Long-term outcomes in pediatric appendiceal carcinoids: Turkey experience.


:The tendency of non-operative management of appendicitis let us explore the natural history of appendiceal carcinoids, compare them with appendicitis patients, and determine the possibility of deciding the extent of the surgery and post-operative follow-up on behalf of the intraoperative findings. A retrospective review was performed of patients with appendicitis between 2009 and 2017. Of 2781 patients, 10 (0.36%) were diagnosed with appendiceal carcinoids. Sixty percent were female with an average age of 13.10 ± 1.73. The mean tumor size was 0.97 ± 0.34 cm with 70% located at the tip. Majority had an insular pattern (n = 9), six had subserosal fat tissue invasion, one had extension to mesoappendix, one had vascular invasion, and two had lymphatic invasion. The average mitotic index was 3.20 ± 1.40/50HPF, and Ki 67 activity was 3 ± 1.7%. The mean follow-up period was 66.40 ± 25.92 months. Patients were further evaluated with ultrasonography (n = 10), CT (n = 3), and MRI (n = 10). Serum markers including chromogranin (n = 9), NSE (n = 6), and 5-HIAA (n = 6) were normal. None required further treatment and had any symptoms of carcinoid syndromes or recurrences post-operatively.Conclusion: Other than appendectomy, no additional surgery or follow-up is required in appendiceal carcinoids less than 1.5 cm in size, regardless of the lymphoid or vascular invasion. What is Known: • The treatment of patients with a 1-2-cm tumor is not clear in both the pediatric and adult populations, and additional resection is needed. • Patients are monitored post-operatively with radiological and/or biochemical testing. What is New: • Appendectomy is curative for tumors less than 2 cm. • No additional surgery or follow-up is required in appendiceal carcinoids less than 1.5 cm in size regardless of the lymphoid or vascular invasion.


Eur J Pediatr


Akova F,Aydin E,Nur Eray Y,Toksoy N,Yalcin S,Altinay S,Tetikkurt US




Has Abstract


2018-12-01 00:00:00














  • Hypercalcaemia in cerebellar medulloblastoma: pathogenesis of solid tumour-associated hypercalcaemia.

    abstract::A 7-year-old boy developed acute, severe hypercalcaemia following the partial excision of a cerebellar medulloblastoma. The serum calcium level was extremely high (19.8 mg/100 ml), but a skeletal survey revealed no apparent bone metastatic lesions; such lesions were only detected by X-ray 3 weeks after the onset of hy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Arisaka O,Obinata K,Yabuta K,Ishimoto K,Sato K

    更新日期:1987-07-01 00:00:00

  • Effects of bilirubin on visual evoked potentials in term infants.

    abstract:UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Chen YJ,Kang WM

    更新日期:1995-08-01 00:00:00

  • Doppler evaluation of renal blood flow velocity as a predictive index of acute renal failure in perinatal asphyxia.

    abstract:UNLABELLED:Aim of our study was to evaluate Doppler renal blood flow velocity in asphyxiated neonates and to correlate renal function to Doppler findings. Doppler renal blood flow velocity was evaluated in 23 severely asphyxiated neonates born at a gestational age > 32 weeks and compared to our standard Doppler data ob...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Luciano R,Gallini F,Romagnoli C,Papacci P,Tortorolo G

    更新日期:1998-08-01 00:00:00

  • Neonatal suppurative parotitis: a study of five cases.

    abstract:UNLABELLED:Suppurative parotitis is uncommon in newborns. During a 9-year study period, five cases of neonatal suppurative parotitis were detected in 3,624 hospital admissions. The relative risk of developing neonatal suppurative parotitis in admitted infants was 5.52 (0.62-49.35). Staphylococcus aureus was the causati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Sabatino G,Verrotti A,de Martino M,Fusilli P,Pallotta R,Chiarelli F

    更新日期:1999-04-01 00:00:00

  • Subacute meningitis caused by Brucella: a diagnostic challenge.

