Abstract:
:Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortisol do not alter GH secretion. A review of the literature shows that GH secretion is consistently depressed in Cushing's disease of central origin and in Cushing's syndrome due to adrenal carcinoma. When acutely administered, doses higher than 100 mg of cortisol (or equivalent amounts of other steroids) per adult are necessary to block GH secretion and the hormones have to be given several hours previously. In long-term steroid treatment, suppression of GH is observed in only 1 out of 3 patients. The effect apparently does not persist beyond elimination of the last dose, i.e. generally not longer than 12 to 24 h. These data can be taken as a rationale for intermittent or alternating dosage schedules, and for the use of short acting derivatives if long-term, high-dose steroid treatment is necessary in children. It remains to be established whether growth deficiency in exogenous hypercortisolism is due to suppression of GH secretion, decreased production of somatomedins, direct antagonism of the action of somatomedins on growing cartilage, or a combination of these mechanisms.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Mühlendahl KE,Weber B,Müller-Hess R,Korth-Schütz S,Helge Hdoi
10.1007/BF00496996subject
Has Abstractpub_date
1978-06-20 00:00:00pages
113-21issue
2eissn
0340-6199issn
1432-1076journal_volume
128pub_type
杂志文章abstract::Cardiac function is impaired in adults or children with hypothyroidism and it can be reversed by levothyroxine (L-T(4)) substitution therapy. However, only a few studies are available on left and right ventricular function in neonates with congenital hypothyroidism (CH), most of which were performed with standard echo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0417-z
更新日期:2007-12-01 00:00:00
abstract::A case of neonatal suppurative parotitis due to Klebsiella pneumoniae is described. This is the first case reported in the last 20 years. Infection with unusual microorganisms should be taken into account when planning antibiotic treatment, especially in hospital acquired infections of the salivary glands in the newbo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957226
更新日期:1993-12-01 00:00:00
abstract::The involvement of minors in clinical research is inevitable to catch up with the lack of drugs labeled for pediatric use. To encourage the responsible conduct of pediatric clinical trials in the EU, an extensive legal framework has been developed over the past decade in which the practical, ethical, legal, social, an...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-008-0915-7
更新日期:2009-10-01 00:00:00
abstract::The present study was done to evaluate the effect of short-term dietary therapy on 148 dyslipidaemic children (24 familial hypercholesterolaemia, 105 non-familial hypercholesterolaemia and 19 hypertriglyceridaemia), detected by mass screening in children at 18 months of age. In the model diet used for treatment, 15% o...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957537
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The treatment of complicated urinary tract infection in children is still a matter of debate. In our hospital, antimicrobial treatment is initiated intravenously, and the duration of this treatment is adapted according to the results of a Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy. AIM:This study wa...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2024-5
更新日期:2013-09-01 00:00:00
abstract::A benign cystic nephroblastoma in a 6-month-old boy is presented. Erroneous interpretation as malignant nephroblastoma led to unnecessarily aggressive therapy. There is no evidence of recurrence or metastatic disease 12 years after the initial resection. As shown in our case and in the others previously reported in th...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00447474
更新日期:1979-05-18 00:00:00
abstract::Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Therefore serum immunoreactive parathyroid hormone (iPTH) and the urinary cyclic adenosine-3',5'-monophosphate excretion (UcAMP) were measured together with other important indices of ca...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00443214
更新日期:1984-01-01 00:00:00
abstract::Two unique associations of disease with Escherichia coli O157:H7 are presented. These cases broaden the spectrum of disease associated with this organism which currently includes bloody and non-bloody diarrhoea, haemolytic-uraemic syndrome, and thrombotic thrombocytopenic purpura. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02106287
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Randomly estimated fasting hyperglycaemia in an asymptomatic individual may represent the first sign of pancreatic beta-cell dysfunction. OBJECTIVE:We aimed at specifying the genetic aetiology of asymptomatic hyperglycaemia in a cohort of children and adolescents. SUBJECTS AND METHODS:We analysed the aet...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0106-3
更新日期:2006-07-01 00:00:00
abstract::We report two Chinese boys with Wiskott-Aldrich syndrome presenting with gastro-intestinal bleeding, eczema and recurrent infection. They had thrombocytopenia and the mean platelet volume was small. Serum IgG and IgA were elevated and lymphocyte proliferation in response to phytohaemagglutinin, concanavalin A and poke...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957573
更新日期:1992-09-01 00:00:00
abstract::We hypothesized that because 45,X/46,XY (X/XY) children share a cell line with Turner syndrome (TS), they also share co-morbidities described in TS. In addition, the presence of the Y chromosome in brain and in other body tissues would influence their function. On the basis of our findings, we aimed to establish optim...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1600-9
更新日期:2012-03-01 00:00:00
abstract::Kawasaki disease (KD) is associated with coronary artery injury. Studies have shown that the endothelial progenitor cell (EPC) participates in the process of arterial repair. Data have been reported that the number of EPC increased significantly in the subacute phase of KD. However, until now, there are no data about ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-009-1014-0
更新日期:2010-03-01 00:00:00
abstract::Adolescents have specific healthcare needs distinct from adults or younger children secondary to anatomical, physiological and socio-behavioural differences. Healthcare providers have been slow to address this, leading the UK Department of Health (2011) to publish 'You're Welcome' quality criteria for services for you...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-016-2815-6
更新日期:2017-02-01 00:00:00
