Antimicrobial resistance in N'Djamena (Chad): Four-year experience of the French Forward Medical and Surgical Team engaged in the "Barkhane Operation".


OBJECTIVES:Knowledge of local antimicrobial resistance (AMR) patterns is required for effective empirical treatment of bacterial diseases. Very little is known about current resistance patterns of common pathogenic bacteria in the African region and particularly in the Sahel region. We aimed to describe the local bacterial epidemiology and to determine whether French recommendations for empirical treatment could be implemented. PATIENTS AND METHODS:We performed a single-center observational study. Data was collected retrospectively from the Forward Medical and Surgical Center (FFMSC) bacterial database from January 2015 to December 2018. All bacteriological analyses, negative or positive, were included. RESULTS:A total of 2194 samples were analyzed. Infectious diseases were urinary tract infections (20.8%), bone and joint infections (20.4%), skin infections of chronic wounds (13.4%), soft tissue abscesses (13%), and gastroenteritis (10.8%). The most frequent infections were enterobacterial infections (43.6%) and staphylococcal infections (31.1%). The prevalence of AMR was 32.1%. Significantly more ESBL-producing bacteria (41.3%) were observed in the Chadian population than in the French population in N'djamena (6.3%) (P<0.001). CONCLUSIONS:We reported a high rate of ESBL-producing bacteria in N'Djamena. The use of empirical antibiotic therapies in the FFMSC may thus be questioned: French recommendations cannot be implemented in such setting and the use of carbapenems or new anti-ESBL antibiotics should be considered. Prospective studies are required to conclude.


Med Mal Infect


Cardinale M,Bourbotte-Salmon F,Scheiwe C,Boulezaz S,Ridet M,Laitselart P




Has Abstract


2020-11-01 00:00:00














  • [Implementing a community surveillance network to monitor antimicrobial resistance: the Labville network].

    abstract:BACKGROUND:In France, antimicrobial resistance monitoring is based on the contribution of many microbiological partners and networks, especially hospital laboratories. In order to complete this surveillance, the InVS implemented a network based on private-sector laboratories (PSL): the Labville network. METHOD:Stratif...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Maugat S,Georges S,Nicolau J,Mevel M,Moreau F,Laurent F,Aubry Damon H,Coignard B

    更新日期:2008-05-01 00:00:00

  • [Adequacy of new systemic antifungal agents prescriptions in a teaching hospital].

    abstract:OBJECTIVES:The aim of this study was to evaluate the adequacy and the conformity of prescriptions of new systemic antifungal drugs to guidelines and scientific data. PATIENTS AND METHODS:Each prescription of liposomal amphotericin B (lip Amb), voriconazole, and caspofungin made between May 2003 and May 2004 in a teach...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Pavese P,Ouachi Z,Vittoz JP,Lebeau B,Foroni L,Allenet B,Stahl JP,François P

    更新日期:2007-12-01 00:00:00

  • [Epidemiology and susceptibility profile of blood culture isolates in an intensive care unit (2002-2005)].

    abstract:INTRODUCTION:The aim of our study was to determine the epidemiological profile and the antibiotics susceptibility of bacteria identified in blood culture in the intensive care unit, to improve empirical antibiotherapy. MATERIAL AND METHOD:A retrospective study was made over a four-year period (2002-2005) in the intens...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Elouennass M,Sahnoun I,Zrara A,Bajjou T,Elhamzaoui S

    更新日期:2008-01-01 00:00:00

  • Ten years of experience with the pneumococcal conjugate 7-valent vaccine in children.

    abstract::In children, pneumococcus became the predominant infectious agent, after the routine use of the Hib conjugate vaccine dramatically decreased Haemophilus Influenzae type b prevalence. The incidence of invasive pneumococcal infections (IPI) and of non-invasive infections due to vaccine serotypes (VS) decreased by 80% in...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Weil Olivier C

    更新日期:2013-08-01 00:00:00

  • [Efficacy of cefotiam hexetil in acute maxillary sinusitis, with a short five day vs ten day treatment].

    abstract:OBJECTIVE:The aim of this multicentric, randomized, double blind study with direct individual benefit, was to compare two therapeutic regimens of cefotiam hexetil administration, 5 days vs 10 days, in acute maxillary sinusitis. METHOD:The study was conducted in ambulatory patients treated by general practitioners acco...

    journal_title:Medecine et maladies infectieuses

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Gehanno P,Loncle-Provot V,Le Kerneau J

