当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PEDIATRICS期刊下所有文献 > Risk factors for hypospadias.

Risk factors for hypospadias.

Abstract：

:Despite being one of the most common congenital defects in boys, the etiology of hypospadias remains largely unknown. In this case-referent study, we evaluated a wide spectrum of potential risk factors for hypospadias. Cases were identified from the hospital information system, and referents were recruited through the parents of the cases. Both parents of cases and referents completed written questionnaires that they received through the mail. Logistic regression analyses were used to assess the independent contribution of different factors to the risk of hypospadias. The final database included 583 cases and 251 referents. Hypospadias more often occurred in children whose father had hypospadias (OR=9.7; 95%CI: 1.3-74.0) and in children with a low birth weight (OR=2.3; 95%CI: 1.2-4.2). Indications for elevated risks were found when mothers were DES-daughters (OR=3.5; 95%CI: 0.8-15.6), fathers were subfertile (OR=1.8; 95%CI: 0.7-4.5), the parents had undergone fertility treatment (OR=2.3; 95%CI: 0.9-5.8), and in twin or triplet pregnancies (OR=2.0; 95%CI: 0.8-5.1). Maternal use of iron supplements (OR=2.2; 95%CI: 0.8-6.0), maternal smoking (OR=1.5; 95%CI: 1.0-2.4), paternal prescriptive drug use (OR=2.6; 95%CI: 1.1-6.6), and paternal exposure to pesticides (OR=2.1; 95%CI: 0.6-7.1) during the 3 months immediately prior to conception or in the first trimester of pregnancy also appeared to increase the risk of hypospadias. The associations found in this study support the hypothesis that genetic predisposition, placental insufficiency, and substances that interfere with natural hormones play a role in the etiology of hypospadias.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Brouwers MM,Feitz WF,Roelofs LA,Kiemeney LA,de Gier RP,Roeleveld N

doi

10.1007/s00431-006-0304-z

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

671-8

issue

7

eissn

0340-6199

issn

1432-1076

journal_volume

166

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PEDIATRICS文献大全
  • The spectrum of care for pediatric refugees and asylum seekers at a tertiary health care facility in Switzerland in 2015.

    abstract：:The aim of this retrospective study was to describe the epidemiology and spectrum of infections of admitted pediatric refugees and asylum seekers in a tertiary referral hospital in a high-income country in Europe. We identified recent refugees and asylum seekers < 18 years of age admitted to the University Children's ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-017-3014-9

    authors： Pohl C,Mack I,Schmitz T,Ritz N

    更新日期：2017-12-01 00:00:00

  • Correlation between pituitary growth hormone reserve and degree of growth failure in children with short stature.

    abstract：:The correlation between a releasable pituitary growth hormone (GH) pool and degree of growth failure was examined in 30 children with GH deficiency (group I) and 19 children with normal short stature (group II). Based on the responsiveness of GH to GH-releasing hormone (GHRH), group I, with low GH responses (below 7 n...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00442468

    authors： Kajiwara S,Igarashi N,Imura E,Sato T

    更新日期：1988-08-01 00:00:00

  • The prevention of preterm birth with the use of antibiotics.

    abstract：UNLABELLED:Infection is a well recognised cause of spontaneous early preterm labour. Preterm labour of infective aetiology is refractory to the use of tocolytic agents and affected women have a higher risk of subsequent chorio-amnionitis and neonatal infection. Antibiotics used prophylactically for the prevention of pr...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/pl00014313

    authors： Lamont RF

    更新日期：1999-12-01 00:00:00

  • Biliary atresia: the Croatian experience 1992-2006.

    abstract：:The objective of this study was to determine the outcomes of Croatian children with biliary atresia. Health records of infants born in Croatia between January 1, 1992 and December 31, 2006 who were diagnosed with biliary atresia and treated at a single university center were reviewed. Survival rates were calculated wi...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-010-1266-8

    authors： Grizelj R,Vuković J,Novak M,Batinica S

    更新日期：2010-12-01 00:00:00

  • Evaluating patient experience in a cystic fibrosis centre using a disease-specific patient satisfaction questionnaire.

