Abstract:
OBJECTIVES:The proper use of antibiotics is a public health priority to preserve their effectiveness. Little data is available on outpatient antibiotic prescriptions, especially in the emergency department. We aimed to assess the quality of outpatient antibiotic prescriptions in our hospital. PATIENTS AND METHODS:Retrospective monocentric study of antibiotic prescriptions written to adult patients managed at the emergency department without hospitalization (November 15th, 2012-November 15th, 2013). Prescriptions were evaluated by an infectious disease specialist and an emergency physician on the basis of local recommendations compiled from national and international guidelines. RESULTS:A total of 760 prescriptions were reviewed. The most frequent indications were urinary tract infections (n=263; 34.6%), cutaneous infections (n=198; 26.05%), respiratory tract infections (n=101; 13.28%), and ENT infections (n=62; 8.15%). The most frequently prescribed antibiotics were fluoroquinolones (n=314; 40.83%) and amoxicillin-clavulanic acid (n=245; 31.85%). Overall, 455 prescriptions (59.86%) did not comply with guidelines. The main reasons for inadequacy were the absence of an indication for antibiotic therapy (n=197; 40.7%), an inadequate spectrum of activity, i.e. too broad, (n=95; 19.62%), and excessive treatment duration (n=87; 17.97%). Rates of inadequate prescriptions were 82.26% for ENT infections, 71.2% for cutaneous infections, 46.53% for respiratory tract infections, and 38.4% for urinary tract infections. CONCLUSION:Antibiotic prescriptions written to outpatients in the emergency department are often inadequate. Enhancing prescribers' training and handing out guidelines is therefore necessary. The quality of these prescriptions should then be re-assessed.
journal_name
Med Mal Infectjournal_title
Medecine et maladies infectieusesauthors
Grenet J,Davido B,Bouchand F,Sivadon-Tardy V,Beauchet A,Tritz T,Guyot C,Perronne C,Gaillard JL,Salomon J,Beaune S,Dinh Adoi
10.1016/j.medmal.2016.04.006subject
Has Abstractpub_date
2016-06-01 00:00:00pages
207-14issue
4eissn
0399-077Xissn
1769-6690pii
S0399-077X(16)30014-2journal_volume
46pub_type
杂志文章abstract:OBJECTIVES:Streptococcus agalactiae (Group B streptococcus) is a major cause of invasive diseases in non-pregnant adults, particularly in the elderly and those with underlying conditions. We describe these conditions and clinical characteristics of patients followed in our teaching hospital. METHODS:We retrospectively...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2007.04.003
更新日期:2007-12-01 00:00:00
abstract::In children, pneumococcus became the predominant infectious agent, after the routine use of the Hib conjugate vaccine dramatically decreased Haemophilus Influenzae type b prevalence. The incidence of invasive pneumococcal infections (IPI) and of non-invasive infections due to vaccine serotypes (VS) decreased by 80% in...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2013.04.006
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Our study dealt with antibiotic resistance and serotypes of Pseudomonas aeruginosa strains isolated from immunocompromised patients in the National Bone Marrow Transplant Center of Tunis as well as molecular typing of ceftazidime resistant strains (CAZ-R). DESIGN:We studied a total of 87 non-replicate P. aer...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2005.08.006
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Protection of French young infants against pertussis only relies on their relatives' vaccination. The alternative is vaccination of pregnant women against pertussis (cocooning strategy), but this strategy is not yet recommended in France. We assessed the acceptance of this strategy among French postpartum wo...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medmal.2019.09.001
更新日期:2019-11-01 00:00:00
abstract::Since the beginning of the HIV epidemic in France, surveys aimed at better understanding risk perceptions of HIV infection and preventive sexual behaviors have been implemented in the general population, and in populations such as IVDU and homosexual men, more concerned by risks of HIV transmission. The objective of t...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2005.03.004
更新日期:2005-05-01 00:00:00
abstract::The first successful culture of Tropheryma whipplei made 10 years ago opened the way for identification of the bacterium and the development of many diagnostic tools. Phylogenetic analyses made it possible to classify it among Gram positive bacilli in the family of Actinomycetes, close to other ubiquitous bacteria of ...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2009.10.017
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to estimate the frequency of methicillin-resistant Staphylococcus aureus (MRSA) strains in the French community and the proportion of Panton-Valentine (PVL)-MRSA. DESIGN:A cross-sectional study was made during a 3-month period in 2003 through a network of private-sector, community-b...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2009.03.007
更新日期:2009-05-01 00:00:00
abstract:UNLABELLED:The aim of this study was to evaluate the clinical efficacy of telithromycin administered for 5 days at a dosage of 800 mg/day, in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) presenting with at least 2 of Anthonisen's criteria including the increase of purulence. METHO...
