Antimicrobial resistance in N'Djamena (Chad): Four-year experience of the French Forward Medical and Surgical Team engaged in the "Barkhane Operation".


OBJECTIVES:Knowledge of local antimicrobial resistance (AMR) patterns is required for effective empirical treatment of bacterial diseases. Very little is known about current resistance patterns of common pathogenic bacteria in the African region and particularly in the Sahel region. We aimed to describe the local bacterial epidemiology and to determine whether French recommendations for empirical treatment could be implemented. PATIENTS AND METHODS:We performed a single-center observational study. Data was collected retrospectively from the Forward Medical and Surgical Center (FFMSC) bacterial database from January 2015 to December 2018. All bacteriological analyses, negative or positive, were included. RESULTS:A total of 2194 samples were analyzed. Infectious diseases were urinary tract infections (20.8%), bone and joint infections (20.4%), skin infections of chronic wounds (13.4%), soft tissue abscesses (13%), and gastroenteritis (10.8%). The most frequent infections were enterobacterial infections (43.6%) and staphylococcal infections (31.1%). The prevalence of AMR was 32.1%. Significantly more ESBL-producing bacteria (41.3%) were observed in the Chadian population than in the French population in N'djamena (6.3%) (P<0.001). CONCLUSIONS:We reported a high rate of ESBL-producing bacteria in N'Djamena. The use of empirical antibiotic therapies in the FFMSC may thus be questioned: French recommendations cannot be implemented in such setting and the use of carbapenems or new anti-ESBL antibiotics should be considered. Prospective studies are required to conclude.


Med Mal Infect


Cardinale M,Bourbotte-Salmon F,Scheiwe C,Boulezaz S,Ridet M,Laitselart P




Has Abstract


2020-11-01 00:00:00














  • 2010 French SPILF-AFSSAPS guiding criteria for Streptococcuspneumoniae acute community-acquired pneumonia: Evaluation in patients of the PACSCAN-ESCAPED cohort.

    abstract:OBJECTIVE:To assess the proportion of patients meeting the 2010 SPILF-AFSSAPS guiding criteria for Streptococcuspneumoniae in patients consulting at the emergency departments of four French university hospitals for acute community-acquired pneumonia (CAP) suspicion. PATIENTS AND METHODS:The PACSCAN study prospectively...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Ben Hayoun M,Tubiana S,Varon E,Naccache JM,Le Floch H,Leport C,Claessens YE,Duval X,PASCAN ESCAPED study group.

    更新日期:2020-09-17 00:00:00

  • [Ocular bartonellosis in an HIV-HVC coinfected patient].

    abstract::Bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. Less often, ocular complications associated with B. henselae infection have been reported in immunocompetent patients and five times in HIV-infected patients. We repo...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Merle De Boever C,Mura F,Brun M,Reynes J

    更新日期:2008-09-01 00:00:00

  • Exploring ways to improve CDI outcomes.

    abstract::Clostridium difficile is an anaerobic spore-forming Gram-positive bacillus recognized as an evolving international health problem. Metronidazole and vancomycin were - until recently - the only drugs available to treat C. difficile infection (CDI). Better knowledge of the pathophysiology and the development of new drug...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Galpérine T,Guery B,French Group of Fecal Microbiota Transplantation (GFTF).

    更新日期:2018-02-01 00:00:00

  • [Levofloxacin in the treatment of acute and bacteriologically documented sinusitis with high risk of complications].

    abstract:OBJECTIVES:The authors had for aim to evaluate the efficacy and tolerance of oral levofloxacin (500 mg once a day during ten days), as a treatment for acute bacterial sinusitis at risk for complications in adult patients. PATIENTS AND METHODS:This was a prospective, multicenter, open, non-comparative, efficacy and tol...

    journal_title:Medecine et maladies infectieuses

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Gehanno P,Pessey JJ,Serrano E

    更新日期:2005-06-01 00:00:00

  • Focus on patients receiving long-term antimicrobial treatments for lyme borreliosis: No lyme but mostly mental disorders.

    abstract:OBJECTIVES:Overdiagnosis of lyme borreliosis leads to unnecessary and increasingly common antimicrobial treatments. We aimed to evaluate patients receiving long-term antimicrobial treatment for lyme borreliosis. METHODS:We included patients referred to a Parisian teaching hospital between January 1st, 2014 and June 30...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Itani O,Haddad E,Pitron V,Pichon F,Caumes E

