Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma.

abstract：BACKGROUND AND OBJECTIVES:Serum beta(2)-microglobulin (s beta(2)m) is an established prognostic factor for multiple myeloma and non-Hodgkin's lymphoma, but only limited data suggest an adverse prognostic significance for Hodgkin's lymphoma (HL). This study was undertaken to examine the impact of s beta(2)m on the progn...

journal_title：Haematologica

authors： Vassilakopoulos TP,Nadali G,Angelopoulou MK,Siakantaris MP,Dimopoulou MN,Kontopidou FN,Karkantaris C,Kokoris SI,Kyrtsonis MC,Tsaftaridis P,Pizzolo G,Pangalis GA

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human metabolic disorder in southern China. We investigated the incidence and distribution of mutations, the molecular pathology of affected females and the haplotype association with G6PD deficiency in patients from the Gu...

journal_title：Haematologica

authors： Yan T,Cai R,Mo O,Zhu D,Ouyang H,Huang L,Zhao M,Huang F,Li L,Liang X,Xu X

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Whether human mesenchymal stem cells (MSC) can be transplanted is controversial and their presence in peripheral blood is not fully accepted. In the present study we have analyzed whether, within the allogeneic transplantation setting, MSC are of host or donor origin. DESIGN AND METHODS:Bone ...

journal_title：Haematologica

authors： Villaron EM,Almeida J,López-Holgado N,Alcoceba M,Sánchez-Abarca LI,Sanchez-Guijo FM,Alberca M,Pérez-Simon JA,San Miguel JF,Del Cañizo MC

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hepatocyte growth factor (HGF) is known to augment the effects of stem cell factor, interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), erythropoetin, and granulocyte colony-stimulating factor, all of which are involved in hematopoiesis. HGF is also known to have a role in...

journal_title：Haematologica

authors： Ovali E,Ratip S,Kibaroglu A,Tekelioglu Y,Cetiner M,Karti S,Aydin F,Bayik M,Akoglu T

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of intensive therapy supported by autologous stem cell transplantation (ASCT) is being investigated as treatment for poor-prognosis follicular lymphomas (FL). A single-center experience is herein reported. DESIGN AND METHODS:From September 1990 to October 1997, 30 consecutive patients ...

journal_title：Haematologica

authors： López R,Martino R,Sureda A,Nomdedéu J,Briones J,Martin-Henao G,García J,Brunet S,Sierra J

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In a prior study, primary resistant acute lymphoblastic leukemia (RES-ALL) was observed in 11 of 176 (6%) adult patients treated with a four drug regimen (IVAP), its incidence being higher in T-cell or Philadelphia (Ph) chromosome/BCR-ABL rearrangement positive ALL cases with a blast cell count...

journal_title：Haematologica

authors： Bassan R,Pogliani E,Lerede T,Fabris P,Rossi G,Morandi S,Casula P,Lambertenghi-Deliliers G,Vespignani M,Izzi T,Coser P,Corneo G,Barbui T

更新日期：1999-12-01 00:00:00

abstract：:In the GIMEMA LAL 0904 protocol, adult Philadelphia positive acute lymphoblastic leukemia patients were treated with chemotherapy for induction and consolidation, followed by maintenance with imatinib. The protocol was subsequently amended and imatinib was incorporated in the induction and post-remission phase togethe...

journal_title：Haematologica

authors： Chiaretti S,Vitale A,Vignetti M,Piciocchi A,Fazi P,Elia L,Falini B,Ronco F,Ferrara F,De Fabritiis P,Luppi M,La Nasa G,Tedeschi A,Califano C,Fanin R,Dore F,Mandelli F,Meloni G,Foà R

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Various experiences show no substantial differences between children and adults in the treatment of Hodgkin's disease. In consideration of some peculiar characteristics of these cases which might influence the therapeutical choice, particularly regarding long-term survival and therapeutical complications, we re...

journal_title：Haematologica

authors： Enrici RM,Anselmo AP,Osti MF,Sbarbati S,Tombolini V,Cartoni C,Mandelli F,Biagini C

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Thrombopoietin has been established as the major regulator of megakaryocyte and platelet production. In this study we evaluated the effects of PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a pegylated and truncated form of thrombopoietin, on the growth and dif...

journal_title：Haematologica

authors： Catani L,Gugliotta L,Motta M,Tazzari P,Baravelli S,Tura S

更新日期：1998-05-01 00:00:00

abstract：:This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in m...

