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Infectious encephalitis: Management without etiological diagnosis 48hours after onset.

Abstract：

INTRODUCTION:The etiological diagnosis of infectious encephalitis is often not established 48hours after onset. We aimed to review existing literature data before providing management guidelines. METHOD:We performed a literature search on PubMed using filters such as "since 01/01/2000", "human", "adults", "English or French", and "clinical trial/review/guidelines". We also used the Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis". RESULTS:With Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis", we retrieved 223 and 258 articles, respectively. With search terms "encephalitis and corticosteroid", we identified 38 articles, and with "encephalitis and doxycycline" without the above-mentioned filters we identified 85 articles. A total of 210 articles were included in the analysis. DISCUSSION:Etiological investigations must focus on recent travels, animal exposures, age, immunodeficiency, neurological damage characteristics, and potential extra-neurological signs. The interest of a diagnosis of encephalitis for which there is no specific treatment is also to discontinue any empirical treatments initially prescribed. Physicians must consider and search for autoimmune encephalitis.

journal_name

Med Mal Infect

journal_title

Medecine et maladies infectieuses

authors

Fillatre P,Crabol Y,Morand P,Piroth L,Honnorat J,Stahl JP,Lecuit M

doi

10.1016/j.medmal.2017.02.004

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

236-251

issue

3

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(17)30086-0

journal_volume

47

pub_type

杂志文章,评审

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