Urinary potassium to urinary potassium plus sodium ratio can accurately identify hypovolemia in nephrotic syndrome: a provisional study.

Abstract:

:There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia. The aim of this study is to validate the use of urinary potassium to the sum of potassium plus sodium ratio (UK/UK+UNa) as an indicator of hypovolemia in nephrotic syndrome, enabling detection of those patients who will benefit from albumin infusion. We prospectively studied 44 nephrotic children and compared different parameters to a control group (36 children). Renal perfusion and glomerular permeability were assessed by measuring clearance of para-aminohippurate and inulin. Vaso-active hormones and urinary sodium and potassium were also measured. Subjects were grouped into low, normal, and high GFR groups. In the low GFR group, significantly lower renal plasma flow (p = 0.01), filtration fraction (p = 0.01), and higher UK/UK+UNa (p = 0.03) ratio were noted. In addition, non-significant higher plasma renin activity (p = 0.11) and aldosteron (p = 0.09) were also seen in the low GFR group. CONCLUSION:A subgroup of patients in nephrotic syndrome has a decrease in glomerular filtration, apparently related to hypovolemia which likely can be detected by a urinary potassium to potassium plus sodium ratio > 0.5-0.6 suggesting benefit of albumin infusion in this subgroup. What is Known: • Volume status can be difficult to assess based on clinical parameters in nephrotic syndrome, and albumin infusion can be associated with development of pulmonary edema and fluid overload in these patients. What is New: • Urinary potassium to the sum of urinary potassium plus sodium ratio can accurately detect hypovolemia in nephrotic syndrome and thus identify those children who would probably respond to albumin infusion.

journal_name

Eur J Pediatr

authors

Keenswijk W,Ilias MI,Raes A,Donckerwolcke R,Walle JV

doi

10.1007/s00431-017-3029-2

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

79-84

issue

1

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-017-3029-2

journal_volume

177

pub_type

杂志文章
  • Effect of inhaled nitric oxide on intrapulmonary right-to-left-shunting in two rabbit models of saline lavage induced surfactant deficiency and meconium instillation.

    abstract::Marked hypoxia secondary to intrapulmonary right-to-left shunting is a characteristic of respiratory failure in human neonates and can sometimes be complicated by additional extrapulmonary right-to-left shunting. To investigate the effect of inhaled nitric oxide (iNO) on intrapulmonary shunting, two typical pulmonary ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050841

    authors: Krause MF,Lienhart HG,Haberstroh J,Hoehn T,Schulte-Mönting J,Leititis JU

    更新日期:1998-05-01 00:00:00

  • Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case.

    abstract::Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to the macrophage--histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteris...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01957571

    authors: Paulli M,Locatelli F,Kindl S,Boveri E,Facchetti F,Porta F,Rosso R,Nespoli L,Magrini U

    更新日期:1992-09-01 00:00:00

  • Heme oxygenase-1 expression in premature and mature neonates during the first week of life.

    abstract::Newborns are exposed to mechanical and oxidative stress during labor and to relative hyperoxia thereafter during the course of adaptation to the extrauterine conditions. Part of the adaptation mechanism is the rapid degradation of fetal hemoglobin and the oxidation of its heme moiety by heme oxygenases (HOs). Heme oxy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0375-x

    authors: Maróti Z,Katona M,Orvos H,Németh I,Farkas I,Túri S

    更新日期:2007-10-01 00:00:00

  • A 2-month-old infant with vomiting, seizures, and progressive apathy.

    abstract::A 2-month-old infant was admitted to hospital because of recurrent vomiting for 1 week, progressive apathy, and focal seizures. The cranial MRI showed a noticeable result. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-012-1681-0

    authors: Larsen A,Martin C,Meyer S,Rohrer T,Papanagiotou P,van der Knaap M,Gortner L

    更新日期:2012-06-01 00:00:00

  • Does the severity of congenital heart defects affect disease-specific health-related quality of life in children in Bosnia and Herzegovina?

    abstract:UNLABELLED:The aim of this study was to assess whether the severity of congenital heart defects (CHD) affects disease-specific health-related quality of life (HRQOL) in children after open heart surgery. One hundred and fourteen children with CHD and one of their parents participated in the study. HRQOL was evaluated b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-009-1060-7

    authors: Tahirović E,Begić H,Nurkić M,Tahirović H,Varni JW

    更新日期:2010-03-01 00:00:00

  • The Dubowitz syndrome.

