Abstract:
:Serum immunoglobulin levels and naturally occurring antibody titres against Streptococcus pneumoniae were measured in seven children aged 1-1.9 years with recurrent pneumococcal acute otitis media (AOM). Three of them had low IgG2 levels. Mean antibody levels of anti-pneumococcal IgG1 and anti-pneumococcal IgG2 were significantly lower in patients when compared to those of healthy controls and children who had less frequent episodes of AOM. Following treatment with intravenous immunoglobulin (IVIG) for 6 months, anti-pneumococcal IgG1 and IgG2 antibody levels increased and the number of episodes of AOM decreased in all patients. Following the discontinuation of IVIG therapy, no AOM episode occurred. Serum levels of anti-pneumococcal IgG1 and IgG2 were normal, which were measured in three subjects at 5, 6, and 12 months after the cessation of IVIG therapy. These results suggested that delayed maturation of anti-pneumococcal antibody production caused recurrent AOM and this condition was corrected by IVIG therapy.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Ishizaka A,Sakiyama Y,Otsu M,Ozutsumi K,Matsumoto Sdoi
10.1007/BF01958979subject
Has Abstractpub_date
1994-03-01 00:00:00pages
174-8issue
3eissn
0340-6199issn
1432-1076journal_volume
153pub_type
杂志文章abstract::Twenty patients with enzymatically proven glycogen storage disease type III (GSD III) aged 3-30 years underwent cardiological evaluation. Seventeen showed subclinical evidence of cardiac involvement in form of ventricular hypertrophy on ECG. Of 16 patients in whom an ECG examination was performed, 13 had abnormal echo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00443106
更新日期:1989-08-01 00:00:00
abstract:UNLABELLED:Bone mineralization of healthy preterm infants fed human milk were compared with that of similar fed preterm formula. Bone mineralization was studied by dual energy X-ray absorptiometry in 43 preterm infants divided into two groups; 21 preterm infants were fed with maternal breast milk and 22 preterm infants...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050864
更新日期:1998-06-01 00:00:00
abstract::We discuss the unusual presentation of acquired toxoplasmosis in a girl with severe and transient hemidystonia as a unique symptom. Serum titres of anti-toxoplasma antibodies increased whereas no specific antibody response in the CSF was observed. While symptomatic drugs were inefficacious, specific anti-toxoplasmosis...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01954489
更新日期:1994-10-01 00:00:00
abstract::In 166 full term, small-for-gestational-age (FT-SGA), 53 preterm, appropriate-for-gestational-age (PT-AGA), 27 PT-SGA and 206 FT-AGA infants a neurological examination at the age of 6 years was carried out. Data were collected on behaviour and school achievement. Major and minor neurological abnormalities were more fr...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441967
更新日期:1988-06-01 00:00:00
abstract:UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-015-2566-9
更新日期:2015-11-01 00:00:00
abstract::Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortiso...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00496996
更新日期:1978-06-20 00:00:00
abstract:UNLABELLED:We report fives sporadic cases of hyperekplexia or startle disease characterized by a highly exaggerated startle reflex and tonic attacks. Affected neonates suffer from prolonged periods of stiffness and are at risk for sudden death from apnea. An early diagnosis is needed. Sudden loud sounds, unexpected tac...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-005-0015-x
更新日期:2006-02-01 00:00:00
abstract::CD3+4-8- double negative cells in peripheral blood lymphocytes were examined in 21 severely handicapped children divided into two groups according to serum IgG level. All children were bedridden and were taking multiple anticonvulsants and there were no apparent clinical differences between these two groups. Serum lev...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01954738
更新日期:1994-12-01 00:00:00
abstract::Polyarteritis nodosa (PAN) is a non-frequent vasculitis of small- and medium-sized vessels. Psoriatic arthritis (PA) is described as a "unique inflammatory arthritis associated with psoriasis" with an inexact prevalence rate due to the lack of widely accepted classification criteria. We describe the case of an 11-year...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1459-9
更新日期:2011-09-01 00:00:00
abstract::Two young boys were referred for evaluation of metabolic myopathy because of elevated serum levels of creatine kinase, cramps and pigmenturia. Immunohistochemical studies of dystrophin in muscle biopsies showed reduced intensity of the stain with a patchy and discontinuous pattern in most fibers. In both patients dyst...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02073385
更新日期:1993-10-01 00:00:00
abstract:UNLABELLED:Neuroleptic malignant syndrome (NMS) is a rare but serious disorder caused by antipsychotic medication including phenothiazines. For sedative purposes, increasing doses of alimemazine were administered to a 4-year-old multiple handicapped girl, with cerebral damage of the basal ganglia. She developed extra-p...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-002-0956-2
更新日期:2002-05-01 00:00:00
abstract:UNLABELLED:Five neonates who suffered from an unexpected long period of respiratory failure, muscular hypotonia, and drowsiness were observed in a retrospective study. Prior to this general depression, unusually high doses of diazepam were administered to all patients via intravenous bolus injection. Serum levels of di...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100745
更新日期:2001-06-01 00:00:00
abstract:UNLABELLED:An 8-year-old boy with frequently recurring pancreatitis-like abdominal pain, Fredrickson type V dyslipidaemia, and significantly decreased post-heparin plasma lipoprotein lipase (LPL) activity is described. In order to exclude familial LPL deficiency, the complete LPL coding gene sequence was analysed revea...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957148
更新日期:1996-08-01 00:00:00
abstract::Despite being one of the most common congenital defects in boys, the etiology of hypospadias remains largely unknown. In this case-referent study, we evaluated a wide spectrum of potential risk factors for hypospadias. Cases were identified from the hospital information system, and referents were recruited through the...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0304-z
更新日期:2007-07-01 00:00:00
