Abstract：
:Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of seven untreated children, whose heights and growth rates at presentation were normal despite GH deficiency secondary to irradiation. GH produced a significant increase in growth velocity over the first 3 years' treatment in CS-PRGHD patients with a mean first year increment of 3 cm/year. Patients, treated to completion of growth, showed a significant increase in leg length standard deviation (SD) score (delta SDS + 0.2) compared to that of the untreated (delta SDS - 0.9) (P less than 0.05). Sitting height SD scores decreased irrespective of GH therapy (by -1.7 for the treated and -2.2 for the untreated). The onset of puberty in the irradiated patients occurred at a mean bone age of 10.7 years in males and 9.9 years in females. This limited the time available for GH therapy. These factors resulted in a decrease in standing height SDS of 0.9 at completion of GH therapy in CS-PRGHD, but a decrease of 1.7 in those not treated with GH. Thus GH therapy failed to induce "catch-up" growth in irradiated patients, but it did prevent further loss of adult stature, with a mean final height SD score of -3.4 in CS-PRGHD patients.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Clayton PE,Shalet SM,Price DAdoi
10.1007/BF00442471subject
Has Abstractpub_date
1988-08-01 00:00:00pages
597-601issue
6eissn
0340-6199issn
1432-1076journal_volume
147pub_type
杂志文章abstract：UNLABELLED:Children with a painful hip present a diagnostic challenge since clinical differentiation between septic arthritis, transient synovitis and Perthes disease may be difficult. Septic arthritis, a potentially life-threatening and debilitating medical emergency, requires early recognition for successful treatmen...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051243
更新日期：1999-11-01 00:00:00
abstract：:Factor VIII procoagulant activity and factor VIII related antigen were examined in 20 full-term and preterm newborn infants during the first days of life. The control group involved 15 adults volunteers. Factor VIII activity was estimated by a one-stage test and factor VIII related antigen was determined by immunelect...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445613
更新日期：1978-07-19 00:00:00
abstract：UNLABELLED:Aminoglycoside prescriptions were rarely evaluated in children care facilities. Because of risk of toxicity, these narrow spectrum antibiotics are commonly misused. In this study, we evaluate aminoglycoside prescription and assess the impact of an information campaign on modalities of prescription and monito...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2691-0
更新日期：2016-05-01 00:00:00
abstract：:To elucidate the basis for the recurrent infections in patients with glycogen storage disease (GSD) Ib we tested polymorphonuclear leukocyte (PMN) function in one patient. Bactericidal capacity and phagocytosis-induced O2 consumption were reduced. Also, phorbol myristate acetate-stimulated superoxide production and gl...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442674
更新日期：1983-09-01 00:00:00
abstract：UNLABELLED:Growth retardation is a consistent finding in Williams-Beuren syndrome. The cause of short stature in this syndrome is unknown. Endocrine studies have failed to reveal abnormalities in the growth hormone-insulin-like growth factor I axis. We report a boy with confirmed Williams-Beuren syndrome, who was found...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051118
更新日期：1999-06-01 00:00:00
abstract：:A 13-year-old boy with a 46,XY,r(7) karyotype presented with growth failure, microcephaly, achromic spots and multiple pigmented naevi. Psychomotor development was normal and no major malformations were present. Comparison with four previously reported patients with ring chromosome 7 shows that the most frequent findi...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01959398
更新日期：1990-04-01 00:00:00
abstract：:An 8-month-old boy and a 7-month-old girl presented with an acute, Coombs-positive auto-immune haemolytic anaemia and severe hepatitis. The clinical manifestations were pallor, jaundice and hepatomegaly. The liver histology revealed diffuse giant cell transformation and extensive necrosis with central-portal bridging....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955929
更新日期：1991-03-01 00:00:00
abstract：:We evaluated chronic kidney disease (CKD) (proteinuria or estimated glomerular filtration rate < 60 mL/min/1.73 m2) or hypertension prevalence in 110 children with juvenile idiopathic arthritis (JIA). CKD and hypertension were clustered under the umbrella term of "renal injury". Median age at the last visit was 14 yea...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03792-4
更新日期：2021-02-01 00:00:00
abstract：UNLABELLED:In patients with Henoch-Schönlein purpura (HSP) presenting with severe gastro-intestinal (GI) symptoms, IgA deposition was studied in endoscopically obtained mucosal biopsies. A total number of 11 patients (male, 7; female, 4) were enrolled in this study; 7 patients underwent upper GI endoscopy and biopsy 1 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02075757
更新日期：1996-02-01 00:00:00
abstract：:The risk factors for recurrent apparent life-threatening event (ALTE) are unclear although the risk of recurrent ALTE is an important consideration for the management of ALTE patients. This study aimed to identify the risk factors for recurrent ALTE. We conducted a secondary analysis of the data from a single center r...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2855-6
更新日期：2017-04-01 00:00:00
abstract：UNLABELLED:In a 2 year period seven patients who presented with stridor, without respiratory compromise, and three patients without obstructive symptoms were prospectively selected, and underwent MRI. In eight patients with a vascular ring and a pulmonary sling, MRI delineated the vascular abnormality and normal great ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050651
更新日期：1997-07-01 00:00:00
abstract：UNLABELLED:In this review, a simplified scheme for classification of cortical malformations is introduced and illustrated based on the work of Barkovich et al. [8]. Detailed MRI studies identify cortical malformations as a major cause of epilepsy in children. Two aspects that are becoming increasingly important for the...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310000452
更新日期：2000-08-01 00:00:00
abstract：UNLABELLED:A 14-year-old boy developed acute quadriplegia, associated with sensory impairment and bowel and urinary dysfunction. MRI of the cervical cord showed diffuse increased signal intensity on T2-weighted images with gadolinium-diethylenetriamine penta-acetic acid enhancement. Based on the clinical presentation a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072107