    更新日期:2020-10-21 00:00:00

  • [Insufficient pneumococcal vaccine coverage in adult inpatients at risk].

    abstract:OBJECTIVE:This study had for aim to assess pneumococcal vaccination rates in hospitalized patients. DESIGN:A prospective study was carried out in two medical wards of the Nice University Hospital, France. Patients were included from December 31, 2007 to February 12, 2008. RESULTS:Hundred and thirty-seven patients, ag...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Risso K,Naqvi A,Pillet S,Leplatois A,Pulcini C

    更新日期:2010-06-01 00:00:00

  • HIV self-testing in adolescents living in Sub-Saharan Africa.

    abstract::Less than 20% of African adolescents aged 10-19 years are aware of their HIV status, whereas HIV screening remains the gateway to care and while AIDS has become the leading cause of death among adolescents in Sub-Saharan Africa. According to the UNAIDS target, scalable HIV testing strategies specific to various age gr...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Tonen-Wolyec S,Koyalta D,Mboumba Bouassa RS,Filali M,Batina-Agasa S,Bélec L

    更新日期:2020-11-01 00:00:00

  • Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic.

    abstract:BACKGROUND:Monkeypox is a zoonosis caused by an Orthopoxvirus of the Poxviridae family. Human infections are often severe and are a public health problem. PATIENTS AND METHOD:We conducted a monkeypox outbreak investigation of suspected case patients in five villages of the Alindao-Mingala Health District following blo...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Kalthan E,Tenguere J,Ndjapou SG,Koyazengbe TA,Mbomba J,Marada RM,Rombebe P,Yangueme P,Babamingui M,Sambella A,Nakoune ER

    更新日期:2018-06-01 00:00:00

  • Limitations of diagnostic tests for bacterial infections.

    abstract::Lyme disease diagnosis is currently based on serology - an indirect diagnostic method - as laboratory cultures are fastidious. The only direct diagnostic method that can be useful with some specimens (cutaneous biopsies or aspiration fluid) is PCR. We aimed to detail the main limitations of serology and PCR testing in...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Eldin C,Parola P,Raoult D

    更新日期:2019-03-01 00:00:00

  • [Subcutaneous abcesses due to Mycobacterium avium due to a reconstitution syndrome in AIDS patients].

    abstract::Clinical presentations of opportunistic infections in AIDS patients have dramatically changed since the introduction of HAART. The immune reconstitution syndrome (IRS) is typical of this change. The authors discuss the case of an AIDS female patient presenting with subcutaneous abcesses and abdominal lymph node enlarg...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Guillaume M,Pavese P,Decouchon C,Brion JP,Stahl JP

    更新日期:2006-08-01 00:00:00

  • Molecular characterization of extended spectrum beta-lactamases produced by Klebsiella pneumoniae clinical strains from a Tunisian Hospital.

    abstract:OBJECTIVES:Extended-spectrum β-lactamases are widespread in hospital settings worldwide. The prevalence of ESBL producing Klebsiella pneumoniae (ESBL-KP) strains isolated from patients has recently increased in Tunisia. We conducted this study to determine the prevalence and the genetic characterization of ESBL-KP in a...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Alibi S,Ferjani A,Boukadida J

    更新日期:2015-04-01 00:00:00

  • The vaccination coverage in dispensaries on Mayotte Island is lacking for natives and migrants alike.

    abstract:OBJECTIVE:Assessing the vaccination coverage rate in Mayotte dispensaries. PATIENTS AND METHODS:Prospective study in three dispensaries from June to July 2019. RESULTS:Of the 162 patients included, 78% (126/162) were natives of the island and 19% (30/162) were from the Comoros Islands. Twenty-three percent (37/162) w...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Pascal C,Lesens O

    更新日期:2020-10-15 00:00:00

  • Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis.

    abstract:PURPOSE:Invasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor. PATIENTS AND METHOD:We reported three additional cases and reviewed 16 previous published cases together wi...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Brochard J,Morio F,Mahe J,Le Pape P,Guimard T,Mahe B,Leterrier M,Morrier M,Raffi F,Boutoille D

    更新日期:2020-11-01 00:00:00

  • Case fatality rates of Ebola virus diseases: a meta-analysis of World Health Organization data.

