Thrombolytic therapy for central venous catheter occlusion.

abstract：:A case of thrombotic thrombocytopenic purpura (TTP) in a 40-year-old bisexual man unaware of being HIV positive is reported. The hematologic syndrome represented the first clinical manifestation of this viral infection. The clinical picture, characterized by severe hemolytic microangiopathic anemia, thrombocytopenia, ...

journal_title：Haematologica

authors： Cruccu V,Parisio E,Pedretti D,Villa A,Confalonieri F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. DESIGN AND METHODS:With the aim of identifying surro...

journal_title：Haematologica

authors： Tracey L,Aggarwal M,García-Cosio M,Villuendas R,Algara P,Sánchez-Beato M,Sánchez-Aguilera A,García JF,Rodríguez A,Camacho FI,Martínez N,Ruiz-Ballesteros E,Mollejo M,Piris MA

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

journal_title：Haematologica

authors： van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：:We studied the immune function of 33 long-term survivors of thalassemia after hematopoietic stem cell transplantation. Lymphocyte subsets, lymphoproliferative response and immunoglobulin were normal but the level of natural killer cells was low. Five and seven patients had suboptimal antibody response at 4 week after ...

journal_title：Haematologica

authors： Li CK,Leung TF,Chan PK,Chick KW,Lee V,Cheung AY

更新日期：2003-10-01 00:00:00

abstract：:Some prospective studies showed that rabbit antithymocyte globulin was inferior to horse antithymocyte globulin as first-line therapy for patients with severe aplastic anemia. We retrospectively analyzed the clinical outcome of 455 children with severe aplastic anemia who received horse antithymocyte globulin (n=297) ...

journal_title：Haematologica

authors： Jeong DC,Chung NG,Cho B,Zou Y,Ruan M,Takahashi Y,Muramatsu H,Ohara A,Kosaka Y,Yang W,Kim HK,Zhu X,Kojima S

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A prospective study to evaluate the role of fludarabine alone or in combination with idarubicin in untreated patients with mantle cell lymphoma (MCL). DESIGN AND METHODS:Twenty-nine untreated patients with mantle cell lymphoma were stochastically treated with intravenous fludarabine at a dose ...

journal_title：Haematologica

authors： Zinzani PL,Magagnoli M,Moretti L,Battista R,Ronconi F,De Renzo A,Zaccaria A,Gentilini P,Guardigni L,Gherlinzoni F,Cellini C,Fattori PP,Bendandi M,Bocchia M,Aitini E,Tura S

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Peripheral blood stem cells (PBSC) following reduced intensity conditioning (RIC) are being increasingly used for allogeneic transplantation in multiple myeloma. The purpose of this study was to compare outcome of patients transplanted with either PBSC or bone marrow (BM) following RIC or myel...

journal_title：Haematologica

authors： Gahrton G,Iacobelli S,Bandini G,Björkstrand B,Corradini P,Crawley C,Hegenbart U,Morgan G,Kröger N,Schattenberg A,Schönland SO,Verdonck LF,Volin L,de Witte T,Niederwieser D,Myeloma Subcommittee of the EBMT.

更新日期：2007-11-01 00:00:00

abstract：:Adults with relapsed/refractory acute lymphoblastic leukemia have an unfavourable prognosis, which is influenced by disease and patient characteristics. To further evaluate these characteristics, a retrospective analysis of 1,706 adult patients with Ph-negative relapsed/refractory B-precursor acute lymphoblastic leuke...

journal_title：Haematologica

authors： Gökbuget N,Dombret H,Ribera JM,Fielding AK,Advani A,Bassan R,Chia V,Doubek M,Giebel S,Hoelzer D,Ifrah N,Katz A,Kelsh M,Martinelli G,Morgades M,O'Brien S,Rowe JM,Stieglmaier J,Wadleigh M,Kantarjian H

