Abstract：
:The laryngo-tracheo-oesophageal cleft is marked by a missing anatomical separation of the oesophagus and the larynx. The cleft can be restricted to the dorsal part of the larynx (type I), extend to the upper area of the trachea (type II) or involve the whole of the trachea (type III). In reviewing our three cases and 82 cases in the literature, clinical features, diagnosis, and therapy of this rare condition are presented. The condition leads almost always to life-threatening disturbances in the form of asphyxia and aspiration pneumonia. The diagnosis is made through direct laryngoscopy. Radiological demonstration of swallowing and tracheo-oesophagoscopy are necessary additional investigations. In many cases further severe malformations of organs are found, i.e., oesophageal atresia and tracheo-oesophageal fistulae. Despite early detection the prognosis remains unfavourable with a mortality of 46%. With few exceptions, an early operative correction of the defect is required. Access to the dorsal laryngeal area is achieved usually by a lateral pharyngotomy. Difficulties arise in securing adequate closure of the dorsal larynx, because of lack of sufficient tissue material. Despite secure closure of the laryngo-tracheo-oesophageal cleft, disturbances of swallowing often persist. Development of speech is not impaired.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Roth B,Rose KG,Benz-Bohm G,Günther Hdoi
10.1007/BF00661903subject
Has Abstractpub_date
1983-03-01 00:00:00pages
41-6issue
1eissn
0340-6199issn
1432-1076journal_volume
140pub_type
杂志文章abstract：:A comprehensive program for proficiency testing of biochemical genetics laboratories is described. Inborn errors of metabolism of amino acids, organic acids, glycosaminoglycans and oligosaccharides are covered, as well as the assay of galactose-1-phosphate. Participants are not only required to report the analytical r...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02138772
更新日期：1994-01-01 00:00:00
abstract：:Olfactory function in children is most commonly evaluated using the odour identification test despite the fact that it is difficult to properly name odorants for young children. The goal of this study was to evaluate the pleasantness rating of odorants by children. The participants were 182 healthy children: the first...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03778-2
更新日期：2020-08-14 00:00:00
abstract：:Paraneoplastic manifestations are signs and symptoms observed in patients with cancer, distant from the tumour or its metastases and not caused by invasion, obstruction or bulk mass. In children with cancer, paraneoplastic manifestations are rare and distinct from those observed in adults. Knowledge about paraneoplast...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01972883
更新日期：1994-11-01 00:00:00
abstract：:Iodine deficiency is well documented in Belgium in adults including pregnant women, adolescents, schoolchildren, and neonates, but no data are available in the age group 6 months-3 years. We investigated the status of iodine nutrition in 111 healthy subjects in this age group in an attempt to evaluate the risk of brai...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310000707
更新日期：2001-04-01 00:00:00
abstract：:By November 1994, 39 pregnancies had been completed in phenylketonuric mothers. Dietary control was post-conception in 6 and 2 of these offspring died of congenital heart disease and 1 other needed surgery for coarctation. There were no heart defects in the 34 offspring of the 33 pregnancies following preconception di...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00014242
更新日期：1996-07-01 00:00:00
abstract：:We report what we believe to be the first case of simultaneous infection by Toxoplasma gondii and cytomegalovirus in a newborn. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496426
更新日期：1988-05-01 00:00:00
abstract：:Complete masculinisation of the external genitalia (type V of Prader classification) is reported in two siblings with normal internal female genitalia, normal ovaries and a 46,XX chromosome constitution in different cell lines without any detectable source of exposure to androgen during pregnancy. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445596
更新日期：1984-06-01 00:00:00
abstract：:We studied the incidence of IgG subclass deficiency in children with recurrent bronchitis. Recurrent bronchitis was defined as three or more episodes a year during at least 2 consecutive years, of bronchopulmonary infection, productive cough with or without fever and/or diffuse râles by physical examination in the abs...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072228
更新日期：1992-04-01 00:00:00
abstract：UNLABELLED:Inflammation of the gastric and duodenal mucosa is the end result of an imbalance between mucosal defensive and aggressive factors. The degree of inflammation and imbalance between defensive and aggressive factors can then result in varying degrees of gastritis and/or frank mucosal ulceration. Gastritis and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310051142
更新日期：1999-07-01 00:00:00
abstract：:We report a prospective, non-blind, randomised, multicentre, parallel group, multinational investigation to compare ceftazidime to aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. In each of the 15 study centres either ceftazidime alone (CAZ) or ceftazidime + ampic...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01954122
更新日期：1992-12-01 00:00:00
abstract：:Lower respiratory tract infections (LRTI) caused by adenovirus can be severe with resultant chronic pulmonary sequelae. More than 50 serotypes have been recognized; however, the exact association of serotype with clinical phenotype is still unclear. There have been no reports on the adenovirus serotype pattern in Hong...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2127-z
更新日期：2014-03-01 00:00:00
abstract：:A 7-year-old girl was admitted with a severe abdominal pain. Abdominal ultrasound and CT revealed a large splenic infarction, leading to the diagnosis of chronic myeloid leukemia. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1675-y
更新日期：2012-07-01 00:00:00
abstract：:A 14-year-old boy had a 6 month history of recurrent macroscopic haematuria. A papillary non-invasive transitional cell carcinoma of the bladder was found at cystoscopy and treated by transurethral resection. In comparison to adults, bladder carcinoma is a rare cause of haematuria in children who appear to have a favo...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442709
更新日期：1988-04-01 00:00:00
abstract：:When a mother with tetralogy of Fallot has a conotruncal anomaly face, her child might have a 22q11.2 deletion and severe congenital heart disease. ...
journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s00431-001-0890-8
更新日期：2002-03-01 00:00:00
abstract：:We studied, in vitro, different commercially available components for pneumothorax drainage, i.e. drainage tubes, Heimlich flutter valve and vacuum control units. The drainage of a pneumothorax by a drainage tube was, as expected, directly dependent on Poiseuille's law and was influenced more by diameter than length. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02024337
更新日期：1989-10-01 00:00:00
abstract：:Though children with Perlman and Wiedemann-Beckwith syndromes have a number of features in common, the two conditions are probably separate entities. The distinction may not always be easy, however, partly because of the extreme rarity of Perlman syndrome, only nine cases of which have been reported so far. We report ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954125
更新日期：1992-12-01 00:00:00
abstract：:To clarify the relationship between hyperbilirubinaemia and abnormal results of biochemical liver function tests in infants with breast milk jaundice (BMJ), 58 breast-fed infants with indirect hyperbilirubinaemia were enrolled in this study. Sera obtained from the above infants were subjected to routine liver function...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955928
更新日期：1991-03-01 00:00:00
abstract：:Neonatal acute respiratory distress syndrome (NARDS) reflects pulmonary surfactant dysfunction, and the usage of bovine surfactant (Calsurf) supplement may therefore be beneficial. To determine whether bovine surfactant given in NARDS can improve oxygenation and survival rate, we conducted a multicenter, randomized tr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03821-2
更新日期：2020-10-21 00:00:00
abstract：:Anthropometric indices (AI) have been known to be associated with age at menarche (AAM). The aim of this longitudinal study was to evaluate the changes in AI and its association with AAM in a community-based population in Iran. From among 10,192 women, we included 6818, aged ≥ 10 years, who were post-menarche at the t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03575-x
更新日期：2020-09-01 00:00:00
abstract：:Purine nucleoside phosphorylase (PNP) deficiency is a rare combined immunodeficiency disorder presenting with clinically recurrent infections, failure to thrive, various neurological disorders, malignancies, and autoimmune diseases. Here, we report two sisters with a fatal course of PNP deficiency due to delay in diag...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1029-6
更新日期：2010-03-01 00:00:00
abstract：UNLABELLED:It has been suggested that chronic treatment with L-thyroxine (L-T4) could be implicated in reducing bone mineral density (BMD). The purpose of this longitudinal study was to determine whether appendicular and axial BMD is decreased by L-T4 treatment in adolescent girls. Thirteen adolescent girls with subcli...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955180
更新日期：1996-06-01 00:00:00
abstract：UNLABELLED:Ischaemic stroke is a rare event in childhood. In approximately one-fourth of cases an underlying cardiac disease can be detected. We investigated the importance of genetic risk factors of venous thromboembolism in childhood or stroke in adulthood as risk factors for ischaemic stroke in children in a multice...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/pl00014336
更新日期：1999-12-01 00:00:00
abstract：:To evaluate the feasibility and clinical usefulness of immunocytochemical detection of bone marrow metastases in neuroblastoma, we studied bone marrow samples from patients undergoing intensive therapy, followed in the majority of cases by autologous bone marrow rescue. Two monoclonal antibodies were used in an indire...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442474
更新日期：1988-08-01 00:00:00
abstract：:A 16-year-old girl is described with abetalipoproteinaemia who underwent liver transplantation for hepatic cirrhosis. After this procedure her serum lipoprotein profile was corrected; however, fat malabsorption and steatorrhea persisted because the primary defect, a mutant microsomal triglyceride-transfer protein, rem...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050882
更新日期：1998-07-01 00:00:00
abstract：:Acute pharyngitis is one of the most frequent causes of primary care physician visits; however, there is no agreement about which is the best strategy to diagnose and manage acute pharyngitis in children. The aim of the current study was to evaluate the cost-effectiveness of the recommended strategies to diagnose and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1410-0
更新日期：2011-08-01 00:00:00
abstract：:A detailed autopsy study of three children with ornithine carbamoyl transferase (OCT) deficiency is presented. Although variable in extent, a basic pattern of neuropathological lesions is discernible. Case 1 shows gross cerebral atrophy, cases 2 and 3 milder lesions in the basal nuclei but also multiple cerebellar het...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00572763
更新日期：1984-02-01 00:00:00
abstract：:To increase our knowledge of the clonal relationship of leukaemia relapse, the genotypes and phenotypes of ten children with acute lymphoblastic leukaemia (ALL) were examined at initial diagnosis and relapse. Seven patients were phenotyped as common ALL, two as mixed, and one as T-cell ALL (T-ALL). Comparative analyse...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441975
更新日期：1988-06-01 00:00:00
abstract：UNLABELLED:Alleviation of suffering is considered to be one of the important goals of medical interventions. Understanding of what constitutes suffering in children admitted to a pediatric intensive care unit (PICU) is lacking. This study aims to assess perceptions by parents, doctors, and nurses of suffering in critic...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2440-1
更新日期：2015-05-01 00:00:00
abstract：:Clinical pharmacists provide beneficial services to adult patients, though their benefits for paediatric hospital patients are less defined. Five databases were searched using the MeSH terms 'clinical pharmacist', 'paediatric/paediatric', 'hospital', and 'intervention' for studies with paediatric patients conducted in...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3187-x
更新日期：2018-08-01 00:00:00
abstract：UNLABELLED:Cystic adenomatoid malformation of the lung (CAML) is a rare pulmonary maldevelopment resulting from an abnormal growth of the terminal bronchial structures. This study proposes a possible management of prenatally diagnosed CAML. A group of nine cases of CAML diagnosed prenatally between January 1990 and Dec...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051233
更新日期：1999-11-01 00:00:00