abstract:UNLABELLED:In this review, a simplified scheme for classification of cortical malformations is introduced and illustrated based on the work of Barkovich et al. [8]. Detailed MRI studies identify cortical malformations as a major cause of epilepsy in children. Two aspects that are becoming increasingly important for the...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s004310000452
更新日期:2000-08-01 00:00:00
abstract:UNLABELLED:To date, the genetic basis of Dubowitz syndrome (short stature, microcephaly, facial abnormalities, eczema) is unknown and vascular complications are not known to be associated with this syndrome. In microcephalic osteodysplastic primordial dwarfism type II (MOPD II; disproportionate short statue, microcepha...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-014-2368-5
更新日期:2014-09-01 00:00:00
abstract:UNLABELLED:In very low birth weight (VLBW) infants, colloid infusion is associated with impaired perinatal lung function and increased oxygen dependency duration. The aim of this study was to determine whether perinatal colloid infusion was associated with abnormal neurodevelopmental outcome. All perinatal fluid input ...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00431-002-0950-8
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Calcaneal apophysitis, or Sever's disease, is a traction apophysitis. It is a frequent cause of heel pain in children. Knowledge about the exact incidence of calcaneal apophysitis in the general population, however, is lacking. DESIGN:Cross-sectional study. METHODS:From 34 general practices, records of pat...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2219-9
更新日期:2014-05-01 00:00:00
abstract:UNLABELLED:Newborn screening for cystic fibrosis (CF), a chronic progressive disease affecting mucus viscosity, has been beneficial in both improving life expectancy and the quality of life for individuals with CF. In New York State from 2007 to 2012 screening for CF involved measuring immunoreactive trypsinogen (IRT) ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-015-2616-3
更新日期:2016-02-01 00:00:00
abstract:UNLABELLED:The phenotypes of chromosomal 22q11.2 microdeletion are quite variable among individuals and hypoparathyroidism (HP) constitutes a definite portion of the clinical spectrum. For the correct diagnosis and pertinent follow up of the HP children due to del22q11.2, we tried to delineate the clinical characterist...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050762
更新日期:1998-01-01 00:00:00
abstract::The long-term consequences of transient neonatal hypoglycemia are sparsely studied. We performed a follow-up of a cohort of neonates with blood glucose recordings < 1.7 mmol/L (< 30 mg/dL), treated with > 2.5 mmol/L (> 45 mg/dL), compared with healthy siblings. Exclusion criteria were gestational age < 35 weeks, sever...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03729-x
更新日期:2020-12-01 00:00:00
abstract::The effects of intravenous injections of the opiate antagonist naloxone (0.005-0.4 mg/kg body weight) on respiratory pattern, apnoea duration and frequency were investigated in six infants with severe sleep apnoea syndrome. Since several authors found elevated plasma- and CSF-levels of endogenous opioids (endorphines)...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00439238
更新日期:1986-10-01 00:00:00
abstract::Despite neonatal lung ultrasound (LU) being diffused worldwide, its introduction in limited-resource areas has not been formally investigated. We conceived a project to introduce it in a level 3 NICU of a developing country and verify if, after a short protocolized training, clinicians may efficaciously use LU. Inter-...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03603-w
更新日期:2020-07-01 00:00:00
abstract::The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely ass...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-017-2949-1
更新日期:2017-08-01 00:00:00
abstract::Lower respiratory tract infections (LRTI) caused by adenovirus can be severe with resultant chronic pulmonary sequelae. More than 50 serotypes have been recognized; however, the exact association of serotype with clinical phenotype is still unclear. There have been no reports on the adenovirus serotype pattern in Hong...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2127-z
更新日期:2014-03-01 00:00:00
abstract::This study was conducted to assess the clinical spectrum, management, and outcome of SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C). We reviewed medical records of children with MIS-C diagnosis seen at the Children's Hospital of Michigan in Detroit between April and June 2020. Thirty-three ch...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-021-03935-1
更新日期:2021-01-16 00:00:00
abstract::Patients with childhood-onset systemic lupus erythematosus (cSLE) are at risk of becoming short adults. To evaluate the growth patterns and risk factors of short final height, a retrospective study was conducted in 97 patients (87 females, 90%) with cSLE who grew from the time of diagnosis and reached their final heig...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03910-2
更新日期:2021-01-03 00:00:00
abstract:UNLABELLED:Administration of human growth hormone (GH) has yielded conflicting results concerning its role on thyroid function in patients with Ullrich-Turner syndrome. Therefore, we investigated the course of thyroid hormone parameters and thyroxin binding globulin in relation to GH therapy, IGF-I and additional oxand...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004310050563
更新日期:1997-02-01 00:00:00
abstract::We describe the natural history of the RTSII phenotype in a 7-year-old boy who developed intrauterine and postnatal growth retardation, failure to thrive and persisting diarrhoea. The growth hormone stimulation test identified an isolated growth hormone deficiency. Since infancy, the patient manifested skin lesions ch...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0447-6
更新日期:2008-02-01 00:00:00
abstract::The objective of this study was to investigate the clinical applicability of pulse oximetry to measure haemoglobin oxygen saturation and heart rate in the first 20 min of life and to analyse the effect of pre- or post-ductal (hand, respectively, foot) fixation of sensors on oxygen saturation. Measurements were carried...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02072072
更新日期:1990-09-01 00:00:00
abstract:UNLABELLED:About 50% of intersex cases are due to male pseudohermaphroditism, and of these cases, 50% are not clarified aetiologically. The association of idiopathic male pseudohermaphroditism and prenatal growth retardation has been recently reported. The aim of this study was to verify whether there was a difference ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-005-1626-y
更新日期:2005-05-01 00:00:00