Simulations of the contractile cycle in cell migration using a bio-chemical-mechanical model.

Abstract:

:Cell migration relies on traction forces in order to propel a cell. Several computational models have been developed that help explain the trajectory that cells take during migration, but little attention has been placed on traction forces during this process. Here, we investigated the spatiotemporal dynamics of cell migration by using a bio-chemical-mechanical contractility model that incorporates the first steps of cell migration on an array of posts. In the model, formation of a new adhesion causes a reactivation of stress fibre assembly within a cell. The model was able to predict the spatial distribution of traction forces observed with previous experiments. Moreover, the model found that the strain energy exerted by the traction forces of a migrating cell underwent a cyclic relationship that rose with the formation of a new adhesion and fell with the release of an adhesion at its rear.

authors

Han SJ,Sniadecki NJ

doi

10.1080/10255842.2011.554412

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

459-68

issue

5

eissn

1025-5842

issn

1476-8259

pii

936740869

journal_volume

14

pub_type

杂志文章
  • Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms.

    abstract::Haemodynamics is believed to play an important role in the initiation, growth and rupture of intracranial aneurysms. In this context, computational haemodynamics has been extensively used in an effort to establish correlations between flow variables and clinical outcome. It is common practice in the application of Dir...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840802654335

    authors: Marzo A,Singh P,Reymond P,Stergiopulos N,Patel U,Hose R

    更新日期:2009-08-01 00:00:00

  • The effects of changing bone and muscle size on limb inertial properties and limb dynamics: a computer simulation.

    abstract::The magnitude and distribution of bone and muscle mass within limbs affect limb inertial properties, maximum movement speed and the energy required to maintain submaximal movements. Musculoskeletal modeling and movement simulations were used to determine how changes in bone and muscle cross-sectional area (and thus ma...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1080/10255840410001727823

    authors: Dellanini L,Hawkins D,Martin B,Stover S

    更新日期:2004-06-01 00:00:00

  • Parametric finite element analysis and closed-form solutions in orthodontics.

    abstract::The goal and clinical relevance of this work was the development of closed formulas that are correct and simple enough for a fast decision making by the orthodontist in the daily praxis. This paper performs a parametric three-dimensional finite element linear analysis on a maxillary central incisor with a root of para...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840290032126

    authors: Provatidis CG

    更新日期:2002-04-01 00:00:00

  • A system for predicting and preventing work-related musculoskeletal disorders among dentists.

    abstract::Work-related musculoskeletal disorders (WMSDs) have become increasingly common among dentists and initiate a series of events that could result in a career ending. This study aims to construct a system for predicting and preventing WMSD among dentists. We used Bayesian network (BN) that describes the mutual relationsh...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2012.672565

    authors: Thanathornwong B,Suebnukarn S,Songpaisan Y,Ouivirach K

    更新日期:2014-01-01 00:00:00

  • A computational prediction for the effective drug and stem cell treatment of human airway burns.

    abstract::Burns in the airway from inhaling hot gases lead to one of the most common causes of death in the United States. In order to navigate tissues with large burn areas, the velocity, temperature, and heat flux distributions throughout the human airway system are computed for the inhalation of hot air using the finite-elem...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2015.1105966

    authors: Park S

    更新日期:2016-01-01 00:00:00

  • A computational study of the EN 1078 impact test for bicycle helmets using a realistic subject-specific finite element head model.

    abstract::In the present study, the free fall impact test in accordance with the EN1078 standard for certification of bicycle helmets is replicated using numerical simulations. The impact scenario is simulated using an experimentally validated, patient-specific head model equipped with and without a bicycle helmet. Head acceler...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2018.1511775

    authors: Sandberg M,Tse KM,Tan LB,Lee HP

    更新日期:2018-09-01 00:00:00

  • Finite element models of the thigh-buttock complex for assessing static sitting discomfort and pressure sore risk: a literature review.

    abstract::Being seated for long periods, while part of many leisure or occupational activities, can lead to discomfort, pain and sometimes health issues. The impact of prolonged sitting on the body has been widely studied in the literature, with a large number of human-body finite element models developed to simulate sitting an...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1080/10255842.2018.1466117

    authors: Savonnet L,Wang X,Duprey S

    更新日期:2018-03-01 00:00:00

  • A two population model of prion transport through a tunnelling nanotube.

    abstract::This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and ac...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2013.763938

    authors: Kuznetsov IA,Kuznetsov AV

    更新日期:2014-11-01 00:00:00

  • Finite element and photoelastic modelling of an abdominal aortic aneurysm: a comparative study.

    abstract::Rupture prediction of abdominal aortic aneurysms (AAAs) remains a clinical challenge. Finite element analysis (FEA) may allow for improved identification for intervention timing, but the method needs further substantiation. In this study, experimental photoelastic method and finite element techniques were compared usi...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.574618

    authors: Callanan A,Morris LG,McGloughlin TM

    更新日期:2012-01-01 00:00:00

  • A mathematical model of epiphyseal development: hypothesis of growth pattern of the secondary ossification centre.

