Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy.

abstract：:Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (AML). Multiple aspects of platelet function are impaired in these patients, associated with altered expression of genes regulated by RUNX1 We aimed to identify RUN...

journal_title：Haematologica

authors： Glembotsky AC,Sliwa D,Bluteau D,Balayn N,Marin Oyarzún CP,Raimbault A,Bordas M,Droin N,Pirozhkova I,Washington V,Goette NP,Marta RF,Favier R,Raslova H,Heller PG

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but t...

journal_title：Haematologica

authors： Khan AE,Gallo V,Linseisen J,Kaaks R,Rohrmann S,Raaschou-Nielsen O,Tjønneland A,Johnsen HE,Overvad K,Bergmann MM,Boeing H,Benetou V,Psaltopoulou T,Trichopoulou A,Masala G,Mattiello A,Grioni S,Tumino R,Vermeulen RC,Pe

更新日期：2008-06-01 00:00:00

abstract：:The long-term repopulating capacity of mobilized peripheral blood (MPB) CD34+ cells can be abrogated during ex vivo expansion due to cell-cycle related changes. In this study, we traced cell cycle kinetic and quiescent status of CD34+ cells during ex vivo expansion with exogenous cytokines. The addition of interleukin...

journal_title：Haematologica

authors： Sanchez-Garcia J,Torres A,Herrera C,Alvarez MA

更新日期：2006-01-01 00:00:00

abstract：:Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearranged leukemia by CRISPR-Cas9 mediated deletion of MN1. MN1 was require...

journal_title：Haematologica

authors： Sharma A,Jyotsana N,Gabdoulline R,Heckl D,Kuchenbauer F,Slany RK,Ganser A,Heuser M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The increasing application of multi-color flow cytometry assays for staging and follow-up in mantle cell lymphoma necessitates that the specificity and sensitivity of this technique are evaluated. Data from prospective clinical trials comparing the clinical applicability of flow cytometry to routine diagnost...

journal_title：Haematologica

authors： Böttcher S,Ritgen M,Buske S,Gesk S,Klapper W,Hoster E,Hiddemann W,Unterhalt M,Dreyling M,Siebert R,Kneba M,Pott C,EU MCL MRD Group.

更新日期：2008-04-01 00:00:00

abstract：:Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to inve...

journal_title：Haematologica

authors： Timmer TC,de Groot R,Rijnhart JJM,Lakerveld J,Brug J,Perenboom CWM,Baart MA,Prinsze FJ,Zalpuri S,van der Schoot EC,de Kort WLAM,van den Hurk K

更新日期：2020-10-01 00:00:00

abstract：:Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...

journal_title：Haematologica

authors： Al-Sharea A,Lee MKS,Whillas A,Michell DL,Shihata WA,Nicholls AJ,Cooney OD,Kraakman MJ,Veiga CB,Jefferis AM,Jackson K,Nagareddy PR,Lambert G,Wong CHY,Andrews KL,Head GA,Chin-Dusting J,Murphy AJ

更新日期：2019-03-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...

journal_title：Haematologica

authors： Silva A,Jotta PY,Silveira AB,Ribeiro D,Brandalise SR,Yunes JA,Barata JT

更新日期：2010-04-01 00:00:00

abstract：:MicroRNA-34b down-regulation in acute myeloid leukemia was previously shown to induce CREB overexpression, thereby causing leukemia proliferation in vitro and in vivo. The role of microRNA-34b and CREB in patients with myeloid malignancies has never been evaluated. We examined microRNA-34b expression and the methylati...

journal_title：Haematologica

authors： Pigazzi M,Manara E,Bresolin S,Tregnago C,Beghin A,Baron E,Giarin E,Cho EC,Masetti R,Rao DS,Sakamoto KM,Basso G

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Loss of heterozygosity (LOH) on the long arm of chromosome 7 (7q) has been frequently reported in several types of human cancer including hematologic malignancies. Moreover, monosomy of chromosome 7 and 7q deletions have been associated in acute myeloid leukemia (AML) with aggressive disease a...

