Abstract:
:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (INT-1) score according to the international prognostic scoring system and low RPS14 expression had a superior median overall survival of not reached versus 25 months compared to INT-1 patients with high RPS14 expression (p=0.0249). Using multivariate analysis, the RPS14 expression status was confirmed as an independent predictor for survival in INT-1 patients.
journal_name
Haematologicajournal_title
Haematologicaauthors
Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing Udoi
10.3324/haematol.2009.008508subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1453-5issue
10eissn
0390-6078issn
1592-8721pii
94/10/1453journal_volume
94pub_type
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