Ten years of experience with the pneumococcal conjugate 7-valent vaccine in children.

Abstract:

:In children, pneumococcus became the predominant infectious agent, after the routine use of the Hib conjugate vaccine dramatically decreased Haemophilus Influenzae type b prevalence. The incidence of invasive pneumococcal infections (IPI) and of non-invasive infections due to vaccine serotypes (VS) decreased by 80% in Europe along with a 30-40% decrease in the global incidence of IPI in this age group, after the implementation of Prevenar 7(®) routine immunization in children below 2 years of age. The decrease of IPI due to VS in other age groups was an indirect benefit. The moderate increase of non-vaccinal serotype IPI incidence did not impede the benefit of the overall program. Serotype 19A was the most frequent and carried resistance to antibiotics. Prevenar 13(®), a second-generation vaccine with six new serotypes, replaced Prevenar 7(®) in most countries after 2010, with available evidence of its effectiveness (United Kingdom, US, France).

journal_name

Med Mal Infect

authors

Weil Olivier C

doi

10.1016/j.medmal.2013.04.006

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

309-21

issue

8

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(13)00136-4

journal_volume

43

pub_type

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