    abstract：UNLABELLED:Medical care for persons with chronic diseases like cystic fibrosis (CF) is provided by multi-professional teams. We assessed the patients' perspective of care by reporting the results of two consecutive patient satisfaction surveys performed within a 2-year interval at our CF centre. The newly developed, di...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-015-2545-1

    authors： Ellemunter H,Stahl K,Smrekar U,Steinkamp G

    更新日期：2015-11-01 00:00:00

  • Clinical recognition of mid-aortic syndrome in children.

    abstract：:Mid-aortic syndrome is characterized by narrowing of the abdominal aorta, usually with the involvement of renal arteries and other visceral branches. The combination of the presence of an abdominal bruit, diminished or absent pulsations of the lower extremities, and a blood pressure discrepancy between upper and lower...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-012-1800-y

    authors： ten Dam K,van der Palen RL,Tanke RB,Schreuder MF,de Jong H

    更新日期：2013-03-01 00:00:00

  • Predictors for place of death among children:A systematic review and meta-analyses of recent literature.

    abstract：:Through a systematic review and meta-analyses, we aimed to determine predictors for place of death among children. We searched online databases for studies published between 2008 and 2019 comprising original quantitative data on predictors for place of death among children. Data regarding study design, population char...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-020-03689-2

    authors： Wolff SL,Christiansen CF,Nielsen MK,Johnsen SP,Schroeder H,Neergaard MA

    更新日期：2020-08-01 00:00:00

  • Variable use of therapeutic interventions for children with human immunodeficiency virus type 1 infection in Europe.

    abstract：UNLABELLED:Although a range of antiretroviral drugs are available for use in children, the appropriate paediatric regimen remains unclear. In a survey to investigate policies and practices relating to the therapeutic management of children infected by the human immunodeficiency virus (HIV), a postal questionnaire was s...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s004310050045

    authors： Bernardi S,Thorne C,Newell ML,Giaquinto C,Tovo PA,Rossi P

    更新日期：2000-03-01 00:00:00

  • Nicotine and cotinine concentrations in the milk of smoking mothers: influence of cigarette consumption and diurnal variation.

    abstract：:The relationship between nicotine and cotinine concentrations in mother's milk (including 24 h profiles) and the number of cigarettes consumed was studied. A total of 206 milk samples were collected from 34 nursing, smoking mothers. The mothers were distributed into three groups: Group I (1-10 cigarettes/day), group I...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00647276

    authors： Luck W,Nau H

    更新日期：1987-01-01 00:00:00

  • Hyperphenylalaninaemia due to dihydropteridine reductase deficiency.

    abstract：:Two siblings with increased levels of serum phenylalanine were detected by newborn screening. The older sibling deteriorated neurologically and mentally, despite early dietary control, and died at the age of 6 1/2 years. In the younger sibling phenylalanine hydroxylase activity in liver tissue was normal. Further inve...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00442368

    authors： Gröbe H,Bartholome K,Milstien S,Kaufman S

    更新日期：1978-09-08 00:00:00

  • Tuberculin skin test in bacille Calmette-Guérin-vaccinated children: how should we interpret the results?

    abstract：BACKGROUND:The tuberculin skin test (TST) is the most useful method for the diagnosis of tuberculosis (TB). There is no evidence about the effect of bacillus Calmette-Guerin (BCG) vaccine on the interpretation of TST results. OBJECTIVE:The aim of this study was to evaluate TST results in a population of immigrants and...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-012-1783-8

    authors： Piñeiro R,Mellado MJ,Cilleruelo MJ,García-Ascaso M,Medina-Claros A,García-Hortelano M

    更新日期：2012-11-01 00:00:00

  • Recombinant human interferon-gamma in patients with chronic granulomatous disease--European follow up study.

    abstract：:This was an uncontrolled, open-label follow up study of a previous 12-month, randomized, double-blind, placebo-controlled trial performed to assess the long-term efficacy and safety of Recombinant Human Interferon Gamma (rIFN-gamma) in patients with chronic granulomatous disease (CGD). In two centres, 28 patients (24 ...

