Cytoplasmic nucleophosmin is not detected in blastic plasmacytoid dendritic cell neoplasm.

abstract：:A case of thrombotic thrombocytopenic purpura (TTP) in a 40-year-old bisexual man unaware of being HIV positive is reported. The hematologic syndrome represented the first clinical manifestation of this viral infection. The clinical picture, characterized by severe hemolytic microangiopathic anemia, thrombocytopenia, ...

journal_title：Haematologica

authors： Cruccu V,Parisio E,Pedretti D,Villa A,Confalonieri F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The benefits of high-dose cytarabine, anthracyclines and hematopoietic stem cell transplantation in the treatment of acute myeloid leukemia (AML) are greater in younger rather than in older patients. We assessed the proportion of patients over 60 years with de novo AML who qualified for intens...

journal_title：Haematologica

authors： Oriol A,Ribera JM,Esteve J,Guàrdia R,Brunet S,Bueno J,Pedro C,Llorente A,Tormo M,Besalduch J,Sánchez JM,Batlle M,Vivancos P,Carreras E,Vilà JM,Julià A,Sierra J,Montserrat E,Feliu E,CETLAM AML-99.

更新日期：2004-07-01 00:00:00

abstract：:Drug resistance impedes the long-term effect of targeted therapies in acute myeloid leukemia (AML), necessitating the identification of mechanisms underlying resistance. Approximately 25% of AML patients carry FLT3 mutations and develop post-treatment insensitivity to FLT3 inhibitors, including sorafenib. Using a geno...

journal_title：Haematologica

authors： Damnernsawad A,Bottomly D,Kurtz SE,Eide CA,McWeeney SK,Tyner JW,Nechiporuk T

更新日期：2020-12-30 00:00:00

abstract：:Normal and clonal hematopoietic progenitor cells have been demonstrated to coexist in chronic-phase chronic myelogenous leukemia (CML), but few data are available on the presence of non neoplastic hematopoiesis during the blastic transformation phase. We used reverse transcription-polymerase chain reaction (RT-PCR) to...

journal_title：Haematologica

authors： Martinelli G,Lemoli RM,Farabegoli P,Zaccaria A,Testoni N,Buzzi M,Fogli M,Visani G,Tosi P,Motta MR

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Cutaneous T-cell lymphomas (CTCL) represent about the 80% of skin lymphomas and comprise a heterogeneous group of diseases with respect to clinical presentation, outcome, histologic and immunophenotypic features. In the recent years, data have been accumulated indicating that clinical and biological differen...

journal_title：Haematologica

authors： Paulli M,Berti E

更新日期：2004-11-01 00:00:00

abstract：:Our objectives were to evaluate thrombotic complications in patients with lupus anticoagulant fulfilling Sapporo criteria, anticoagulated with an intended INR 2.0-3.0 due to venous and arterial thrombosis. In our series standard anticoagulation was safe and efficacious in preventing recurrences in patients with system...

journal_title：Haematologica

authors： Casais P,Alberto MF,Gennari LC,Grosso SH,Meschengieser SS,Lazzari MA

更新日期：2004-04-01 00:00:00

abstract：:The effect of treatment with 1,25-dihydroxyvitamin D3 administered at the dose of 1.50-3.00 ug/day for at least 12 months was evaluated in three patients with idiopathic myelofibrosis and in five patients with idiopathic thrombocythemia. This treatment did not cause any significant change in the hematological values o...

journal_title：Haematologica

authors： Foa P,Maiolo AT,Cortellaro M,Ortolani S,Pogliani E,Deliliers GL,Iurlo A,Zocchi L,Gualdoni A,Polli E

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a re...

journal_title：Haematologica

authors： Ram R,Storb R,Sandmaier BM,Maloney DG,Woolfrey A,Flowers ME,Maris MB,Laport GG,Chauncey TR,Lange T,Langston AA,Storer B,Georges GE

