Abstract：
:Clostridium difficile is an anaerobic spore-forming Gram-positive bacillus recognized as an evolving international health problem. Metronidazole and vancomycin were - until recently - the only drugs available to treat C. difficile infection (CDI). Better knowledge of the pathophysiology and the development of new drugs completely modified the management of initial episodes and recurrences of CDI. Fidaxomicin significantly reduced recurrences compared with vancomycin. New drugs are also currently evaluated (cadazolid, surotomycin, ridinilazole, rifaximin). Gut microbiota homeostasis was clearly shown to be a key determinant in recurrences as demonstrated by the development of gut microbiota transplantation and alternative microbiota substitution. Passive immunotherapy and vaccinal approaches are also currently being evaluated. In conclusion, CDI treatment has evolved with the development of new therapeutic pathways which now need to be implemented in international guidelines.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Galpérine T,Guery B,French Group of Fecal Microbiota Transplantation (GFTF).doi
10.1016/j.medmal.2017.10.009subject
Has Abstractpub_date
2018-02-01 00:00:00pages
10-17issue
1eissn
0399-077Xissn
1769-6690pii
S0399-077X(17)30847-8journal_volume
48pub_type
杂志文章,评审abstract：OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2010.09.021
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the adequacy and the conformity of prescriptions of new systemic antifungal drugs to guidelines and scientific data. PATIENTS AND METHODS:Each prescription of liposomal amphotericin B (lip Amb), voriconazole, and caspofungin made between May 2003 and May 2004 in a teach...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.05.009
更新日期：2007-12-01 00:00:00
abstract：:Travellers' diarrhoea represents the most frequent health problem when travelling in developing countries. In most cases it is a self-limited disease. Nonetheless it can cause incapacitation and significant morbidity. It can become persistent in up to 3% of travellers who have suffered from acute diarrhoea in regions ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.09.003
更新日期：2007-12-01 00:00:00
abstract：UNLABELLED:Immunization against meningococcus C has been recommended in France since 2009 (infants from 12 to 24 months of age, and catch up vaccination up to 25 years of age). It has been reimbursed since January 2010. We had for aim to assess the vaccine coverage in 2011. METHOD:The study population included mothers...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2013.01.001
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:Pseudomonas aeruginosa is a major causative agent of hospital infections. Studies on this subject being rare in Algeria, we determined the antibiotic susceptibility of P. aeruginosa and investigated the mechanisms of beta-lactam resistance and the spread of multidrug resistant strains in the university affili...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.01.009
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:This study had for aim to describe the clinical aspects and favoring factors of mucosal Leishmaniasis in an Amazonian population of 30,000 habitants in Guajara-Mirim (Rondonia-Brazil). MATERIAL AND METHOD:A descriptive study was made of 16 patients with mucosal Leishmaniasis among 170 patients infected by L...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.03.012
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:The authors had for objective to describe patients with confirmed influenza A(H1N1)pdm09 admitted to an intensive care unit (ICU) in a university hospital and to identify risk factors correlated with the severity of the disease. DESIGN:A prospective study was conducted in an university hospital during the A(...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2013.01.016
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:Streptococcus agalactiae (Group B streptococcus) is a major cause of invasive diseases in non-pregnant adults, particularly in the elderly and those with underlying conditions. We describe these conditions and clinical characteristics of patients followed in our teaching hospital. METHODS:We retrospectively...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.04.003
更新日期：2007-12-01 00:00:00
abstract：INTRODUCTION:The aim of our study was to determine the epidemiological profile and the antibiotics susceptibility of bacteria identified in blood culture in the intensive care unit, to improve empirical antibiotherapy. MATERIAL AND METHOD:A retrospective study was made over a four-year period (2002-2005) in the intens...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.10.006
更新日期：2008-01-01 00:00:00
abstract：:Lyme disease diagnosis is currently based on serology - an indirect diagnostic method - as laboratory cultures are fastidious. The only direct diagnostic method that can be useful with some specimens (cutaneous biopsies or aspiration fluid) is PCR. We aimed to detail the main limitations of serology and PCR testing in...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2018.12.004
更新日期：2019-03-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) was first reported in the city of Wuhan, China. The disease rapidly spread to the rest of China, to Southern-East Asia, then to Europe, America, and on to the rest of the world. COVID-19 is associated with a betacoronavirus named SARS-CoV-2. The virus penetrates the organism thr...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2020.09.012
更新日期：2020-11-01 00:00:00
abstract：:Military personnel in operations have always paid a high toll to infections, particularly epidemics. Currently, 40 000 servicemen serve overseas in various missions and operations of various durations in various countries. Infectious hazards persist in spite of the implementation of preventive measures. They are prima...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/s0399-077x(96)80183-1
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:Septic arthritis of the facet joint is a rare clinical entity. We report 11 cases of facet joint infections diagnosed in our institution. PATIENTS AND METHOD:Patients were identified via the computerized patients record (PMSI). Their features were collected and compared with published data. RESULTS:The clin...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2015.04.001
更新日期：2015-06-01 00:00:00
