Abstract:
OBJECTIVE:Improving the use of antimicrobial drugs is a national objective. To this end an evaluation of clinical practice was implemented on prescribed antibiotics in elderly patients, in the Besançon Teaching Hospital. DESIGN:In 2005, a clinical audit compared the adequacy of antibiotic prescriptions to national guidelines in 37 patients. An improvement plan was implemented, including the drafting of local guidelines (adapted national guidelines) "Antibiotic prescription in elderly patients" by a multidisciplinary team. The Antibiotics Committee approved it. A retrospective study compared antibiotic prescription of 62 patients to these guidelines. The methodology was based on Gyssen's algorithm. The assessment criteria were: relevance of the indication, absence of a better alternative, respect of recommended dose, duration, and timing. RESULTS:The rate of overall conformity was 26% in 2005, 57% in 2007. Antibiotic choice was adequate in 61% of cases in 2005, 78% in 2007. In 63% of cases, a more efficient alternative was advised in 2005, 10% of cases in 2007. Treatment duration, dose, and timing were adequate in 54 - 92 - 96% in 2005 respectively and 86 - 92 - 100% of cases in 2007. Ciprofloxacin was prescribed in first line for 42% of urinary infections in 2005, 0% in 2007. CONCLUSIONS:This approach improved antibiotic prescriptions because of better guideline observance by physicians. The main improvement concerned fluoroquinolones. It should be continued to confirm antibiotic good use and protect our hospital bacterial ecology.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Raymond S,Bourdelin M,Becker M,Henon T,Patry I,Leroy J,Limat Sdoi
10.1016/j.medmal.2011.02.002subject
Has Abstractpub_date
2011-06-01 00:00:00pages
330-5issue
6eissn
0399-077Xissn
1769-6690pii
S0399-077X(11)00054-0journal_volume
41pub_type
杂志文章abstract:BACKGROUND:The extended-release formulation of clarithromycin (CLA-ER) allows using this macrolide as a single daily dose. The purpose of this study was to evaluate the efficacy and safety of the CLA-ER formulation (500 mgx2) vs telithromycin (TELI) (400 mgx2) as a short course 5-day treatment, once a day, in patients ...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.medmal.2005.07.002
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:HIV patients have a high rate of infectious complications. Vaccination, though less efficient in case of severe immunosuppression, can prevent some of these infections. Since 2006, new vaccine recommendations have been elaborated in France. We studied the vaccine status of HIV+ patients for influenza, Stre...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medmal.2010.06.005
更新日期:2010-12-01 00:00:00
abstract::In children, pneumococcus became the predominant infectious agent, after the routine use of the Hib conjugate vaccine dramatically decreased Haemophilus Influenzae type b prevalence. The incidence of invasive pneumococcal infections (IPI) and of non-invasive infections due to vaccine serotypes (VS) decreased by 80% in...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2013.04.006
更新日期:2013-08-01 00:00:00
abstract:UNLABELLED:Immunization against meningococcus C has been recommended in France since 2009 (infants from 12 to 24 months of age, and catch up vaccination up to 25 years of age). It has been reimbursed since January 2010. We had for aim to assess the vaccine coverage in 2011. METHOD:The study population included mothers...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2013.01.001
更新日期:2013-02-01 00:00:00
abstract::Clinical presentations of opportunistic infections in AIDS patients have dramatically changed since the introduction of HAART. The immune reconstitution syndrome (IRS) is typical of this change. The authors discuss the case of an AIDS female patient presenting with subcutaneous abcesses and abdominal lymph node enlarg...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2006.05.006
更新日期:2006-08-01 00:00:00
abstract::The TORO 1 and TORO 2 clinical trials compared the efficacy and safety of enfuvirtide in combination with an optimized background antiretroviral regimen and optimized background regimen alone in HIV-1 infected patients. The patients had had previous treatment with each of the three classes of antiretroviral drugs and ...
