Comparison of the bronchodilating effect of oxitropium bromide and fenoterol in asthmatic children.

Abstract:

:Using a randomized double blind study design, the bronchodilating effect of 200 micrograms inhaled oxitropium bromide (OB) was compared with 200 micrograms inhaled fenoterol (F) after an interval of 20 min, in 20 asthmatic children aged 12.7 years (range: 4.9-15.1 years), suffering from mild bronchoconstriction (mean forced expiratory volume during ls: 73.4%, range: 51%-85%). Both drugs induced a comparable degree of bronchodilatation and no significant differences were found between the OB group and the F group, suggesting equipotency for both drugs after a 20 min interval, at the 200 micrograms dose level. Furthermore, a significant improvement of lung function parameters was detected in both groups after subsequent administration of 400 micrograms F, indicating that inhalation of 200 micrograms of OB or F results in submaximal bronchodilation in asthmatic children suffering from mild bronchoconstriction.

journal_name

Eur J Pediatr

authors

Van Bever HP,Desager KN,Pauwels JH,Vermeire PA

doi

10.1007/BF02190670

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

604-6

issue

8

eissn

0340-6199

issn

1432-1076

journal_volume

153

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1997-06-01 00:00:00

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    authors: Van den Broeck J,Vanderschueren-Lodeweyckx M,Eggermont E

    更新日期:1988-04-01 00:00:00

  • Neurodevelopmental outcome after prenatal exposure to opiates.

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    journal_title:European journal of pediatrics

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    doi:10.1007/s004310050923

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    更新日期:1998-09-01 00:00:00

  • Clinical practice treatment of HIV infection in children.

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    journal_title:European journal of pediatrics

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  • Congenital diaphragmatic eventration and hernia sac compared to CDH with true defects: a retrospective cohort study.

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  • Hemidystonia secondary to acquired toxoplasmosis in a non-immunodeficient patient.

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    pub_type: 杂志文章

    doi:10.1007/BF01954489

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    更新日期:1994-10-01 00:00:00

  • Long term renal prognosis of Henoch-Schönlein purpura in an unselected childhood population.

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    journal_title:European journal of pediatrics

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    更新日期:1988-02-01 00:00:00

  • Transient neutropenia in children with febrile illness and associated infectious agents: 2 years' follow-up.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-1965-z

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  • The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442614

    authors: Cremer P,Lakomek M,Beck W,Prindull G

    更新日期:1988-01-01 00:00:00

  • The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity.

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    journal_title:European journal of pediatrics

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    authors: Simental-Mendía LE,Ortega-Pacheco CJ,García-Guerrero E,Sicsik-Aragón MA,Guerrero-Romero F,Martínez-Aguilar G

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  • A patient with Dent disease and features of Bartter syndrome caused by a novel mutation of CLCN5.

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    更新日期:1978-09-08 00:00:00

  • Total serum bilirubin levels during the first 2 days of life and subsequent neonatal morbidity in very low birth weight infants: a retrospective review.

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    pub_type: 杂志文章,评审

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  • Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis.

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    journal_title:European journal of pediatrics

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    pub_type: 杂志文章,评审

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    更新日期:1999-01-01 00:00:00

  • Prevalence of iron deficiency and related factors in Spanish adolescents.

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    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章

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    authors: Amato M,Inaebnit D

    更新日期:1991-02-01 00:00:00

  • Fomepizole as a therapeutic strategy in paediatric methanol poisoning. A case report and review of the literature.

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    pub_type: 杂志文章,评审

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  • Benign cystic nephroblastoma.

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    doi:10.1007/BF00447474

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  • Gastritis and peptic ulcer disease in childhood.

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    更新日期:1999-07-01 00:00:00

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