    abstract::This paper introduces a 'hypothesis about the growth pattern of the secondary ossification centre (SOC)', whereby two phases are assumed. First, the formation of cartilage canals as an event essential for the development of the SOC. Second, once the canals are merged in the central zone of the epiphysis, molecular fac...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2010.484810

    authors: Garzón-Alvarado DA,Peinado Cortés LM,Cárdenas Sandoval RP

    更新日期:2011-01-01 00:00:00

  • Use of the normalcy index for the assessment of abnormal gait in the anterior cruciate ligament deficiency combined with meniscus injury.

    abstract::The normalcy index (NI) has been implemented by several studies as a simple index for quantitatively analyzing diffident gait abnormalities, such as children with cerebral palsy and idiopathic toe-walkers. However, whether the NI can be used in anterior cruciate ligament (ACL) deficiency with different types of menisc...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1789119

    authors: Liu X,Huang H,Ren S,Rong Q,Ao Y

    更新日期:2020-11-01 00:00:00

  • Feature selection based on a fuzzy complementary criterion: application to gait recognition using ground reaction forces.

    abstract::An efficient wavelet-based feature selection (FS) method is proposed in this paper for subject recognition using ground reaction force measurements. Our approach relies on a local fuzzy evaluation measure with respect to patterns that reveal the adequacy of data coverage for each feature. Furthermore, FS is driven by ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.554408

    authors: Moustakidis SP,Theocharis JB,Giakas G

    更新日期:2012-01-01 00:00:00

  • Effects of using the unloaded configuration in predicting the in vivo diastolic properties of the heart.

    abstract::Computational models are increasingly being used to investigate the mechanical properties of cardiac tissue. While much insight has been gained from these studies, one important limitation associated with computational modeling arises when using in vivo images of the heart to generate the reference state of the model....

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2016.1183122

    authors: Nikou A,Dorsey SM,McGarvey JR,Gorman JH 3rd,Burdick JA,Pilla JJ,Gorman RC,Wenk JF

    更新日期:2016-12-01 00:00:00

  • A finite element model of the face including an orthotropic skin model under in vivo tension.

    abstract::Computer models of the human face have the potential to be used as powerful tools in surgery simulation and animation development applications. While existing models accurately represent various anatomical features of the face, the representation of the skin and soft tissues is very simplified. A computer model of the...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2013.820720

    authors: Flynn C,Stavness I,Lloyd J,Fels S

    更新日期:2015-01-01 00:00:00

  • Numerical simulation of deformed red blood cell by utilizing neural network approach and finite element analysis.

    abstract::In order to have research on the deformation characteristics and mechanical properties of human red blood cells (RBCs), finite element models of RBC optical tweezers stretching and atomic force microscope (AFM) indentation were established. Non-linear elasticity of cell membrane was determined by using the neo-Hookean...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1791836

    authors: Wang Y,Sang J,Ao R,Ma Y,Fu B

    更新日期:2020-11-01 00:00:00

  • Optimisation of solute transport in dialysers using a three-dimensional finite volume model.

    abstract::Dialyser manufacturers only provide limited information about mass removal under well-defined flow and solute conditions in commercially available dialysers for hemodialysis. This computational study aimed at assessing the solute transport efficiency in a dialyser for different geometries (fiber lengths and diameters)...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840601002728

    authors: Eloot S,Vierendeels J,Verdonck P

    更新日期:2006-12-01 00:00:00

  • A neurofuzzy inference system based on biomechanical features for the evaluation of the effects of physical training.

    abstract::The current study aimed to evaluate physical training effects. For this purpose, a classifier was implemented by taking into account biomechanical features selected from force-plate measurements and a neurofuzzy algorithm for data management and relevant decision-making. Measurements included two sets of sit-to-stand ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10255840701550915

    authors: Vannozzi G,Pecoraro F,Caserotti P,Cappozzo A

    更新日期:2008-02-01 00:00:00

  • Multi-objective reliability based design optimization using Kriging surrogate model for cementless hip prosthesis.

    abstract::Design optimization for cementless hip prosthesis signifies one of the key topics of research to improve its performances. However, majority of the studies have not considered the presence of uncertainties while it has been shown that a deterministic optimization leads to an unreliable design. In this paper, a multi-o...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1768247

    authors: Dammak K,El Hami A

    更新日期:2020-09-01 00:00:00

  • Numerical investigation of oxygen mass transfer in a helical-type artery bypass graft.

    abstract::Local oxygen lack in arterial walls (hypoxia) plays a very important role in the initiation, progression and development of intimal hyperplasia (IH) and thrombosis. Aiming to find out whether a helical-type artery bypass graft (ABG) is hypoxia beneficial, a numerical study was carried out to compare oxygen transport b...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2012.702764

    authors: Zheng T,Wen J,Jiang W,Deng X,Fan Y

    更新日期:2014-04-01 00:00:00

  • A poroviscohyperelastic model for numerical analysis of mechanical behavior of single chondrocyte.