    journal_title：European journal of pediatrics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01957365

    authors： Weening RS,Leitz GJ,Seger RA

    更新日期：1995-04-01 00:00:00

  • Ethical issues about the paradigm shift in the treatment of children with trisomy 18.

    abstract：:Until recently, trisomy 18 was considered a disease incompatible with life, with a high percentage of electively terminated pregnancies. The usual behavior was denial of treatment. But some medical interventions have changed the survival of children. A search for articles published in the PubMed database on the latest...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-019-03531-4

    authors： Silberberg A,Robetto J,Grimaux G,Nucifora L,Moreno Villares JM

    更新日期：2020-03-01 00:00:00

  • Does the severity of congenital heart defects affect disease-specific health-related quality of life in children in Bosnia and Herzegovina?

    abstract：UNLABELLED:The aim of this study was to assess whether the severity of congenital heart defects (CHD) affects disease-specific health-related quality of life (HRQOL) in children after open heart surgery. One hundred and fourteen children with CHD and one of their parents participated in the study. HRQOL was evaluated b...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-009-1060-7

    authors： Tahirović E,Begić H,Nurkić M,Tahirović H,Varni JW

    更新日期：2010-03-01 00:00:00

  • Systematic review: probiotics for functional constipation in children.

    abstract：:We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children. The MEDLINE, EMBASE, and Cochrane Library databases; clinical trial registries; and reference lists of included studies were searched to February 2017 for randomized controlled trials (RCTs) performed in c...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-017-2972-2

    authors： Wojtyniak K,Szajewska H

    更新日期：2017-09-01 00:00:00

  • On the influence of age on immunity in Down's syndrome.

    abstract：:In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF00477543

    authors： Seger R,Buchinger G,Ströder J

    更新日期：1977-01-26 00:00:00

  • Diagnosis and management of acute pharyngitis in a paediatric population: a cost-effectiveness analysis.

    abstract：:Acute pharyngitis is one of the most frequent causes of primary care physician visits; however, there is no agreement about which is the best strategy to diagnose and manage acute pharyngitis in children. The aim of the current study was to evaluate the cost-effectiveness of the recommended strategies to diagnose and ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-011-1410-0

    authors： Giraldez-Garcia C,Rubio B,Gallegos-Braun JF,Imaz I,Gonzalez-Enriquez J,Sarria-Santamera A

    更新日期：2011-08-01 00:00:00

  • Schinzel-Giedion syndrome.

    abstract：:We describe a female infant with the Schinzel-Giedion syndrome. Features present in 11 patients include coarse face, midface retraction, urogenital anomalies, poor skull vault mineralisation and variable anomalies of the long bones. Outcome is poor and mental retardation is the rule among survivors. Prenatal diagnosis...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01955902

    authors： Verloes A,Moës D,Palumbo L,Elmer C,François A,Bricteux G

    更新日期：1993-05-01 00:00:00

  • Two hyperandrogenic adolescent girls with congenital portosystemic shunt.

    abstract：UNLABELLED:We describe two adolescent girls with a congenital portosystemic shunt who exhibited hyperandrogenism in addition to insulin resistant hyperinsulinaemia. Case 1 was referred to our clinic to undergo a routine clinical work-up prior to tonsillectomy at 14 years of age. Mild liver dysfunction was identified an...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s004310000539

    authors： Satoh M,Yokoya S,Hachiya Y,Hachiya M,Fujisawa T,Hoshino K,Saji T

    更新日期：2001-05-01 00:00:00

  • Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine.

    abstract：:An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3 weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF01957008

    authors： Van Gool S,Brock P,Van Laer P,Van Damme-Lombaerts R,Proesmans W,Casteels-Van Daele M

    更新日期：1994-07-01 00:00:00

  • Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk.

    abstract：:Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150 μg because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens wer...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-019-03391-y

    authors： Löwensteyn YN,Jansen NJG,van Heerde M,Klein RH,Kneyber MCJ,Kuiper JW,Riedijk MA,Verlaat CWM,Visser IHE,van Waardenburg DA,van Hasselt PM

