Abstract：
UNLABELLED:Ischaemic stroke is a rare event in childhood. In approximately one-fourth of cases an underlying cardiac disease can be detected. We investigated the importance of genetic risk factors of venous thromboembolism in childhood or stroke in adulthood as risk factors for ischaemic stroke in children in a multicentre survey focusing on patients with a cardiac disease. 38 of 162 white infants and children (neonate-18 years) with ischaemic stroke were suffering from a cardiac disorder. An age-matched group of 100 children from the same geographic areas as the patients served as controls. Patients and controls were analysed for increased lipoprotein (a) levels > 30 mg/dl, for the presence of the factor V (FV) G1691A mutation, the prothrombin (PT) G20210 A variant, and deficiencies of protein C, protein S, and antithrombin. The following frequencies (patients vs. controls), odds ratios (OR) and confidence intervals (CI) of single risk factors were found: Lp(a) > 30 mg/dl (18.4% vs. 5%; OR/CI: 4.3/1.3-14.4; p = 0.03), FV G1691A (13.2% vs. 4%; OR/CI 3.63/0.92-14.3; p = 0.12) protein C type I deficiency (15.8% vs. 1%; OR/CI: 18.5/2.15-16.0; p = 0.0017), anticardiolipin antibodies (10.5% vs. 0%; p = 0.0051). No protein S or antithrombin deficiency was found. Combinations of haemostatic disorders were found in 10.5% of cases but in none of the controls (Fisher 0.005). CONCLUSION:While FV G1691A and prothrombin G20210 A mutations show no significant data in our study, lipoprotein (a) levels >30 mg/dl protein C deficiency, anticardiolipin antibodies and combined prothrombotic disorders seem to be important risk factors for manifestation of ischaemic strokes in children with underlying cardiac disorders.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Sträter R,Vielhaber H,Kassenböhmer R,von Kries R,Göbel U,Nowak-Göttl Udoi
10.1007/pl00014336keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
S122-5eissn
0340-6199issn
1432-1076journal_volume
158 Suppl 3pub_type
杂志文章,多中心研究abstract：:In this study, we compare the prevalence of alcohol and cigarette use among Polish adolescents with type 1 diabetes mellitus (T1DM) (n = 209), aged 15-18 years, with that of a large cohort of their healthy peers, using standardized questionnaire used in the European School Survey Project on Alcohol and Drugs (ESPAD). ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2895-y
更新日期：2017-06-01 00:00:00
abstract：UNLABELLED:Nemaline myopathy, one of the most benign myopathies in older children and adults, may be rarely associated with early death in the neonate. The authors report two cases, describing the ante- and postnatal clinical courses. Family history may help in establishing the diagnosis, but this was not the case in t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955190
更新日期：1996-06-01 00:00:00
abstract：:Vascularization of the arms has been studied by impedance plethysmography (rheography) in eight children with Poland syndrome, a common malformation characterized by unilateral hand anomaly and ipsilateral aplasia of the inferior head of the pectoralis major muscle. A marked decrease of the velocity of the systolic in...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496922
更新日期：1978-05-22 00:00:00
abstract：:This review deals with podocyte proteins that play a significant role in the structure and function of the glomerular filter. Genetic linkage studies has identified several genes involved in the development of nephrotic syndrome and contributed to the understanding of the pathophysiology of glomerular proteinuria and/...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-009-1017-x
更新日期：2009-11-01 00:00:00
abstract：UNLABELLED:We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION:Pulm...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050684
更新日期：1997-08-01 00:00:00
abstract：:From time to time, paediatricians are confronted with children who might suffer from a primary immunodeficiency disease. For practical purposes, these children can be divided into four main clinical categories: (1) a relatively large group of children with recurrent ear-nose and throat and lower respiratory tract infe...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310100797
更新日期：2001-10-01 00:00:00
abstract：:The objectives of this study were to determine if any specific clinical signs, symptoms, or comorbidities could reliably predict underlying feeding difficulty and need for further evaluation (i.e., video swallow study, VSS) in infants with Down syndrome, to establish the prevalence of gastrostomy tube placement (G-tub...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03591-x
更新日期：2020-06-01 00:00:00
abstract：UNLABELLED:Storage of human breast milk by freezing or refrigeration of milk with and without heating have been recommended. This can hardly be avoided because of the social circumstances of most mothers who are regularly separated from their infants because of work or schooling as well as the particular needs of some ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310000577
更新日期：2000-11-01 00:00:00
abstract：:Cardiac imaging has had significant influence on the science and practice of pediatric cardiology. Especially the development and improvements made in non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance imaging (MRI), have been extremely important. Technical advancements in the field ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-007-0544-6
更新日期：2008-01-01 00:00:00
abstract：:Serum bile acids and their conjugates were analysed in 20 breast-fed infants with prolonged jaundice. The mean total bile acid levels in serum were increased in the breast-fed infants with jaundice, as compared with those in either breast- or bottle-fed infants without jaundice. However, there were no significant diff...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00491922
更新日期：1985-05-01 00:00:00
abstract：UNLABELLED:The aims of this study were to analyze reproductive outcomes of women and men born very preterm (gestational age <32 weeks) or with a very low birth weight (<1500 g) in 1983 in the Netherlands and to compare their reproductive outcomes with the total population at a similar age of 28 years. Young adults who ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2470-8
更新日期：2015-06-01 00:00:00
abstract：UNLABELLED:A 14-year-old boy developed acute quadriplegia, associated with sensory impairment and bowel and urinary dysfunction. MRI of the cervical cord showed diffuse increased signal intensity on T2-weighted images with gadolinium-diethylenetriamine penta-acetic acid enhancement. Based on the clinical presentation a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072107
更新日期：1995-05-01 00:00:00
abstract：:The present study was done to evaluate the effect of short-term dietary therapy on 148 dyslipidaemic children (24 familial hypercholesterolaemia, 105 non-familial hypercholesterolaemia and 19 hypertriglyceridaemia), detected by mass screening in children at 18 months of age. In the model diet used for treatment, 15% o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957537
更新日期：1993-11-01 00:00:00
abstract：:Cough and wheezing are the predominant symptoms of acute bronchitis. Hitherto, the evaluation of respiratory symptoms was limited to subjective methods such as questionnaires. The main objective of this study was to objectively determine the time course of cough and wheezing in children with acute bronchitis. The impa...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00431-019-03426-4
更新日期：2019-09-01 00:00:00
abstract：:Thrombocypenic purpura was noted in a 3-year-old Japanese girl with an active varicella infection. The administration of intravenous gamma globulin (IVG) drastically improved bleeding manifestations as well as the active varicella infection. We believe that IVG should be the first choice of therapy for thrombocytopeni...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441611
更新日期：1987-09-01 00:00:00
abstract：:Retraction Note to: Eur J Pediatr (1994) 153:668-671 DOI 10.1007/BF02190689. This article, "Adenosine triphosphate treatment for supraventricular tachycardia in infants", published in the European Journal of Pediatrics (1994) 153/9: 668-671, Springer-Verlag 1994, has been retracted at the request of the Publisher as i...
