Abstract：
UNLABELLED:There are a number of respiratory diseases affecting infants in which there is surfactant dysfunction or deficiency. Surfactant is inactivated by cholesterol, free fatty acids and bilirubin in meconium aspiration syndrome, by haemoglobin and red blood cell lipids in pulmonary haemorrhage and plasma proteins are the culprit in conditions associated with increased alveolar capillary permeability. Surfactant production can be adversely affected by damage to the type 2 pneumocytes by viruses and neutrophil derived reactive oxygen metabolites. Not surprisingly, therefore, the efficacy of exogenous surfactant has been tested, usually in animal models and anecdotal series in "non respiratory distress syndrome" respiratory disorders. Improvements in oxygenation have usually been described. Relatively few randomized trials, however, have been performed, but those undertaken have demonstrated longer term benefits. In term infants with severe respiratory failure, surfactant administration significantly shortened the duration of extracorporeal membrane oxygenation and, in those in the early phase of severe respiratory failure or with meconium aspiration syndrome, it significantly reduced the need for extracorporeal membrane oxygenation. In meconium aspiration syndrome, a smaller number of surfactant treated patients compared to controls developed airleaks. Surfactant administration was also associated with a reduction in the duration of ventilation and intensive care unit stay in patients with meconium aspiration syndrome or bronchiolitis. Those data are very promising and should encourage studies to identify the optimum type of surfactant, dosage regimen and administration method. CONCLUSION:Further randomized trials are required to fully assess the efficacy and cost benefit ratio of surfactant treatment in "non respiratory distress syndrome" respiratory diseases.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Greenough Adoi
10.1007/pl00008398keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
635-40issue
9eissn
0340-6199issn
1432-1076journal_volume
159pub_type
杂志文章,评审abstract：:Pediatric palliative care (PPC) focuses on children and adolescents with life-limiting diseases. It may be initiated at various points of the disease trajectory, if possible early enough to support living with the best possible quality of life despite a limited lifespan. From birth to adolescence, children with a broa...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-012-1710-z
更新日期：2013-02-01 00:00:00
abstract：:West syndrome or infantile spasms is one of the most frequent epileptic syndromes in the first year of life. The clinical symptoms of infantile spasms are very different than any other type of seizure because of both the absence of paroxysmal motor phenomena (i.e., as in a convulsion) and the lack of significant durat...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-012-1813-6
更新日期：2012-11-01 00:00:00
abstract：:A 10-year-old boy with chyluria due to a congenital fistulous communication between the lymphatic system and the bladder is described. Chyluria can be parasitic or non-parasitic. Many causes of non-parasitic chyluria have been reported. Lymphography is the preoperative imaging procedure of choice since it demonstrates...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02073895
更新日期：1992-01-01 00:00:00
abstract：:Tinea of the nails is not an exclusively adult pathology. The pediatrician should include this entity in the differential diagnosis. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0332-8
更新日期：2007-09-01 00:00:00
abstract：:To reveal the influence of therapeutically induced changes of arterial blood pressure on cerebral circulation, pulsed Doppler measurements of blood velocity in the right internal carotid artery were performed in 23 neonates. A positive correlation between mean arterial blood pressure and time-averaged maximum blood ve...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441596
更新日期：1987-09-01 00:00:00
abstract：:Congenital diaphragmatic eventration (CDE) and congenital diaphragmatic hernia (CDH) with or without hernia sac are three different types of congenital diaphragmatic malformations, which this study evaluates. All surgically treated patients with CDE or Bochdalek type CDH between 2000 and 2016 were included in this ret...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03576-w
更新日期：2020-06-01 00:00:00
abstract：:Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3096-z
更新日期：2018-04-01 00:00:00
abstract：:A case of neonatal suppurative parotitis due to Klebsiella pneumoniae is described. This is the first case reported in the last 20 years. Infection with unusual microorganisms should be taken into account when planning antibiotic treatment, especially in hospital acquired infections of the salivary glands in the newbo...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957226
更新日期：1993-12-01 00:00:00
abstract：:A 10-month-old infant is described who suffered from extensive atopic dermatitis, failure to thrive, hypoalbuminaemia and oedema. Large amounts of sticky exudate were lost through the skin and were shown to be rich in albumin. As renal and intestinal loss of protein was excluded, the patient's condition was ascribed t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00446072
更新日期：1986-08-01 00:00:00
abstract：:Paediatric patients are more vulnerable to drug administration errors due to a lack of appropriate drug dosages and strengths for use in this group of patients. Therefore, the aim of the present study was to determine the extent and types of drug administration errors in two paediatric wards and to identify measures t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1084-z
更新日期：2010-05-01 00:00:00
abstract：UNLABELLED:Adipsic hypernatraemia is an uncommon disorder in childhood caused by a defect in the osmoregulation of thirst, leading to impairment of water homeostasis and chronic hyperosmolality of body fluids. Adipsia is often associated with an abnormality in osmoregulated vasopressin secretion due to the close proxim...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1495-9
更新日期：2004-10-01 00:00:00
abstract：UNLABELLED:Implementation of guidelines for group B streptococcal (GBS) prepartum screening (PS) rarely has been prospectively evaluated. To assess PS at 35-37 weeks of gestation and compare its predictive value to that of an intrapartum screening (IS) within 7 days of delivery, a surveillance cohort study was conducte...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2548-y
更新日期：2015-06-01 00:00:00
abstract：:Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants patent extensions when pediatric labeling is provided. We investi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0381-z
