Abstract：
OBJECTIVES:The main objective of this study was to compare the efficacy of three regimens of malaria prevention during pregnancy for the reduction of anemia between the first and third antenatal consultations. The first treatment arm was the classical weekly chemoprophylaxis with chloroquine; the other two were the intermittent preventive treatment using either three doses of chloroquine or sulfadoxine-pyrimethamine. DESIGN:We conducted an open, randomized, three-arm study in a rural district of Burkina Faso. A cohort was constituted by 648 pregnant women of any parity. RESULTS:The hemoglobin gain was more significant with the intermittent preventive treatment using sulfadoxine-pyrimethamine compared to the other treatment arms. The hemoglobin increased from 10.3g/dl (at the first antenatal consultation) to 11.4 g/dl (at the third antenatal consultation). In the three arms of treatment, the chemoprophylaxis reduced the prevalence of moderate anemia and severe anemia. The reduction of moderate anemia was more substantial in the sulfadoxine-pyrimethamine arm (65.6 to 36.7%) at second antenatal consultation (p=0.069) and third antenatal consultation (p=0.014). Conversely, in the two chloroquine arms, there was no significant reduction either at second antenatal consultation (p=0.72) or third antenatal consultation (p=0.55). The prevalence of peripheral parasitemia decreased in all treatment groups. However, it was significantly higher in the sulfadoxine-pyrimethamine group (44.3%). CONCLUSIONS:Intermittent preventive treatment with three doses of sulfadoxine-pyrimethamine is a more effective strategy to prevent maternal anemia during pregnancy in Burkina Faso.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Ouédraogo A,Bougouma EC,Diarra A,Konaté AT,Nébié I,Tiono AB,Sirima SBdoi
10.1016/j.medmal.2007.10.012subject
Has Abstractpub_date
2008-04-01 00:00:00pages
180-6issue
4eissn
0399-077Xissn
1769-6690pii
S0399-077X(07)00385-Xjournal_volume
38pub_type
杂志文章,随机对照试验abstract：:We report a fatal case of Chromobacterium violaceum septicemia in a 42-year-old farm worker living in the French West Indies. The bacteria found in the muddy soil and the stagnant water of tropical and subtropical regions is rarely a source of human infection. ...
journal_title：Medecine et maladies infectieuses
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pub_type： 杂志文章
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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journal_title：Medecine et maladies infectieuses
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