    abstract::The Dubowitz syndrome is a rare, autosomal, recessively inherited disorder of intrauterine and postnatal growth retardation leading to microcephaly, moderate mental retardation and such characteristic facial anomalies as telecanthus, epicanthic folds, blepharophimosis, ptosis, broadening of the bridge and tip of the n...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00496039

    authors: Küster W,Majewski F

    更新日期:1986-04-01 00:00:00

  • Feeding difficulty and gastrostomy tube placement in infants with Down syndrome.

    abstract::The objectives of this study were to determine if any specific clinical signs, symptoms, or comorbidities could reliably predict underlying feeding difficulty and need for further evaluation (i.e., video swallow study, VSS) in infants with Down syndrome, to establish the prevalence of gastrostomy tube placement (G-tub...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03591-x

    authors: Poskanzer SA,Hobensack VL,Ciciora SL,Santoro SL

    更新日期:2020-06-01 00:00:00

  • Use of social networking sites by parents of very low birth weight infants: experiences and the potential of a dedicated site.

    abstract:UNLABELLED:The objective of this study was to study the experiences of parents of preterm infants who use social networking sites and the potential of such sites for gathering information and facilitating personal exchange. An anonymous self-reporting questionnaire was administered to parents of infants below 1,500 g b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2067-7

    authors: Gabbert TI,Metze B,Bührer C,Garten L

    更新日期:2013-12-01 00:00:00

  • Idiopathic male pseudohermaphroditism is associated with prenatal growth retardation.

    abstract:UNLABELLED:About 50% of intersex cases are due to male pseudohermaphroditism, and of these cases, 50% are not clarified aetiologically. The association of idiopathic male pseudohermaphroditism and prenatal growth retardation has been recently reported. The aim of this study was to verify whether there was a difference ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-005-1626-y

    authors: de Andrade Machado Neto F,Moreno Morcillo A,Trevas Maciel-Guerra A,Guerra-Junior G

    更新日期:2005-05-01 00:00:00

  • Immunoglobulin deficiency with increased immunoglobulin M in three siblings: effect of long-term immunoglobulin therapy.

    abstract::Diagnosis of immunoglobulin deficiency with increased IgM (hyper-IgM syndrome) was made in three siblings (two girls and a boy) on the basis of history, physical findings, and laboratory data. The prominent clinical findings were recurrent viral and bacterial infections of the respiratory tract. The most severe infect...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441406

    authors: Maródi L,Szabó I,Kalmár A

    更新日期:1988-12-01 00:00:00

  • Bone marrow hypoplasia in anorexia nervosa.

    abstract::Within a 2-year period, from March 1974 until May 1976 10 patients with anorexia nervosa were seen at the children's university hospitals of München (2 patients) and Giessen (8 patients). The patients were 10-16 years old, with one exception all girls, and had the typical cachexia, hypothermia, bradycardia, gray, hair...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00452416

    authors: Lampert F,Lau B

    更新日期:1976-12-09 00:00:00

  • Does UTI cause prolonged jaundice in otherwise well infants?

    abstract:UNLABELLED:The symptoms of urinary tract infections in infants are very non-specific and have historically included prolonged hyperbilirubinaemia. We studied the results of routine urine samples in 319 infants with prolonged jaundice. Convincing findings of UTI was not found in any of these children even if one of them...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2499-3

    authors: Chowdhury T,Kisat H,Tullus K

    更新日期:2015-07-01 00:00:00

  • Prevalence of iron deficiency and related factors in Spanish adolescents.

    abstract::Iron deficiency anaemia continues to be the world's most important cause of years lived with disability in children and adolescents. Assessment of iron deficiency traditionally depended on laboratory parameters that may be modified by inflammation states, including obesity, which is nowadays a current condition in ado...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03651-2

    authors: Ibáñez-Alcalde MM,Vázquez-López MÁ,López-Ruzafa E,Lendínez-Molinos FJ,Bonillo-Perales A,Parrón-Carreño T

    更新日期:2020-10-01 00:00:00

  • The use of ethanol in paediatric formulations in New Zealand.

