In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.

abstract：:A new, sensitive method combining seminested polymerase chain reaction (PCR) and heteroduplex analysis was used to detect follicular lymphoma (FL) cells in peripheral blood. Based on the detection of IgH rearrangement in DNA from peripheral blood leukocytes, the method demonstrated the presence of monoclonal B cells i...

journal_title：Haematologica

authors： Oehadian A,Koide N,Mu MM,Hassan F,Yoshida T,Yokochi T

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND ...

journal_title：Haematologica

authors： Stamatopoulos B,Meuleman N,De Bruyn C,Delforge A,Bron D,Lagneaux L

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Classical Hodgkin's lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma-associated macrophages. High levels of expression of both the monocyte/macrophage lineage-associated antigens CD68 and CD163 have been...

journal_title：Haematologica

authors： Kamper P,Bendix K,Hamilton-Dutoit S,Honoré B,Nyengaard JR,d'Amore F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recent progress in the development of diagnostic techniques has greatly facilitated the monitoring of minimal residual disease (MRD) in patients with chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT), the only curative treatment for this disease. The presence of...

journal_title：Haematologica

authors： Román J,Alvarez MA,Torres A

更新日期：2000-10-01 00:00:00

abstract：:A parent whose child affected by hemophilia develops an inhibitor has to cope with strong emotions and anxieties related to the acceptance of this second diagnosis when just having severe hemophilia seems nothing compared to having antibodies that neutralize factor infusions and the possibility of uncontrolled hemorrh...

journal_title：Haematologica

authors： Gargallo B

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

journal_title：Haematologica

authors： van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

更新日期：2005-10-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:It has been shown that fludarabine (FLU) is superior to conventional treatment in B-CLL for rate and quality of response, leading to CR even at the molecular level. In this paper we report our preliminary results with this drug in B-CLL patients. METHODS AND PATIENTS:Twenty-seven B-CLL patients (16 refracto...

journal_title：Haematologica

authors： Spriano M,Clavio M,Carrara P,Canepa L,Miglino M,Pierri I,Celesti L,Rossi E,Vimercati R,Bruni R

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...

journal_title：Haematologica

authors： Woods AI,Meschengieser SS,Blanco AN,Salviú MJ,Farías CE,Kempfer AC,Lazzari MA

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Interleukin-17A is the signature cytokine of the Th17 subset and drives inflammatory pathology, but its relevance to autoantibody-mediated diseases is unclear. Th1 cells secreting interferon-γ have been implicated in autoimmune hemolytic anemia, so the aim was to determine which cytokine is more closely asso...

journal_title：Haematologica

authors： Hall AM,Zamzami OM,Whibley N,Hampsey DP,Haggart AM,Vickers MA,Barker RN

更新日期：2012-10-01 00:00:00

abstract：:Translocation t(9;14)(p13;q32) involving PAX5 and IGH genes was first described in lymphoplasmacytic lymphoma. New data suggest that this translocation is not restricted to a specific morphologic subtype but occurs in other B-cell lymphomas. We present three cases with a diagnosis of splenic marginal zone lymphoma and...

journal_title：Haematologica

authors： Baró C,Salido M,Domingo A,Granada I,Colomo L,Serrano S,Solé F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human metabolic disorder in southern China. We investigated the incidence and distribution of mutations, the molecular pathology of affected females and the haplotype association with G6PD deficiency in patients from the Gu...

journal_title：Haematologica

authors： Yan T,Cai R,Mo O,Zhu D,Ouyang H,Huang L,Zhao M,Huang F,Li L,Liang X,Xu X

更新日期：2006-10-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased risk of lymphoma. Despite frequent hematologic abnormalities, literatur...

journal_title：Haematologica

authors： Xie Y,Pittaluga S,Price S,Raffeld M,Hahn J,Jaffe ES,Rao VK,Maric I

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We further characterized a novel type of chimeric BCR-ABL mRNA transcript detected in a patient with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML). DESIGN AND METHODS:We used reverse-transcription polymerase chain reaction (RT-PCR) and sequence analysis of the fusion re...

journal_title：Haematologica

authors： Martinelli G,Terragna C,Amabile M,Montefusco V,Testoni N,Ottaviani E,de Vivo A,Mianulli A,Saglio G,Tura S

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosome-positive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors dasatinib and bosutinib and the imatinib analog nilotinib. In the curre...

journal_title：Haematologica

authors： Puttini M,Redaelli S,Moretti L,Brussolo S,Gunby RH,Mologni L,Marchesi E,Cleris L,Donella-Deana A,Drueckes P,Sala E,Lucchini V,Kubbutat M,Formelli F,Zambon A,Scapozza L,Gambacorti-Passerini C

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...

