Abstract：
INTRODUCTION:An increase of syphilis cases has been recorded in the past few decades, especially among HIV-infected patients. These patients often present with concomitant primary and secondary lesions or extensive presentations of syphilis. OBJECTIVE:Our goal was to compare alternative regimens to the recommended penicillin treatment. METHOD:We retrospectively studied 116 patient files (80% HIV1-infected) treated for a first episode of early syphilis. RESULTS:Patients mainly presented with symptoms of secondary syphilis. In 15.5% of the cases patients were asymptomatic and 17.2% of patients with secondary syphilis presented with neurologic or ophthalmic symptoms. Some less usual clinical presentations included diffuse polyadenopathy or isolated fever. The time to serological response was similar among those treated with benzathine-penicillin (n=52), ceftriaxone (n=49), or doxycycline (n=15). CONCLUSION:Ceftriaxone and doxycycline could be suitable alternatives to penicillin in the treatment of early syphilis in HIV-infected patients. These two treatments have a concomitant effectiveness even for asymptomatic forms of neurosyphilis.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Psomas KC,Brun M,Causse A,Atoui N,Reynes J,Le Moing Vdoi
10.1016/j.medmal.2011.10.003subject
Has Abstractpub_date
2012-01-01 00:00:00pages
15-9issue
1eissn
0399-077Xissn
1769-6690pii
S0399-077X(11)00319-2journal_volume
42pub_type
杂志文章abstract：:Clinical presentations of opportunistic infections in AIDS patients have dramatically changed since the introduction of HAART. The immune reconstitution syndrome (IRS) is typical of this change. The authors discuss the case of an AIDS female patient presenting with subcutaneous abcesses and abdominal lymph node enlarg...
journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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pub_type： 杂志文章,实务指引,评审
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journal_title：Medecine et maladies infectieuses
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doi：10.1016/j.medmal.2006.08.004
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journal_title：Medecine et maladies infectieuses
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pub_type： 杂志文章,多中心研究
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doi：10.1016/j.medmal.2007.11.014
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journal_title：Medecine et maladies infectieuses
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doi：10.1016/j.medmal.2007.01.010
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pub_type： 杂志文章,多中心研究
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