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Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients.

Abstract：

INTRODUCTION:No therapy has yet proven effective in COVID-19. Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. METHOD:We conducted a retrospective case-control study in the Nord Franche-Comté Hospital, France. We compared the outcome of patients treated with TCZ and patients without TCZ considering a combined primary endpoint: death and/or ICU admissions. RESULTS:Patients with TCZ (n=20) had a higher Charlson comorbidity index (5.3 [±2.4] vs 3.4 [±2.6], P=0.014), presented with more severe forms (higher level of oxygen therapy at 13L/min vs 6L/min, P<0.001), and had poorer biological findings (severe lymphopenia: 676/mm3 vs 914/mm3, P=0.037 and higher CRP level: 158mg/L vs 105mg/L, P=0.017) than patients without TCZ (n=25). However, death and/or ICU admissions were higher in patients without TCZ than in the TCZ group (72% vs 25%, P=0.002). CONCLUSION:Despite the small sample size and retrospective nature of the work, this result strongly suggests that TCZ may reduce the number of ICU admissions and/or mortality in patients with severe SARS-CoV-2 pneumonia.

journal_name

Med Mal Infect

journal_title

Medecine et maladies infectieuses

authors

Klopfenstein T,Zayet S,Lohse A,Balblanc JC,Badie J,Royer PY,Toko L,Mezher C,Kadiane-Oussou NJ,Bossert M,Bozgan AM,Charpentier A,Roux MF,Contreras R,Mazurier I,Dussert P,Gendrin V,Conrozier T,HNF Hospital Tocilizumab m

doi

10.1016/j.medmal.2020.05.001

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

397-400

issue

5

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(20)30129-3

journal_volume

50

pub_type

杂志文章

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