    abstract::The aim of this paper is to use a poroviscohyperelastic (PVHE) model, which is developed based on the porohyperelastic (PHE) model to explore the mechanical deformation properties of single chondrocytes. Both creep and relaxation responses are investigated by using finite element analysis models of micropipette aspira...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2014.996875

    authors: Nguyen TD,Oloyede A,Gu Y

    更新日期:2016-01-01 00:00:00

  • Influence of fluid-flow direction on effective permeability of the vertebral end plate: an analytical model.

    abstract::Convective transports in the vertebral end plate (VEP) play a significant role in the homeostasis of the spine. A few studies hypothesised that the hydraulic resistance or effective permeability of the VEP could be dependant upon fluid-flow direction. Results were influenced by species, region of interest within the e...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2010.518960

    authors: Swider P,Accadbled F,Laffosse JM,Sales de Gauzy J

    更新日期:2012-01-01 00:00:00

  • Multi disease-prediction framework using hybrid deep learning: an optimal prediction model.

    abstract::Big data and its approaches are generally helpful for healthcare and biomedical sectors for predicting the disease. For trivial symptoms, the difficulty is to meet the doctors at any time in the hospital. Thus, big data provides essential data regarding the diseases on the basis of the patient's symptoms. For several ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1869726

    authors: Ampavathi A,Saradhi TV

    更新日期:2021-01-11 00:00:00

  • Application of a semi-automatic cartilage segmentation method for biomechanical modeling of the knee joint.

    abstract::Manual segmentation of articular cartilage from knee joint 3D magnetic resonance images (MRI) is a time consuming and laborious task. Thus, automatic methods are needed for faster and reproducible segmentations. In the present study, we developed a semi-automatic segmentation method based on radial intensity profiles ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2017.1375477

    authors: Liukkonen MK,Mononen ME,Tanska P,Saarakkala S,Nieminen MT,Korhonen RK

    更新日期:2017-10-01 00:00:00

  • A generic musculoskeletal model of the juvenile lower limb for biomechanical analyses of gait.

    abstract::The aim of this study was to develop a generic musculoskeletal model of a healthy 10-year-old child and examine the effects of geometric scaling on the calculated values of lower-limb muscle forces during gait. Subject-specific musculoskeletal models of five healthy children were developed from in vivo MRI data, and t...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1817405

    authors: Hainisch R,Kranzl A,Lin YC,Pandy MG,Gfoehler M

    更新日期:2020-09-17 00:00:00

  • A solution method for the determination of cardiac potential distributions with an alternating current source.

    abstract::A recently presented solution method for the bidomain model (Johnston et al. 2006), which involves the application of direct current for studying electrical potential in a slab of cardiac tissue, is extended here to allow the use of an applied alternating current. The advantage of using AC current, in a four-electrode...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840701747594

    authors: Johnston BM,Johnston PR,Kilpatrick D

    更新日期:2008-06-01 00:00:00

  • Global/local head models to analyse cerebral blood vessel rupture leading to ASDH and SAH.

    abstract::Blunt and rotational head impacts due to vehicular collisions, falls and contact sports cause relative motion between the brain and skull. This increases the normal and shear stresses in the (skull/brain) interface region consisting of cerebrospinal fluid (CSF) and subarachnoid space (SAS) trabeculae. The relative mot...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840903064897

    authors: Zoghi-Moghadam M,Sadegh AM

    更新日期:2009-02-01 00:00:00

  • An efficient algorithm for retinal blood vessel segmentation using h-maxima transform and multilevel thresholding.

    abstract::Retinal blood vessel detection and analysis play vital roles in early diagnosis and prevention of several diseases, such as hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. This paper presents an automated algorithm for retinal blood vessel segmentation. The proposed algorithm takes advanta...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2010.545949

    authors: Saleh MD,Eswaran C

    更新日期:2012-01-01 00:00:00

  • Linking mutated primary structure of adrenoleukodystrophy protein with X-linked adrenoleukodystrophy.

    abstract::The phenotype expression in X-linked adrenoleukodystrophy is one of the most intriguing issues of the disease, because there is no general correlation between the type of ABCD1 gene mutation and the clinical phenotype. In this study, we use the cross-impact analysis to build a descriptively quantitative relationship b...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840903279974

    authors: Yan S,Wu G

    更新日期:2010-06-01 00:00:00

  • A micromechanical procedure for modelling the anisotropic mechanical properties of brain white matter.

    abstract::This paper proposes a micromechanics algorithm utilising the finite element method (FEM) for the analysis of heterogeneous matter. The characterisation procedure takes the material properties of the constituents, axons and extracellular matrix (ECM) as input data. The material properties of both the axons and the matr...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840903097871

    authors: Abolfathi N,Naik A,Sotudeh Chafi M,Karami G,Ziejewski M

    更新日期:2009-06-01 00:00:00

  • Subject-specific body segment parameters' estimation using biplanar X-rays: a feasibility study.

    abstract::In order to improve the reliability of children's models, the aim of this study was to determine the subject-specific masses and 3D locations of the centres of mass (CoM) of body segments using biplanar X-rays. Previous methods, validated on upper leg segments, were applied to the whole body. Six children and six adul...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255841003717608

    authors: Sandoz B,Laporte S,Skalli W,Mitton D

    更新日期:2010-12-01 00:00:00