更新日期：2016-12-01 00:00:00

abstract：:We studied wild-type FLT3 mRNA expression at diagnosis in bone marrow samples from 85 patients with acute myeloid leukemia (AML), 23 of whom were in complete remission, and determined its utility as a marker for minimal residual disease (MRD). We conclude that FLT3 expression is of limited value as a prognostic marker...

journal_title：Haematologica

authors： Kainz B,Fonatsch C,Schwarzinger I,Sperr WR,Jäger U,Gaiger A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma. DESIGN AND METHODS:MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human micr...

journal_title：Haematologica

authors： Wang W,Corrigan-Cummins M,Hudson J,Maric I,Simakova O,Neelapu SS,Kwak LW,Janik JE,Gause B,Jaffe ES,Calvo KR

更新日期：2012-04-01 00:00:00

abstract：:Forty-six patients with chronic myeloid leukemia receiving imatinib mesylate (39 in chronic phase, one in accelerated phase, and six in blastic crisis), were studied for a 20-62 month follow-up period by cytogenetics and fluorescence in situ hybridization using dual-color, dual-fusion BCR and ABL probes. This approach...

journal_title：Haematologica

authors： Calabrese G,Fantasia D,Di Gianfilippo R,Stuppia L,Di Lorenzo R,Palka G

更新日期：2006-07-01 00:00:00

abstract：:In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fuse...

journal_title：Haematologica

authors： Gorello P,Brandimarte L,La Starza R,Pierini V,Bury L,Rosati R,Martelli MF,Vandenberghe P,Wlodarska I,Mecucci C

更新日期：2008-09-01 00:00:00

abstract：:Twenty-five adult patients with resistant or early relapsing Hodgkin's disease have been treated with CAV combination chemotherapy (CCNU, melphalan and etoposide). All patients had previously received both MOPP and ABVD regimens (23 patients as primary therapy and two as first salvage). High-energy radiotherapy had be...

journal_title：Haematologica

authors： Brusamolino E,Castelli G,Pagnucco G,Orlandi E,Malagó D,Lazzarino M,Bernasconi C

更新日期：1990-07-01 00:00:00

abstract：:Heart disease is the leading cause of mortality and one of the main causes of morbidity in beta-thalassemia. The clinical spectrum of the thalassemia syndrome ranges from the severe, transfusion--dependent thalassemia major and the asymptomatic carrier state. Thalassemia intermedia represents a milder form and is usua...

journal_title：Haematologica

authors： Aessopos A,Kati M,Farmakis D

更新日期：2007-05-01 00:00:00

abstract：:A case of stiff-man syndrome (SMS), a rare and dramatic CNS disease characterized by continuous muscle activity and painful spasms resembling a chronic form of tetanus, occurring in a patient with Hodgkin's disease (HD) is reported. The patient developed the clinical features of SMS at the same time as the HD relapse....

journal_title：Haematologica

authors： Ferrari P,Federico M,Grimaldi LM,Silingardi V

更新日期：1990-11-01 00:00:00

abstract：:Second central nervous system (CNS) relapses represent about 7.3% of subsequent recurrences of childhood acute lymphoblastic leukemia (ALL). In most children these subsequent CNS relapses occur during the first 18 months after diagnosis of the first relapse (mean 1.42 +/- 0.73 years). We present a patient who suffered...

journal_title：Haematologica

authors： Eckert C,Einsiedel HG,Hartmann R,von Stackelberg A,Völpel S,Guggemos A,Hanzsch N,Kawan L,Seeger K,Henze G

更新日期：2004-07-01 00:00:00

abstract：:n patients with Kasabach-Merritt syndrome (KMS), local activation of coagulation commonly results in disseminated intravascular coagulation (DIC). Progress of DIC is associated with 30-40% mortality as a result of uncontrollable hemorrhage. A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as ...

journal_title：Haematologica

authors： Ontachi Y,Asakura H,Omote M,Yoshida T,Matsui O,Nakao S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hydroxyurea (HU) is known to increase gamma-globin chain expression in postnatal life. The efficacy of HU treatment in thalassemia patients is still unclear. The aim of this study was to monitor treatment of a large cohort of patients with beta-thalassemia major in order to establish the respo...