journal_title：Haematologica

authors： Renda G,Zurro M,Malatesta G,Ruggieri B,De Caterina R

更新日期：2010-12-01 00:00:00

abstract：:Chronic lymphocytic leukemia is frequently associated with immune disturbances. The relationship between chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established. The responsible mechanisms, particularly the role of leukemic cells...

journal_title：Haematologica

authors： Hodgson K,Ferrer G,Montserrat E,Moreno C

更新日期：2011-05-01 00:00:00

abstract：:Chronic lymphocytic leukemia is an incurable B-cell malignancy that is associated with tumor cell-mediated T-cell dysfunction. It therefore represents a challenging disease for T-cell immunotherapeutics. The CD19/CD3 bi-specific antibody construct blinatumomab (AMG103 or MT103) has been tested clinically in non-Hodgki...

journal_title：Haematologica

authors： Wong R,Pepper C,Brennan P,Nagorsen D,Man S,Fegan C

更新日期：2013-12-01 00:00:00

abstract：:Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients' peripheral blood with...

journal_title：Haematologica

authors： Basquiera AL,Fassetta F,Soria N,Barral JM,Ricchi B,García JJ

更新日期：2007-05-01 00:00:00

abstract：:The mammalian target of rapamycin plays an important role in multiple myeloma. The allosteric mammalian target of rapamycin inhibitor everolimus has long been approved for immunosuppression and has shown activity in certain cancers. This investigator-initiated phase I trial explored the use of everolimus in relapsed a...

journal_title：Haematologica

authors： Günther A,Baumann P,Burger R,Kellner C,Klapper W,Schmidmaier R,Gramatzki M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chromosome 5 and/or 7 abnormalities are cytogenetic findings indicative of a poor prognosis in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The only potential cure for such patients is allogeneic stem cell transplantation (SCT). As data on allogeneic SCT in thi...

journal_title：Haematologica

authors： van der Straaten HM,van Biezen A,Brand R,Schattenberg AV,Egeler RM,Barge RM,Cornelissen JJ,Schouten HC,Ossenkoppele GJ,Verdonck LF,Netherlands Stem Cell Transplant Registry \TYPHON\.

更新日期：2005-10-01 00:00:00

abstract：:Chronic graft-versus-host disease is a serious complication in long-term survivors of allogeneic hematopoietic stem cell transplantation, with several organ systems affected. Chronic graft-versus-host disease is an important cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation. This a...

journal_title：Haematologica

authors： Kapur R,Ebeling S,Hagenbeek A

更新日期：2008-11-01 00:00:00

abstract：:Primary vaginal non-Hodgkin lymphoma is really uncommon and may be misdiagnosed as inflammatory disease or solid cancer, so careful diagnostic procedures are needed, particularly as far as pathological and immunocytochemical evaluation is concerned. Most of these lymphomas present with follicular patterns and limited ...

journal_title：Haematologica

authors： Lonardi F,Ferrari V,Pavanato G,Bonciarelli G,Jirillo A,Balli M

更新日期：1994-03-01 00:00:00

abstract：:We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemo...

journal_title：Haematologica

authors： Liberato NL,Bollati P,Chiofalo F,Filipponi M,Poli M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS:We investiga...

journal_title：Haematologica

authors： Wade R,Di Bernardo MC,Richards S,Rossi D,Crowther-Swanepoel D,Gaidano G,Oscier DG,Catovsky D,Houlston RS

更新日期：2011-10-01 00:00:00

abstract：:The lupus anticoagulant (LAC) and anticardiolipin antibody (ACA) syndromes require particular therapeutic approaches: thrombotic accidents are an indication for oral anticoagulant therapy (OAT), whereas severe thrombocytopenia may require the special treatments used for immunologic thrombocytopenic purpura (ITP). We d...

journal_title：Haematologica

authors： Ballerini G,Gemmati D,Moratelli S,Morelli P,Serino ML

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

journal_title：Haematologica

authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Thrombopoietin has been established as the major regulator of megakaryocyte and platelet production. In this study we evaluated the effects of PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a pegylated and truncated form of thrombopoietin, on the growth and dif...

journal_title：Haematologica

authors： Catani L,Gugliotta L,Motta M,Tazzari P,Baravelli S,Tura S

更新日期：1998-05-01 00:00:00

abstract：:Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymph...

journal_title：Haematologica

authors： Plešingerová H,Janovská P,Mishra A,Smyčková L,Poppová L,Libra A,Plevová K,Ovesná P,Radová L,Doubek M,Pavlová Š,Pospíšilová Š,Bryja V

更新日期：2018-02-01 00:00:00

abstract：:The control of mRNA stability plays a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation and tumorigenesis. HNRNPA0, which encodes an RNA-binding protein shown to regulate transcript stability via binding to the AU-rich elements of mRNAs, is located within the commonly...

journal_title：Haematologica

authors： Young DJ,Stoddart A,Nakitandwe J,Chen SC,Qian Z,Downing JR,Le Beau MM

更新日期：2014-06-01 00:00:00