Abstract：
:Fourteen children aged 9 months-4 years with moderate to severe mental retardation and varying neurologic lesions were referred for severe and continuous nocturnal sleep disturbances and very abnormal day/night schedules. All children had previously been given hypnotic medications and behavioral treatments which had little or no effect on nocturnal sleep. The severity of the sleep disturbances significantly affected family life and was a major handicap to the children. All children were treated with light therapy (minimum 4000 lux). Five children responded to treatment and had normal sleep-wake cycles at the most recent post-treatment evaluation (2-5 years after the first treatment). Two of the patients' families were unable to follow the prescribed regimen. Treatment failed in 7 children. One of these seven children spontaneously improved 3 years later. In three of the failure children the neurologic problem progressively worsened, leading to death in one of them. Phototherapy is a treatment worth pursuing in children with very significant sleep/wake disruption which is unresponsive to behavioral or other treatments. It has few side-effects and may lead to normalization of the sleep-wake cycle. Recent improvement in the technology used to monitor the 24-h temperature rhythm over several days and the present commercial availability of "light boxes" should render these therapeutic trials easier than at the time of these initial investigations.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Guilleminault C,McCann CC,Quera-Salva M,Cetel Mdoi
10.1007/BF01953995subject
Has Abstractpub_date
1993-09-01 00:00:00pages
754-9issue
9eissn
0340-6199issn
1432-1076journal_volume
152pub_type
杂志文章abstract：:Following a description of the genetic aspects of the human histocompatibility antigens system HLA and its principle typing methods, this paper reviews the relationship between HLA antigens, transplantation immunology and certain diseases. In particular, the role of the lymphocyte-defined antigens of the HLA-D system ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF00441576
更新日期：1980-03-01 00:00:00
abstract：:Portal hypertension was observed in a 17-year-old girl with urticaria pigmentosa since 2 months of age. Liver biopsies showed portal and sinusoidal infiltration with mast cells although spleen biopsies showed only fibrosis. CONCLUSION. Portal hypertension is a complication of systemic mastocytosis that can lead to dea...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959789
更新日期：1995-10-01 00:00:00
abstract：:A five-year-old-girl with a history of recurrent hypoglycemia presented with acidosis, intractable vomiting, and abdominal tenderness; the diagnosis of acute pancreatitis was made by abdominal ultrasonography and supportive biochemical studies. Urinary organic acid analysis revealed metabolites suggestive of HMG-CoA l...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00540255
更新日期：1984-09-01 00:00:00
abstract：UNLABELLED:This study was aimed to describe the epidemiology, clinical features, and prognosis of respiratory adenoviral infections among children in Suzhou, China. From 1 January 2006 to 31 December 2012, medical records of 474 hospitalized patients with respiratory adenovirus infection were reviewed retrospectively. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2188-z
更新日期：2014-04-01 00:00:00
abstract：UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that c...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00431-014-2416-1
更新日期：2015-04-01 00:00:00
abstract：:Acid-base disturbances have been usually evaluated with the traditional Henderson-Hasselbach method and Stewart's physiochemical approach by quantifying anions of tissue acids (TA). It is hypothesized that an increase in tissue acids during metabolic acidosis would cause a compensatory decrease in the plasma chloride ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1666-4
更新日期：2012-06-01 00:00:00
abstract：:Pulmonary arterial hypertension is characterised by the presence of pulmonary hypertension (mean pulmonary artery pressure >25 mmHg at rest or >30 mmHg during exercise ) and normal pulmonary wedge pressure (<12 mmHg). Several risk factors for pulmonary arterial hypertension have been described. In the absence of any f...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-1012-y
更新日期：2002-10-01 00:00:00
abstract：LARYNGOSCOPE BURNS IN NEONATAL INTUBATION:Following burns during neonatal intubation, we mounted an in vitro study of laryngoscopes to determine the temperatures reached during clinical use. The temperature of 10 different bulb laryngoscopes heads and two fibre optic heads were measured with a thermocouple, once opened...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03381-0
更新日期：2019-07-01 00:00:00
abstract：:Health-related quality of life (HRQOL) is an important indicator of the burden of illness in moderate-to-severe plaque psoriasis. This study evaluated self-reported generic HRQOL among pediatric patients with moderate-to-severe plaque psoriasis based on pooled baseline clinical trial data and compared them to four com...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1587-2
更新日期：2012-03-01 00:00:00
abstract：:The burden of community-acquired pneumonia (CAP) in high-income countries is still significant. The introduction of pneumococcal conjugate vaccines (PCV) has reduced the overall need for hospitalization for CAP. However, it is not clear whether children with underlying disease also have benefitted from the PCV immuniz...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-016-2843-2
更新日期：2017-03-01 00:00:00
abstract：:We report on a 3-year-old boy presenting with left-sided eyelid myocloni due to an intracranial abscess harboring Haemophilus paraphrophilus. This is the first description of an intracranial infection with this pathogen in a child. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0560-6
更新日期：2008-06-01 00:00:00
abstract：:Perinatal transmission remains the main cause of HIV infection in the pediatric population. Treatment of HIV-infected children has become less of a problem in resource-rich countries with a remarkable decrease of perinatal infections, resulting in an effective prevention of mother-to-child transmission and antiretrovi...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-008-0914-8