    abstract:UNLABELLED:Children's right to access safe and effective medicines is recognised globally. Ethanol, used in paediatric liquid formulations as a solvent and preservative, is associated with safety concerns with respect to both acute ingestion and chronic exposure. In addition, families may have cultural or religious val...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-1972-0

    authors: Svirskis D,Toh M,Ram S

    更新日期:2013-07-01 00:00:00

  • Respiratory hospitalizations and respiratory syncytial virus prophylaxis in special populations.

    abstract::Palivizumab utilization, compliance, and outcomes were examined in infants with preexisting medical diseases within the Canadian Registry Database (CARESS) to aid in developing guidelines for potential "at-risk" infants in the future. Infants who received ≥1 dose of palivizumab during the 2006-2010 respiratory syncyti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1654-8

    authors: Paes B,Mitchell I,Li A,Lanctôt KL

    更新日期:2012-05-01 00:00:00

  • The urgent matter of online pro-eating disorder content and children: clinical practice.

    abstract:UNLABELLED:During the last decade, much concern has been expressed about online pro-eating disorder communities (e.g., pro-anorexia websites and blogs) which encourage their users to engage in disordered eating behavior. The aim of the current paper is to reemphasize the importance of pro-eating disorder communities in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-015-2487-7

    authors: Custers K

    更新日期:2015-04-01 00:00:00

  • Breastfeeding may improve nocturnal sleep and reduce infantile colic: potential role of breast milk melatonin.

    abstract:UNLABELLED:Melatonin is secreted during the night in adults but not in infants. It has a hypnotic effect as well as a relaxing effect on the smooth muscle of the gastrointestinal tract. It is plausible that breast milk, which consists of melatonin, may have an effect on improving infants' sleep and reducing infantile c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1659-3

    authors: Cohen Engler A,Hadash A,Shehadeh N,Pillar G

    更新日期:2012-04-01 00:00:00

  • Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.

    abstract::The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02024330

    authors: Stopyrowa J,Fyderek K,Sikorska B,Kowalczyk D,Zembala M

    更新日期:1989-10-01 00:00:00

  • Fear effects by the media.

    abstract:UNLABELLED:Both news media and entertainment fiction may lead to short-term and enduring fright reactions. Even TV programs, movies and news made for children may trigger fear. Preoperational children (3 to 7 years of age) are most afraid of fantasy characters, transformations and interpersonal violence. Operational ch...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1632-1

    authors: Custers K,Van den Bulck J

    更新日期:2012-04-01 00:00:00

  • Reproductive outcomes of women and men born very preterm and/or with a very low birth weight in 1983: a longitudinal cohort study in the Netherlands.

    abstract:UNLABELLED:The aims of this study were to analyze reproductive outcomes of women and men born very preterm (gestational age <32 weeks) or with a very low birth weight (<1500 g) in 1983 in the Netherlands and to compare their reproductive outcomes with the total population at a similar age of 28 years. Young adults who ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-014-2470-8

    authors: van Gendt AW,van der Pal SM,Hermes W,Walther FJ,van der Pal-de Bruin KM,de Groot CJ

    更新日期:2015-06-01 00:00:00

  • Abbreviated oesophageal pH monitoring in infants.

    abstract::The results of 24 h oesophageal pH monitoring, performed in 129 infants aged 6-10 weeks, were compared to those in the same patients after shorter periods (3, 6, 9 and 12 h). In the investigated population there was no significant difference between the reflux index (percentage of time with a pH < 4.0) after 12 or 24 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01959212

    authors: Vandenplas Y,Casteels A,Naert M,Derde MP,Blecker U

    更新日期:1994-02-01 00:00:00

  • Distribution of plasma copeptin levels and influence of obesity in children and adolescents.

    abstract::In recent years, a more stable AVP surrogate, called copeptin, has been used as an adjuvant diagnostic tool for dysnatremia in adults and appears to be promising even in the pediatric age. The aim of this study is to present the distribution of plasma copeptin in a large pediatric cohort and to observe the influence o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03777-3

    authors: Tuli G,Munarin J,Tessaris D,Einaudi S,Matarazzo P,de Sanctis L

    更新日期:2021-01-01 00:00:00

  • Total serum bilirubin levels during the first 2 days of life and subsequent neonatal morbidity in very low birth weight infants: a retrospective review.