journal_title：Haematologica

authors： Yavarian M,Karimi M,Bakker E,Harteveld CL,Giordano PC

更新日期：2004-10-01 00:00:00

abstract：:We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemo...

journal_title：Haematologica

authors： Liberato NL,Bollati P,Chiofalo F,Filipponi M,Poli M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Gastrointestinal bleeding is a frequent complication of liver cirrhosis (LC) and represents an important warning sign of imminent death. Platelet dysfunction is an abnormality occurring prevalently in severe liver failure, and could well predispose to bleeding. METHODS:One hundred and two patients with live...

journal_title：Haematologica

authors： Violi F,Leo R,Basili S,Ferro D,Cordova C,Balsano F,CALC Group.

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Aggressive diffuse large cell non-Hodgkin's lymphoma (DLCL) occurring late after a solid organ transplant fails to regress after discontinuation of immunosuppression. Moreover, chemotherapy treatment is associated with a high mortality rate due to severe toxicity. Since the majority of post-tr...

journal_title：Haematologica

authors： Dotti G,Rambaldi A,Fiocchi R,Motta T,Torre G,Viero P,Gridelli B,Barbui T

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Identification and characterization of hematopoietic stem cells in peripheral blood (PB) and cord blood (CB) have suggested feasible alternatives to conventional allogeneic bone marrow (BM) transplantation. The growing interest in this use of allogeneic stem cells has prompted the Working Group...

journal_title：Haematologica

authors： Bertolini F,de Vincentiis A,Lanata L,Lemoli RM,Maccario R,Majolino I,Ponchio L,Rondelli D,Tabilio A,Zanon P,Tura S

更新日期：1997-03-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：:The introduction of agents inhibiting the BCR-associated kinases such as ibrutinib has dramatically changed treatments algorithms of chronic lymphocytic leukaemia (CLL) as well as the role of different adverse prognosticators. We evaluated the efficacy of ibrutinib as single agent, in a real-life context, on 180 patie...

journal_title：Haematologica

authors： Del Poeta G,Biagi A,Laurenti L,Chiarenza A,Pozzo F,Innocenti I,Postorino M,Rossi FM,Del Principe MI,Bomben R,de Fabritiis P,Bruno A,Cantonetti M,Di Raimondo F,Zucchetto A,Gattei V

更新日期：2020-07-30 00:00:00

abstract：:This review deals with the chronic lymphoproliferative disease of large granular lymphocytes endowed with T and natural killer cell characteristics. The disease is sufficiently characterized to allow its distinction from other lymphoproliferative disorders of the T cell type. The heterogeneous clinical course and labo...

journal_title：Haematologica

authors： Bassan R,Rambaldi A,Barbui T

更新日期：1989-01-01 00:00:00

abstract：:Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear. Using both pharmacological and genetic approaches we describe a mechanism by...

journal_title：Haematologica

authors： Berger M,Raslan Z,Aburima A,Magwenzi S,Wraith KS,Spurgeon BEJ,Hindle MS,Law R,Febbraio M,Naseem KM

更新日期：2020-03-01 00:00:00

abstract：:Patients with hypogammaglobulinemia who do not fulfill all the classical diagnostic criteria for common variable immunodeficiency (reduction of two immunoglobulin isotypes and a reduced response to vaccination) constitute a diagnostic and therapeutic dilemma, because information concerning the clinical and immunologic...

journal_title：Haematologica

authors： Driessen GJ,Dalm VA,van Hagen PM,Grashoff HA,Hartwig NG,van Rossum AM,Warris A,de Vries E,Barendregt BH,Pico I,Posthumus S,van Zelm MC,van Dongen JJ,van der Burg M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis - acute myeloid leukemia with myelodysplasia-related changes (≥20% myeloblasts of all nucleated c...

journal_title：Haematologica

authors： Bacher U,Haferlach C,Alpermann T,Kern W,Schnittger S,Haferlach T

更新日期：2011-09-01 00:00:00