Primary gastric non-Hodgkin's lymphoma in a population-based registry.

abstract：:Staining for CD27 and CD201 (endothelial protein C receptor) has been recently suggested as an alternative to stem cell antigen-1 (Sca1) to identify hematopoietic stem cells in inbred mouse strains with low or nil expression of SCA1. However, whether staining for CD27 and CD201 is compatible with low fms-like tyrosine...

journal_title：Haematologica

authors： Nowlan B,Williams ED,Doran MR,Levesque JP

更新日期：2020-01-01 00:00:00

abstract：:In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fuse...

journal_title：Haematologica

authors： Gorello P,Brandimarte L,La Starza R,Pierini V,Bury L,Rosati R,Martelli MF,Vandenberghe P,Wlodarska I,Mecucci C

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：:The majority of responses produced in patients with low-grade lymphomas are unique among non-Hodgkin's lymphomas (NHL), and even with a more intensive chemotherapy regimen, they are only partial; the very few complete responses which are induced are usually of short duration and do not influence overall survival. Ther...

journal_title：Haematologica

authors： Zinzani PL

更新日期：1997-09-01 00:00:00

abstract：:Successful expansion of hematopoietic stem cells would benefit the use of hematopoietic stem cell transplants in the clinic. Several angiopoietin-like proteins, including angiopoietin-like 7, can support the activity of hematopoietic stem cells. However, effects of ANGPTL7 on human hematopoietic stem cells and the dow...

journal_title：Haematologica

authors： Xiao Y,Jiang Z,Li Y,Ye W,Jia B,Zhang M,Xu Y,Wu D,Lai L,Chen Y,Chang Y,Huang X,Liu H,Qing G,Liu P,Li Y,Xu B,Zhong M,Yao Y,Pei D,Li P

更新日期：2015-05-01 00:00:00

abstract：:This review deals with the chronic lymphoproliferative disease of large granular lymphocytes endowed with T and natural killer cell characteristics. The disease is sufficiently characterized to allow its distinction from other lymphoproliferative disorders of the T cell type. The heterogeneous clinical course and labo...

journal_title：Haematologica

authors： Bassan R,Rambaldi A,Barbui T

更新日期：1989-01-01 00:00:00

abstract：:Acute myeloid leukemia carrying cytoplasmic mutated nucleophosmin (NPMc(+) AML) and blastic plasmacytoid dendritic cell neoplasm have been included as new entities in the 4(th) edition (2008) WHO classification of myeloid neoplasms. These conditions may show clinical and pathological overlapping features (leukemic and...

journal_title：Haematologica

authors： Facchetti F,Pileri SA,Agostinelli C,Martelli MP,Paulli M,Venditti A,Martelli MF,Falini B

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Folate deficiency in the general population is associated with a risk of cardiovascular disease and various cancers. The aim of this study was to evaluate folate status in Italian blood donors and its relationship with gender and smoking habit. DESIGN AND METHODS:A prospective study of 201 fi...

journal_title：Haematologica

authors： Cafolla A,Dragoni F,Girelli G,Tosti ME,Costante A,Pastorelli D,Bedogni G,Scott S

更新日期：2000-07-01 00:00:00

abstract：:The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin. As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transf...

journal_title：Haematologica

authors： Mirciov CSG,Wilkins SJ,Hung GCC,Helman SL,Anderson GJ,Frazer DM

更新日期：2018-10-01 00:00:00

abstract：:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...

journal_title：Haematologica

authors： Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We investigated whether cytogenetic findings (CG) on day 21 (D21) of the first course of chemotherapy predicted subsequent outcome in patients who presented with CG abnormalities. DESIGN AND METHODS:D21 CG analysis was performed in 197 patients. RESULTS:Nineteen percent of the patients had e...

journal_title：Haematologica

authors： Konopleva M,Cheng SC,Cortes JE,Hayes KJ,Pierce SA,Andreeff M,Giles FJ,O'Brien S,Kantarjian HM,Estey EH

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for spec...

journal_title：Haematologica

authors： Méhes G,Kovács G,Kajtár B,Lacza A,Várnai A,Losonczy H,Pajor L

更新日期：2006-10-01 00:00:00

abstract：:Inherited bone marrow failure syndromes are experiments of nature characterized by impaired hematopoiesis with cancer and leukemia predisposition. The mutations associated with inherited bone marrow failure syndromes affect fundamental cellular pathways, such as DNA repair, telomere maintenance, or proteostasis. How t...

journal_title：Haematologica

authors： Oyarbide U,Topczewski J,Corey SJ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties. In the current study, we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-versus-host disease wit...

journal_title：Haematologica

authors： Caballero-Velázquez T,Sánchez-Abarca LI,Gutierrez-Cosio S,Blanco B,Calderon C,Herrero C,Carrancio S,Serrano C,del Cañizo C,San Miguel JF,Pérez-Simón JA

更新日期：2012-09-01 00:00:00

abstract：:Alemtuzumab serum levels and clinical response after subcutaneous administration (10 mg 3 times/week for six weeks) have been explored in 29 chronic lymphocytic leukemia patients receiving the monoclonal antibody as consolidation. Serum concentrations after each administration gradually increased during the first week...