journal_title：Haematologica

authors： Mohty M,Avinens O,Faucher C,Viens P,Blaise D,Eliaou JF

更新日期：2007-07-01 00:00:00

abstract：:Differentiation of erythroblasts to mature red blood cells involves dynamic changes of the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in acti...

journal_title：Haematologica

authors： Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

更新日期：2014-07-01 00:00:00

abstract：:Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co-administered with ...

journal_title：Haematologica

authors： Rahmani M,Aust MM,Hawkins E,Parker RE,Ross M,Kmieciak M,Reshko LB,Rizzo KA,Dumur CI,Ferreira-Gonzalez A,Grant S

更新日期：2015-12-01 00:00:00

abstract：:The control of mRNA stability plays a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation and tumorigenesis. HNRNPA0, which encodes an RNA-binding protein shown to regulate transcript stability via binding to the AU-rich elements of mRNAs, is located within the commonly...

journal_title：Haematologica

authors： Young DJ,Stoddart A,Nakitandwe J,Chen SC,Qian Z,Downing JR,Le Beau MM

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:How to reach the correct diagnosis of a lymph node enlargement is still a problem which strongly challenges the knowledge and experience of the clinician. Organized and specifically oriented literature on the right sequential steps and the logical criteria that should guide this diagnostic appr...

journal_title：Haematologica

authors： Ghirardelli ML,Jemos V,Gobbi PG

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The incidence of primary gastric non-Hodgkin's lymphoma (NHL) appears to have increased worldwide in recent years, and this seems to be confirmed by large-sample population studies. METHODS AND RESULTS:We derived our data from the Lombardy Cancer Registry, which provides the incidence of cancer in the provi...

journal_title：Haematologica

authors： Pinotti G,Novario R,Berrino F,Bianchi P,Comi MA,Gamba MC,Venco A

更新日期：1992-09-01 00:00:00

abstract：:HTLV-1 infections and their associated diseases are very rare in Italy, as well as in most parts of Europe, occurring prevalently in subjects related to endemic areas. The HTLV-1-associated leukemia/lymphoma, ATLL, is a very aggressive T-cell non-Hodgkin's lymphoma which can be difficult to recognize in non-endemic ar...

journal_title：Haematologica

authors： Menin C,Bulian P,Filippi F,Buttarello M,Casado C,Lopez-Galindez C,De Rossi A,Chieco-Bianchi L,Del Mistro A

更新日期：2003-07-01 00:00:00

abstract：:To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...

journal_title：Haematologica

authors： Casaña P,Cabrera N,Haya S,Cid AR,Aznar JA

更新日期：2006-08-01 00:00:00

abstract：:There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, s...

journal_title：Haematologica

authors： Etienne-Julan M,Belloy MS,Decastel M,Dougaparsad S,Ravion S,Hardy-Dessources MD

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients affected by Hodgkin's disease (HD) in pathologic stage IA-IIA have a strong possibility of remission and long-term survival when treated with radiotherapy to extended fields. However, 20-30% of cases relapse in the five years following treatment and consequently need further therapy. T...

journal_title：Haematologica

authors： Enrici RM,Anselmo AP,Donato V,Falchetto Osti M,Santoro M,Tombolini V,Mandelli F

更新日期：1999-10-01 00:00:00

abstract：:Antiphospholipid antibody syndrome is an autoimmune disease characterized by the presence of so-called antiphospholipid antibodies and clinical manifestations such as recurrent thromboembolic or pregnancy complications. Although the main antigenic determinant for antiphospholipid antibodies has been identified as the ...

journal_title：Haematologica

authors： de Moerloose P,Fickentscher C,Boehlen F,Tiercy JM,Kruithof EKO,Brandt KJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We tested the principle of local International Normalized Ratio (INR) calibration using INR calibrator plasmas (PT Calibration Plasma Kit, Behring), two thomboplastin reagents (Neoplastin plus, rabbit brain, Stago, and Recombiplastin, recombinant human tissue factor, Ortho Diagnostics) and the...

journal_title：Haematologica

authors： Testa S,Morstabilini G,Fattorini A,Galli L,Denti N,D'Angelo A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Improvements in the management of childhood acute lymphoblastic leukemia (ALL) did not prevent 20% to 30% of patients suffering from relapse. Moreover, the probability of relapse can rise up to 50% for some children presenting with very high risk (VHR) factors. Intensive chemotherapy and espec...

