Control of proven pulmonary and suspected CNS aspergillus infection with itraconazole in a patient with chronic granulomatous disease.

Abstract:

:An 11-year-old boy with chronic granulomatous disease caused by cytochrome b deficiency developed right upper lung lobe aspergillosis. Intracerebral lesions developed on maximum doses of flucytosine and amphotericin B. Treatment with 16 mg/kg oral itraconazole was followed by a dramatic clinical improvement and almost complete disappearance of the intracerebral lesions. Plasma itraconazole levels were between 40 and 3440 ng/ml depending on concomitant medication. Toxicity was restricted to transient elevation of alkaline phosphatase and gamma glutamyl transferase. We conclude that further trials with itraconazole are justified in high risk patients in whom conventional therapy has failed.

journal_name

Eur J Pediatr

authors

Kloss S,Schuster A,Schroten H,Lamprecht J,Wahn V

doi

10.1007/BF01958428

keywords:

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

483-5

issue

7

eissn

0340-6199

issn

1432-1076

journal_volume

150

pub_type

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