abstract::Health-related quality of life (HRQOL) is an important indicator of the burden of illness in moderate-to-severe plaque psoriasis. This study evaluated self-reported generic HRQOL among pediatric patients with moderate-to-severe plaque psoriasis based on pooled baseline clinical trial data and compared them to four com...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1587-2
更新日期:2012-03-01 00:00:00
abstract::Neonatal diabetes, which may be transient or permanent, is rare. Most patients are full-term but small- for-date infants. Typical symptoms of diabetes mellitus occur within the first 4 weeks of life, requiring insulin therapy and very strict blood glucose monitoring. Subsequent growth and psychomotor development are u...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF01958635
更新日期:1995-12-01 00:00:00
abstract::Human metapneumovirus (hMPV) is a recently discovered pathogen in respiratory tract infection. The published literature suggests milder illness severity in hMPV compared with respiratory syncytial virus (RSV) infection. In two consecutive seasons, 637 nasopharyngeal aspirates from pediatric patients were tested by hMP...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0105-4
更新日期:2006-07-01 00:00:00
abstract:LARYNGOSCOPE BURNS IN NEONATAL INTUBATION:Following burns during neonatal intubation, we mounted an in vitro study of laryngoscopes to determine the temperatures reached during clinical use. The temperature of 10 different bulb laryngoscopes heads and two fibre optic heads were measured with a thermocouple, once opened...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03381-0
更新日期:2019-07-01 00:00:00
abstract::The description and analysis of the utilisation of medical services is of particular importance reflecting childhood morbidity. Therefore, our aim was to describe episode- and person-based rates of hospital admission in Germany, by focusing on the three most important clinically relevant categories, accident injuries,...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-008-0859-y
更新日期:2009-08-01 00:00:00
abstract::Patients with Turner syndrome (n = 33) were subjected to a sequential oestrogen/gestagen replacement therapy (21 days 2 mg oestradiol valerate plus 0.5 mg norgestrel for 10 days) for 1-4 years. In individuals aged 12-17 years, growth velocities before treatment ranged between 2.9 and 1.9 cm/year and increased to 6.8-3...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00439400
更新日期:1986-09-01 00:00:00
abstract:UNLABELLED:To monitor infant care practices associated with risks for sudden infant death, 400 Belgian families with infants less than 6 months old were questioned by 21 paediatricians during routine visits to local paediatric practices and well baby services (11 in urban centres, 10 in rural areas). Because of incompl...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100783
更新日期:2001-08-01 00:00:00
abstract::A 4.5-year-old male patient is described with chorioretinopathy, minor facial anomalies, delayed closure of the fontanel, mental retardation, moderate hypotonia, epilepsy and hepatic fibrosis. Postural control, intentional vocalising and manual dexterity were superior to the performance of patients with classical Zell...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441774
更新日期:1985-11-01 00:00:00
abstract::Phenylketonuria's (PKU) treatment based on low-protein diet may affect other metabolic pathways, such as that of asymmetric dimethylarginine (ADMA). The aim of this study was to evaluate the reliability of ADMA as a biomarker of adequate metabolic control and possible nutritional risk in a long-term PKU patient popula...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-019-03365-0
更新日期:2019-06-01 00:00:00
abstract:UNLABELLED:The 6-min walk test is a simple and accurate method to measure functional exercise capacity in children. We provide smooth reference curves for the modified 6-min walk test in 696 healthy children and adolescents aged 4-19 years, enabling calculation of sex-, age-, and height-specific Z-scores. CONCLUSION:T...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-014-2454-8
更新日期:2015-06-01 00:00:00
abstract::We have previously shown that breast-fed infants have a considerably larger thymus at 4 months than formula-fed infants. The aim of the present study was to investigate whether breast-feeding also influences the thymic size in late infancy. In a cohort of 50 infants, all being partially breast-fed when recruited at 8 ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310051258
更新日期:1999-12-01 00:00:00
abstract::We report a prospective, non-blind, randomised, multicentre, parallel group, multinational investigation to compare ceftazidime to aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. In each of the 15 study centres either ceftazidime alone (CAZ) or ceftazidime + ampic...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF01954122
更新日期:1992-12-01 00:00:00
abstract::Pediatric palliative care (PPC) focuses on children and adolescents with life-limiting diseases. It may be initiated at various points of the disease trajectory, if possible early enough to support living with the best possible quality of life despite a limited lifespan. From birth to adolescence, children with a broa...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-012-1710-z
更新日期:2013-02-01 00:00:00
abstract::A 22 years old female with the late-onset of argininosuccinic aciduria was successfully treated for 5 months with a mixture of essential amino acids and their keto-analogues. There was a marked change in plasma ammonia, plasma amino acids and argininosuccinic acid excretion. A long term anabolic response was reflected...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445607
更新日期:1978-07-19 00:00:00
abstract:INTRODUCTION:Population modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the drug will be used clinically. DISCUSSION:The advantages of these models in paediatric studies are that they can be used to analyse sparse data, sam...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-006-0188-y
更新日期:2006-11-01 00:00:00
abstract::Since the first description by Catel and Manzke of hyperphalangy and clinodactyly of the index finger associated with Robin malformation sequence, seven further cases have been published. In two families more than one case occurred. Another family is presented with possibly two affected boys showing variable features ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442455
更新日期:1984-08-01 00:00:00