Myocardial performance in children with autoimmune hepatitis: Doppler tissue imaging study.

Abstract:

:Autoimmune hepatitis (AIH) is a member of autoimmune diseases family which can increase risk of cardiovascular morbidity and mortality. This study aimed to assess subclinical impact of AIH on global myocardial performance in affected children using Doppler tissue imaging (DTI) and to correlate it with total serum immunoglobulin-G (IgG). Thirty children with AIH (mean age = 12.67 ± 2.9 years) was included as the study group and 20 age- and sex-matched healthy children (mean age = 11.93 ± 2.66 years) as the control group. Conventional two-dimensional echocardiography was performed to both groups and DTI were used to determine right ventricular (RV) and left ventricular (LV) Tei indexes. Total serum IgG levels at initial diagnosis of AIH were correlated to the cardiac functions of AIH patients. RV and LV Tei indexes were significantly higher in AIH group (mean ± SD: 0.46 ± 0.088 vs. 0.26 ± 0.01, P < 0.0001 and 0.45 ± 0.086 vs. 0.31 ± 0.02, P < 0.0001, respectively). Also, total IgG concentrations were correlated positively with the LV Tei index (r = 0.69, P < 0.0001) and with the RV Tei index (r = 0.61, P < 0.0003) and correlated negatively with the mitral systolic (Sm) velocity (r = -0.76, P < 0.0001) and with tricuspid systolic (Sm) velocity (r = -0.66, P < 0.0001). On the other hand, fractional shortening did not correlate with serum IgG concentrations (r = -0.04, P = 0.821). In conclusion, the DTI technique appears to be more sensitive than conventional echocardiography in the early detection of myocardial dysfunction in AIH children.

journal_name

Eur J Pediatr

authors

Abo-Haded HM,Barakat TS,Hafez MM

doi

10.1007/s00431-013-2073-9

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1511-9

issue

11

eissn

0340-6199

issn

1432-1076

journal_volume

172

pub_type

临床试验,杂志文章
  • Screening for cystic fibrosis in New York State: considerations for algorithm improvements.

    abstract:UNLABELLED:Newborn screening for cystic fibrosis (CF), a chronic progressive disease affecting mucus viscosity, has been beneficial in both improving life expectancy and the quality of life for individuals with CF. In New York State from 2007 to 2012 screening for CF involved measuring immunoreactive trypsinogen (IRT) ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2616-3

    authors: Kay DM,Maloney B,Hamel R,Pearce M,DeMartino L,McMahon R,McGrath E,Krein L,Vogel B,Saavedra-Matiz CA,Caggana M,Tavakoli NP

    更新日期:2016-02-01 00:00:00

  • Serum levels of carboxyterminal propeptide of type I procollagen in healthy children from 1st year of life to adulthood and in metabolic bone diseases.

    abstract::Type I collagen is the major component of bone matrix; circulating carboxyterminal propeptide of type I procollagen (P-I-CP) levels reflect type I collagen synthesis in tissues and may be an useful index to investigate bone metabolism. We measured P-I-CP by a new radioimmunoassay in 300 healthy children and adolescent...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01959087

    authors: Saggese G,Bertelloni S,Baroncelli GI,Di Nero G

    更新日期:1992-10-01 00:00:00

  • Doppler evaluation of renal blood flow velocity as a predictive index of acute renal failure in perinatal asphyxia.

    abstract:UNLABELLED:Aim of our study was to evaluate Doppler renal blood flow velocity in asphyxiated neonates and to correlate renal function to Doppler findings. Doppler renal blood flow velocity was evaluated in 23 severely asphyxiated neonates born at a gestational age > 32 weeks and compared to our standard Doppler data ob...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050905

    authors: Luciano R,Gallini F,Romagnoli C,Papacci P,Tortorolo G

    更新日期:1998-08-01 00:00:00

  • Systematic review: probiotics for functional constipation in children.

    abstract::We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children. The MEDLINE, EMBASE, and Cochrane Library databases; clinical trial registries; and reference lists of included studies were searched to February 2017 for randomized controlled trials (RCTs) performed in c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-017-2972-2

    authors: Wojtyniak K,Szajewska H

    更新日期:2017-09-01 00:00:00

  • Late-onset adrenal hypoplasia congenita caused by a novel mutation of the DAX-1 gene.