    更新日期:2004-10-01 00:00:00

  • The impact of the web and social networks on vaccination. New challenges and opportunities offered to fight against vaccine hesitancy.

    abstract:OBJECTIVE:Vaccine hesitancy is a growing and threatening trend, increasing the risk of disease outbreaks and potentially defeating health authorities' strategies. We aimed to describe the significant role of social networks and the Internet on vaccine hesitancy, and more generally on vaccine attitudes and behaviors. M...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Stahl JP,Cohen R,Denis F,Gaudelus J,Martinot A,Lery T,Lepetit H

    更新日期:2016-05-01 00:00:00

  • The vaccination coverage in dispensaries on Mayotte Island is lacking for natives and migrants alike.

    abstract:OBJECTIVE:Assessing the vaccination coverage rate in Mayotte dispensaries. PATIENTS AND METHODS:Prospective study in three dispensaries from June to July 2019. RESULTS:Of the 162 patients included, 78% (126/162) were natives of the island and 19% (30/162) were from the Comoros Islands. Twenty-three percent (37/162) w...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Pascal C,Lesens O

    更新日期:2020-10-15 00:00:00

  • [MRI of knee tuberculous arthritis].

    abstract::Tuberculous arthritis is rare and the diagnosis may be confused with inflammatory arthritis. Only few cases, explored by MRI, have been reported in the literature. We report 3 cases of tuberculous arthritis of the knee revealed by insidious pain. The abnormalities revealed by MRI suggested tuberculosis. Diagnosis was ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Oueslati S,Douira W,Dhieb R,Charada L,Mlika N,Rezgui L,Zaouia K,Jamoussi M,Mnif N,Chaabene M

    更新日期:2007-09-01 00:00:00

  • [Optimized clinical use of vancomycin, a prospective observational study in a Paris teaching hospital].

    abstract:INTRODUCTION:Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal funct...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Taieb F,Le Monnier A,Bille E,Lanternier F,Mechai F,Ribadeau-Dumas F,Maenulein E,Forge C,Corriol O,Nassif X,Lortholary O,Zahar JR

    更新日期:2010-05-01 00:00:00

  • HIV self-testing in adolescents living in Sub-Saharan Africa.

    abstract::Less than 20% of African adolescents aged 10-19 years are aware of their HIV status, whereas HIV screening remains the gateway to care and while AIDS has become the leading cause of death among adolescents in Sub-Saharan Africa. According to the UNAIDS target, scalable HIV testing strategies specific to various age gr...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Tonen-Wolyec S,Koyalta D,Mboumba Bouassa RS,Filali M,Batina-Agasa S,Bélec L

    更新日期:2020-11-01 00:00:00

  • Key features of bone and joint infections following the implementation of reference centers in France.

    abstract:OBJECTIVES:French reference centers for bone and joint infections (BJI) were implemented from 2009 onwards to improve the management of complex BJIs. This study compared BJI burden before and after the implementation of these reference centers. PATIENTS AND METHODS:BJI hospital stays were selected from the 2008 and 20...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Laurent E,Gras G,Druon J,Rosset P,Baron S,Le-Louarn A,Rusch E,Bernard L,Grammatico-Guillon L

    更新日期:2018-06-01 00:00:00

  • [Evolution of influenza vaccination coverage in France from 2001 to 2006].

    abstract:INTRODUCTION:The increased risk of a new influenza pandemic has raised awareness of the need for high influenza vaccination rates. OBJECTIVES:This study aims at assessing trends in influenza vaccination coverage from 2001 to 2006 in France, at understanding the drivers and barriers, and to identify vaccination intenti...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Lina B,Holm MV,Szucs TD

    更新日期:2008-03-01 00:00:00

  • [Adherence to antibiotherapy guidelines for acute community-acquired pneumonia in adults, in a teaching hospital].

    abstract:OBJECTIVE:The authors had for aim to assess the conformity of antibiotic prescription with guidelines, for the management of community-acquired pneumonia, in a French University Hospital. DESIGN:This prospective study included adults patients hospitalized for pneumonia over a period of six months. The attending physic...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Martinez JS,Le Falher G,Corne P,Bourdin A,Lequellec A,Delabre JP,Makinson A,Hansel S,Reynes J,Le Moing V

    更新日期:2010-08-01 00:00:00

  • Hepatitis B virus vaccination by French family physicians.