abstract：:The variola virus was the first biological agent to be used as a military weapon. It is considered as one of the main agents that could potentially be used in the context of bioterrorism. Smallpox was declared eradicated in 1980. So, in case of a confirmed or suspected case of smallpox, a deliberate, intentional origi...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2003.09.009
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to describe the characteristics of patients hospitalized for a peritonsillar abscess over a 1-year period and to evaluate the proportion of patients exposed to anti-inflammatory and antibiotic drugs before hospitalization. DESIGN:Adult patients hospitalized in the ENT department...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.02.010
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:Extended-spectrum β-lactamases are widespread in hospital settings worldwide. The prevalence of ESBL producing Klebsiella pneumoniae (ESBL-KP) strains isolated from patients has recently increased in Tunisia. We conducted this study to determine the prevalence and the genetic characterization of ESBL-KP in a...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2015.01.010
更新日期：2015-04-01 00:00:00
abstract：:Over the past 20 years, some Enterobacteriaceae mainly Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis have demonstrated acquisition of plasmids secreting ESBL. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeu...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2014.03.010
更新日期：2014-09-01 00:00:00
abstract：:Allergic reactions to penicillins have been reported since the 1950s, shortly after their introduction as therapeutic agents. An increasing number of reported anaphylactic reactions and other adverse effects proved this to be a serious public health problem. Fifty years later, betalactam-induced hypersensitivity is th...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2008.09.011
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:The extended-release formulation of clarithromycin (CLA-ER) allows using this macrolide as a single daily dose. The purpose of this study was to evaluate the efficacy and safety of the CLA-ER formulation (500 mgx2) vs telithromycin (TELI) (400 mgx2) as a short course 5-day treatment, once a day, in patients ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medmal.2005.07.002
更新日期：2005-10-01 00:00:00
abstract：INTRODUCTION:Meningoencephalitis is the most common central nervous system complication caused by Mycoplasma pneumoniae. Its frequency is probably underestimated. OBJECTIVE:The study's aim was to determine the retrospectively incidence of M. pneumoniae meningoencephalitis among other cases of encephalitis diagnosed in...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.03.006
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVES:We had for aim to assess antibiotic consumption and to better understand their use in nursing homes so as to target messages on relevant practice procedures sent to prescribers. DESIGN:The MedQual network asked nursing homes with in-house pharmacies to participate in a retrospective collection of yearly ant...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2015.05.006
更新日期：2015-08-01 00:00:00
abstract：:Staphylococcus aureus nasal colonization is a well-known independent risk factor for infection caused by this bacterium. Screening and decolonization of carriers have been proven effective in reducing S. aureus infections in some populations. However, a gap remains between what has been proven effective and what is cu...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2016.10.005
更新日期：2017-09-01 00:00:00
abstract：:There are still many uncertainties regarding the benefit of public reporting on indicators of healthcare-associated infections. Publishing the results of performance indicators in healthcare facilities seems to stimulate quality insurance activity, but for the moment, without any demonstrated impact on the rates of he...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2013.03.002
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Acinetobacter baumannii is a ubiquitous pathogen resistant to desiccation and responsible for healthcare-associated infections (HAI), especially in intensive care units (ICU) where it is responsible for 5-10% of HAIs. An A. baumannii outbreak occurred in the ICU of the University Hospital of Angers, France...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2017.06.003
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:We wanted to determine the age-specific prevalence of selected sexually transmitted infections while assessing the risk factors among hidden female sex workers (HFSW). METHODS:One hundred HFSW over 15 years of age were recruited in an impoverished area of Antananarivo, Madagascar. After oral informed consen...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.01.007
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:Varicella occurring in healthy adults may extend to the lungs. Diagnosing this complication is sometimes difficult because of the discrepancy between imaging and clinical presentation usually reported in this affection. METHOD:The authors report the result of a retrospective study on 106 immunocompetent p...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.09.025
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS:Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS:Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2017.09.001
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the prevalence of low bone mineral density (BMD) and associated factors in antiretroviral therapy (ART)-naive HIV-infected young men. METHODS:In this cross-sectional study, dual-energy X-ray absorptiometry (DXA) was used to measure BMD. BMD at the lumbar spine, total hip and femoral n...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2018.02.009
更新日期：2018-10-01 00:00:00
abstract：:Bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. Less often, ocular complications associated with B. henselae infection have been reported in immunocompetent patients and five times in HIV-infected patients. We repo...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.06.006
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:A preliminary analysis of data consistency on different types of bacterial resistance by infection site and causative agents was conducted using the French hospital discharge database (French acronym PMSI) to assess the use of the database in a national cartography tool. MATERIAL AND METHODS:Hospital stays i...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2018.03.007
更新日期：2018-10-01 00:00:00
