitis, monocytopenia, B- and NK-cell lymphopenia, and myelodysplasia. The phenotype was a mixture of the monocytopenia and mycobacterial infection (MonoMAC) and Emberger syndromes. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1715-7
更新日期：2012-08-01 00:00:00
abstract：:A male infant with transient citrullinemia is described. Initially, he was found to have hypertyrosinemia and hypermethioninemia upon routine neonatal screening for inborn errors of metabolism performed at 4 days of age and was revealed to have citrullinemia upon detailed examination of plasma amino acids. At 30 days ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445674
更新日期：1983-10-01 00:00:00
abstract：UNLABELLED:A 9-year-old boy lost almost all his small bowel after an acute volvulus due to a congenital, but previously unsuspected malrotation. Survival using total parenteral nutrition is possible in these cases, but the medical burden is heavy. Small intestinal transplantation was performed for the first time in the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1294-8
更新日期：2003-11-01 00:00:00
abstract：:Malignant thymoma was found in an 8-year-old Japanese boy with growth hormone (GH) deficiency who had received GH therapy for 3 years and 5 months. There may be a possible relationship between the occurrence of malignant thymoma and GH therapy. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02073374
更新日期：1993-10-01 00:00:00
abstract：:The phenylalanine hydroxylase (PAH) deficiency trait is heterogeneous with a continuum of metabolic phenotypes ranging from classical phenylketonuria (PKU) to mild hyperphenylalaninaemia (MHP). More than 200 mutations in the PAH gene are associated with PAH deficiency. From theoretical considerations or in vitro expre...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014253
更新日期：1996-07-01 00:00:00
abstract：UNLABELLED:Growth hormone (GH) secretion was determined by evaluating circadian GH profiles for 24 h and GH responses to clonidine stimulation test and insulin-stimulated hypoglycaemia (ITT), in nine prepubertal children with beta-thalassaemia major (TM) and 17 with non-GH deficient short stature (NGHDSS). The TM child...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02029352
更新日期：1995-06-01 00:00:00
