Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival.

Abstract:

:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (INT-1) score according to the international prognostic scoring system and low RPS14 expression had a superior median overall survival of not reached versus 25 months compared to INT-1 patients with high RPS14 expression (p=0.0249). Using multivariate analysis, the RPS14 expression status was confirmed as an independent predictor for survival in INT-1 patients.

journal_name

Haematologica

journal_title

Haematologica

authors

Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

doi

10.3324/haematol.2009.008508

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1453-5

issue

10

eissn

0390-6078

issn

1592-8721

pii

94/10/1453

journal_volume

94

pub_type

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