    abstract::Mutation in the orphan nuclear receptor DAX-1 gene causes X-linked adrenal hypoplasia congenita (AHC). Affected male children classically suffer a salt-losing crisis and adrenal insufficiency in their early infancy or, in some rare exceptions, with late-onset subtype. We report here a patient manifesting late-onset ad...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0779-x

    authors: Yang F,Hanaki K,Kinoshita T,Kawashima Y,Nagaishi J,Kanzaki S

    更新日期:2009-03-01 00:00:00

  • Complications of percutaneous liver biopsy in infants and children.

    abstract:UNLABELLED:In this study, 144 consecutive percutaneous liver biopsies performed with a 1.6 mm Menghini needle, during a 2-year period were reviewed. All the children were aged under 15 years, 57 patients less than 1 year and 87 more than 1 year. All biopsies were adequate and the mean number of portal tracts examined w...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02079063

    authors: Lachaux A,Le Gall C,Chambon M,Regnier F,Loras-Duclaux I,Bouvier R,Pinzaru M,Stamm D,Hermier M

    更新日期:1995-08-01 00:00:00

  • Omalizumab in the treatment of eosinophilic esophagitis and food allergy.

    abstract::Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab, in order to improve food intolerance--the major distressing factor in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-011-1540-4

    authors: Rocha R,Vitor AB,Trindade E,Lima R,Tavares M,Lopes J,Dias JA

    更新日期:2011-11-01 00:00:00

  • Tracheal bronchus associated with VACTERL.

    abstract:UNLABELLED:Tracheal bronchus (TB) associated with VACTERL has not been reported previously. A 5-month-old girl with VACTERL association was ventilator-dependent following surgical closure of a patent ductus arteriosus (PDA). Chest radiographs showed persistent hyperinflation of the right upper lobe. Bronchoscopy showed...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-002-1109-3

    authors: Kairamkonda V,Thorburn K,Sarginson R

    更新日期:2003-03-01 00:00:00

  • Late onset subgaleal hemorrhage infection with Streptococcus pneumoniae?

    abstract::We report a case of an infected subgaleal hematoma caused by an unusual micro-organism in a previously healthy 11-month-old girl. Our patient presented at the emergency department with an increasing scalp swelling for 2 weeks, and culture of the evacuated fluid yielded Streptococcus pneumoniae. Although she was born a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-009-0922-3

    authors: Slap F,Jeurissen A,Van Havenbergh T,Deckers F,Mariën P,Van Mol C

    更新日期:2009-06-01 00:00:00

  • Respiratory and arousal responses to hypoxia in apnoeic infants reinvestigated.

    abstract::Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE). Respiratory movements and transcutaneous gas pressures (tcPO2 and tcPCO2) were continuously monitored during the 10 min test. The c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441560

    authors: Milerad J,Hertzberg T,Wennergren G,Lagercrantz H

    更新日期:1989-04-01 00:00:00

  • Treatment of status epilepticus with thiopentone sodium anaesthesia in a child.

    abstract::A 4-month-old infant was admitted to the Pediatric Intensive Care Unit with Pneumococcal meningitis. A few hours after admission he developed intractable convulsions that could not be stopped with phenytoin, phenobarbitone and a continuous drip of diazepam. Thiopentone sodium anaesthesia was induced for 24 h terminati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441663

    authors: Goitein KJ,Mussaffi H,Melamed E

    更新日期:1983-04-01 00:00:00

  • Enteral feeding in infants

    abstract:UNLABELLED:Establishing enteral feeding in the very low birth weight infant as soon as possible after birth has been shown to promote growth and reduce the need for intravenous lines. Human milk can be administered either as a continuous infusion or as intermittent boluses. The aim of this study was to investigate the ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310100814

    authors: Rojahn A,Lindgren CG

    更新日期:2001-10-01 00:00:00

  • Fibrodysplasia ossificans progressiva (FOP): watch the great toes!

