Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation.

abstract：BACKGROUND:Treatment of older patients with non-Hodgkin's lymphoma (NHL) is difficult and conflicting. Lower responsiveness to therapy has been reported; however, the high risk of treatment morbidity, drug-dose reduction, and the occurrence of unrelated deaths might account for the poor outcome of NHL in the elderly. ...

journal_title：Haematologica

authors： Orlandi E,Lazzarino M,Brusamolino E,Castelli G,Pagnucco G,Morra E,Bernasconi C

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS:We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based ...

journal_title：Haematologica

authors： Barragán E,Montesinos P,Camos M,González M,Calasanz MJ,Román-Gómez J,Gómez-Casares MT,Ayala R,López J,Fuster Ó,Colomer D,Chillón C,Larrayoz MJ,Sánchez-Godoy P,González-Campos J,Manso F,Amador ML,Vellenga E,Lowenberg B

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS:We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurre...

journal_title：Haematologica

authors： Ferrero D,Pogliani EM,Rege-Cambrin G,Fava C,Mattioli G,Dellacasa C,Campa E,Perfetti P,Fumagalli M,Boccadoro M

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied ...

journal_title：Haematologica

authors： Buyse M,Michiels S,Squifflet P,Lucchesi KJ,Hellstrand K,Brune ML,Castaigne S,Rowe JM

更新日期：2011-08-01 00:00:00

abstract：:In this article we summarize the clinical outcome of unrelated placental/umbilical cord blood (CB) transplantation, discuss the biological characteristics of CB hematopoietic progenitor/stem cells (HPC) and balance the relative advantages and disadvantages of this therapy as compared with transplantation of other HPC ...

journal_title：Haematologica

authors： Sirchia G,Rebulla P

更新日期：1999-08-01 00:00:00

abstract：:A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n = 43) were allogeneic recipients with osteonecrosis, and the controls (n = 129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed t...

journal_title：Haematologica

authors： Faraci M,Calevo MG,Lanino E,Caruso S,Messina C,Favr C,Iori A,Santaron S,Bonanomi S,Rondelli R,Dini G,Haupt R,AIEOP-SCT Group.

更新日期：2006-08-01 00:00:00

abstract：:The introduction of agents inhibiting the BCR-associated kinases such as ibrutinib has dramatically changed treatments algorithms of chronic lymphocytic leukaemia (CLL) as well as the role of different adverse prognosticators. We evaluated the efficacy of ibrutinib as single agent, in a real-life context, on 180 patie...

journal_title：Haematologica

authors： Del Poeta G,Biagi A,Laurenti L,Chiarenza A,Pozzo F,Innocenti I,Postorino M,Rossi FM,Del Principe MI,Bomben R,de Fabritiis P,Bruno A,Cantonetti M,Di Raimondo F,Zucchetto A,Gattei V

更新日期：2020-07-30 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acquired red cell aplasia (RCA) is a rare disorder and can be either idiopathic or associated with certain diseases, pregnancy, or drugs. In exceptionally rare cases, it has been reported to co-exist with other autoimmune cytopenias. We report a high incidence of RCA and autoimmune hemolytic a...

journal_title：Haematologica

authors： Elimelakh M,Dayton V,Park KS,Gruessner AC,Sutherland D,Howe RB,Reding MT,Eastlund T,van Burik JA,Singleton TP,Gruessner RW,Key NS

更新日期：2007-08-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma originates from a background of diverse chronic inflammatory disorders at various anatomic sites. The genetics underlying its development, particularly in those associated with autoimmune disorders, is poorly characterized. By whole exome sequencing of 21 cases of MALT...

journal_title：Haematologica

authors： Moody S,Thompson JS,Chuang SS,Liu H,Raderer M,Vassiliou G,Wlodarska I,Wu F,Cogliatti S,Robson A,Ashton-Key M,Bi Y,Goodlad J,Du MQ

更新日期：2018-08-01 00:00:00

abstract：:We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 de...

