Abstract：
:To evaluate the feasibility and clinical usefulness of immunocytochemical detection of bone marrow metastases in neuroblastoma, we studied bone marrow samples from patients undergoing intensive therapy, followed in the majority of cases by autologous bone marrow rescue. Two monoclonal antibodies were used in an indirect immunoenzymatic assay to test 384 samples collected from multiple bone marrow sites during 79 staging procedures in 48 patients. Of 578 immunocytochemical tests, 59 (10%) yielded non-evaluable results. Analysis by individual bone marrow sites showed an agreement between cytological and immunocytochemical examinations in 276 of 309 (89%) evaluable tests with 5 A7 and in 179 of 210 (85%) with UJ 13 A. Infiltration by neuroblastoma cells was reported in 9% of samples by cytology, in 6% by immunochemistry with 5 A7 and in 16% with 13 A. Analysis of results by staging demonstrated agreement between cytological examination and immunocytochemical detection with both monoclonal antibodies in 60 of 75 (80%) evaluable stagings. Bone marrow metastasis was detected by cytology in 22% of stagings, by immunochemistry with 5 A7 in 23%, with UJ 13 A in 25%. Detailed analysis of discordant results revealed that they were related partly to bone marrow sampling variability associated with focal and minimal metastasis of neuroblastoma cells. These data suggest the clinical usefulness of immunocytochemical detection as a complementary test to cytological examination for accurate evaluation of bone marrow infiltration in patients with disseminated neuroblastoma.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Beck D,Maritaz O,Gross N,Favrot M,Vultier N,Bailly C,Villa I,Gentilhomme O,Philip Tdoi
10.1007/BF00442474subject
Has Abstractpub_date
1988-08-01 00:00:00pages
609-12issue
6eissn
0340-6199issn
1432-1076journal_volume
147pub_type
杂志文章abstract：:The tendency of non-operative management of appendicitis let us explore the natural history of appendiceal carcinoids, compare them with appendicitis patients, and determine the possibility of deciding the extent of the surgery and post-operative follow-up on behalf of the intraoperative findings. A retrospective revi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3258-z
更新日期：2018-12-01 00:00:00
abstract：:The laryngo-tracheo-oesophageal cleft is marked by a missing anatomical separation of the oesophagus and the larynx. The cleft can be restricted to the dorsal part of the larynx (type I), extend to the upper area of the trachea (type II) or involve the whole of the trachea (type III). In reviewing our three cases and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00661903
更新日期：1983-03-01 00:00:00
abstract：:Five patients, 11 months to 3 4/12 years old with severe normochromic, normocytis anemia and reticulocytopenia are reported. At the height of erythropoietic arrest when erythroid precursor cells were completely absent, undifferentiated stem cells (transitional cells), accumulated in the bone marrow. They disappeared a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00497680
更新日期：1976-08-16 00:00:00
abstract：:Congenital diaphragmatic eventration (CDE) and congenital diaphragmatic hernia (CDH) with or without hernia sac are three different types of congenital diaphragmatic malformations, which this study evaluates. All surgically treated patients with CDE or Bochdalek type CDH between 2000 and 2016 were included in this ret...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03576-w
更新日期：2020-06-01 00:00:00
abstract：:Neonatal acute respiratory distress syndrome (NARDS) reflects pulmonary surfactant dysfunction, and the usage of bovine surfactant (Calsurf) supplement may therefore be beneficial. To determine whether bovine surfactant given in NARDS can improve oxygenation and survival rate, we conducted a multicenter, randomized tr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03821-2
更新日期：2020-10-21 00:00:00
abstract：UNLABELLED:The aim of this study was to analyze changes in adipose tissue (AT) distribution, intrahepatic lipids (IHL), and insulin resistance (IR) among a group of obese adolescents undergoing a 7-months low-level lifestyle intervention. Thirty-nine obese Caucasian adolescents (mean age 13.9 years, body mass index sta...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2577-6
更新日期：2015-12-01 00:00:00
abstract：:This paper describes the design of a study to follow the development of boys and girls in secondary schools from the age of 12 through 17 on an annual basis, in order to acquire more information concerning the growth and development of teenagers. In this study, both physical and psychological characteristics are measu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442158
更新日期：1978-10-12 00:00:00
abstract：:Adverse drug reactions (ADRs) are a significant problem in children, affecting one in ten children in hospital. Within the community, one in 500 children will experience an adverse drug reaction each year. Pharmacovigilance has been useful in detecting suspected ADRs. However, most ADRs are unreported and often not su...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-012-1871-9
更新日期：2013-05-01 00:00:00
abstract：:We aimed to assess the prevalence and outcomes of esophageal perforation in very low birth weight infants. This retrospective cohort study utilized the US National Inpatient Sample dataset for the years 2000 to 2017. A total of 1,755,418 very low birth weight infants were included; of them, 861 (0.05%) were diagnosed ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03894-z
更新日期：2021-02-01 00:00:00
abstract：:Twenty-eight children whose parents reported sleep apnoea were investigated. In 15 infants apnoeic periods during sleep could be confirmed during clinical observation. Ventilatory responses to CO2 were measured in all infants, in 23 during sleep in 5 only when awake. A very wide range of CO2 sensitivities was found. I...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496030
更新日期：1986-04-01 00:00:00
abstract：UNLABELLED:The objective of this study was to describe the characteristics of children who required mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) support for respiratory syncytial virus (RSV) bronchiolitis, and to identify risk factors associated with disease severity assessed by duration of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1580-0
更新日期：2005-02-01 00:00:00
abstract：:Severe neonatal centronuclear myopathy is inherited as an X-linked condition characterized by primary asphyxia, extreme muscular hypotonia and absent spontaneous movements. We report seven cases from three families to point out the importance of diagnosis with regard to prognosis, outcome and genetic counselling. In h...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072056