journal_title：Haematologica

authors： Montagna M,Montillo M,Avanzini MA,Tinelli C,Tedeschi A,Visai L,Ricci F,Vismara E,Morra E,Regazzi M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recently, a chimeric monoclonal antibody (MoAb) directed against the CD20 antigen (rituximab) has been successfully introduced in the treatment of several CD20-positive B-cell neoplasias and particularly of follicular lymphomas. Based on these premises we evaluated the efficacy and the toxicit...

journal_title：Haematologica

authors： Lauria F,Lenoci M,Annino L,Raspadori D,Marotta G,Bocchia M,Forconi F,Gentili S,La Manda M,Marconcini S,Tozzi M,Baldini L,Zinzani PL,Foà R

更新日期：2001-10-01 00:00:00

abstract：:Adults with relapsed/refractory acute lymphoblastic leukemia have an unfavourable prognosis, which is influenced by disease and patient characteristics. To further evaluate these characteristics, a retrospective analysis of 1,706 adult patients with Ph-negative relapsed/refractory B-precursor acute lymphoblastic leuke...

journal_title：Haematologica

authors： Gökbuget N,Dombret H,Ribera JM,Fielding AK,Advani A,Bassan R,Chia V,Doubek M,Giebel S,Hoelzer D,Ifrah N,Katz A,Kelsh M,Martinelli G,Morgades M,O'Brien S,Rowe JM,Stieglmaier J,Wadleigh M,Kantarjian H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The association between lymphoproliferative disease and AIDS is now well known, but only non-Hodgkin's lymphomas (LNH) are surely related to HIV infection. Hodgkin's disease (HD) occurs rarely in HIV seropositives, so it is impossible to establish a connection between AIDS and this neoplasm. METHODS AND RES...

journal_title：Haematologica

authors： Novati S,Malfitano A,Sacchi P,Patruno SF,Tornari PM,Rondanelli EG

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The risk for donors of allogeneic hematopoietic stem cells transplants is generally considered negligible. Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this opinion. DESIGN AND METH...

journal_title：Haematologica

authors： Halter J,Kodera Y,Ispizua AU,Greinix HT,Schmitz N,Favre G,Baldomero H,Niederwieser D,Apperley JF,Gratwohl A

更新日期：2009-01-01 00:00:00

abstract：:Drug resistance impedes the long-term effect of targeted therapies in acute myeloid leukemia (AML), necessitating the identification of mechanisms underlying resistance. Approximately 25% of AML patients carry FLT3 mutations and develop post-treatment insensitivity to FLT3 inhibitors, including sorafenib. Using a geno...

journal_title：Haematologica

authors： Damnernsawad A,Bottomly D,Kurtz SE,Eide CA,McWeeney SK,Tyner JW,Nechiporuk T

更新日期：2020-12-30 00:00:00

abstract：:The main purpose of this work is to give methodologic details and further verification regarding the predictive system recently elaborated for Hodgkin's disease (HD) patients, by which, under standard accuracy and conventional treatment, patient survival can be directly estimated (within a given confidence interval) w...

journal_title：Haematologica

authors： Gobbi PG,Gobbi PG,Mazza P,Zinzani PL

更新日期：1989-01-01 00:00:00

abstract：:Treatment of primary breast lymphoma (PBL) remains unsatisfactory. We assess a clinical study to evaluate efficacy and toxicity of a dose dense regimen (CEOP-14) and rituximab in 32 previously untreated female patients with PBL in early stage. There was no difference in complete response rate (87%), event free-surviva...

journal_title：Haematologica

authors： Avilés A,Castañeda C,Neri N,Cleto S,Nambo MJ

更新日期：2007-08-01 00:00:00

abstract：:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representa...

journal_title：Haematologica

authors： MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RF

更新日期：2006-02-01 00:00:00

abstract：:Krüppel-like factor 4 is a transcription factor with anti-proliferative effects in differentiated cells, but with the ability to reprogram adult cells into cell-cycling pluripotent cells. In cancer, Krüppel-like factor 4 acts as either an anti-oncogene or an oncogene. We analyzed Krüppel-like factor 4 gene expression ...

journal_title：Haematologica

authors： Schoenhals M,Kassambara A,Veyrune JL,Moreaux J,Goldschmidt H,Hose D,Klein B

更新日期：2013-09-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...

journal_title：Haematologica

authors： Anguita E,Villegas A,Iborra F,Hernández A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Subcutaneous Ara-C plus interferon (IFN) produces more cytogenetic responses than IFN in chronic myeloid leukemia (CML) but a greater toxicity. The objective of this study was to determine the efficacy and tolerance of IFN plus oral Ara-C ocfosfate (YNK-01) in IFN-resistant CML patients. DESI...

journal_title：Haematologica

authors： Cervantes F,Sureda A,Hernández-Boluda JC,Martino R,Brunet S,Borrego D,Antich JL,Montserrat E

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human metabolic disorder in southern China. We investigated the incidence and distribution of mutations, the molecular pathology of affected females and the haplotype association with G6PD deficiency in patients from the Gu...

journal_title：Haematologica

authors： Yan T,Cai R,Mo O,Zhu D,Ouyang H,Huang L,Zhao M,Huang F,Li L,Liang X,Xu X

更新日期：2006-10-01 00:00:00

abstract：:Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been perfor...

journal_title：Haematologica

authors： Eyre TA,Djebbari F,Kirkwood AA,Collins GP

更新日期：2020-07-01 00:00:00