Limited value of FLT3 mRNA expression in the bone marrow for prognosis and monitoring of patients with acute myeloid leukemia.

Abstract:

:We studied wild-type FLT3 mRNA expression at diagnosis in bone marrow samples from 85 patients with acute myeloid leukemia (AML), 23 of whom were in complete remission, and determined its utility as a marker for minimal residual disease (MRD). We conclude that FLT3 expression is of limited value as a prognostic marker and for MRD monitoring.

journal_name

Haematologica

journal_title

Haematologica

authors

Kainz B,Fonatsch C,Schwarzinger I,Sperr WR,Jäger U,Gaiger A

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

695-6

issue

5

eissn

0390-6078

issn

1592-8721

journal_volume

90

pub_type

信件
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  • Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state.

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    authors: Fioritoni G,Iacone A,D'Antonio D,Dragani A,Quaglietta AM,Accorsi P,Angelini A,Spadano A,Natale D,Berardi A

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    authors: Bento MC,Chang KT,Guan Y,Liu E,Caldas G,Gatti RA,Prchal JT

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  • CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.

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