更新日期：2007-08-01 00:00:00
abstract：:Phenylketonuria's (PKU) treatment based on low-protein diet may affect other metabolic pathways, such as that of asymmetric dimethylarginine (ADMA). The aim of this study was to evaluate the reliability of ADMA as a biomarker of adequate metabolic control and possible nutritional risk in a long-term PKU patient popula...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-019-03365-0
更新日期：2019-06-01 00:00:00
abstract：UNLABELLED:Overweight and obesity are major public health issues. Childhood obesity often persists throughout adulthood. Recently a higher prevalence of obesity in adults whose mothers smoked during pregnancy was reported. The aim of this study was to assess whether this association is also detectable in pre-school chi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-0983-z
更新日期：2002-08-01 00:00:00
abstract：:We aimed to demonstrate the value of monitoring infants with arteriovenous malformation (AVM) during endovascular embolization with integrated evaluation of hemodynamics (IEH) and guiding decisions according to the underlying pathophysiology. This is a retrospective analysis of the perioperative hemodynamics data for ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03735-z
更新日期：2021-01-01 00:00:00
abstract：:Urinary tract infection (UTI) is a common bacterial infection among infants and children. Predicting which children with upper UTI will develop long-term sequelae remains difficult. We aimed at evaluating the predictive value of urine concentrations of interleukin-6 (UIL-6) and interleukin-8 (UIL-8) in subsequent rena...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1914-2
更新日期：2013-06-01 00:00:00
abstract：:The role of the type-2 T helper (Th2) cell-mediated immune response in the immunopathogenesis of atopic dermatitis (AD) is well documented. Whether polarized immunoresponse is confined to antigen-specific T cells or is distributed among all T cell subsets is still controversial. We investigated frequencies of interleu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0319-5
更新日期：2007-08-01 00:00:00
abstract：UNLABELLED:Over the last decade, substantial progress has been made in the field of pertussis research. This includes better understanding of virulence mechanisms and their influence on the pathogenicity of Bordetella pertussis, increased awareness of the broad spectrum of disease and more insight into the host's immun...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00008429
更新日期：2001-04-01 00:00:00
abstract：:An 11-year-old boy with chronic granulomatous disease caused by cytochrome b deficiency developed right upper lung lobe aspergillosis. Intracerebral lesions developed on maximum doses of flucytosine and amphotericin B. Treatment with 16 mg/kg oral itraconazole was followed by a dramatic clinical improvement and almost...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01958428
更新日期：1991-05-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s004310051338
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:The surgical approach to the inguinal canal in girls is identical to that in boys. The sliding hernia which contains the ovary with or without the fallopian tube occurs occasionally in female patients. In our clinical experience, we found that a hydrocele in the labium, also presenting with an asymptomatic p...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1226-7
更新日期：2003-07-01 00:00:00
abstract：:An 18-month-old child with partial DiGeorge syndrome developed aplastic anaemia during an acute adenovirus infection. Assessment of the child's immune system revealed T-cell subset abnormalities consistent with DiGeorge syndrome. A possible link between the underlying immune deficiency and the observed complication is...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442482
更新日期：1988-08-01 00:00:00
abstract：:We describe here an infant with a large, solitary, fluid-filled lung cyst and hyperinflation of adjacent lung tissue in the same lobe. The combination of a fluid-filled cyst and ectatic emphysema in the same lobe suggests bronchial collapse and airway obstruction as a contributory mechanism for this unusual roentgenog...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00447379
更新日期：1979-10-01 00:00:00
abstract：UNLABELLED:Early recognition by newborn screening and oral biotin supplementation may prevent clinical and neurological deficits in profound biotinidase deficiency (residual plasma biotinidase activity <10%). In order to evaluate possible correlations of molecular characteristics, onset and continuation of treatment an...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1351-3
更新日期：2003-12-01 00:00:00
abstract：UNLABELLED:This paper presents data obtained by questionnaires sent to local hospitals and metabolic centres in Germany, Austria, Italy and Switzerland concerning the survival and outcome of patients with urea cycle disorders treated between 1975 and 1986. A total of 130 questionnaires were sent out of which 88 questio...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1188-9
更新日期：2003-06-01 00:00:00
abstract：:To increase our knowledge of the clonal relationship of leukaemia relapse, the genotypes and phenotypes of ten children with acute lymphoblastic leukaemia (ALL) were examined at initial diagnosis and relapse. Seven patients were phenotyped as common ALL, two as mixed, and one as T-cell ALL (T-ALL). Comparative analyse...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441975
更新日期：1988-06-01 00:00:00
abstract：:It is known that the 5%-10% of adults infected with hepatitis B virus (HBV) develop a chronic infection and that HBV infection acquired at birth by an hepatitis B surface antigen (HBsAg)/hepatitis B "e" antigen (HBeAg)-positive mother almost invariably leads to chronic infection. Little information is, however, availa...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954381
更新日期：1992-03-01 00:00:00
abstract：:This systematic review and meta-analysis assessed the effects of early fortification (EF) versus late fortification (LF) of breast milk (BM) on growth of preterm infants. Randomized and quasi-randomized controlled trials (RCTs) dealing with the effects of EF versus LF on growth parameters, incidence of adverse events,...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-020-03677-6
更新日期：2020-07-01 00:00:00
abstract：:Fourteen children aged 9 months-4 years with moderate to severe mental retardation and varying neurologic lesions were referred for severe and continuous nocturnal sleep disturbances and very abnormal day/night schedules. All children had previously been given hypnotic medications and behavioral treatments which had l...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01953995
更新日期：1993-09-01 00:00:00