journal_title：European journal of pediatrics
pub_type： 撤回出版物
doi：10.1007/s00431-015-2640-3
更新日期：2015-11-01 00:00:00
abstract：:Five males are reported with severe X-linked arthrogryposis. Main findings are marked respiratory insufficiency and feeding problems, multiple contractures, deformities of chest and vertebral column, and typical facies. Most of these findings can be explained by a pronounced prenatal and postnatal muscle weakness. The...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02072628
更新日期：1991-07-01 00:00:00
abstract：:Proper nutrition throughout childhood and adolescence is crucial for normal bone development. We investigated whether adherence to Christian Orthodox Church fasting is characterized by periodic avoidance of animal foods (including dairy products), since childhood affects stature or bone health in young adults. This cr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03542-1
更新日期：2020-04-01 00:00:00
abstract：:Complete masculinisation of the external genitalia (type V of Prader classification) is reported in two siblings with normal internal female genitalia, normal ovaries and a 46,XX chromosome constitution in different cell lines without any detectable source of exposure to androgen during pregnancy. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445596
更新日期：1984-06-01 00:00:00
abstract：:Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealin...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03328-5
更新日期：2019-04-01 00:00:00
abstract：:Rasmussen's syndrome (RS) is a rare acquired progressive inflammatory encephalopathy characterized by drug-resistant partial seizures and cognitive deterioration resulting from a gradual impairment and a subsequent atrophy of a single brain hemisphere. It was firstly described by Theodore Rasmussen in 1958. The origin...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-010-1148-0
更新日期：2010-08-01 00:00:00
abstract：UNLABELLED:Although dexamethasone (DEX) is used widely in neonates with chronic, and even recently with acute respiratory disease, its potential side-effects on human cerebral and ocular haemodynamics remain unknown. The effects of DEX on cerebral and ocular blood flow velocities were assessed in preterm infants with l...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s004310050550
更新日期：1997-01-01 00:00:00
abstract：:There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia. The aim of this study is to validate the use of urinary potassium to the sum of potassium plus sodium ratio (UK/UK+UNa) as an indicator of hypovolemia in nephrotic synd...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-3029-2
更新日期：2018-01-01 00:00:00
abstract：:The renal function of 12 patients with non vitamin B12 responsive methylmalonic acidaemia has been investigated. Eight patients had reduced glomerular filtration rates, but the plasma creatinine concentration was only raised in those with values of less than 40 ml/min per 1.73 m2 surface area. The reduction in glomeru...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444131
更新日期：1989-01-01 00:00:00
abstract：UNLABELLED:A total of 22 Japanese patients with hypophosphatasia were included in a study analysing the relationship between mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene and the severity of the phenotype in Japanese patients with hypophosphatasia. The enzymatic activity of some of the identifi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1612-9
更新日期：2005-05-01 00:00:00
abstract：:Pediatric headache is an increasingly reported phenomenon. Cervicogenic headache (CGH) is a subgroup of headache, but there is limited information about cervical spine physical examination signs in children with CGH. Therefore, a cross-sectional study was designed to investigate cervical spine physical examination sig...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2046-z
更新日期：2013-10-01 00:00:00
abstract：UNLABELLED:The effect of different feeding regimens, notably the use of hydrolysed cow's milk formulas, on the development of allergic reactions and the development of cow's milk protein-IgG antibodies is still disputed. We prospectively compared the development of allergic manifestations and cow's milk protein-IgG ant...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02002723
更新日期：1996-04-01 00:00:00
abstract：UNLABELLED:Severe head injuries in children (under 15 years of age) have many features that differentiate them from head injuries in adults. In such cases, non-surgical treatment cannot always prevent fatal herniation. We report on seven cases of children with severe head injury, presenting with decorticate posturing a...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-001-0864-x
更新日期：2002-02-01 00:00:00
abstract：UNLABELLED:In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a traini...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004310051010
更新日期：1999-01-01 00:00:00
abstract：UNLABELLED:In order to determine the response to high-frequency oscillatory ventilation (HFOV), used as an "early rescue" therapy, in a cohort of paediatric patients with acute respiratory distress syndrome (ARDS), a prospective clinical study was performed in a tertiary care paediatric intensive care unit. Ten consecu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1544-4
更新日期：2005-01-01 00:00:00