    abstract::A case of subacute meningitis caused by Brucella mellitensis is described. The meningitis was refractory to an antibiotic regime. Diagnosis was established by raised antibody titres to Brucella in serum and cerebrospinal fluid (CSF) and positive bone marrow and blood cultures. While treatment with tetracycline trimeth...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Korman S,Srugo I,Tal Y,Jaffe M,Cahane Z,Wellish G

    更新日期:1988-11-01 00:00:00

  • Poly-, syn- and oligodactylyl, aplasia or hypoplasia of fibula, hypoplasia of pelvis and bowing of femora in three sibs--a new autosomal recessive syndrome.

    abstract::An apparently hitherto undescribed, severe skeletal syndrome is reported in 3 siblings (2 boys, 1 girl) in a family of Turkish-Arabian descent. Major manifestations include: hypoplasia of the pelvis, congenital dislocation of the hip, severe bowing of femora, aplasia or hypoplasia of fibulae, absence or coalescence of...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Fuhrmann W,Fuhrmann-Rieger A,de Sousa F

    更新日期:1980-03-01 00:00:00

  • The accuracy of voiding urosonography in detecting vesico-ureteral reflux: a summary of existing data.

    abstract:UNLABELLED:The primary objective of this review was to assess the diagnostic accuracy of voiding urosonography (VUS) in detecting reflux (VUR). As a secondary objective, the reported technical suggestions and diagnostic mistakes were shown to improve the examination protocol and provide the most accurate results. Using...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Valentini AL,De Gaetano AM,Destito C,Marino V,Minordi LM,Marano P

    更新日期:2002-07-01 00:00:00

  • Haematuria in an adolescent due to bladder carcinoma.

    abstract::A 14-year-old boy had a 6 month history of recurrent macroscopic haematuria. A papillary non-invasive transitional cell carcinoma of the bladder was found at cystoscopy and treated by transurethral resection. In comparison to adults, bladder carcinoma is a rare cause of haematuria in children who appear to have a favo...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Rayner RJ,Watson AR,Bishop MC

    更新日期:1988-04-01 00:00:00

  • Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism.

    abstract::Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism. We report two siblings (6 years apart) with transient hypoparathyroidism presented with ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Poomthavorn P,Ongphiphadhanakul B,Mahachoklertwattana P

    更新日期:2008-04-01 00:00:00

  • Cardiovascular changes in children with mucopolysaccharide storage diseases and related disorders--clinical and echocardiographic findings in 64 patients.

    abstract::Cardiovascular abnormalities were evaluated in 64 children aged between 1 year 9 months and 25 years with mucopolysaccharidoses (MPS) and related disorders. A heart murmur was heard in 18 patients, but in only 6 was it characteristic for specific valvular lesions. Echocardiography was performed in 63 children. In one ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Dangel JH

    更新日期:1998-07-01 00:00:00

  • Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life.

    abstract::Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Janaillac M,Beausoleil TP,Barrington KJ,Raboisson MJ,Karam O,Dehaes M,Lapointe A

    更新日期:2018-04-01 00:00:00

  • Children's experiences of congenital heart disease: a systematic review of qualitative studies.

    abstract::We aimed to describe the experiences of children and adolescents with congenital heart disease (CHD). Electronic databases were searched until August 2016. Qualitative studies of children's perspectives on CHD were included. Data was extracted using thematic synthesis. From 44 studies from 12 countries involving 995 c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Chong LSH,Fitzgerald DA,Craig JC,Manera KE,Hanson CS,Celermajer D,Ayer J,Kasparian NA,Tong A

    更新日期:2018-03-01 00:00:00

  • Intracellular production of IL-2, IL-4, IFN-gamma, and TNF-alpha by peripheral blood CD3+ and CD4+ T cells in children with atopic dermatitis.

    abstract::The role of the type-2 T helper (Th2) cell-mediated immune response in the immunopathogenesis of atopic dermatitis (AD) is well documented. Whether polarized immunoresponse is confined to antigen-specific T cells or is distributed among all T cell subsets is still controversial. We investigated frequencies of interleu...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Machura E,Mazur B,Kwiecień J,Karczewska K

    更新日期:2007-08-01 00:00:00

  • Abnormal results of biochemical liver function tests in breast-fed infants with prolonged indirect hyperbilirubinaemia.