journal_title:Medecine et maladies infectieuses
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.medmal.2005.08.008
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To determine predictive factors of treatment interruption (TI) duration within a cohort of HIV-1 infected patients having stopped their treatment with CD4 above 350 cells per mm(3). DESIGN:Data were collected from computerized medical records. Patients were selected if they were HIV-1 positive, 18 years of a...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2006.01.009
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Assessing the vaccination coverage rate in Mayotte dispensaries. PATIENTS AND METHODS:Prospective study in three dispensaries from June to July 2019. RESULTS:Of the 162 patients included, 78% (126/162) were natives of the island and 19% (30/162) were from the Comoros Islands. Twenty-three percent (37/162) w...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.10.011
更新日期:2020-10-15 00:00:00
abstract::Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Seco...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.medmal.2019.04.381
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Extended-spectrum β-lactamases are widespread in hospital settings worldwide. The prevalence of ESBL producing Klebsiella pneumoniae (ESBL-KP) strains isolated from patients has recently increased in Tunisia. We conducted this study to determine the prevalence and the genetic characterization of ESBL-KP in a...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2015.01.010
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:We performed a prospective multicenter study to assess dryness and irritation of hands of staff in care facilities, and to show that disinfection with alcohol-based hand rub is better tolerated than classic hand washing with mild soap. METHOD:Dryness and irritation were self-evaluated by volunteers and heter...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medmal.2010.09.021
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Acinetobacter baumannii is a ubiquitous pathogen resistant to desiccation and responsible for healthcare-associated infections (HAI), especially in intensive care units (ICU) where it is responsible for 5-10% of HAIs. An A. baumannii outbreak occurred in the ICU of the University Hospital of Angers, France...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2017.06.003
更新日期:2017-10-01 00:00:00
abstract::Among children, an epidemiologic shift has caused an increase in non-albicans Candida infections and invasive aspergillosis, as well as infections by pathogens that were previously uncommon. These infections are frequent causes of infectious morbidity in immunocompromised children. Treatment options are limited for ch...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/s0399-077x(07)80054-0
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Most antibiotic therapies are initiated in the emergency unit (EU). To better understand the antibiotic consumption survey in this unit, we compared our results to two neighbor hospitals. This quantitative data was then compared to a quality assessment of antibiotic prescription (audit). METHODS:The quant...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2008.10.020
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:The aim of this multicentric, randomized, double blind study with direct individual benefit, was to compare two therapeutic regimens of cefotiam hexetil administration, 5 days vs 10 days, in acute maxillary sinusitis. METHOD:The study was conducted in ambulatory patients treated by general practitioners acco...
journal_title:Medecine et maladies infectieuses
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2004-10-01 00:00:00
abstract:UNLABELLED:Self-medication with antibiotics is all the more disturbing in developing countries where this type of medication is easily available, and often without any prescription. OBJECTIVES:The authors wanted to assess and describe self-medication with antibiotics and identify the factors and public perception asso...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2009.10.002
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:One-stage replacement arthroplasty for treatment of periprosthetic joint infection (PJI) results in similar cure rate than two-stage (around 85-92%), but antibiotic therapy duration is not well established. The aim of this study was to evaluate the efficacy of a short six-week antibiotic course in periprosth...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2020.03.003
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known. PATIENTS AND METHODS:Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or kne...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2017.09.016
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Increasing antimicrobial resistance in bacteria is a major health problem and requires the implementation of stringent policies to optimize the use of antibiotics. DESIGN:In 2003 the authors conducted a study in southwestern French hospitals, using a questionnaire to assess the implementation of antibiotic p...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2005.09.004
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:We aimed to describe the challenge faced by the national reference laboratory to support the national HIV/AIDS response in Madagascar. METHODS:Collaboration between the National Reference Laboratory of Madagascar (NRLM) and foreign partners (a laboratory and an international organization) on the basis of a t...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2016.03.003
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:Temocillin was introduced in 2015 in the French guidelines for the treatment of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae urinary tract infections. Little susceptibility data is available. We investigated the in vitro activity of temocillin against ESBL-producing Enterobacteriaceae...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2018.10.007
更新日期:2019-02-01 00:00:00
abstract::Lyme disease diagnosis is currently based on serology - an indirect diagnostic method - as laboratory cultures are fastidious. The only direct diagnostic method that can be useful with some specimens (cutaneous biopsies or aspiration fluid) is PCR. We aimed to detail the main limitations of serology and PCR testing in...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2018.12.004
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Improving the use of antimicrobial drugs is a national objective. To this end an evaluation of clinical practice was implemented on prescribed antibiotics in elderly patients, in the Besançon Teaching Hospital. DESIGN:In 2005, a clinical audit compared the adequacy of antibiotic prescriptions to national gui...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2011.02.002
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the prevalence of low bone mineral density (BMD) and associated factors in antiretroviral therapy (ART)-naive HIV-infected young men. METHODS:In this cross-sectional study, dual-energy X-ray absorptiometry (DXA) was used to measure BMD. BMD at the lumbar spine, total hip and femoral n...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2018.02.009
更新日期:2018-10-01 00:00:00
abstract::The TORO 1 and TORO 2 clinical trials compared the efficacy and safety of enfuvirtide in combination with an optimized background antiretroviral regimen and optimized background regimen alone in HIV-1 infected patients. The patients had had previous treatment with each of the three classes of antiretroviral drugs and ...
journal_title:Medecine et maladies infectieuses
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-09-01 00:00:00
abstract::Any person travelling in countries where yellow fever (YF) is endemic and without presenting contra-indication for the vaccination against YF may be vaccinated. This vaccination can very rarely induce a potentially lethal neurotropic or viscerotropic disease. In severely immunodeficient patients, the vaccination is co...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2008.06.031
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Varicella occurring in healthy adults may extend to the lungs. Diagnosing this complication is sometimes difficult because of the discrepancy between imaging and clinical presentation usually reported in this affection. METHOD:The authors report the result of a retrospective study on 106 immunocompetent p...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章
doi:10.1016/j.medmal.2008.09.025
更新日期:2009-02-01 00:00:00
abstract::This review concerning the major lower respiratory tract pathogens in France has for aim to describe the epidemiology of resistance to beta-lactams, macrolides, ketolides, and fluoroquinolones especially in Streptococcus pneumoniae and Haemophilus influenzae. It should also provide new insights on the mechanisms of ac...
journal_title:Medecine et maladies infectieuses
pub_type: 杂志文章,评审
doi:10.1016/j.medmal.2006.05.015
更新日期:2006-11-01 00:00:00