Abstract：
OBJECTIVE:Pneumocystis pneumonia (PCP) is now predominantly observed in immunosuppressed non-HIV-infected patients. The sensitivity of the PCR is here higher than direct examination (DE) of respiratory secretions because the infection is caused by a lower inoculum of Pneumocystis jirovecii (P. jirovecii). The objective of our retrospective study was to assess the contribution of quantitative PCR (qPCR) in the diagnosis of PCP. PATIENTS AND METHODS:All patients hospitalized for PCP suspicion with a positive qPCR were included. Irrespective of the qPCR value, patients were initially classified into two groups (infection and colonization [PCP ruled out]) based on clinical, radiological, and microbiological data. Both groups were then compared based on the qPCR value. RESULTS:Between 2013 and 2016, 150 patients were included; 75% of them were not infected with HIV. The diagnosis of PCP was retained for 129 patients and rejected for 21 patients. The DE was negative in 60% of PCP cases. The median value of qPCR was 76,650copies/mL among infected patients and 3220copies/mL among colonized patients. The threshold corresponding to a specificity of 100% was 56,000copies/mL. The optimal value to distinguish an infection from a colonization was 10,100copies/mL. CONCLUSION:Our study confirms the diagnostic value of the qPCR in immunosuppressed patients, especially when the DE is negative. When the qPCR is˂56,000copies/mL, the result should be interpreted based on the clinical context and paraclinical examinations.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Issa N,Gabriel F,Baulier G,Mourissoux G,Accoceberry I,Guisset O,Camou Fdoi
10.1016/j.medmal.2018.04.396subject
Has Abstractpub_date
2018-10-01 00:00:00pages
474-480issue
7eissn
0399-077Xissn
1769-6690pii
S0399-077X(17)30606-6journal_volume
48pub_type
杂志文章abstract：OBJECTIVES:We wanted to determine the age-specific prevalence of selected sexually transmitted infections while assessing the risk factors among hidden female sex workers (HFSW). METHODS:One hundred HFSW over 15 years of age were recruited in an impoverished area of Antananarivo, Madagascar. After oral informed consen...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.01.007
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the prevalence of low bone mineral density (BMD) and associated factors in antiretroviral therapy (ART)-naive HIV-infected young men. METHODS:In this cross-sectional study, dual-energy X-ray absorptiometry (DXA) was used to measure BMD. BMD at the lumbar spine, total hip and femoral n...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2018.02.009
更新日期：2018-10-01 00:00:00
abstract：UNLABELLED:Immunization against meningococcus C has been recommended in France since 2009 (infants from 12 to 24 months of age, and catch up vaccination up to 25 years of age). It has been reimbursed since January 2010. We had for aim to assess the vaccine coverage in 2011. METHOD:The study population included mothers...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2013.01.001
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:Adults with hematological malignancies are at high-risk of Clostridium difficile infection (CDI), but no guidelines for CDI treatment are available in this population. Our primary objective was to evaluate the clinical outcomes in CDI patients with hematological malignancies. Our secondary objectives were to...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2017.07.002
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVES:Overdiagnosis of lyme borreliosis leads to unnecessary and increasingly common antimicrobial treatments. We aimed to evaluate patients receiving long-term antimicrobial treatment for lyme borreliosis. METHODS:We included patients referred to a Parisian teaching hospital between January 1st, 2014 and June 30...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2020.10.018
更新日期：2020-10-21 00:00:00
abstract：UNLABELLED:In France, according to the National Epidemiology Observatory of Bacterial Resistance to Antibiotics, 15.3% of outpatient urinary Escherichia coli isolates were fluoroquinolone-resistant in 2010. This puts to question the relevance of empirical fluoroquinolone therapy for community-acquired acute pyelonephri...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:This study had for aim to describe the clinical aspects and favoring factors of mucosal Leishmaniasis in an Amazonian population of 30,000 habitants in Guajara-Mirim (Rondonia-Brazil). MATERIAL AND METHOD:A descriptive study was made of 16 patients with mucosal Leishmaniasis among 170 patients infected by L...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.03.012
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:Protection of French young infants against pertussis only relies on their relatives' vaccination. The alternative is vaccination of pregnant women against pertussis (cocooning strategy), but this strategy is not yet recommended in France. We assessed the acceptance of this strategy among French postpartum wo...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2019.09.001
更新日期：2019-11-01 00:00:00
abstract：UNLABELLED:Vaccine coverage against hepatitis B virus (HBV) in France has decreased to one of the lowest levels among countries that recommend it, over the last decade. The probable cause was that the vaccine was suspected to induce demyelinating diseases. We studied the factors limiting the use of HBV vaccine amongst ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2011.07.002
更新日期：2011-10-01 00:00:00
abstract：:Bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. Less often, ocular complications associated with B. henselae infection have been reported in immunocompetent patients and five times in HIV-infected patients. We repo...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.06.006
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Although urinary tract infections are the second leading cause of infections among patients aged above 65 years, data on bacterial epidemiology of urinary specimens in these patients is scarce. Our aim was to describe the main bacterial species found at significant levels in urine specimens of the elderly and...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:The authors had for aim to evaluate the efficacy and tolerance of oral levofloxacin (500 mg once a day during ten days), as a treatment for acute bacterial sinusitis at risk for complications in adult patients. PATIENTS AND METHODS:This was a prospective, multicenter, open, non-comparative, efficacy and tol...