    abstract:UNLABELLED:Vaccine coverage against hepatitis B virus (HBV) in France has decreased to one of the lowest levels among countries that recommend it, over the last decade. The probable cause was that the vaccine was suspected to induce demyelinating diseases. We studied the factors limiting the use of HBV vaccine amongst ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: François M,Alla F,Rabaud C,Raphaël F

    更新日期:2011-10-01 00:00:00

  • Risk factors for quinolone-resistance in women presenting with Escherichia coli acute pyelonephritis.

    abstract:UNLABELLED:In France, according to the National Epidemiology Observatory of Bacterial Resistance to Antibiotics, 15.3% of outpatient urinary Escherichia coli isolates were fluoroquinolone-resistant in 2010. This puts to question the relevance of empirical fluoroquinolone therapy for community-acquired acute pyelonephri...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,多中心研究


    authors: Bedoin M,Cazorla C,Lucht F,Berthelot P,Boyer M,Carricajo A,Guérin T,Viallon A

    更新日期:2014-05-01 00:00:00

  • [Epidemiology of patients harboring extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBLE), on admission].

    abstract:OBJECTIVE:The incidence of extended-spectrum beta-lactamase-producing enterobacteria (ESBLE) has regularly increased over the last few years. However, little is known about epidemiology of ESBLE carriers in France. The objective of this study was to determine the ESBLE carriers or infected patients profile, identified ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Guillet M,Bille E,Lecuyer H,Taieb F,Masse V,Lanternier F,Lage-Ryke N,Talbi A,Degand N,Lortholary O,Nassif X,Zahar JR

    更新日期:2010-11-01 00:00:00

  • [Inter-individual and intra-individual pharmacokinetic variability during teicoplanin therapy in geriatric patients].

    abstract:OBJECTIVES:The authors had for aim to assess the inter- and intra-individual variability of teicoplanin pharmacokinetic parameters in geriatric patients. METHODS:A cohort of 90 geriatric patients, treated with teicoplanin, was used to build two models describing the pharmacokinetics of teicoplanin, at the beginning an...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Uhart M,Leroy B,Michaud A,Maire P,Bourguignon L

    更新日期:2013-07-01 00:00:00

  • [Risk factors for dryness or irritation of staff hands in nine healthcare institutions].

    abstract:OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,多中心研究


    authors: Sacleux P,Bozec A,Veyres P,Negrin N,Vandenbos F,Bondiau PY,Duval MJ,Lambert S,Mazzoni L,Chapuis V,Bodokh I,Dandine M,Chamorey E

    更新日期:2011-03-01 00:00:00

  • Antibiotic susceptibility and mechanisms of beta-lactam resistance among clinical strains of Pseudomonas aeruginosa: first report in Algeria.

    abstract:OBJECTIVE:Pseudomonas aeruginosa is a major causative agent of hospital infections. Studies on this subject being rare in Algeria, we determined the antibiotic susceptibility of P. aeruginosa and investigated the mechanisms of beta-lactam resistance and the spread of multidrug resistant strains in the university affili...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Drissi M,Ahmed ZB,Dehecq B,Bakour R,Plésiat P,Hocquet D

    更新日期:2008-04-01 00:00:00

  • [From Whipple's disease to Tropheryma whipplei infections].

    abstract::The first successful culture of Tropheryma whipplei made 10 years ago opened the way for identification of the bacterium and the development of many diagnostic tools. Phylogenetic analyses made it possible to classify it among Gram positive bacilli in the family of Actinomycetes, close to other ubiquitous bacteria of ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Lagier JC,Fenollar F,Raoult D

    更新日期:2010-07-01 00:00:00

  • [The point on human rabies in Senegal from 1986 to 2005].

    abstract::Between 1986 and 2005, 54 patients were hospitalized for rabies in the infectious diseases clinic, with an average of 3 cases a year. The patients came from almost all regions of Senegal, Dakar (11 cases), Thiès (9 cases), and Fatick (9 cases). They were native of rural and suburban zones. The median age was 19 years ...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Diop SA,Manga NM,Dia NM,Ndour CT,Seydi M,Soumare M,Diop BM,Sow PS

    更新日期:2007-12-01 00:00:00

  • Importance of Madagascar's HIV/AIDS reference laboratory.

    abstract:OBJECTIVE:We aimed to describe the challenge faced by the national reference laboratory to support the national HIV/AIDS response in Madagascar. METHODS:Collaboration between the National Reference Laboratory of Madagascar (NRLM) and foreign partners (a laboratory and an international organization) on the basis of a t...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Andriantsimietry SH,Razanakolona RL