journal_title：Haematologica

authors： Basiricò R,Pirrotta R,Fabbiano F,Mirto S,Cascio L,Pagano M,Cammarata G,Magrin S,Santoro A

更新日期：2003-04-01 00:00:00

abstract：:Granulocyte transfusions are used to treat neutropenic patients with life-threatening bacterial or fungal infections that do not respond to anti-microbial drugs. Donor neutrophils that have been mobilized with granulocyte-colony stimulating factor (G-CSF) and dexamethasone are functional in terms of antibacterial acti...

journal_title：Haematologica

authors： Gazendam RP,van de Geer A,van Hamme JL,Tool AT,van Rees DJ,Aarts CE,van den Biggelaar M,van Alphen F,Verkuijlen P,Meijer AB,Janssen H,Roos D,van den Berg TK,Kuijpers TW

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present ...

journal_title：Haematologica

authors： R'zik S,Loo M,Beguin Y

更新日期：2001-03-01 00:00:00

abstract：:A probabilistic model was used to compare cryoprecipitate to viral inactivated, commercial fibrinogen concentrate to evaluate with regard to the recipient's risk of exposure to an emergent AIDS-like epidemic. In patients who occasionally need a therapeutic dose of fibrinogen, commercial fibrinogen would be marginally ...

journal_title：Haematologica

authors： Pereira A

更新日期：2007-06-01 00:00:00

abstract：:Krüppel-like factor 4 is a transcription factor with anti-proliferative effects in differentiated cells, but with the ability to reprogram adult cells into cell-cycling pluripotent cells. In cancer, Krüppel-like factor 4 acts as either an anti-oncogene or an oncogene. We analyzed Krüppel-like factor 4 gene expression ...

journal_title：Haematologica

authors： Schoenhals M,Kassambara A,Veyrune JL,Moreaux J,Goldschmidt H,Hose D,Klein B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

journal_title：Haematologica

authors： de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

更新日期：2004-11-01 00:00:00

abstract：:We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients ...

journal_title：Haematologica

authors： Zipperer E,Pelz D,Nachtkamp K,Kuendgen A,Strupp C,Gattermann N,Haas R,Germing U

更新日期：2009-05-01 00:00:00

abstract：:β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients. Two main strategies for treatment are currently being investigated: (i) gene transfer of a normal β-globin gene; (ii) reactivation of the endogenous γ-globin gene....

journal_title：Haematologica

authors： Manchinu MF,Marongiu MF,Poddie D,Casu C,Latini V,Simbula M,Galanello R,Moi P,Cao A,Porcu S,Ristaldi MS

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Imatinib induces complete cytogenetic responses (CCR) in the majority of patients with chronic myeloid leukemia (CML) in chronic phase (CP). However, a subgroup of patients is refractory at the cytogenetic level. Clinically, it would be advantageous to identify such patients a priori, since th...

journal_title：Haematologica

authors： Crossman LC,Mori M,Hsieh YC,Lange T,Paschka P,Harrington CA,Krohn K,Niederwieser DW,Hehlmann R,Hochhaus A,Druker BJ,Deininger MW

更新日期：2005-04-01 00:00:00

abstract：:Aplastic anemia is usually treated with immunosuppression or allogeneic transplant, depending on patient and disease characteristics. Syngeneic transplant offers a rare treatment opportunity with minimal transplant-related mortality, and offers an insight into disease mechanisms. We present here a retrospective analys...

journal_title：Haematologica

authors： Gerull S,Stern M,Apperley J,Beelen D,Brinch L,Bunjes D,Butler A,Ganser A,Ghavamzadeh A,Koh MB,Komarnicki M,Kröger N,Maertens J,Maschan A,Peters C,Rovira M,Sengeløv H,Socié G,Tischer J,Oneto R,Passweg J,Marsh J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：:Heart disease is the leading cause of mortality and one of the main causes of morbidity in beta-thalassemia. The clinical spectrum of the thalassemia syndrome ranges from the severe, transfusion--dependent thalassemia major and the asymptomatic carrier state. Thalassemia intermedia represents a milder form and is usua...