    abstract:OBJECTIVE:Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. METHODS:We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. RESULTS:Twenty outbreaks, includi...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,meta分析


    authors: Lefebvre A,Fiet C,Belpois-Duchamp C,Tiv M,Astruc K,Aho Glélé LS

    更新日期:2014-09-01 00:00:00

  • Reverse transcriptase-PCR for the detection of Astrovirus in children with nosocomial acute diarrhoea in Naples, Italy.

    abstract:OBJECTIVE:This study was made to determine the incidence of nosocomial viral gastroenteritis in all children aged 0-4 years, admitted in the Pediatric Hospital over a 3-year period. METHODS:Astrovirus was detected by reverse transcriptase-PCR; routine diagnostic tests for Rotavirus, Adenovirus, and common bacterial pa...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Galdiero E,Marinelli A,Pisciotta MG,Pagliara I,Di Monteforte ES,Liguori G

    更新日期:2005-04-01 00:00:00

  • [Chromobacterium violaceum septicemia: first case report in the French West Indies].

    abstract::We report a fatal case of Chromobacterium violaceum septicemia in a 42-year-old farm worker living in the French West Indies. The bacteria found in the muddy soil and the stagnant water of tropical and subtropical regions is rarely a source of human infection. ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Grégory A,Ribollet D,Pailla K,Bourgade M,Alma S

    更新日期:2007-09-01 00:00:00

  • [Optimized clinical use of vancomycin, a prospective observational study in a Paris teaching hospital].

    abstract:INTRODUCTION:Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal funct...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Taieb F,Le Monnier A,Bille E,Lanternier F,Mechai F,Ribadeau-Dumas F,Maenulein E,Forge C,Corriol O,Nassif X,Lortholary O,Zahar JR

    更新日期:2010-05-01 00:00:00

  • Acceptance of pregnant women's vaccination against pertussis among French women and health professionals: PREVACOQ-1 and -2 studies.

    abstract:OBJECTIVES:Protection of French young infants against pertussis only relies on their relatives' vaccination. The alternative is vaccination of pregnant women against pertussis (cocooning strategy), but this strategy is not yet recommended in France. We assessed the acceptance of this strategy among French postpartum wo...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,多中心研究


    authors: Lefebvre M,Grossi O,Chalopin M,Ferré C,Prel E,Coutherut J,Briend-Godet V,Biron C,Raffi F

    更新日期:2019-11-01 00:00:00

  • Prevalence and risk factors for low bone mineral density in antiretroviral therapy-naive HIV-infected young men.

    abstract:OBJECTIVE:We aimed to investigate the prevalence of low bone mineral density (BMD) and associated factors in antiretroviral therapy (ART)-naive HIV-infected young men. METHODS:In this cross-sectional study, dual-energy X-ray absorptiometry (DXA) was used to measure BMD. BMD at the lumbar spine, total hip and femoral n...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Paccou J,Viget N,Drumez E,Cortet B,Robineau O

    更新日期:2018-10-01 00:00:00

  • Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure.

    abstract:OBJECTIVE:The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known. PATIENTS AND METHODS:Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or kne...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Bouaziz A,Uçkay I,Lustig S,Boibieux A,Lew D,Hoffmeyer P,Neyret P,Chidiac C,Ferry T

    更新日期:2018-05-01 00:00:00

  • [Description of patients with confirmed influenza A(H1N1)pdm09 admitted to an intensive care unit and identification of severity risk factors].

    abstract:OBJECTIVE:The authors had for objective to describe patients with confirmed influenza A(H1N1)pdm09 admitted to an intensive care unit (ICU) in a university hospital and to identify risk factors correlated with the severity of the disease. DESIGN:A prospective study was conducted in an university hospital during the A(...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Payet C,Lutringer-Magnin D,Cassier P,Lina B,Argaud L,Allaouchiche B,Vanhems P

    更新日期:2013-02-01 00:00:00

  • [Epidemiology and susceptibility profile of blood culture isolates in an intensive care unit (2002-2005)].

    abstract:INTRODUCTION:The aim of our study was to determine the epidemiological profile and the antibiotics susceptibility of bacteria identified in blood culture in the intensive care unit, to improve empirical antibiotherapy. MATERIAL AND METHOD:A retrospective study was made over a four-year period (2002-2005) in the intens...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Elouennass M,Sahnoun I,Zrara A,Bajjou T,Elhamzaoui S