更新日期：2009-04-01 00:00:00
abstract：:Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population-based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03955-x
更新日期：2021-01-20 00:00:00
abstract：:Abnormalities of chromosome 14 are encountered infrequently in clinical cytogenetics and only few studies of paracentric inversion have been published. This paper reports the first case of hypospadias associated with paracentric inversion of chromosome 14. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441748
更新日期：1986-02-01 00:00:00
abstract：UNLABELLED:Successful therapy of vasodilatory shock in adults and children with arginine-vasopressin (AVP) has been reported previously. Data on the use of vasopressin in neonates is limited. This retrospective study reports the effects of AVP-treatment in neonates with catecholamine-resistant systemic vasodilatation a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0400-0
更新日期：2007-12-01 00:00:00
abstract：:Several methods have been used for lung function testing in the ventilated newborn. The interest in the field has been stimulated by the recent appearance of commercially available equipment for assessment of mechanical parameters and of functional residual capacity in this group. Nevertheless, lung function testing i...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02179669
更新日期：1994-01-01 00:00:00
abstract：UNLABELLED:The aim of this study was to establish the correlations between the polymorphisms of the genes interleukin (IL)-6 572, 190, and 174 in obese children. We assessed 222 hospitalized children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2315-5
更新日期：2014-10-01 00:00:00
abstract：:Relevant findings are reported in an 8-year-old boy with skin infection due to Staphylococcus aureus producing toxic shock syndrome toxin-1 without shock but with an increase in antibody titre against the toxin. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444123
更新日期：1989-01-01 00:00:00
abstract：:We present clinical and biochemical data on a further patient with hyperargininaemia and the results of neurophysiological tests both before and during dietary treatment with an essential amino acid mixture. With normalisation of plasma arginine concentrations, neurological functions improved and brain stem auditory e...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02171562
更新日期：1990-02-01 00:00:00
abstract：:A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and delib...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00716479
更新日期：1987-05-01 00:00:00
abstract：:A 7-year-old boy developed acute, severe hypercalcaemia following the partial excision of a cerebellar medulloblastoma. The serum calcium level was extremely high (19.8 mg/100 ml), but a skeletal survey revealed no apparent bone metastatic lesions; such lesions were only detected by X-ray 3 weeks after the onset of hy...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444958
更新日期：1987-07-01 00:00:00
abstract：:From time to time, paediatricians are confronted with children who might suffer from a primary immunodeficiency disease. For practical purposes, these children can be divided into four main clinical categories: (1) a relatively large group of children with recurrent ear-nose and throat and lower respiratory tract infe...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310100797
更新日期：2001-10-01 00:00:00
abstract：:The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02024330
更新日期：1989-10-01 00:00:00
abstract：UNLABELLED:Both news media and entertainment fiction may lead to short-term and enduring fright reactions. Even TV programs, movies and news made for children may trigger fear. Preoperational children (3 to 7 years of age) are most afraid of fantasy characters, transformations and interpersonal violence. Operational ch...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1632-1
更新日期：2012-04-01 00:00:00
abstract：:Since traction-associated hypertension seems to be a relatively unknown phenomenon, a survey was done of its incidence in children treated with skeletal traction for fractures and orthopaedic diseases. The correlation with hypercalcaemia, a possible aetiological factor, was also explored. Blood pressure was recorded t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957765
更新日期：1992-07-01 00:00:00
abstract：UNLABELLED:In a national prospective study of risk factors for mother-to-child transmission of human immunodeficiency virus (HIV), 316 children of HIV-positive mothers were followed up for at least 6 months. Infection status was determined in 254 of them and 46 were found to be infected giving a transmission rate of 18...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02074831
更新日期：1995-07-01 00:00:00
abstract：UNLABELLED:Growth retardation is a consistent finding in Williams-Beuren syndrome. The cause of short stature in this syndrome is unknown. Endocrine studies have failed to reveal abnormalities in the growth hormone-insulin-like growth factor I axis. We report a boy with confirmed Williams-Beuren syndrome, who was found...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051118
更新日期：1999-06-01 00:00:00
abstract：:This is a report on two mentally retarded sibs with similar anomalies (sagittal craniosynostosis, complex cardiovascular malformations, mandibular ankylosis) and various dysmorphic features. They could represent a "new" probably monogenic syndrome. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00647293
更新日期：1987-01-01 00:00:00
abstract：UNLABELLED:We investigated the clinical and biochemical characteristics of a 6-year-old Japanese boy with very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. He had hypoketotic hypoglycaemia, exercise- and fasting-induced lethargy, hepatomegaly and cardiomegaly. Significant laboratory findings included elevated ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00008368
更新日期：2000-12-01 00:00:00
abstract：UNLABELLED:The aim of this study was to provide growth and sexual maturation reference data for Turkish children living in The Netherlands. We also compared these references with the reference data of children of Dutch origin and with Turkish reference data collected in Turkey and elsewhere in Europe. Cross-sectional g...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1292-x
更新日期：2003-11-01 00:00:00
