The role of IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's obesity.

Abstract:

UNLABELLED:The aim of this study was to establish the correlations between the polymorphisms of the genes interleukin (IL)-6 572, 190, and 174 in obese children. We assessed 222 hospitalized children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted of 102 obesity patients. The two groups underwent IL-6 572 C/G, 190 C/T, and 174 G/C polymorphism testing, measurement of anthropometric parameters (mid-upper arm circumference and tricipital skinfold thickness), and paraclinical evaluation (protein, albumin, leptin, adiponectin, and vascular endothelial growth factor (VEGF)). We observed that phenotype CC was more frequent in obese children for IL-6 572 (p = 0.0001), whereas CG heterozygotes were more frequent in the obese group for the IL-6 190 gene (62.7 %; p = 0.0001). Leptin was dependent on IL-6 572 and IL-6 174 gene polymorphisms and albumin, whereas adiponectin was dependent on the IL-6 174 gene polymorphism. Body mass index (BMI), mid-upper arm circumference (MUAC), and tricipital skinfold thickness (TST) serum albumin levels correlated with C allele carriers of the IL-6 572 and IL-6 190 genes in children with obesity, whereas the CC genotype of IL-6 174 was a protective factor for obesity. CONCLUSION:Obesity is most frequently associated in children with IL-6 174 C allele carriers and with IL-6 190 C allele carriers.

journal_name

Eur J Pediatr

authors

Oana MC,Claudia B,Carmen D,Maria PA,Septimiu V,Claudiu M

doi

10.1007/s00431-014-2315-5

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1285-96

issue

10

eissn

0340-6199

issn

1432-1076

journal_volume

173

pub_type

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