    abstract::To clarify the relationship between hyperbilirubinaemia and abnormal results of biochemical liver function tests in infants with breast milk jaundice (BMJ), 58 breast-fed infants with indirect hyperbilirubinaemia were enrolled in this study. Sera obtained from the above infants were subjected to routine liver function...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Tazawa Y,Abukawa D,Watabe M,Nakagawa M,Yamada M

    更新日期:1991-03-01 00:00:00

  • Buccal cell DNA analysis in premature and term neonates: screening for mutations of the complete coding region for the cystic fibrosis transmembrane conductance regulator.

    abstract:UNLABELLED:Traditionally, cystic fibrosis (CF) is diagnosed either by measuring sweat electrolyte levels or by screening for mutations using genomic DNA isolated from leucocytes. The aim of this work was to develop a modified fast and non-invasive tool for the collection of cell samples and the genetic analysis of the ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bennett LC,Kraemer R,Liechti-Gallati S

    更新日期:2000-01-01 00:00:00

  • Pseudohyperkalaemia in Kawasaki disease.

    abstract::Pseudohyperkalaemia was observed in 3 of 16 patients with Kawasaki disease showing remarkably increased platelet counts. Their plasma potassium concentration, which is not affected by in vitro coagulation, was in the normal range despite the increased serum level. A significant correlation was observed between the pla...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Shimizu T,Yamashiro Y,Yabuta K

    更新日期:1992-07-01 00:00:00

  • Hydrops fetalis and pulmonary lymphangiectasia due to FOXC2 mutation: an autosomal dominant hereditary lymphedema syndrome with variable expression.

    abstract:UNLABELLED:Non-immune hydrops fetalis may find its origin within genetically determined lymphedema syndromes, caused by mutations in FOXC2 and SOX-18. We describe a newborn girl, diagnosed with non-immune hydrops fetalis at a gestational age of 30 weeks. Family history revealed the presence of an autosomal dominant lat...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: de Bruyn G,Casaer A,Devolder K,Van Acker G,Logghe H,Devriendt K,Cornette L

    更新日期:2012-03-01 00:00:00

  • On the influence of age on immunity in Down's syndrome.

    abstract::In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Seger R,Buchinger G,Ströder J

    更新日期:1977-01-26 00:00:00

  • Fibrodysplasia ossificans progressiva (FOP): watch the great toes!

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder and the most disabling condition of heterotopic (extraskeletal) ossification in humans. Extraskeletal bone formation associated with inflammation preceding the osseous conversion usually begins in the first decade, predominantly in the head, neck, ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kartal-Kaess M,Shore EM,Xu M,Schwering L,Uhl M,Korinthenberg R,Niemeyer C,Kaplan FS,Lauten M

    更新日期:2010-11-01 00:00:00

  • Exhaled nitric oxide levels in infants with chronic lung disease.

    abstract:UNLABELLED:Chronic lung disease (CLD) is an inflammatory disorder; in patients with other inflammatory disorders exhaled nitric oxide (NO) levels are elevated. The aim of this study was to test the hypothesis that prematurely born infants with CLD would have elevated exhaled NO levels compared to those without CLD and ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Leipälä JA,Williams O,Sreekumar S,Cheeseman P,Rafferty GF,Hannam S,Milner A,Greenough A

    更新日期:2004-09-01 00:00:00

  • Correlation between the cord vitamin D levels and regulatory T cells in newborn infants.

    abstract::Vitamin D is important for calcium homeostasis, muscle, and bone health. It has also immunomodulatory capacities in vivo and in vitro. Regulatory T cells (Treg) have been found to suppress a number of T cell-mediated immune disorders, including allergic responses and autoimmune diseases. This study aimed to investigat...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Güven A,Ecevit A,Sözer O,Tarcan A,Tarcan A,Ozbek N

    更新日期:2012-08-01 00:00:00

  • The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia.

    abstract::L-asparaginase is an effective antileukaemic drug and a potent inhibitor of hepatic protein synthesis. Its effect on lipid metabolism was studied in two cohorts of children with ALL, one of whom received L-asparaginase concomitantly with three other drugs (protocol BFM 79). In the second protocol (BFM 83) administrati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Cremer P,Lakomek M,Beck W,Prindull G

