Abstract：
:The fight against multi-drug resistant Gram-negative bacilli (MDRGNB), especially extended-spectrum β-lactamase producing Enterobacteriaceae, is about to be lost in our country. The emergence of new resistance mechanisms to carbapenems in these Enterobacteriaceae exposes patients to a risk of treatment failure without any other therapeutic options. This dramatic situation is paradoxical because we are well aware of the 2 major factors responsible for this situation: 1) MDRO cross-transmission, associated with a low compliance to standard precautions, especially hand hygiene, and 2) overexposure of patients to antibiotics. The implementation of a "search and isolate" policy, which was justified to control the spread of some MDRO that remained rare in the country, was not associated with a better adherence to standard precautions. The antibiotic policy and the measures implemented to control antibiotic consumptions have rarely been enforced and have shown inconsistent results. Notably, no significant decrease of antibiotic consumption has been observed. There is no excuse for these poor results, because some authors evaluating the effectiveness of programs for the control of MDRO have reported their positive effects on antimicrobial resistance without any detrimental effects. It is now urgent to deal with the 2 major factors by establishing an educational and persuasive program with quantified and opposable objectives. Firstly, we have to improve the observance of hand hygiene above 70%. Secondly, we have to define and reach a target for the reduction of antibiotic consumption both in community and in hospital settings.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Zahar JR,Lesprit Pdoi
10.1016/j.medmal.2014.07.006subject
Has Abstractpub_date
2014-09-01 00:00:00pages
405-11issue
9eissn
0399-077Xissn
1769-6690pii
S0399-077X(14)00183-8journal_volume
44pub_type
杂志文章,评审abstract：UNLABELLED:Vaccine coverage against hepatitis B virus (HBV) in France has decreased to one of the lowest levels among countries that recommend it, over the last decade. The probable cause was that the vaccine was suspected to induce demyelinating diseases. We studied the factors limiting the use of HBV vaccine amongst ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2011.07.002
更新日期：2011-10-01 00:00:00
abstract：:The first successful culture of Tropheryma whipplei made 10 years ago opened the way for identification of the bacterium and the development of many diagnostic tools. Phylogenetic analyses made it possible to classify it among Gram positive bacilli in the family of Actinomycetes, close to other ubiquitous bacteria of ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2009.10.017
更新日期：2010-07-01 00:00:00
abstract：INTRODUCTION:Most antibiotic therapies are initiated in the emergency unit (EU). To better understand the antibiotic consumption survey in this unit, we compared our results to two neighbor hospitals. This quantitative data was then compared to a quality assessment of antibiotic prescription (audit). METHODS:The quant...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2008.10.020
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:The main objective of this study was to compare the efficacy of three regimens of malaria prevention during pregnancy for the reduction of anemia between the first and third antenatal consultations. The first treatment arm was the classical weekly chemoprophylaxis with chloroquine; the other two were the int...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medmal.2007.10.012
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:This study had for aim to assess pneumococcal vaccination rates in hospitalized patients. DESIGN:A prospective study was carried out in two medical wards of the Nice University Hospital, France. Patients were included from December 31, 2007 to February 12, 2008. RESULTS:Hundred and thirty-seven patients, ag...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.12.004
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:Meningoencephalitis is the most common central nervous system complication caused by Mycoplasma pneumoniae. Its frequency is probably underestimated. OBJECTIVE:The study's aim was to determine the retrospectively incidence of M. pneumoniae meningoencephalitis among other cases of encephalitis diagnosed in...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.03.006
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal funct...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2009.10.004
更新日期：2010-05-01 00:00:00
abstract：:The aim of this review was to describe the current knowledge of Legionnaires' disease (LD) illustrated by the epidemiological situation in France in 2013. LD is a severe pneumonia commonly caused by Legionella pneumophila serogroup 1. The diagnosis is usually based on the urinary antigen test. This rapid method reduce...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2015.01.015
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2010.09.021
更新日期：2011-03-01 00:00:00
abstract：:Staphylococcus aureus nasal colonization is a well-known independent risk factor for infection caused by this bacterium. Screening and decolonization of carriers have been proven effective in reducing S. aureus infections in some populations. However, a gap remains between what has been proven effective and what is cu...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2016.10.005
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:The increasing resistance of Helicobacter pylori to clarithromycin led to developing new eradication treatment regimens. The objective of our observational study was to determine the proportion of H. pylori strains resistant to clarithromycin in infected patients in Reunion Island and to suggest a first-line ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.06.004
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:This prospective study had for aim to determine the frequency and characteristics of cardiovascular events in the course of tetanus. PATIENTS AND METHODS:From September to December 2002, we studied all patients over 4 years of age presenting with tetanus without any documented underlying disease. RESULTS:T...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2005.09.005
更新日期：2005-09-01 00:00:00
abstract：:Leptospirosis is a zoonosis found worldwide, the main reservoir of which is the rat. Human infection generally results from exposure to contaminated river or lake water or animals. Around 600 cases are diagnosed per year in France. Half of these cases occur in French overseas territories, where the incidence can be mo...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2012.11.005
