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Tigecycline-based prolonged salvage therapy in patients presenting with complex bone and joint infection.

Abstract：

OBJECTIVES:To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS:Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS:Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most frequently isolated bacteria were Enterobacteriaceae and staphylococci. Tigecycline (50mg BID, mainly in combination (69.4%), mean duration of 58 days) was indicated for multidrug resistance (90.6%) and/or previous antibiotic intolerance (36.1%), and/or as second- or third-line therapy (69.4%). Six patients (16.7%) experienced early treatment discontinuation for adverse event (4 severe vomiting, 1 pancreatitis, 1 asymptomatic lipase increase). Clinical success was observed in 23 of 30 assessable patients who completed the tigecycline therapy (mean follow-up: 54.1±57.7 weeks). CONCLUSION:Prolonged tigecycline-based therapy could be an alternative in patients presenting with BJI requiring salvage therapy, especially if multidrug-resistant Enterobacteriaceae and/or staphylococci are involved.

journal_name

Med Mal Infect

journal_title

Medecine et maladies infectieuses

authors

Wach J,Dinh A,Dutronc H,Sipahi OR,Candevir A,Valour F,Zeller V,Lustig S,Laurent F,Chidiac C,Ferry T,Lyon BJI study group.

doi

10.1016/j.medmal.2017.09.001

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

53-57

issue

1

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(16)30661-8

journal_volume

48

pub_type

杂志文章,多中心研究

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