journal_title：Haematologica

authors： Morkbak AL,Hvas AM,Milman N,Nexo E

更新日期：2007-12-01 00:00:00

abstract：:By combining the polymerase chain reaction (PCR) of the gamma globin gene promoters with synthetic oligonucleotide analysis we have diagnosed the -196 C----T and the -117 G----A substitutions in heterozygous carriers of non deletional A gamma HPFH from two unrelated Italian families. The identification of the beta-tha...

journal_title：Haematologica

authors： Gottardi E,Alfarano A,Serra A,Sciarratta G,Bertero MT,Saglio G,Camaschella C

更新日期：1990-01-01 00:00:00

abstract：:Aplastic anemia is usually treated with immunosuppression or allogeneic transplant, depending on patient and disease characteristics. Syngeneic transplant offers a rare treatment opportunity with minimal transplant-related mortality, and offers an insight into disease mechanisms. We present here a retrospective analys...

journal_title：Haematologica

authors： Gerull S,Stern M,Apperley J,Beelen D,Brinch L,Bunjes D,Butler A,Ganser A,Ghavamzadeh A,Koh MB,Komarnicki M,Kröger N,Maertens J,Maschan A,Peters C,Rovira M,Sengeløv H,Socié G,Tischer J,Oneto R,Passweg J,Marsh J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A phase II study was conducted to investigate the effects of a therapeutic program based on the combination of fludarabine and cytarabine (ARA-C) administered as a sequential continuous infusion in untreated elderly patients with acute myeloid leukemia (AML). DESIGN AND METHODS:Sixty-three pa...

journal_title：Haematologica

authors： Ferrara F,D'Arco AM,De Simone M,Mele G,Califano C,Pocali B,Danise P,Palmieri S

更新日期：2005-06-01 00:00:00

abstract：:As the defective genes for more and more genetic disorders become unravelled, it is clear that patients with apparently identical genotypes can have many different clinical conditions even in simple monogenic disorders. Beta thalassemia occurs when there is a deficiency in the synthesis of beta globin chains. The clin...

journal_title：Haematologica

authors： Thein SL

更新日期：2005-05-01 00:00:00

abstract：:Our objectives were to evaluate thrombotic complications in patients with lupus anticoagulant fulfilling Sapporo criteria, anticoagulated with an intended INR 2.0-3.0 due to venous and arterial thrombosis. In our series standard anticoagulation was safe and efficacious in preventing recurrences in patients with system...

journal_title：Haematologica

authors： Casais P,Alberto MF,Gennari LC,Grosso SH,Meschengieser SS,Lazzari MA

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cord blood (CB) is a valuable source of stem cells. Most CB units are still cryopreserved in single bags in the world's CB banks. Thawing a single CB unit, dividing it into two parts, expanding the smaller one and refreezing the other would optimize ex vivo expansion of CB progenitors prior to...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Saracco P,Doria A,Fazio L,Albiani R,Cordero Di Montezemolo L,Perugini L,Incarbone E

更新日期：2003-01-01 00:00:00

abstract：:Post-transfusion hepatitis (PTH) is a major problem in patients with acute leukemias requiring blood products during induction or consolidation therapy. In fact, PTH causes delays of chemotherapy with major violations in the timing of protocols. In order to assess the efficacy and safety of a short course of alpha-int...

journal_title：Haematologica

authors： Almasio P,Mirto S,Malleo C,Di Marco V,Caronia F,Craxi A

更新日期：1991-09-01 00:00:00

abstract：:Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe a...

journal_title：Haematologica

authors： Buerkli S,Pei SN,Hsiao SC,Lee CT,Zeder C,Zimmermann MB,Moretti D

更新日期：2020-10-05 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS:We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in...

journal_title：Haematologica

authors： Alter BP,Rosenberg PS,Giri N,Baerlocher GM,Lansdorp PM,Savage SA

更新日期：2012-03-01 00:00:00

abstract：:Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...

