Abstract：
PURPOSE:Invasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor. PATIENTS AND METHOD:We reported three additional cases and reviewed 16 previous published cases together with cases from the international pharmacovigilance database. RESULTS:Patients were mainly treated for chronic lymphocytic leukemia. Cryptococcosis mostly occurred during the first six months (66%) and especially the first two months (44%) of treatment. Clinical presentation is often pulmonary (68%) and the outcome is usually favorable despite ibrutinib continuation. CONCLUSION:Clinicians must be aware of this infection in patients with hematological malignancies on ibrutinib.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Brochard J,Morio F,Mahe J,Le Pape P,Guimard T,Mahe B,Leterrier M,Morrier M,Raffi F,Boutoille Ddoi
10.1016/j.medmal.2020.07.005subject
Has Abstractpub_date
2020-11-01 00:00:00pages
742-745issue
8eissn
0399-077Xissn
1769-6690pii
S0399-077X(20)30673-9journal_volume
50pub_type
杂志文章abstract：:For the next decade, COPD will become the third cause of mortality in the world. COPD is mainly due to cigarette smoking and presents different levels of severity according to people, probably linked to environmental and genetic factors, which are not well documented. Recent publications pointed out bacterial bronchia...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2005.12.006
更新日期：2006-05-01 00:00:00
abstract：:Since the beginning of the HIV epidemic in France, surveys aimed at better understanding risk perceptions of HIV infection and preventive sexual behaviors have been implemented in the general population, and in populations such as IVDU and homosexual men, more concerned by risks of HIV transmission. The objective of t...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2005.03.004
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:We had for aim to determine the characteristics of carbapenemase-producing enterobacteria (CPE) carriers and to assess the economic impact of isolation measures leading to loss of activity (closed beds, prolonged hospital stays) and additional personnel hours. PATIENTS AND METHODS:We conducted a retrospecti...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2014.06.004
更新日期：2014-07-01 00:00:00
abstract：:Treatment indications for tuberculosis-infection depend on each case, but also on public health policy in each country. This policy usually made at the national level depends on tuberculosis epidemiology of the population concerned and on the country's socio-economic level of development, and more especially of its he...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：:The variola virus was the first biological agent to be used as a military weapon. It is considered as one of the main agents that could potentially be used in the context of bioterrorism. Smallpox was declared eradicated in 1980. So, in case of a confirmed or suspected case of smallpox, a deliberate, intentional origi...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2003.09.009
更新日期：2004-01-01 00:00:00
abstract：:In children, pneumococcus became the predominant infectious agent, after the routine use of the Hib conjugate vaccine dramatically decreased Haemophilus Influenzae type b prevalence. The incidence of invasive pneumococcal infections (IPI) and of non-invasive infections due to vaccine serotypes (VS) decreased by 80% in...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2013.04.006
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:Pneumocystis pneumonia (PCP) is now predominantly observed in immunosuppressed non-HIV-infected patients. The sensitivity of the PCR is here higher than direct examination (DE) of respiratory secretions because the infection is caused by a lower inoculum of Pneumocystis jirovecii (P. jirovecii). The objective...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2018.04.396
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To determine predictive factors of treatment interruption (TI) duration within a cohort of HIV-1 infected patients having stopped their treatment with CD4 above 350 cells per mm(3). DESIGN:Data were collected from computerized medical records. Patients were selected if they were HIV-1 positive, 18 years of a...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.01.009
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Monkeypox is a zoonosis caused by an Orthopoxvirus of the Poxviridae family. Human infections are often severe and are a public health problem. PATIENTS AND METHOD:We conducted a monkeypox outbreak investigation of suspected case patients in five villages of the Alindao-Mingala Health District following blo...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2018.02.010
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:Although urinary tract infections are the second leading cause of infections among patients aged above 65 years, data on bacterial epidemiology of urinary specimens in these patients is scarce. Our aim was to describe the main bacterial species found at significant levels in urine specimens of the elderly and...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:The increasing resistance of Helicobacter pylori to clarithromycin led to developing new eradication treatment regimens. The objective of our observational study was to determine the proportion of H. pylori strains resistant to clarithromycin in infected patients in Reunion Island and to suggest a first-line ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.06.004
更新日期：2016-10-01 00:00:00
abstract：:HHV-8 belongs to the herpesviridae family, to the gammaherpesvirinae subfamily, and to the rhadinovirus genus. Whereas several viral homologues exist in non human primates, HHV-8 is the only rhadinovirus known in human. HHV-8 is mainly the etiological agent of the four clinico-epidemiological forms of Kaposi's sarcoma...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2005.02.009
更新日期：2005-05-01 00:00:00
abstract：GOAL:This study had for aim to determine the mortality rate and the factors affecting mortality among 70 children admitted for septic shock secondary to a community acquired infection. PATIENTS AND METHODS:A retrospective analysis was made of patients admitted between January 1998 and August 2005, in a pediatric ICU f...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.11.002
更新日期：2009-12-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) was first reported in the city of Wuhan, China. The disease rapidly spread to the rest of China, to Southern-East Asia, then to Europe, America, and on to the rest of the world. COVID-19 is associated with a betacoronavirus named SARS-CoV-2. The virus penetrates the organism thr...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2020.09.012