    更新日期:2016-05-01 00:00:00

  • [Policies for the use of antibiotic in 99 Southwestern French hospitals in 2002].

    abstract:OBJECTIVE:Increasing antimicrobial resistance in bacteria is a major health problem and requires the implementation of stringent policies to optimize the use of antibiotics. DESIGN:In 2003 the authors conducted a study in southwestern French hospitals, using a questionnaire to assess the implementation of antibiotic p...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Rogues AM,Dumartin C,Parneix P,Prudhon H,Placet-Thomazeau B,Beneteau C,Dosque JP,Marty N,Labadie JC,Gachie JP

    更新日期:2005-11-01 00:00:00

  • [Cases of imported cholera in France, summer 2005. A. Tarantola for the incident management teams].

    abstract::Cholera is a bacterial infection, which causes digestive symptoms and massive diarrhoea. It may lead to dehydration and death if appropriate medical management is not rapidly initiated. Most cases of infection by choleric vibrio, however, remain symptom-free or may mimic common gastroenteritis. A review of two cases o...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Groupes de Gestion des Incidents.,Ajzenman C,Bizet MC,Dufraisse MP,Falip E,Fournier JM,Etchegorry MG,Haeghebaert S,Isnard H,Le Loc'h H,Mansir T,Quilici ML,Raqbi F,Raud E,Roberto Y,Scanvic A,Senellier M,Sirot S,Taranto

    更新日期:2006-06-01 00:00:00

  • [Self-medication with antibiotics obtained from private pharmacies in Abidjan, Ivory Coast].

    abstract:UNLABELLED:Self-medication with antibiotics is all the more disturbing in developing countries where this type of medication is easily available, and often without any prescription. OBJECTIVES:The authors wanted to assess and describe self-medication with antibiotics and identify the factors and public perception asso...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Hounsa A,Kouadio L,De Mol P

    更新日期:2010-06-01 00:00:00

  • Urinary tract infections in patients with neurogenic bladder.

    abstract::Urinary tract infections (UTIs) in patients with neurogenic bladder are a major public health issue due to their high incidence and major consequences. Despite their frequency and potential severity, their physiopathology and management are poorly known. We provide a narrative literature review on the epidemiology, ph...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,评审


    authors: Dinh A,Davido B,Duran C,Bouchand F,Gaillard JL,Even A,Denys P,Chartier-Kastler E,Bernard L

    更新日期:2019-10-01 00:00:00

  • Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis.

    abstract:PURPOSE:Invasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor. PATIENTS AND METHOD:We reported three additional cases and reviewed 16 previous published cases together wi...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Brochard J,Morio F,Mahe J,Le Pape P,Guimard T,Mahe B,Leterrier M,Morrier M,Raffi F,Boutoille D

    更新日期:2020-11-01 00:00:00

  • [Analysis of motivations for antiflu vaccination of the Clermont-Ferrand University Hospital staff].

    abstract:OBJECTIVE:The vaccination of hospital staff decreases patient mortality and disorganization of services due to sick leave. The main aim of our study was to determine the Clermont-Ferrand University hospital (CHU) personnel's motivations for or against antiflu vaccination to increase the effectiveness of prevention camp...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章


    authors: Kelly C,Dutheil F,Haniez P,Boudet G,Rouffiac K,Traore O,Chamoux A

    更新日期:2008-11-01 00:00:00

  • Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis.

    abstract::Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Seco...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章,实务指引,评审


    authors: Figoni J,Chirouze C,Hansmann Y,Lemogne C,Hentgen V,Saunier A,Bouiller K,Gehanno JF,Rabaud C,Perrot S,Caumes E,Eldin C,de Broucker T,Jaulhac B,Roblot F,Toubiana J,Sellal F,Vuillemet F,Sordet C,Fantin B,Lina G,Goc

    更新日期:2019-08-01 00:00:00

  • [Treatment of latent tuberculosis-infection: aiming at a change of practices in France].

    abstract::Treatment indications for tuberculosis-infection depend on each case, but also on public health policy in each country. This policy usually made at the national level depends on tuberculosis epidemiology of the population concerned and on the country's socio-economic level of development, and more especially of its he...

    journal_title:Medecine et maladies infectieuses

    pub_type: 杂志文章



    更新日期:2004-08-01 00:00:00