Abstract：
OBJECTIVE:The increasing resistance of Helicobacter pylori to clarithromycin led to developing new eradication treatment regimens. The objective of our observational study was to determine the proportion of H. pylori strains resistant to clarithromycin in infected patients in Reunion Island and to suggest a first-line treatment in agreement with the local ecology. PATIENTS AND METHODS:We included 200 patients who underwent esophagogastroduodenoscopy at the University Hospital of Saint-Pierre from February to July 2014. H. pylori was isolated from 73 patients. RESULTS:A wild-type susceptibility profile to clarithromycin was observed in 64 isolates (87.7%) and nine isolates (12.3%) had a resistant mutation profile. CONCLUSION:With a proportion of resistant strains below the critical threshold of 15%, physicians in Reunion Island may continue to prescribe the usual treatment regimen as a first-line option (clarithromycin, amoxicillin, and proton pump inhibitor for 14 days).
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Zemali N,Guillemot G,Jaubert J,Picot S,Thomas E,Becquart JP,Camuset G,Gérardin P,Michault A,Kwiatek Sdoi
10.1016/j.medmal.2016.06.004subject
Has Abstractpub_date
2016-10-01 00:00:00pages
385-389issue
7eissn
0399-077Xissn
1769-6690pii
S0399-077X(16)30105-6journal_volume
46pub_type
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