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[Adequacy of new systemic antifungal agents prescriptions in a teaching hospital].

Abstract：

OBJECTIVES:The aim of this study was to evaluate the adequacy and the conformity of prescriptions of new systemic antifungal drugs to guidelines and scientific data. PATIENTS AND METHODS:Each prescription of liposomal amphotericin B (lip Amb), voriconazole, and caspofungin made between May 2003 and May 2004 in a teaching hospital were reviewed by an infectious diseases specialist. He used criteria based on marketing authorization, national recommendations, and scientific data. RESULTS:One hundred and fifteen files were studied during the 12-month period and 203 prescriptions analyzed. Most patients were immunodepressed. The indication of the treatment was appropriate for 127 prescriptions (62.6%). Dose and drug interactions were compliant with prescription rules for 158 prescriptions (77.8%). Among the causes of misuse, 16.3% concerned combinations of antifungals. Prescriptions of liposomal amphotericin B, voriconazole and caspofungin complied with guidelines respectively in 69.7, 60.6 and 36.8% of the cases. Among the 127 appropriate prescriptions, the use of cheaper molecules with an equivalent clinical effectiveness would have allowed saving 13.6% of the total cost of these prescriptions. CONCLUSIONS:This study will lead us to implement policies for new antifungal prescription.

journal_name

Med Mal Infect

journal_title

Medecine et maladies infectieuses

authors

Pavese P,Ouachi Z,Vittoz JP,Lebeau B,Foroni L,Allenet B,Stahl JP,François P

doi

10.1016/j.medmal.2007.05.009

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

S223-8

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(07)00230-2

journal_volume

37 Suppl 3

pub_type

杂志文章

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