journal_title：Medecine et maladies infectieuses
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.medmal.2005.06.001
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal funct...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.10.004
更新日期：2010-05-01 00:00:00
abstract：UNLABELLED:The aim of this study was to evaluate the clinical efficacy of telithromycin administered for 5 days at a dosage of 800 mg/day, in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) presenting with at least 2 of Anthonisen's criteria including the increase of purulence. METHO...
journal_title：Medecine et maladies infectieuses
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.medmal.2005.08.008
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:Improving the use of antimicrobial drugs is a national objective. To this end an evaluation of clinical practice was implemented on prescribed antibiotics in elderly patients, in the Besançon Teaching Hospital. DESIGN:In 2005, a clinical audit compared the adequacy of antibiotic prescriptions to national gui...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2011.02.002
更新日期：2011-06-01 00:00:00
abstract：:Tuberculous arthritis is rare and the diagnosis may be confused with inflammatory arthritis. Only few cases, explored by MRI, have been reported in the literature. We report 3 cases of tuberculous arthritis of the knee revealed by insidious pain. The abnormalities revealed by MRI suggested tuberculosis. Diagnosis was ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.10.006
更新日期：2007-09-01 00:00:00
abstract：:Military personnel in operations have always paid a high toll to infections, particularly epidemics. Currently, 40 000 servicemen serve overseas in various missions and operations of various durations in various countries. Infectious hazards persist in spite of the implementation of preventive measures. They are prima...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/s0399-077x(96)80183-1
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. METHODS:We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. RESULTS:Twenty outbreaks, includi...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,meta分析
doi：10.1016/j.medmal.2014.08.005
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:Pseudomonas aeruginosa is a major causative agent of hospital infections. Studies on this subject being rare in Algeria, we determined the antibiotic susceptibility of P. aeruginosa and investigated the mechanisms of beta-lactam resistance and the spread of multidrug resistant strains in the university affili...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.01.009
更新日期：2008-04-01 00:00:00
abstract：:Lactobacilli rhamnosus infections are rare and occur in patients with severe conditions causing immunosuppression and/or in those who have received intense antibiotic treatment such as with teicoplanin and vancomycin. We report two cases which occurred within a period of 48 hours, during regression of pancreatitis in ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.10.005
更新日期：2008-01-01 00:00:00
abstract：AIM:The aim of this study was to investigate the phenotypic and genotypic properties of clumping factor- and protein A- negative MRSA. METHODS:Two hundred ninety-four strains were studied. The production of protein A was determined by immunoblotting, clumping factor (CF) and coagulase by conventional tests with rabbit...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2006.07.006
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION:An increase of syphilis cases has been recorded in the past few decades, especially among HIV-infected patients. These patients often present with concomitant primary and secondary lesions or extensive presentations of syphilis. OBJECTIVE:Our goal was to compare alternative regimens to the recommended pen...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2011.10.003
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To study the efficacy and safety of micafungin for prophylaxis of invasive fungal infections in patients undergoing induction chemotherapy for acute myeloid leukemia. PATIENTS AND METHODS:A prospective observational single-center study of 41 patients from the hematology department between May 2012 and April ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.03.008
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2010.09.021
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:This retrospective study was undertaken to assess epidemiological and clinical aspects as well as outcome of tetanus cases in patients over 28 days of age, so as to issue recommendations. PATIENTS AND METHODS:This study included patients admitted to the Fann teaching hospital in Dakar from 2001 to 2003. Age,...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2004.11.003
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:We aimed to describe the challenge faced by the national reference laboratory to support the national HIV/AIDS response in Madagascar. METHODS:Collaboration between the National Reference Laboratory of Madagascar (NRLM) and foreign partners (a laboratory and an international organization) on the basis of a t...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Acinetobacter baumannii is a ubiquitous pathogen resistant to desiccation and responsible for healthcare-associated infections (HAI), especially in intensive care units (ICU) where it is responsible for 5-10% of HAIs. An A. baumannii outbreak occurred in the ICU of the University Hospital of Angers, France...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2017.06.003
更新日期：2017-10-01 00:00:00
abstract：:Less than 20% of African adolescents aged 10-19 years are aware of their HIV status, whereas HIV screening remains the gateway to care and while AIDS has become the leading cause of death among adolescents in Sub-Saharan Africa. According to the UNAIDS target, scalable HIV testing strategies specific to various age gr...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2020.07.007
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:The increasing resistance of Helicobacter pylori to clarithromycin led to developing new eradication treatment regimens. The objective of our observational study was to determine the proportion of H. pylori strains resistant to clarithromycin in infected patients in Reunion Island and to suggest a first-line ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.06.004
更新日期：2016-10-01 00:00:00
abstract：:Lyme disease diagnosis is currently based on serology - an indirect diagnostic method - as laboratory cultures are fastidious. The only direct diagnostic method that can be useful with some specimens (cutaneous biopsies or aspiration fluid) is PCR. We aimed to detail the main limitations of serology and PCR testing in...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2018.12.004
更新日期：2019-03-01 00:00:00