    更新日期:2008-01-01 00:00:00

  • [Cases of imported cholera in France, summer 2005. A. Tarantola for the incident management teams].

    abstract::Cholera is a bacterial infection, which causes digestive symptoms and massive diarrhoea. It may lead to dehydration and death if appropriate medical management is not rapidly initiated. Most cases of infection by choleric vibrio, however, remain symptom-free or may mimic common gastroenteritis. A review of two cases o...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Groupes de Gestion des Incidents.,Ajzenman C,Bizet MC,Dufraisse MP,Falip E,Fournier JM,Etchegorry MG,Haeghebaert S,Isnard H,Le Loc'h H,Mansir T,Quilici ML,Raqbi F,Raud E,Roberto Y,Scanvic A,Senellier M,Sirot S,Taranto

    更新日期:2006-06-01 00:00:00

  • [Epidemiological aspects of human herpesvirus 8 infection and of Kaposi's sarcoma].

    abstract::HHV-8 belongs to the herpesviridae family, to the gammaherpesvirinae subfamily, and to the rhadinovirus genus. Whereas several viral homologues exist in non human primates, HHV-8 is the only rhadinovirus known in human. HHV-8 is mainly the etiological agent of the four clinico-epidemiological forms of Kaposi's sarcoma...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Plancoulaine S,Gessain A

    更新日期:2005-05-01 00:00:00

  • [Management of invasive fungal infections in pediatric patient].

    abstract::Among children, an epidemiologic shift has caused an increase in non-albicans Candida infections and invasive aspergillosis, as well as infections by pathogens that were previously uncommon. These infections are frequent causes of infectious morbidity in immunocompromised children. Treatment options are limited for ch...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Groll A

    更新日期:2007-01-01 00:00:00

  • [Pseudomonas stutzeri osteitis: A case study].

    abstract::We report a case of osteitis in a 46-year-old patient, caused by Pseudomonas stutzeri following an open fracture of the left femur. The patient was treated with 1g ceftazidime every 8 hours for two weeks combined with 160 mg/day of amikacin for 10 days. A second-line ofloxacin oral treatment at 400 mg/day was then giv...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Elouennass M,Frikh M,Raissouni Z,Bajjou T,Ouaaline M

    更新日期:2006-10-01 00:00:00

  • Vaccination against meningococcus C. vaccinal coverage in the French target population.

    abstract:UNLABELLED:Immunization against meningococcus C has been recommended in France since 2009 (infants from 12 to 24 months of age, and catch up vaccination up to 25 years of age). It has been reimbursed since January 2010. We had for aim to assess the vaccine coverage in 2011. METHOD:The study population included mothers...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Stahl JP,Cohen R,Denis F,Gaudelus J,Lery T,Lepetit H,Martinot A

    更新日期:2013-02-01 00:00:00

  • Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis.

    abstract:INTRODUCTION:An increase of syphilis cases has been recorded in the past few decades, especially among HIV-infected patients. These patients often present with concomitant primary and secondary lesions or extensive presentations of syphilis. OBJECTIVE:Our goal was to compare alternative regimens to the recommended pen...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Psomas KC,Brun M,Causse A,Atoui N,Reynes J,Le Moing V

    更新日期:2012-01-01 00:00:00

  • In vitro activity of temocillin against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae strains isolated from urinary tract infections in France.

    abstract:OBJECTIVES:Temocillin was introduced in 2015 in the French guidelines for the treatment of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae urinary tract infections. Little susceptibility data is available. We investigated the in vitro activity of temocillin against ESBL-producing Enterobacteriaceae...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Duployez C,Loïez C,Cattoen C,Wallet F,Vachée A

    更新日期:2019-02-01 00:00:00

  • [Clinical efficacy and tolerance of enfuvirtide (Fuzeon), new antiretroviral inhibitors of intracellular penetration of human immunodeficiency virus (HIV) type 1].

    abstract::The TORO 1 and TORO 2 clinical trials compared the efficacy and safety of enfuvirtide in combination with an optimized background antiretroviral regimen and optimized background regimen alone in HIV-1 infected patients. The patients had had previous treatment with each of the three classes of antiretroviral drugs and ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Raffi F

    更新日期:2004-09-01 00:00:00