journal_title：Haematologica

authors： Aessopos A,Kati M,Farmakis D

更新日期：2007-05-01 00:00:00

abstract：:The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigation...

journal_title：Haematologica

authors： Asmar F,Punj V,Christensen J,Pedersen MT,Pedersen A,Nielsen AB,Hother C,Ralfkiaer U,Brown P,Ralfkiaer E,Helin K,Grønbæk K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recently, a chimeric monoclonal antibody (MoAb) directed against the CD20 antigen (rituximab) has been successfully introduced in the treatment of several CD20-positive B-cell neoplasias and particularly of follicular lymphomas. Based on these premises we evaluated the efficacy and the toxicit...

journal_title：Haematologica

authors： Lauria F,Lenoci M,Annino L,Raspadori D,Marotta G,Bocchia M,Forconi F,Gentili S,La Manda M,Marconcini S,Tozzi M,Baldini L,Zinzani PL,Foà R

更新日期：2001-10-01 00:00:00

abstract：:In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fuse...

journal_title：Haematologica

authors： Gorello P,Brandimarte L,La Starza R,Pierini V,Bury L,Rosati R,Martelli MF,Vandenberghe P,Wlodarska I,Mecucci C

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The association between lymphoproliferative disease and AIDS is now well known, but only non-Hodgkin's lymphomas (LNH) are surely related to HIV infection. Hodgkin's disease (HD) occurs rarely in HIV seropositives, so it is impossible to establish a connection between AIDS and this neoplasm. METHODS AND RES...

journal_title：Haematologica

authors： Novati S,Malfitano A,Sacchi P,Patruno SF,Tornari PM,Rondanelli EG

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Our objective was to improve the outcome of cord blood (CB) transplantation in adults, by overcoming the limitations imposed by the low number of stem cells present in CB units. DESIGN AND METHODS:We combined single CB units and co-infusion of third party donor (TPD)-derived peripheral blood ...

journal_title：Haematologica

authors： Magro E,Regidor C,Cabrera R,Sanjuán I,Forès R,Garcia-Marco JA,Ruiz E,Gil S,Bautista G,Millán I,Madrigal A,Fernandez MN

更新日期：2006-05-01 00:00:00

abstract：:We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemo...

journal_title：Haematologica

authors： Liberato NL,Bollati P,Chiofalo F,Filipponi M,Poli M

更新日期：1996-01-01 00:00:00

abstract：:The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic p...

journal_title：Haematologica

authors： Liu A,Li S,Donnenberg V,Fu J,Gollin SM,Ma H,Lu C,Stolz DB,Mapara MY,Monaghan SA,Lentzsch S

更新日期：2018-10-01 00:00:00

abstract：:Primary vaginal non-Hodgkin lymphoma is really uncommon and may be misdiagnosed as inflammatory disease or solid cancer, so careful diagnostic procedures are needed, particularly as far as pathological and immunocytochemical evaluation is concerned. Most of these lymphomas present with follicular patterns and limited ...

journal_title：Haematologica

authors： Lonardi F,Ferrari V,Pavanato G,Bonciarelli G,Jirillo A,Balli M

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...

journal_title：Haematologica

authors： Bernd HW,Ziepert M,Thorns C,Klapper W,Wacker HH,Hummel M,Stein H,Hansmann ML,Ott G,Rosenwald A,Müller-Hermelink HK,Barth TF,Möller P,Cogliatti SB,Pfreundschuh M,Schmitz N,Trümper L,Höller S,Löffler M,Feller AC,Ger

更新日期：2009-11-01 00:00:00