更新日期：2013-01-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) was first reported in the city of Wuhan, China. The disease rapidly spread to the rest of China, to Southern-East Asia, then to Europe, America, and on to the rest of the world. COVID-19 is associated with a betacoronavirus named SARS-CoV-2. The virus penetrates the organism thr...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2020.09.012
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:The etiological diagnosis of infectious encephalitis is often not established 48hours after onset. We aimed to review existing literature data before providing management guidelines. METHOD:We performed a literature search on PubMed using filters such as "since 01/01/2000", "human", "adults", "English or ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2017.02.004
更新日期：2017-05-01 00:00:00
abstract：UNLABELLED:In France, according to the National Epidemiology Observatory of Bacterial Resistance to Antibiotics, 15.3% of outpatient urinary Escherichia coli isolates were fluoroquinolone-resistant in 2010. This puts to question the relevance of empirical fluoroquinolone therapy for community-acquired acute pyelonephri...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：:Twenty people died of rabies in France between 1970 and 2003 (compared to 55,000 yearly worldwide), 80% on returning from Africa. Dogs were the contaminating animals in 90% of the cases and children were the most common victims. The last instance of rabies in a native French animal was reported in 1998. However the il...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2004.07.031
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:The authors had for aim, to determine the frequency and the main clinical forms of severe malaria and to evaluate its management. PATIENTS AND METHODS:A cross-sectional investigation was made in the "Complexe Pediatrique" of Bangui, the only children hospital of the CAR capital, from 12 January to 12 Septemb...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2003.09.003
更新日期：2004-02-01 00:00:00
abstract：:Clinical presentations of opportunistic infections in AIDS patients have dramatically changed since the introduction of HAART. The immune reconstitution syndrome (IRS) is typical of this change. The authors discuss the case of an AIDS female patient presenting with subcutaneous abcesses and abdominal lymph node enlarg...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.05.006
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To study the efficacy and safety of micafungin for prophylaxis of invasive fungal infections in patients undergoing induction chemotherapy for acute myeloid leukemia. PATIENTS AND METHODS:A prospective observational single-center study of 41 patients from the hematology department between May 2012 and April ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.03.008
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. METHODS:We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. RESULTS:Twenty outbreaks, includi...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,meta分析
doi：10.1016/j.medmal.2014.08.005
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:Vaccine hesitancy is a growing and threatening trend, increasing the risk of disease outbreaks and potentially defeating health authorities' strategies. We aimed to describe the significant role of social networks and the Internet on vaccine hesitancy, and more generally on vaccine attitudes and behaviors. M...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,评审
doi：10.1016/j.medmal.2016.02.002
更新日期：2016-05-01 00:00:00
abstract：:Travellers' diarrhoea represents the most frequent health problem when travelling in developing countries. In most cases it is a self-limited disease. Nonetheless it can cause incapacitation and significant morbidity. It can become persistent in up to 3% of travellers who have suffered from acute diarrhoea in regions ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2007.09.003
更新日期：2007-12-01 00:00:00
abstract：INTRODUCTION:No therapy has yet proven effective in COVID-19. Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. METHOD:We conducted a retrospective case-control study in the Nord Franche-Comté Hospital, France. We compared the outcome of patients treated with TCZ and patients without ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2020.05.001
更新日期：2020-08-01 00:00:00
abstract：:Tuberculous arthritis is rare and the diagnosis may be confused with inflammatory arthritis. Only few cases, explored by MRI, have been reported in the literature. We report 3 cases of tuberculous arthritis of the knee revealed by insidious pain. The abnormalities revealed by MRI suggested tuberculosis. Diagnosis was ...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.10.006
更新日期：2007-09-01 00:00:00
abstract：:We report a case of osteitis in a 46-year-old patient, caused by Pseudomonas stutzeri following an open fracture of the left femur. The patient was treated with 1g ceftazidime every 8 hours for two weeks combined with 160 mg/day of amikacin for 10 days. A second-line ofloxacin oral treatment at 400 mg/day was then giv...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2006.07.007
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:Our study dealt with antibiotic resistance and serotypes of Pseudomonas aeruginosa strains isolated from immunocompromised patients in the National Bone Marrow Transplant Center of Tunis as well as molecular typing of ceftazidime resistant strains (CAZ-R). DESIGN:We studied a total of 87 non-replicate P. aer...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2005.08.006
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:We aimed to describe the challenge faced by the national reference laboratory to support the national HIV/AIDS response in Madagascar. METHODS:Collaboration between the National Reference Laboratory of Madagascar (NRLM) and foreign partners (a laboratory and an international organization) on the basis of a t...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:The authors had for objective to assess systemic antifungal treatment for candidemia in non-neutropenic patients, in intensive care units (ICU), and compare the results with French 2004 recommendations. STUDY DESIGN:A retrospective multicenter study (nine ICU in two teaching hospitals) was made. PATIENTS AN...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medmal.2010.06.007
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:Knowledge of local antimicrobial resistance (AMR) patterns is required for effective empirical treatment of bacterial diseases. Very little is known about current resistance patterns of common pathogenic bacteria in the African region and particularly in the Sahel region. We aimed to describe the local bacte...
journal_title：Medecine et maladies infectieuses
pub_type： 杂志文章
doi：10.1016/j.medmal.2019.12.009
更新日期：2020-11-01 00:00:00