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder and the most disabling condition of heterotopic (extraskeletal) ossification in humans. Extraskeletal bone formation associated with inflammation preceding the osseous conversion usually begins in the first decade, predominantly in the head, neck, ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-010-1232-5

    authors: Kartal-Kaess M,Shore EM,Xu M,Schwering L,Uhl M,Korinthenberg R,Niemeyer C,Kaplan FS,Lauten M

    更新日期:2010-11-01 00:00:00

  • Prediction of final height in boys with non-tumorous hypopituitarism.

    abstract::The total height gain was studied in 19 adult male subjects with non-tumorous hypopituitarism after they had been treated with human growth hormone (hGH) for more than 3 years and achieved final adult height. In patients with a history of breech delivery or severe perinatal asphyxia, a high multiple correlation was fo...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442688

    authors: Van den Broeck J,Vanderschueren-Lodeweyckx M,Eggermont E

    更新日期:1988-04-01 00:00:00

  • Zinc deficiency in an exclusively breast-fed preterm infant.

    abstract:UNLABELLED:A formerly premature, exclusively breast-fed infant with severe zinc deficiency syndrome is presented. He showed the characteristic erosive skin changes, including alopecia, as seen in acrodermatitis enteropathica. In addition, he manifested a failure to thrive and irritability. The diagnosis was confirmed b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01972977

    authors: Heinen F,Matern D,Pringsheim W,Leititis JU,Brandis M

    更新日期:1995-01-01 00:00:00

  • Interchangeability of a hepatitis A vaccine second dose: Avaxim 80 following a first dose of Vaqta 25 or Havrix 720 in children in Turkey.

    abstract:INTRODUCTION:This randomised, observer-blind clinical trial conducted in Turkey evaluated the immunogenicity, safety and interchangeability of three paediatric inactivated hepatitis A vaccines in 424 seronegative children between 1 and 15 years of age. METHODS:Potential subjects were screened for anti-hepatitis A viru...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00431-007-0432-0

    authors: Soysal A,Gokçe I,Pehlivan T,Bakir M

    更新日期:2007-06-01 00:00:00

  • Benign cystic nephroblastoma.

    abstract::A benign cystic nephroblastoma in a 6-month-old boy is presented. Erroneous interpretation as malignant nephroblastoma led to unnecessarily aggressive therapy. There is no evidence of recurrence or metastatic disease 12 years after the initial resection. As shown in our case and in the others previously reported in th...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00447474

    authors: Havers W,Stambolis C

    更新日期:1979-05-18 00:00:00

  • Arginine-vasopressin in neonates with vasodilatory shock after cardiopulmonary bypass.

    abstract:UNLABELLED:Successful therapy of vasodilatory shock in adults and children with arginine-vasopressin (AVP) has been reported previously. Data on the use of vasopressin in neonates is limited. This retrospective study reports the effects of AVP-treatment in neonates with catecholamine-resistant systemic vasodilatation a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0400-0

    authors: Lechner E,Hofer A,Mair R,Moosbauer W,Sames-Dolzer E,Tulzer G

    更新日期:2007-12-01 00:00:00

  • Osteoarticular infections due to Kingella kingae in children.

    abstract::By the description of two cases of osteoarticular infections due to Kingella kingae in two young children we wish to draw the attention of clinicians to invasive infections due to this micro-organism. Since its biological characterization in 1976, K. kingae has been increasingly reported as a human pathogen. Most comm...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02072618

    authors: Lacour M,Duarte M,Beutler A,Auckenthaler R,Suter S

    更新日期:1991-07-01 00:00:00

  • Severe respiratory infection with Branhamella catarrhalis in an African child.

    abstract::A pure growth of Branhamella catarrhalis was obtained from a purulent bronchial exudate in a 28-month-old Rwandese girl, hospitalized for acute inspiratory dyspnoea with fever. The outcome was favourable under treatment with ampicillin, although the isolate was shown to produce a beta-lactamase in vitro. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442307

    authors: Bogaerts J,Lepage P,Vande Weghe JP,Vandepitte J

    更新日期:1985-03-01 00:00:00

  • Serum immunoreactive erythropoietin of children in health and disease.

    abstract::Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and congenital heart diseases (n = 70). In healthy children siEPO levels dec...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01959395

    authors: Eckardt KU,Hartmann W,Vetter U,Pohlandt F,Burghardt R,Kurtz A

    更新日期:1990-04-01 00:00:00

  • Evaluation of the indications for early exchange transfusion in rhesus haemolytic disease during phototherapy.

