Abstract:
:Cell migration relies on traction forces in order to propel a cell. Several computational models have been developed that help explain the trajectory that cells take during migration, but little attention has been placed on traction forces during this process. Here, we investigated the spatiotemporal dynamics of cell migration by using a bio-chemical-mechanical contractility model that incorporates the first steps of cell migration on an array of posts. In the model, formation of a new adhesion causes a reactivation of stress fibre assembly within a cell. The model was able to predict the spatial distribution of traction forces observed with previous experiments. Moreover, the model found that the strain energy exerted by the traction forces of a migrating cell underwent a cyclic relationship that rose with the formation of a new adhesion and fell with the release of an adhesion at its rear.
journal_name
Comput Methods Biomech Biomed Enginauthors
Han SJ,Sniadecki NJdoi
10.1080/10255842.2011.554412subject
Has Abstractpub_date
2011-05-01 00:00:00pages
459-68issue
5eissn
1025-5842issn
1476-8259pii
936740869journal_volume
14pub_type
杂志文章abstract::Haemodynamics is believed to play an important role in the initiation, growth and rupture of intracranial aneurysms. In this context, computational haemodynamics has been extensively used in an effort to establish correlations between flow variables and clinical outcome. It is common practice in the application of Dir...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840802654335
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abstract::The magnitude and distribution of bone and muscle mass within limbs affect limb inertial properties, maximum movement speed and the energy required to maintain submaximal movements. Musculoskeletal modeling and movement simulations were used to determine how changes in bone and muscle cross-sectional area (and thus ma...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 临床试验,杂志文章
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abstract::The goal and clinical relevance of this work was the development of closed formulas that are correct and simple enough for a fast decision making by the orthodontist in the daily praxis. This paper performs a parametric three-dimensional finite element linear analysis on a maxillary central incisor with a root of para...
journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2012.672565
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abstract::Burns in the airway from inhaling hot gases lead to one of the most common causes of death in the United States. In order to navigate tissues with large burn areas, the velocity, temperature, and heat flux distributions throughout the human airway system are computed for the inhalation of hot air using the finite-elem...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2015.1105966
更新日期:2016-01-01 00:00:00
abstract::In the present study, the free fall impact test in accordance with the EN1078 standard for certification of bicycle helmets is replicated using numerical simulations. The impact scenario is simulated using an experimentally validated, patient-specific head model equipped with and without a bicycle helmet. Head acceler...
journal_title:Computer methods in biomechanics and biomedical engineering
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更新日期:2018-09-01 00:00:00
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journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章,评审
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journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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doi:10.1080/10255842.2011.554408
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journal_title:Computer methods in biomechanics and biomedical engineering
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abstract::In order to have research on the deformation characteristics and mechanical properties of human red blood cells (RBCs), finite element models of RBC optical tweezers stretching and atomic force microscope (AFM) indentation were established. Non-linear elasticity of cell membrane was determined by using the neo-Hookean...
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journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章,随机对照试验
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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