更新日期：1995-05-01 00:00:00
abstract：:Anthropometric indices (AI) have been known to be associated with age at menarche (AAM). The aim of this longitudinal study was to evaluate the changes in AI and its association with AAM in a community-based population in Iran. From among 10,192 women, we included 6818, aged ≥ 10 years, who were post-menarche at the t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03575-x
更新日期：2020-09-01 00:00:00
abstract：UNLABELLED:Overweight and obesity are major public health issues. Childhood obesity often persists throughout adulthood. Recently a higher prevalence of obesity in adults whose mothers smoked during pregnancy was reported. The aim of this study was to assess whether this association is also detectable in pre-school chi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-0983-z
更新日期：2002-08-01 00:00:00
abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is probably a genetically transmitted disease affecting infants and very young children. Cardinal symptoms are fever, hepatosplenomegaly, and pancytopenia. Frequently meningeal involvement is seen, manifested by neurologic symptoms and a lymphohistiocytic pleocytosis w...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF00443367
更新日期：1983-06-01 00:00:00
abstract：:Septo-optic dysplasia (SOD) is a heterogeneous brain midline anomaly associated with ophthalmological, endocrinological, and/or neurodevelopmental symptoms. The clinical phenotype correlates with abnormal brain magnetic resonance imaging (MRI) findings. However, variations of the septum pellucidum (SP) appearance and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0666-x
更新日期：2008-11-01 00:00:00
abstract：:We aimed to determine whether precocious adrenarche (PA) has a different impact on screening tests for metabolic issues and pubertal timing in boys and girls born appropriate for gestational age (AGA). Puberty and initial metabolic screening results of 47 girls and 23 boys with PA born AGA followed up from our outpati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1796-3
更新日期：2012-11-01 00:00:00
abstract：:To evaluate the ambulatory management of ileo-colic intussusception in infants and children, a retrospective study over 3 years of 113 children treated for ileo-colic intussusception in a paediatric emergency department was undertaken with the aim of shortening the length of stay. A total of 113 children aged 10 days ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051184
更新日期：1999-09-01 00:00:00
abstract：:We describe here an infant with a large, solitary, fluid-filled lung cyst and hyperinflation of adjacent lung tissue in the same lobe. The combination of a fluid-filled cyst and ectatic emphysema in the same lobe suggests bronchial collapse and airway obstruction as a contributory mechanism for this unusual roentgenog...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00447379
更新日期：1979-10-01 00:00:00
abstract：:In this study, we compare the prevalence of alcohol and cigarette use among Polish adolescents with type 1 diabetes mellitus (T1DM) (n = 209), aged 15-18 years, with that of a large cohort of their healthy peers, using standardized questionnaire used in the European School Survey Project on Alcohol and Drugs (ESPAD). ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2895-y
更新日期：2017-06-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2172-7
更新日期：2014-05-01 00:00:00
abstract：:Recent data indicate that insulin-like growth factor II (IGF II) and lysosomal enzymes bind to a common receptor. We measured serum IGF I and II levels in 16 patients with various lysosomal storage disorders. The IGF serum concentrations were normal as long as no marked liver disease was present. Under these condition...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02073885
更新日期：1992-01-01 00:00:00
abstract：:Chronic hepatitis B virus infection is among the most common causes of chronic liver disease in children. The aim of this study was to document prospectively our experiences related to lamivudine and high-dose interferon-alpha2a combination in naïve, e antigen positive, chronic hepatitis B virus infection treatment in...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-006-0220-2
更新日期：2007-03-01 00:00:00
abstract：:Despite advancement in medical care, Rh alloimmunisation remains a major cause of neonatal hyperbilirubinaemia, neuro-morbidity, and late-onset anaemia. Delayed cord clamping (DCC), a standard care now-a-days, is yet not performed in Rh-alloimmunised infants due to paucity of evidence. Hence, we randomised these infan...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03578-8
更新日期：2020-06-01 00:00:00
abstract：:Despite being one of the most common congenital defects in boys, the etiology of hypospadias remains largely unknown. In this case-referent study, we evaluated a wide spectrum of potential risk factors for hypospadias. Cases were identified from the hospital information system, and referents were recruited through the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0304-z
更新日期：2007-07-01 00:00:00
abstract：:The study material consisted of 251 newborn light-treated infants with rhesus haemolytic disease (RHD) caused by anti-D. 139 infants were treated with ordinary phototherapy (white single light) and 112 infants with intensive phototherapy (blue double light). An evaluation was made as to wheter the indications for earl...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444752
更新日期：1980-01-01 00:00:00
abstract：:We report here our findings in two Japanese siblings who experienced recurrent bacterial and viral infections since early infancy. Recent symptoms included diarrhoea, conjunctivitis, rashes, headache, sore throat, joint pain, vomiting and vertigo, all similar to those seen in toxic shock syndrome, except for shock. Th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01956412
更新日期：1994-05-01 00:00:00
abstract：:Patients suffering from a mitochondrial (encephalo-)myopathy have a remarkable clinical heterogeneity. A reliable and extensive investigation must be performed in order to obtain a correct diagnosis, but many factors may influence the ultimate results of these investigations leading, under certain circumstances, to an...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01956139
更新日期：1993-03-01 00:00:00
abstract：UNLABELLED:Primary spontaneous pneumothorax (PSP) is not uncommon, and its recurrence is often a challenging clinical problem. Surgical management and predisposing factors for the recurrence of PSP, however, have not yet been well elucidated in adolescent patients. The major aim of this study was to investigate factors...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2352-0
更新日期：2014-11-01 00:00:00