journal_title:Medecine et maladies infectieuses
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To assess the proportion of patients meeting the 2010 SPILF-AFSSAPS guiding criteria for Streptococcuspneumoniae in patients consulting at the emergency departments of four French university hospitals for acute community-acquired pneumonia (CAP) suspicion. PATIENTS AND METHODS:The PACSCAN study prospectively...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.09.004
更新日期:2020-09-17 00:00:00
abstract:INTRODUCTION:No therapy has yet proven effective in COVID-19. Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. METHOD:We conducted a retrospective case-control study in the Nord Franche-Comté Hospital, France. We compared the outcome of patients treated with TCZ and patients without ...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.05.001
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The authors had for aim, to determine the frequency and the main clinical forms of severe malaria and to evaluate its management. PATIENTS AND METHODS:A cross-sectional investigation was made in the "Complexe Pediatrique" of Bangui, the only children hospital of the CAR capital, from 12 January to 12 Septemb...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2003.09.003
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:This retrospective study was undertaken to assess epidemiological and clinical aspects as well as outcome of tetanus cases in patients over 28 days of age, so as to issue recommendations. PATIENTS AND METHODS:This study included patients admitted to the Fann teaching hospital in Dakar from 2001 to 2003. Age,...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2004.11.003
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Streptococcus agalactiae (Group B streptococcus) is a major cause of invasive diseases in non-pregnant adults, particularly in the elderly and those with underlying conditions. We describe these conditions and clinical characteristics of patients followed in our teaching hospital. METHODS:We retrospectively...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2007.04.003
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:The proper use of antibiotics is a public health priority to preserve their effectiveness. Little data is available on outpatient antibiotic prescriptions, especially in the emergency department. We aimed to assess the quality of outpatient antibiotic prescriptions in our hospital. PATIENTS AND METHODS:Retr...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2016.04.006
更新日期:2016-06-01 00:00:00
abstract::Leptospirosis is a zoonosis found worldwide, the main reservoir of which is the rat. Human infection generally results from exposure to contaminated river or lake water or animals. Around 600 cases are diagnosed per year in France. Half of these cases occur in French overseas territories, where the incidence can be mo...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2012.11.005
更新日期:2013-01-01 00:00:00
abstract::Lactobacilli rhamnosus infections are rare and occur in patients with severe conditions causing immunosuppression and/or in those who have received intense antibiotic treatment such as with teicoplanin and vancomycin. We report two cases which occurred within a period of 48 hours, during regression of pancreatitis in ...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2007.10.005
更新日期:2008-01-01 00:00:00
abstract::Climatic factors (temperature, wind, humidity) and their changes play a major role in the epidemiology of infectious diseases, mainly those vector borne or water-borne. In terms of respiratory tract infections, the role of cold remains controversial, although evident in popular belief: the winter peak is multifactoria...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2008.12.002
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medmal.2010.09.021
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Invasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor. PATIENTS AND METHOD:We reported three additional cases and reviewed 16 previous published cases together wi...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.07.005
更新日期:2020-11-01 00:00:00
abstract::Military personnel in operations have always paid a high toll to infections, particularly epidemics. Currently, 40 000 servicemen serve overseas in various missions and operations of various durations in various countries. Infectious hazards persist in spite of the implementation of preventive measures. They are prima...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/s0399-077x(96)80183-1
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:Pneumocystis pneumonia (PCP) is now predominantly observed in immunosuppressed non-HIV-infected patients. The sensitivity of the PCR is here higher than direct examination (DE) of respiratory secretions because the infection is caused by a lower inoculum of Pneumocystis jirovecii (P. jirovecii). The objective...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2018.04.396
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS:Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS:Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medmal.2017.09.001
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Pneumococcal infections are a major public health problem because of the virulence of this bacterium and its ability to develop resistance. MATERIAL AND METHOD:Two hundred and ninety-four strains of Streptococcus pneumoniae were isolated from sterile (56.8%) and non-sterile samples (43.2%), from January 2...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2011.12.001
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:This study had for aim to describe the clinical aspects and favoring factors of mucosal Leishmaniasis in an Amazonian population of 30,000 habitants in Guajara-Mirim (Rondonia-Brazil). MATERIAL AND METHOD:A descriptive study was made of 16 patients with mucosal Leishmaniasis among 170 patients infected by L...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2007.03.012
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:We aimed to describe the challenge faced by the national reference laboratory to support the national HIV/AIDS response in Madagascar. METHODS:Collaboration between the National Reference Laboratory of Madagascar (NRLM) and foreign partners (a laboratory and an international organization) on the basis of a t...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2016.03.003
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:Overdiagnosis of lyme borreliosis leads to unnecessary and increasingly common antimicrobial treatments. We aimed to evaluate patients receiving long-term antimicrobial treatment for lyme borreliosis. METHODS:We included patients referred to a Parisian teaching hospital between January 1st, 2014 and June 30...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.10.018
更新日期:2020-10-21 00:00:00
abstract::Twenty people died of rabies in France between 1970 and 2003 (compared to 55,000 yearly worldwide), 80% on returning from Africa. Dogs were the contaminating animals in 90% of the cases and children were the most common victims. The last instance of rabies in a native French animal was reported in 1998. However the il...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2004.07.031
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Monkeypox is a zoonosis caused by an Orthopoxvirus of the Poxviridae family. Human infections are often severe and are a public health problem. PATIENTS AND METHOD:We conducted a monkeypox outbreak investigation of suspected case patients in five villages of the Alindao-Mingala Health District following blo...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2018.02.010
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:We had for aim to assess antibiotic consumption and to better understand their use in nursing homes so as to target messages on relevant practice procedures sent to prescribers. DESIGN:The MedQual network asked nursing homes with in-house pharmacies to participate in a retrospective collection of yearly ant...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2015.05.006
更新日期:2015-08-01 00:00:00
abstract::Any person travelling in countries where yellow fever (YF) is endemic and without presenting contra-indication for the vaccination against YF may be vaccinated. This vaccination can very rarely induce a potentially lethal neurotropic or viscerotropic disease. In severely immunodeficient patients, the vaccination is co...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2008.06.031
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:The aim of our study was to determine the epidemiological profile and the antibiotics susceptibility of bacteria identified in blood culture in the intensive care unit, to improve empirical antibiotherapy. MATERIAL AND METHOD:A retrospective study was made over a four-year period (2002-2005) in the intens...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2007.10.006
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:French reference centers for bone and joint infections (BJI) were implemented from 2009 onwards to improve the management of complex BJIs. This study compared BJI burden before and after the implementation of these reference centers. PATIENTS AND METHODS:BJI hospital stays were selected from the 2008 and 20...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2018.02.004
更新日期:2018-06-01 00:00:00