    abstract::To determine the relationship between total serum bilirubin (TSB) during the first 2 days of life and subsequent neonatal morbidity in very low birth weight (VLBW, less than 1500 g) infants. We performed a prospective study of 582 VLBW infants born between July 1, 2005 and December 31, 2009. TSB was measured in umbili...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1634-z

    authors: Zhu J,Xu Y,Zhang G,Bao Y,Wu M,Du L

    更新日期:2012-04-01 00:00:00

  • Response to single oral dose vitamin D in obese vs non-obese vitamin D-deficient children.

    abstract::Obese individuals are prone to vitamin D deficiency because of sequestration of vitamin D in their body fat. We planned to evaluate the rise in serum 25(OH)D levels in vitamin D-deficient obese vs normal body mass index(BMI) children, after administration of identical single dose of vitamin D. Twenty-two obese and 22 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03831-0

    authors: Tayde A,Mittal M,Khadgawat R,Sharma S,Sreenivas V,Rai A

    更新日期:2020-10-12 00:00:00

  • A new method for screening for hyperammonemia.

    abstract::A new method for the detection of hyperammonemia, using a kit based on the principle of microdiffusion of ammonia, is described. The method requires only one drop of blood and takes only 15 min to complete. Experiments for recovery and reproducibility were satisfactory, and good correlation was obtained when compared ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442347

    authors: Tada K,Okuda K,Watanabe K,Iimura Y,Yamada S

    更新日期:1979-02-08 00:00:00

  • Male pseudohermaphroditism due to 5 alpha-reductase deficiency in a Swedish family.

    abstract::Three sibs with an inherited form of male pseudohermaphroditism are described. They were all born with ambiguous external genitalia but no diagnosis of a possible enzyme defect was made during childhood. First seen at the ages of 16, 14 and 10 years respectively, they were investigated in order to establish the pathog...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441984

    authors: Ivarsson SA,Nielsen MD,Lindberg T

    更新日期:1988-06-01 00:00:00

  • Clinical characteristics and outcome of children stung by scorpion.

    abstract:UNLABELLED:Scorpion envenomation is a health problem in children in tropical and subtropical regions. The aim of this study was to evaluate demographic and clinical characteristics as well as outcomes in referred children to Assiut University Children Hospital during the year 2012 with a history of scorpion sting. The ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2244-8

    authors: Mohamad IL,Elsayh KI,Mohammad HA,Saad K,Zahran AM,Abdallah AM,Tawfeek MS,Monazea EM

    更新日期:2014-06-01 00:00:00

  • Stress response and procedural pain in the preterm newborn: the role of pharmacological and non-pharmacological treatments.

    abstract:UNLABELLED:Repeated invasive procedures occur routinely in neonates who require intensive care, causing pain at a time when it is developmentally unexpected. Multiple lines of evidence suggest that repeated and prolonged pain exposure alters their subsequent pain processing, long-term development, and behaviour. Primar...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00431-011-1655-7

    authors: Gitto E,Pellegrino S,Manfrida M,Aversa S,Trimarchi G,Barberi I,Reiter RJ

    更新日期:2012-06-01 00:00:00

  • Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae causing invasive infections and acute otitis media in children.

    abstract:UNLABELLED:A prospective study was conducted to determine the serotypes and antibiotic resistance patterns of pneumococcal isolates from children with invasive pneumococcal disease (IPD) and acute otitis media (AOM). From October 2001 to May 2002, 65 children with IPD (28 bacteraemic pneumonia, 24 bacteraemia without f...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-004-1447-4

    authors: Zissis NP,Syriopoulou V,Kafetzis D,Daikos GL,Tsilimingaki A,Galanakis E,Tsangaropoulou I

    更新日期:2004-07-01 00:00:00

  • Factors associated with proceeding to surgical intervention and recurrence of primary spontaneous pneumothorax in adolescent patients.

    abstract:UNLABELLED:Primary spontaneous pneumothorax (PSP) is not uncommon, and its recurrence is often a challenging clinical problem. Surgical management and predisposing factors for the recurrence of PSP, however, have not yet been well elucidated in adolescent patients. The major aim of this study was to investigate factors...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-014-2352-0

    authors: Chiu CY,Chen TP,Wang CJ,Tsai MH,Wong KS

    更新日期:2014-11-01 00:00:00