    abstract::The study material consisted of 251 newborn light-treated infants with rhesus haemolytic disease (RHD) caused by anti-D. 139 infants were treated with ordinary phototherapy (white single light) and 112 infants with intensive phototherapy (blue double light). An evaluation was made as to wheter the indications for earl...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00444752

    authors: Ebbesen F

    更新日期:1980-01-01 00:00:00

  • Deletion of the short arm of chromosome 9. A clinically recognisable entity.

    abstract::A partial deletion of the short arm of chromosome 9 is reported in a female newborn and a 12.5 year-old male. The features expressed by both patients, and especially the peculiar type of the craniofacial dysmorphism, confirm the existence of a typical clinical syndrome associated with this partial autosomal monosomy. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441473

    authors: Fryns JP,Pedersen JC,Duyck H,Fabry G,Van den Berghe H

    更新日期:1980-09-01 00:00:00

  • Overweight and obesity in European children and adolescents.

    abstract::The conclusions of this mini-workshop are not substantially different from those previously published based on the USA experience [9]. This does not necessarily mean that there are no important differences between Europe and the USA, rather it reflects the paucity of data, especially in Europe. Moreover, European data...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/pl00014362

    authors: Jebb SA,Lambert J

    更新日期:2000-09-01 00:00:00

  • Growth failure due to protein loss in dermatitis.

    abstract::A 10-month-old infant is described who suffered from extensive atopic dermatitis, failure to thrive, hypoalbuminaemia and oedema. Large amounts of sticky exudate were lost through the skin and were shown to be rich in albumin. As renal and intestinal loss of protein was excluded, the patient's condition was ascribed t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00446072

    authors: Abrahamov A,Schifmann R,Goldstein R,Tal Y,Freier S

    更新日期:1986-08-01 00:00:00

  • Severe neonatal asphyxia due to X-linked centronuclear myopathy.

    abstract::Severe neonatal centronuclear myopathy is inherited as an X-linked condition characterized by primary asphyxia, extreme muscular hypotonia and absent spontaneous movements. We report seven cases from three families to point out the importance of diagnosis with regard to prognosis, outcome and genetic counselling. In h...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02072056

    authors: Braga SE,Gerber A,Meier C,Weiersmüller A,Zimmermann A,Herrmann U,Liechti S,Moser H

    更新日期:1990-12-01 00:00:00

  • Isolated dihydroxyacetonephosphate-acyl-transferase deficiency in rhizomelic chondrodysplasia punctata: clinical presentation, metabolic and histological findings.

    abstract:UNLABELLED:Rhizomelic chondrodysplasia punctata (RCDP) is clinically characterized by symmetrical shortening of the proximal limbs, contractures of joints, a characteristic dysmorphic face, and cataracts. In the classical form an impairment of several peroxisomal functions and enzymes (plasmalogen synthesis, phytanic a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02532526

    authors: Hebestreit H,Wanders RJ,Schutgens RB,Espeel M,Kerckaert I,Roels F,Schmausser B,Schrod L,Marx A

    更新日期:1996-12-01 00:00:00

  • Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.

    abstract:UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00431-014-2416-1

    authors: Ogawa Y,Irikura M,Kobaru Y,Tomiyasu M,Kochiyama Y,Uriu M,Ishitsuka Y,Kondo Y,Yukawa E,Kamada N,Ohno H,Yamazaki T,Irie T

    更新日期:2015-04-01 00:00:00

  • Rett syndrome in a patient with medium chain acyl-CoA dehydrogenase deficiency.

    abstract::A female patient with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency developed normally until 13 months of age after which she showed a gradual developmental delay, followed by progressive dementia, and a decrease in head circumference growth culminating in the diagnosis of Rett syndrome at 3.5 years. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954516

    authors: Beekman RP,Hofstee N,Smeitink JA,Poll-The BT,Duran M

    更新日期:1994-04-01 00:00:00

  • Pulse oximetry used for documenting oxygen saturation and right-to-left shunting immediately after birth.

    abstract::The objective of this study was to investigate the clinical applicability of pulse oximetry to measure haemoglobin oxygen saturation and heart rate in the first 20 min of life and to analyse the effect of pre- or post-ductal (hand, respectively, foot) fixation of sensors on oxygen saturation. Measurements were carried...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02072072

    authors: Meier-Stauss P,Bucher HU,Hürlimann R,König V,Huch R

    更新日期:1990-09-01 00:00:00