    更新日期：2019-07-01 00:00:00

  • Effects of bilirubin on visual evoked potentials in term infants.

    abstract：UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF02079073

    authors： Chen YJ,Kang WM

    更新日期：1995-08-01 00:00:00

  • Circadian growth hormone secretion in short multitransfused prepubertal children with thalassaemia major.

    abstract：UNLABELLED:Growth hormone (GH) secretion was determined by evaluating circadian GH profiles for 24 h and GH responses to clonidine stimulation test and insulin-stimulated hypoglycaemia (ITT), in nine prepubertal children with beta-thalassaemia major (TM) and 17 with non-GH deficient short stature (NGHDSS). The TM child...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF02029352

    authors： Katzos G,Harsoulis F,Papadopoulou M,Athanasiou M,Sava K

    更新日期：1995-06-01 00:00:00

  • Myocardial performance in children with autoimmune hepatitis: Doppler tissue imaging study.

    abstract：:Autoimmune hepatitis (AIH) is a member of autoimmune diseases family which can increase risk of cardiovascular morbidity and mortality. This study aimed to assess subclinical impact of AIH on global myocardial performance in affected children using Doppler tissue imaging (DTI) and to correlate it with total serum immu...

    journal_title：European journal of pediatrics

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00431-013-2073-9

    authors： Abo-Haded HM,Barakat TS,Hafez MM

    更新日期：2013-11-01 00:00:00

  • Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.

    abstract：:The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/BF02024330

    authors： Stopyrowa J,Fyderek K,Sikorska B,Kowalczyk D,Zembala M

    更新日期：1989-10-01 00:00:00

  • COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities.

    abstract：:Data show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and de...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,评审

    doi：10.1007/s00431-020-03801-6

    authors： Williams N,Radia T,Harman K,Agrawal P,Cook J,Gupta A

    更新日期：2020-09-10 00:00:00

  • Congenital hyperekplexia: five sporadic cases.

    abstract：UNLABELLED:We report fives sporadic cases of hyperekplexia or startle disease characterized by a highly exaggerated startle reflex and tonic attacks. Affected neonates suffer from prolonged periods of stiffness and are at risk for sudden death from apnea. An early diagnosis is needed. Sudden loud sounds, unexpected tac...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-005-0015-x

    authors： Rivera S,Villega F,de Saint-Martin A,Matis J,Escande B,Chaigne D,Astruc D

    更新日期：2006-02-01 00:00:00

  • Epidemiology and burden of rotavirus diarrhea in day care centers in Lyon, France.

    abstract：:This study gives, for the first time, an estimate of the incidence and the cost of rotavirus infection in day care centers in Lyon, France. ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00431-006-0187-z

    authors： Floret D,Lina B,Pinchinat S,Billaud G,Aït-Belghiti F,Largeron N,Bellemin B,Trang CN,Fau C,Gaspard C,Mamoux V,Marcelon L

    更新日期：2006-12-01 00:00:00

  • Toxic shock syndrome and streptococcal myositis: three case reports.

    abstract：UNLABELLED:Group A streptococcal (GAS) infection is the most common cause of bacterial pharyngitis and has an important role in the pathogenesis of post-infective phenomena including rheumatic fever and glomerulonephritis. Mortality from GAS is uncommon, particularly in the paediatric population. Toxic shock syndrome r...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-002-1032-7

    authors： Watkins R,Vyas H

    更新日期：2002-09-01 00:00:00

  • Haemophilus paraphrophilus, a rare cause of intracerebral abscess in children.

    abstract：:We report on a 3-year-old boy presenting with left-sided eyelid myocloni due to an intracranial abscess harboring Haemophilus paraphrophilus. This is the first description of an intracranial infection with this pathogen in a child. ...

    journal_title：European journal of pediatrics

    pub_type： 杂志文章

    doi：10.1007/s00431-007-0560-6

    authors： Hoefele J,Kroener C,Berweck S,Peraud A,Grabein B,Wintergerst U,Liese J

    更新日期：2008-06-01 00:00:00