更新日期：2011-08-01 00:00:00

abstract：:Spontaneous Rh blood group changes are a striking sign, reported to occur mainly in patients with hematologic disorders. Upon routine blood grouping, 2 unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4), clinically relevant for blood transfusion and fetom...

journal_title：Haematologica

authors： Dauber EM,Mayr WR,Hustinx H,Schönbacher M,Budde H,Legler TJ,König M,Haas OA,Fritsch G,Körmöczi GF

更新日期：2019-03-01 00:00:00

abstract：:Classical Hodgkin lymphoma is one of the most common lymphomas and shares clinical and genetic features with primary mediastinal B-cell lymphoma. In this retrospective study, we analyzed the recurrent hotspot mutation of the exportin 1 (XPO1, p.E571K) gene, previously identified in primary mediastinal B-cell lymphoma,...

journal_title：Haematologica

authors： Camus V,Stamatoullas A,Mareschal S,Viailly PJ,Sarafan-Vasseur N,Bohers E,Dubois S,Picquenot JM,Ruminy P,Maingonnat C,Bertrand P,Cornic M,Tallon-Simon V,Becker S,Veresezan L,Frebourg T,Vera P,Bastard C,Tilly H,Jardin

更新日期：2016-09-01 00:00:00

abstract：:Our preliminary results suggest the existence of quantitative and qualitative differences in immune cells and type1 and type2 cytokines between granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood grafts (G-PB). Our findings suggest that lower T-cell hyporesponsi...

journal_title：Haematologica

authors： Jun HX,Jun CY,Yu ZX

更新日期：2005-05-01 00:00:00

abstract：:The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for relapsed/refractory diffuse large B-cell lymphoma patients treated on the Canadian Cancer Trials Group (CCTG) LY12 prospective study. In 91 cases, sufficient histologic mater...

journal_title：Haematologica

authors： Bosch M,Akhter A,Chen BE,Mansoor A,Lebrun D,Good D,Crump M,Shepherd L,Scott DW,Stewart DA

更新日期：2018-02-01 00:00:00

abstract：:The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules. We studied the impact of matched and mismatched HLA-A (265 versus 429), -B (230 v...

journal_title：Haematologica

authors： Lazaryan A,Wang T,Spellman SR,Wang HL,Pidala J,Nishihori T,Askar M,Olsson R,Oudshoorn M,Abdel-Azim H,Yong A,Gandhi M,Dandoy C,Savani B,Hale G,Page K,Bitan M,Reshef R,Drobyski W,Marsh SG,Schultz K,Müller CR,Fer

更新日期：2016-10-01 00:00:00

abstract：:Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological processes. Indeed, t...

journal_title：Haematologica

authors： Vilar R,Fish RJ,Casini A,Neerman-Arbez M

更新日期：2020-01-31 00:00:00

abstract：:Phase I/II studies of gemtuzumab ozogamicin (GO) in pediatric refractory/relapsed acute myeloid leukemia (AML) have been reported. We present the cases of two children with relapsed AML who were treated with GO plus cytarabine, leading to a decrease of minimal residual disease down to levels not previously obtained. T...

journal_title：Haematologica

authors： Brethon B,Auvrignon A,Cayuela JM,Lapillonne H,Leverger G,Baruchel A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor. Hereditary type I protein S deficiency (low total and low free protein S) is a well-established risk factor for venous thrombosis, whereas t...

journal_title：Haematologica

authors： Castoldi E,Maurissen LF,Tormene D,Spiezia L,Gavasso S,Radu C,Hackeng TM,Rosing J,Simioni P

更新日期：2010-09-01 00:00:00

abstract：:Chronic lymphocytic leukemia is frequently associated with immune disturbances. The relationship between chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established. The responsible mechanisms, particularly the role of leukemic cells...