更新日期：1990-12-01 00:00:00
abstract：UNLABELLED:Familial Mediterranean fever (FMF) is characterised by recurrent fever and serositis. The most important complication of the disease is amyloidosis. Cheap and non-invasive methods would be important in predicting or establishing the early diagnosis of amyloidosis. For this purpose, we studied the role of uri...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1173-3
更新日期：2003-05-01 00:00:00
abstract：:Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism. The mean basal concentration of plasma PRL was significantly higher (P less than 0.01) in primary hypothyroi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441493
更新日期：1982-10-01 00:00:00
abstract：UNLABELLED:The aim was to determine whether semi-quantitative procalcitonin (PCT-Q) measurements on admission can identify the severity of meningococcal infection in children. A total of 65 children (mean age 2.4 years) with meningococcal disease were included in a prospective study. All patients were treated with anti...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-005-1761-5
更新日期：2006-01-01 00:00:00
abstract：:A mother carrying a fetus affected with 21-hydroxylase deficiency received prenatal treatment with dexamethasone (0.5 mg, tid, p.o.) started from the very beginning of the 8th week of gestation. Prenatal diagnosis had to rely on amniocentesis with karyotyping and steroid hormone determination, because HLA and DNA data...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02190657
更新日期：1994-08-01 00:00:00
abstract：:A 7-year-old girl was admitted with a severe abdominal pain. Abdominal ultrasound and CT revealed a large splenic infarction, leading to the diagnosis of chronic myeloid leukemia. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1675-y
更新日期：2012-07-01 00:00:00
abstract：UNLABELLED:The severity and duration of immunosuppression caused by corticosteroids (CSs) usage have not been extensively studied. We aimed to investigate the effects of CSs on the various compartments of immune system in relation to timing of initiation and persistence of therapy. Pediatric patients with idiopathic ne...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-016-2694-x
更新日期：2016-05-01 00:00:00
abstract：UNLABELLED:Reports on schistosomiasis in children growing up in Europe are rare despite increased travel activity. We report on eight male and three female German children aged 50 months to 15 years with schistosomiasis. Six children were asymptomatic, whereas two presented with typical signs of Katayama fever. Persist...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051326
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:Schimke immuno-osseous dysplasia is a multisystem disorder consisting of spondylo-epiphysial dysplasia, progressive renal insufficiency due to focal segmental glomerulosclerosis, and immunodeficiency. Cerebrovascular complications have only been described in five patients. Here we report a patient with promi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050714
更新日期：1997-10-01 00:00:00
abstract：:Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150 μg because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens wer...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03391-y
更新日期：2019-07-01 00:00:00
abstract：:Early identification of infants being at high risk to become obese at their later childhood or adolescence can be of vital importance in any obesity prevention initiative. The aim of the present study was to examine the utility and applicability of the "Childhood Obesity Risk Evaluation (CORE)" index as a screening to...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2799-2
更新日期：2016-12-01 00:00:00
abstract：UNLABELLED:In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a traini...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004310051010
更新日期：1999-01-01 00:00:00
abstract：UNLABELLED:The effect of different feeding regimens, notably the use of hydrolysed cow's milk formulas, on the development of allergic reactions and the development of cow's milk protein-IgG antibodies is still disputed. We prospectively compared the development of allergic manifestations and cow's milk protein-IgG ant...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02002723
更新日期：1996-04-01 00:00:00
abstract：:Since traction-associated hypertension seems to be a relatively unknown phenomenon, a survey was done of its incidence in children treated with skeletal traction for fractures and orthopaedic diseases. The correlation with hypercalcaemia, a possible aetiological factor, was also explored. Blood pressure was recorded t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957765
更新日期：1992-07-01 00:00:00
abstract：:Serum lysozyme activity was measured in samples from children with acute leukemia, malignant tumours, and in normal children. All children with acute lymphatic leukemia (ALL) had significantly reduced levels of lysozyme at diagnosis, and none of the children fell within the normal range. Children with ALL in complete ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00493542
更新日期：1978-04-20 00:00:00
abstract：:Eight patients with the syndrome of benign paroxysmal vertigo of childhood are presented. This symptom complex is characterized by attacks of vertigo in young children combined with nystagmus, ataxia and transiently decreased vestibular function, but without impaired consciousness. Diagnostic and follow-up studies rev...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01846035
更新日期：1980-08-01 00:00:00
abstract：:The updated Dutch guidelines on Neonatal Resuscitation assimilate the latest evidence in neonatal resuscitation. Important changes with regard to the 2004 guidelines and controversial issues concerning neonatal resuscitation are reviewed, and recommendations for daily practice are provided and argued in the context of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1091-0
更新日期：2010-05-01 00:00:00
abstract：:Our prior studies of the molecular epidemiology of group A streptococcus (GAS) pharyngitis indicated that the most common emm types associated with pediatric pharyngitis in North America were 12, 1, 28, and 4. We previously reported that the proportions of pediatric pharyngitis due to emm types 12 and 4 decreased with...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0819-6
更新日期：2009-06-01 00:00:00
abstract：UNLABELLED:In phenylketonuria, compliance and diet is a difficult issue; it is hard to quantify and is under-researched. It is influenced by many factors. Failure to consume prescribed quantity of protein substitute has been commonly reported and is probably affected by their acceptability, format and timing of adminis...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014375
更新日期：2000-10-01 00:00:00