更新日期：2020-11-01 00:00:00
abstract：:Tuberculous arthritis is rare and the diagnosis may be confused with inflammatory arthritis. Only few cases, explored by MRI, have been reported in the literature. We report 3 cases of tuberculous arthritis of the knee revealed by insidious pain. The abnormalities revealed by MRI suggested tuberculosis. Diagnosis was ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.10.006
更新日期：2007-09-01 00:00:00
abstract：:Among children, an epidemiologic shift has caused an increase in non-albicans Candida infections and invasive aspergillosis, as well as infections by pathogens that were previously uncommon. These infections are frequent causes of infectious morbidity in immunocompromised children. Treatment options are limited for ch...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/s0399-077x(07)80054-0
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:Overdiagnosis of lyme borreliosis leads to unnecessary and increasingly common antimicrobial treatments. We aimed to evaluate patients receiving long-term antimicrobial treatment for lyme borreliosis. METHODS:We included patients referred to a Parisian teaching hospital between January 1st, 2014 and June 30...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2020.10.018
更新日期：2020-10-21 00:00:00
abstract：:The first successful culture of Tropheryma whipplei made 10 years ago opened the way for identification of the bacterium and the development of many diagnostic tools. Phylogenetic analyses made it possible to classify it among Gram positive bacilli in the family of Actinomycetes, close to other ubiquitous bacteria of ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2009.10.017
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:The incidence of extended-spectrum beta-lactamase-producing enterobacteria (ESBLE) has regularly increased over the last few years. However, little is known about epidemiology of ESBLE carriers in France. The objective of this study was to determine the ESBLE carriers or infected patients profile, identified ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2010.04.006
更新日期：2010-11-01 00:00:00
abstract：:The epidemiology of S. pneumoniae invasive infections in France, over the last few years, was modified by two public health measures. A nationwide campaign for the rationalization of antibiotic prescription was implemented in 2001 and vaccination of young children with the pneumococcal 7-valent conjugate vaccine in 20...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2012.04.002
更新日期：2012-08-01 00:00:00
abstract：:Twenty people died of rabies in France between 1970 and 2003 (compared to 55,000 yearly worldwide), 80% on returning from Africa. Dogs were the contaminating animals in 90% of the cases and children were the most common victims. The last instance of rabies in a native French animal was reported in 1998. However the il...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2004.07.031
更新日期：2004-12-01 00:00:00
abstract：:Severe sepsis, which is related to a high mortality rate, requires a very specific antibiotic strategy, which must be adapted to each case. The appropriateness of empiric therapy is based on the delay before administration of the molecule, the bacterial resistance profile, and the kinetic and/or dynamic properties of ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2006.02.002
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the adequacy and the conformity of prescriptions of new systemic antifungal drugs to guidelines and scientific data. PATIENTS AND METHODS:Each prescription of liposomal amphotericin B (lip Amb), voriconazole, and caspofungin made between May 2003 and May 2004 in a teach...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.05.009
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to describe the characteristics of patients hospitalized for a peritonsillar abscess over a 1-year period and to evaluate the proportion of patients exposed to anti-inflammatory and antibiotic drugs before hospitalization. DESIGN:Adult patients hospitalized in the ENT department...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.02.010
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:To report a case of septic arthritis due to H. parainfluenzae and to review the clinical and microbiological characteristics of published case patients. PATIENTS AND METHODS:Data was collected on age, sex, infection localization, underlying risk factors, symptom onset-diagnosis interval, analytical findings...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2017.08.002
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Nosocomial infections are a matter of concern in surgical wards. Their incidence is constantly increasing, especially among immunocompromised patients who are vulnerable to colonization by opportunistic pathogens such as Staphylococcus aureus. The bacterium accumulates resistance mechanisms against antibio...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2011.09.010
更新日期：2011-12-01 00:00:00
abstract：:Clinical presentations of opportunistic infections in AIDS patients have dramatically changed since the introduction of HAART. The immune reconstitution syndrome (IRS) is typical of this change. The authors discuss the case of an AIDS female patient presenting with subcutaneous abcesses and abdominal lymph node enlarg...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.05.006
更新日期：2006-08-01 00:00:00
abstract：UNLABELLED:Immunization against meningococcus C has been recommended in France since 2009 (infants from 12 to 24 months of age, and catch up vaccination up to 25 years of age). It has been reimbursed since January 2010. We had for aim to assess the vaccine coverage in 2011. METHOD:The study population included mothers...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2013.01.001
更新日期：2013-02-01 00:00:00
abstract：:Between 1986 and 2005, 54 patients were hospitalized for rabies in the infectious diseases clinic, with an average of 3 cases a year. The patients came from almost all regions of Senegal, Dakar (11 cases), Thiès (9 cases), and Fatick (9 cases). They were native of rural and suburban zones. The median age was 19 years ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2007.01.010
更新日期：2007-12-01 00:00:00
abstract：:Allergic reactions to penicillins have been reported since the 1950s, shortly after their introduction as therapeutic agents. An increasing number of reported anaphylactic reactions and other adverse effects proved this to be a serious public health problem. Fifty years later, betalactam-induced hypersensitivity is th...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2008.09.011
更新日期：2009-05-01 00:00:00