    更新日期:1988-01-01 00:00:00

  • Perinatal COVID-19: review of current evidence and practical approach towards prevention and management.

    abstract::The clinical spectrum of the perinatal COVID-19 and prospective data on neonatal outcomes remains largely unexplored. Most of the existing literature is in the form of case series or single-centre experience. In this review, we aim to summarize available literature on the clinical spectrum of COVID-19 in neonates and ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Vardhelli V,Pandita A,Pillai A,Badatya SK

    更新日期:2020-11-12 00:00:00

  • N-acetylglutamate synthetase deficiency: diagnosis, management and follow-up of a rare disorder of ammonia detoxication.

    abstract::We report the 9-year follow-up of a patient suffering from N-acetylglutamate synthetase deficiency, an urea cycle disorder leading to severe neonatal hyperammonaemia. Hitherto two patients from two families with this inborn error of metabolism had been observed. Our management consisted mainly of a protein-restricted ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Schubiger G,Bachmann C,Barben P,Colombo JP,Tönz O,Schüpbach D

    更新日期:1991-03-01 00:00:00

  • Successful prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract::A mother carrying a fetus affected with 21-hydroxylase deficiency received prenatal treatment with dexamethasone (0.5 mg, tid, p.o.) started from the very beginning of the 8th week of gestation. Prenatal diagnosis had to rely on amniocentesis with karyotyping and steroid hormone determination, because HLA and DNA data...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Wudy SA,Homoki J,Teller WM

    更新日期:1994-08-01 00:00:00

  • Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes.

    abstract::In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of age fro...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Auzanneau M,Karges B,Neu A,Kapellen T,Wudy SA,Grasemann C,Krauch G,Gerstl EM,Däublin G,Holl RW

    更新日期:2021-02-01 00:00:00

  • Investigation of the nutritional state of children in a Congolese village. II. Plasma fatty acid composition.

    abstract::The fatty acid status of an unselected group of 84 Congolese children was determined by estimating the fatty acid composition of the plasma phospholipid (PL) and cholesterolester (CE) fractions using capillary gas chromatography. In comparison with North American and European children a wide range of values and low me...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Leichsenring M,Doehring-Schwerdtfeger E,Laryea MD,Diamouangana J,Bremer HJ

    更新日期:1988-11-01 00:00:00

  • Urinary concentration of cytokines in children with acute pyelonephritis.

    abstract::Urinary tract infection (UTI) is a common bacterial infection among infants and children. Predicting which children with upper UTI will develop long-term sequelae remains difficult. We aimed at evaluating the predictive value of urine concentrations of interleukin-6 (UIL-6) and interleukin-8 (UIL-8) in subsequent rena...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Renata Y,Jassar H,Katz R,Hochberg A,Nir RR,Klein-Kremer A

    更新日期:2013-06-01 00:00:00

  • Prognostic utility of the semi-quantitative procalcitonin test, neutrophil count and C-reactive protein in meningococcal infection in children.

    abstract:UNLABELLED:The aim was to determine whether semi-quantitative procalcitonin (PCT-Q) measurements on admission can identify the severity of meningococcal infection in children. A total of 65 children (mean age 2.4 years) with meningococcal disease were included in a prospective study. All patients were treated with anti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Casado-Flores J,Blanco-Quirós A,Nieto M,Asensio J,Fernández C

    更新日期:2006-01-01 00:00:00

  • Physical symptoms in very young children assessed for sexual abuse: a mixed method analysis from the ASAC study.

    abstract::So far, a recognizable pattern of clinical symptoms for child sexual abuse (CSA), especially in young male children, is lacking. To improve early recognition of CSA, we reviewed physical complaints, physical examination, and tests on sexually transmitted infections (STIs) in confirmed victims (predominantly preschool ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Vrolijk-Bosschaart TF,Brilleslijper-Kater SN,Widdershoven GA,Teeuw ARH,Verlinden E,Voskes Y,van Duin EM,Verhoeff AP,Benninga MA,Lindauer RJL

    更新日期:2017-10-01 00:00:00