journal_title：Haematologica

authors： Uderzo C,Balduzzi A

更新日期：2002-08-01 00:00:00

abstract：:Fludarabine (FLU) is a new antimetabolite chemotherapeutic agent with promising activity in lymphoproliferative disorders and, in particular, in low-grade non-Hodgkin's lymphoma (LG-NHL). Recently, a few reports have described interesting results using FLU in polychemotherapy regimens. In order to evaluate FLU in comb...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Gherlinzoni F,Merla E,Gozzetti A,Tura S

更新日期：1996-03-01 00:00:00

abstract：:Diffuse large B-cell lymphoma can be classified by gene expression profiling into germinal center and activated B-cell subtypes with different prognoses after rituximab-CHOP. The importance of previously recognized prognostic markers, such as Bcl-2 protein expression and BCL2 gene abnormalities, has been questioned in...

journal_title：Haematologica

authors： Visco C,Tzankov A,Xu-Monette ZY,Miranda RN,Tai YC,Li Y,Liu WM,d'Amore ES,Li Y,Montes-Moreno S,Dybkær K,Chiu A,Orazi A,Zu Y,Bhagat G,Wang HY,Dunphy CH,His ED,Zhao XF,Choi WW,Zhao X,van Krieken JH,Huang Q,Ai W

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Routine electrophoretic analysis fails to detect a monoclonal component (MC) in a considerable portion of AL amyloidosis patients. We investigated whether the combination of immunofixation (IF) on agarose gel electrophoresis and bone marrow plasma cell (BMPC) light chain kappa/lambda ratio analysis could con...

journal_title：Haematologica

authors： Perfetti V,Garini P,Vignarelli MC,Marinone MG,Zorzoli I,Merlini G

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Abnormalities in the expression of cell adhesion molecules (CAM) are thought to influence the patterns of intranodal growth and hematogeneous spread of malignant cells in chronic lymphoproliferative disorders (LPD). Therefore, the characterization of CAM phenotypic profiles of the neoplastic cl...

journal_title：Haematologica

authors： Lúcio PJ,Faria MT,Pinto AM,da Silva MR,Correia Júnior ME,da Costa RJ,Parreira AB

更新日期：1998-02-01 00:00:00

abstract：:Dickkopf-1 (DKK1), broadly expressed by tumor cells from human multiple myeloma (MM) and other cancers but absent from most normal tissues, may be an ideal target for immunotherapy. Our previous studies have shown that DKK1 (peptide)-specific cytotoxic T lymphocytes can effectively lyse primary MM cells in vitro. To d...

journal_title：Haematologica

authors： Li R,Zheng C,Wang Q,Bi E,Yang M,Hou J,Fu W,Yi Q,Qian J

更新日期：2020-02-20 00:00:00

abstract：:It is well known that thalassemic patients exhibit an increased frequency of thrombotic events. Most individuals with resistance to activated protein C (APCR) are the result of a point mutation replacing Arg 506 with Gln in the factor V aminoacidic sequence (factor V Leiden). Recently APCR has been shown to account fo...

journal_title：Haematologica

authors： Giordano P,Sabato V,Schettini F,De Mattia D,Iolascon A

更新日期：1997-11-01 00:00:00

abstract：:Extramedullary (EM) disease in patients with acute myeloid leukemia (AML) is a known phenomenon. Since the prevalence of EM AML has so far only been clinically determined on examination, we performed a prospective study in patients with AML. The aim of the study was to determine the prevalence of metabolically active ...

journal_title：Haematologica

authors： Stölzel F,Lüer T,Löck S,Parmentier S,Kuithan F,Kramer M,Alakel NS,Sockel K,Taube F,Middeke JM,Schetelig J,Röllig C,Paulus T,Kotzerke J,Ehninger G,Bornhäuser M,Schaich M,Zoephel K

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:To date, multiple myeloma remains an incurable malignancy due to the persistence of minimal residual disease in the bone marrow. In this setting, monoclonal antibodies against myeloma-specific cell surface antigens represent a promising therapeutic approach, which is however hampered by a lack of appropriate...

journal_title：Haematologica

authors： Atanackovic D,Panse J,Hildebrandt Y,Jadczak A,Kobold S,Cao Y,Templin J,Meyer S,Reinhard H,Bartels K,Lajmi N,Zander AR,Marx AH,Bokemeyer C,Kröger N

更新日期：2011-10-01 00:00:00