journal_title：Haematologica

authors： Hodgson K,Ferrer G,Montserrat E,Moreno C

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Long-term central venous catheters have improved the quality of care for patients with chronic illnesses, but are complicated by obstructions which can result in delay of treatment or catheter removal. DESIGN AND METHODS:This paper reviews thrombolytic treatment for catheter obstruction. Literature from Med...

journal_title：Haematologica

authors： Baskin JL,Reiss U,Wilimas JA,Metzger ML,Ribeiro RC,Pui CH,Howard SC

更新日期：2012-05-01 00:00:00

abstract：:Juvenile hemochromatosis is a severe form of hereditary iron overload. It can be caused by mutations in either hepcidin or hemojuvelin genes. In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carryi...

journal_title：Haematologica

authors： Wallace DF,Dixon JL,Ramm GA,Anderson GJ,Powell LW,Subramaniam N

更新日期：2005-02-01 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations (including deletions) in a variety of cancer types, including T-cell acute lymphoblastic leukemia. Here we review mutation-associated mechanisms that ...

journal_title：Haematologica

authors： Mendes RD,Canté-Barrett K,Pieters R,Meijerink JP

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Autologous peripheral stem cell transplantation (APSCT) is increasingly used for various hematologic malignancies and solid tumors. The objective of this study was to analyze the immune reconstitution after APSCT and see if there was any correlation with diagnosis, age, type of high-dose thera...

journal_title：Haematologica

authors： Steingrimsdottir H,Gruber A,Björkholm M,Svensson A,Hansson M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver er...

journal_title：Haematologica

authors： Ji P,Yeh V,Ramirez T,Murata-Hori M,Lodish HF

更新日期：2010-12-01 00:00:00

abstract：:The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. As a model gene all exons of the antithrombin gene were amplified in a one tube multiplex polymerase chain reaction (PCR) and the products separated according to their size by reverse-phase ion-pair hig...

journal_title：Haematologica

authors： Pavlova A,El-Maarri O,Luxembourg B,Lindhoff-Last E,Kochhan L,Bruhn HD,Delev D,Watzka M,Seifried E,Oldenburg J

更新日期：2006-09-01 00:00:00

abstract：:Antiphospholipid antibody syndrome is an autoimmune disease characterized by the presence of so-called antiphospholipid antibodies and clinical manifestations such as recurrent thromboembolic or pregnancy complications. Although the main antigenic determinant for antiphospholipid antibodies has been identified as the ...

journal_title：Haematologica

authors： de Moerloose P,Fickentscher C,Boehlen F,Tiercy JM,Kruithof EKO,Brandt KJ

更新日期：2017-08-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：:n patients with Kasabach-Merritt syndrome (KMS), local activation of coagulation commonly results in disseminated intravascular coagulation (DIC). Progress of DIC is associated with 30-40% mortality as a result of uncontrollable hemorrhage. A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as ...

journal_title：Haematologica

authors： Ontachi Y,Asakura H,Omote M,Yoshida T,Matsui O,Nakao S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Increased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary...

journal_title：Haematologica

authors： Del Turco S,Basta G,Lazzerini G,Evangelista M,Rainaldi G,Tanganelli P,Christensen JH,Schmidt EB,De Caterina R

更新日期：2008-06-01 00:00:00

abstract：:The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly sele...

journal_title：Haematologica

authors： Kanuri G,Chichula D,Sawhney R,Kuriakose K,De'Souza S,Pais F,Arumugam K,Shet AS

更新日期：2018-12-01 00:00:00

abstract：:Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression vi...

journal_title：Haematologica

authors： Solimando AG,Da Vià MC,Leone P,Borrelli P,Croci GA,Tabares P,Brandl A,Di Lernia G,Bianchi FP,Tafuri S,Steinbrunn T,Balduini A,Melaccio A,De Summa S,Argentiero A,Rauert-Wunderlich H,Frassanito MA,Ditonno P,Henke E,Kl

更新日期：2020-04-30 00:00:00