journal_title：Haematologica

authors： Al-Sharea A,Lee MKS,Whillas A,Michell DL,Shihata WA,Nicholls AJ,Cooney OD,Kraakman MJ,Veiga CB,Jefferis AM,Jackson K,Nagareddy PR,Lambert G,Wong CHY,Andrews KL,Head GA,Chin-Dusting J,Murphy AJ

更新日期：2019-03-01 00:00:00

abstract：:Interleukin-10 failed to modify either the percentage of bcl-2+ cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and fludarabine-induced apoptosis. The cytokine at 0.1 ng/mL induced an increase of cell survival both in the absence or in the presence of 2-chlorodeoxyadenosine, while no diffe...

journal_title：Haematologica

authors： Morabito F,Filangeri M,Sculli G,Oliva B

更新日期：1998-11-01 00:00:00

abstract：:Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten trial groups contributed remission samples from patients aged 1.0-17.9 years treated for acute lymphobl...

journal_title：Haematologica

authors： Wolthers BO,Frandsen TL,Patel CJ,Abaji R,Attarbaschi A,Barzilai S,Colombini A,Escherich G,Grosjean M,Krajinovic M,Larsen E,Liang DC,Möricke A,Rasmussen KK,Samarasinghe S,Silverman LB,van der Sluis IM,Stanulla M,Tulstr

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：:In this open label pilot safety study 80 children over 3 months old with deep venous thrombosis were treated with enoxaparin with a target 4 h anti-factor Xa activity between 0.5-0.8 IU/mL. The children were stratified to receive once daily or twice daily doses. The study end-points were post-thrombotic syndrome, re-t...

journal_title：Haematologica

authors： Schobess R,Düring C,Bidlingmaier C,Heinecke A,Merkel N,Nowak-Göttl U

更新日期：2006-12-01 00:00:00

abstract：:Second-line therapy for corticosteroid-refractory or -dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints. Six-month freedom from treatment failure has been proposed as a novel clinical trial endpoint and is defined by the absence of dea...

journal_title：Haematologica

authors： Das-Gupta E,Greinix H,Jacobs R,Zhou L,Savani BN,Engelhardt BG,Kassim A,Worel N,Knobler R,Russell N,Jagasia M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present ...

journal_title：Haematologica

authors： R'zik S,Loo M,Beguin Y

更新日期：2001-03-01 00:00:00

abstract：:Multiple myeloma is preceded by an asymptomatic phase, comprising monoclonal gammopathy of uncertain significance and smoldering myeloma. Compared to the former, smoldering myeloma has a higher and non-uniform rate of progression to clinical myeloma, reflecting a subset of patients with higher risk. We evaluated the g...

journal_title：Haematologica

authors： Khan R,Dhodapkar M,Rosenthal A,Heuck C,Papanikolaou X,Qu P,van Rhee F,Zangari M,Jethava Y,Epstein J,Yaccoby S,Hoering A,Crowley J,Petty N,Bailey C,Morgan G,Barlogie B

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...

journal_title：Haematologica

authors： Woods AI,Meschengieser SS,Blanco AN,Salviú MJ,Farías CE,Kempfer AC,Lazzari MA

更新日期：2001-04-01 00:00:00

abstract：:The mouse pro-B cell line Ba/F3 has gained major interest as a model system to investigate oncogenic tyrosine kinases and to determine the efficacy of kinase inhibitors. While Ba/F3 cells are suitable to study oncogenic kinases derived from various cell types, the signaling networks in Ba/F3 cells are B-cell specific....

journal_title：Haematologica

authors： Kleppe M,Mentens N,Tousseyn T,Wlodarska I,Cools J

更新日期：2011-05-01 00:00:00

abstract：:Treatment of primary breast lymphoma (PBL) remains unsatisfactory. We assess a clinical study to evaluate efficacy and toxicity of a dose dense regimen (CEOP-14) and rituximab in 32 previously untreated female patients with PBL in early stage. There was no difference in complete response rate (87%), event free-surviva...

journal_title：Haematologica

authors： Avilés A,Castañeda C,Neri N,Cleto S,Nambo MJ

更新日期：2007-08-01 00:00:00